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Science 15 June 1990:
Vol. 248. no. 4961, pp. 1410 - 1413
DOI: 10.1126/science.2162560
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Articles
Science, Vol 248, Issue 4961, 1410-1413
Copyright © 1990 by American Association for the Advancement of Science
Fibroblast growth factor receptor is a portal of cellular entry for herpes simplex virus type 1
RJ Kaner,
A Baird,
A Mansukhani,
C Basilico,
BD Summers,
RZ Florkiewicz,
and
DP Hajjar
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Herpes simplex virus type 1 (HSV-1) is a ubiquitous pathogen responsible for considerable morbidity in the general population. The results presented herein establish the basic fibroblast growth factor (FGF) receptor as a means of entry of HSV-1 into vertebrate cells. Inhibitors of basic FGF binding to its receptor and competitive polypeptide antagonists of basic FGF prevented HSV-1 uptake. Chinese hamster ovary (CHO) cells that do not express FGF receptors are resistant to HSV-1 entry; however, HSV-1 uptake is dramatically increased in CHO cells transfected with a complementary DNA encoding a basic FGF receptor. The distribution of this integral membrane protein in vivo may explain the tissue and cell tropism of HSV-1.
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