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Science 22 June 1990:
Vol. 248. no. 4962, pp. 1547 - 1550
DOI: 10.1126/science.2163110
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Articles

Science, Vol 248, Issue 4962, 1547-1550
Copyright © 1990 by American Association for the Advancement of Science

articles

beta-Arrestin: a protein that regulates beta-adrenergic receptor function

MJ Lohse, JL Benovic, J Codina, MG Caron, and RJ Lefkowitz

Howard Hughes Medical Institute, Department of Medicine, Biochemistry and Cell Biology, Durham, NC 27710.

Homologous or agonist-specific desensitization of beta-adrenergic receptors is thought to be mediated by a specific kinase, the beta-adrenergic receptor kinase (beta ARK). However, recent data suggest that a cofactor is required for this kinase to inhibit receptor function. The complementary DNA for such a cofactor was cloned and found to encode a 418-amino acid protein homologous to the retinal protein arrestin. The protein, termed beta-arrestin, was expressed and partially purified. It inhibited the signaling function of beta ARK-phosphorylated beta-adrenergic receptors by more than 75 percent, but not that of rhodopsin. It is proposed that beta-arrestin in concert with beta ARK effects homologous desensitization of beta-adrenergic receptors.


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Genetics 155, 1281-1295
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Short Term Feedback Regulation of cAMP in FRTL-5 Thyroid Cells. ROLE OF PDE4D3 PHOSPHODIESTERASE ACTIVATION.
N. Oki, S.-I. Takahashi, H. Hidaka, and M. Conti (2000)
J. Biol. Chem. 275, 10831-10837
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Arrestin Binding to the M2 Muscarinic Acetylcholine Receptor Is Precluded by an Inhibitory Element in the Third Intracellular Loop of the Receptor.
K. B. Lee, J. A. Ptasienski, R. Pals-Rylaarsdam, V. V. Gurevich, and M. M. Hosey (2000)
J. Biol. Chem. 275, 9284-9289
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Human Complement 5a (C5a) Anaphylatoxin Receptor (CD88) Phosphorylation Sites and Their Specific Role in Receptor Phosphorylation and Attenuation of G Protein-mediated Responses. DESENSITIZATION OF C5a RECEPTOR CONTROLS SUPEROXIDE PRODUCTION BUT NOT RECEPTOR SEQUESTRATION IN HL-60 CELLS.
T. Christophe, M.-J. Rabiet, M. Tardif, M.-D. Milcent, and F. Boulay (2000)
J. Biol. Chem. 275, 1656-1664
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Phosphorylation Uncouples the Gastrin-releasing Peptide Receptor from Gq.
G. S. Kroog, X. Jian, L. Chen, J. K. Northup, and J. F. Battey (1999)
J. Biol. Chem. 274, 36700-36706
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Recent Advances in Cardiac {beta}2-Adrenergic Signal Transduction.
R.-P. Xiao, H. Cheng, Y.-Y. Zhou, M. Kuschel, and E. G. Lakatta (1999)
Circ. Res. 85, 1092-1100
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Phosphorylation of Tumor Necrosis Factor Receptor CD120a (p55) by p42mapk/erk2 Induces Changes in Its Subcellular Localization.
V. Cottin, A. Van Linden, and D. W. H. Riches (1999)
J. Biol. Chem. 274, 32975-32987
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Association of beta -Arrestin with G Protein-coupled Receptors during Clathrin-mediated Endocytosis Dictates the Profile of Receptor Resensitization.
R. H. Oakley, S. A. Laporte, J. A. Holt, L. S. Barak, and M. G. Caron (1999)
J. Biol. Chem. 274, 32248-32257
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Differential Phosphorylation Paradigms Dictate Desensitization and Internalization of the N-Formyl Peptide Receptor.
D. C. Maestes, R. M. Potter, and E. R. Prossnitz (1999)
J. Biol. Chem. 274, 29791-29795
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Systemic Expression of Rat Soluble Retinal Antigen Induces Resistance to Experimental Autoimmune Uveoretinitis.
S. W. McPherson, J. P. Roberts, and D. S. Gregerson (1999)
J. Immunol. 163, 4269-4276
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beta 2-Adrenergic Receptor Down-regulation. EVIDENCE FOR A PATHWAY THAT DOES NOT REQUIRE ENDOCYTOSIS.
R. Jockers, S. Angers, A. Da Silva, P. Benaroch, A. D. Strosberg, M. Bouvier, and S. Marullo (1999)
J. Biol. Chem. 274, 28900-28908
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How the protease thrombin talks to cells.
S. R. Coughlin (1999)
PNAS 96, 11023-11027
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Regulation of beta -Adrenoceptor Signaling in Cardiac Function and Disease.
N. Dzimiri (1999)
Pharmacol. Rev. 51, 465-502
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Visualization of Agonist-induced Association and Trafficking of Green Fluorescent Protein-tagged Forms of Both beta -Arrestin-1 and the Thyrotropin-releasing Hormone Receptor-1.
D. A. Groarke, S. Wilson, C. Krasel, and G. Milligan (1999)
J. Biol. Chem. 274, 23263-23269
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{beta}-Arrestin-Related Proteins in Ocular Tissues.
C. Nicolas-Leveque, I. Ghedira, J. P. Faure, and M. Mirshahi (1999)
Invest. Ophthalmol. Vis. Sci. 40, 1812-1818
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Trafficking of Proteinase-activated Receptor-2 and beta -Arrestin-1 Tagged with Green Fluorescent Protein. beta -ARRESTIN-DEPENDENT ENDOCYTOSIS OF A PROTEINASE RECEPTOR.
O. Dery, M. S. Thoma, H. Wong, E. F. Grady, and N. W. Bunnett (1999)
J. Biol. Chem. 274, 18524-18535
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Modulation of C3a Activity: Internalization of the Human C3a Receptor and its Inhibition by C5a.
B. Settmacher, D. Bock, H. Saad, S. Gartner, C. Rheinheimer, J. Kohl, W. Bautsch, and A. Klos (1999)
J. Immunol. 162, 7409-7416
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