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Science 29 June 1990:
Vol. 248. no. 4963, pp. 1643 - 1646
DOI: 10.1126/science.1973003
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Articles

Science, Vol 248, Issue 4963, 1643-1646
Copyright © 1990 by American Association for the Advancement of Science

articles

Induction of neonatal tolerance to Mlsa antigens by CD8+ T cells

Webb SR and J Sprent

Department of Immunology, Research Institute of Scripps Clinic, La Jolla 92037.

Antigen-specific tolerance of T cells to minor lymphocyte stimulatory (Mls) antigens can be induced in mice by neonatal injection of foreign lymphohematopoietic cells. Although immune responses to Mlsa antigens are controlled by B cells, CD8+ T cells were the most effective cell type for induction of Mlsa tolerance. Tolerance was evident in both thymus and lymph nodes and could be induced by as few as 2 x 10(4) CD8+ T cells; these cells were 50 to 100 times as potent as CD4+ cells or B cells in causing functional tolerance and deletion of V beta 6+ T cells. Thus, intrathymic contact with antigens expressed on CD8+ T cells may play an important role in controlling the normal development of tolerance.


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