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Science 15 June 1990:
Vol. 248. no. 4961, pp. 1380 - 1388
DOI: 10.1126/science.1972595
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Articles

Science, Vol 248, Issue 4961, 1380-1388
Copyright © 1990 by American Association for the Advancement of Science

articles

Autoimmune diseases: the failure of self tolerance

AA Sinha, MT Lopez, and HO McDevitt

Department of Microbiology and Immunology, Stanford University School of Medicine, CA 94305.

The ability to discriminate between self and nonself antigens is vital to the functioning of the immune system as a specific defense against invading microorganisms. Failure of the immune system to "tolerate" self tissues can result in pathological autoimmune states leading to debilitating illness and sometimes death. The induction of autoimmunity involves genetic and environmental factors that have focused the attention of researchers on the trimolecular complex formed by major histocompatibility complex molecules, antigen, and T cell receptors. Detailed molecular characterization of these components points to potential strategies for disease intervention.


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