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Science 22 June 1990:
Vol. 248. no. 4962, p. 1473
DOI: 10.1126/science.1473-a
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Articles

Tick Anticoagulant Peptide (TAP) Is a Novel Inhibitor of Blood Coagulation Factor Xa

Lloyd Waxman 1, Donna E. Smith 1, Karen E. Arcuri 1, and George P. Vlasuk 1

1 Biological Chemistry Department, Merck Sharp & Dohme Research Laboratories, West Point, PA 19486

In the report "Tick anticoagulant peptide (TAP) is a novel inhibitor of blood coagulation factor Xa" by L. Waxman et al. (4 May, p. 593), the second sentence of the caption of figure 2 was printed incorrectly. It should have read, "Determination of the Intrinsic Ki was done by fitting the observed data (•) with nonlinear regression analysis to the ratio of inhibited velocity (vi) to uninhibited velocity (Vo) described by the equation Vi/Vo = [Et - It K*i] + [(It + K*i - Et)2 + 4KiEt]1/2/2Et derived by Morrison for tight-binding inhibition (7) (solid line), where Et and It are the total amount of enzyme and inhibitor, respectively, included in the assay."

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Science. ISSN 0036-8075 (print), 1095-9203 (online)