Related Content
Search Google Scholar for:
|
|
Science 15 June 1990:
Vol. 248. no. 4961, pp. 1373 - 1379
DOI: 10.1126/science.2356469
|
|
Articles
Science, Vol 248, Issue 4961, 1373-1379
Copyright © 1990 by American Association for the Advancement of Science
The need for central and peripheral tolerance in the B cell repertoire
CC Goodnow,
S Adelstein,
and
A Basten
Centenary Institute for Cancer Medicine and Cell Biology, University of Sydney, New South Wales, Australia.
The immune system normally avoids producing antibodies that react with autologous ("self") antigens by censoring self-reactive T and B cells. Unlike the T cell repertoire, antibody diversity is generated within the B cell repertoire in two phases; the first occurs by gene rearrangement in primary lymphoid organs, and the second phase involves antigen-driven hypermutation in peripheral lymphoid organs. The possibility that distinct cellular mechanisms may impose self tolerance at these two different phases of B cell diversification may explain recent findings in transgenic mouse models, in which self-reactive B cells appear to be silenced both by functional inactivation and by physical elimination.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- B lymphocytes: how they develop and function.
- T. W. LeBien and T. F. Tedder (2008)
Blood
112, 1570-1580
| Abstract »
| Full Text »
| PDF »
- Short-Lived Plasmablasts Dominate the Early Spontaneous Rheumatoid Factor Response: Differentiation Pathways, Hypermutating Cell Types, and Affinity Maturation Outside the Germinal Center.
- J. William, C. Euler, and M. J. Shlomchik (2005)
J. Immunol.
174, 6879-6887
| Abstract »
| Full Text »
| PDF »
- Central nervous system mechanisms in Sjogren's syndrome.
- O P van Bijsterveld, A A Kruize, and R L A W Bleys (2003)
Br. J. Ophthalmol.
87, 128-130
| Full Text »
| PDF »
- Does CD40 Ligation Induce B Cell Negative Selection?.
- J. Martinez-Barnetche, V. Madrid-Marina, R. A. Flavell, and J. Moreno (2002)
J. Immunol.
168, 1042-1049
| Abstract »
| Full Text »
| PDF »
- Disruption of T Cell Tolerance to Self-Immunoglobulin Causes Polyclonal B Cell Stimulation Followed by Inactivation of Responding Autoreactive T Cells.
- A. Choudhury, P. Mukherjee, S. K. Basu, A. George, S. Rath, and V. Bal (2000)
J. Immunol.
164, 1713-1721
| Abstract »
| Full Text »
| PDF »
- Epitope-Specific Antibody and Suppression of Autoantibody Responses Against a Hybrid Self Protein.
- G. L. Lohnas, S. F. Roberts, A. Pilon, and A. Tramontano (1998)
J. Immunol.
161, 6518-6525
| Abstract »
| Full Text »
| PDF »
- Generation of the Germline Peripheral B Cell Repertoire: VH81X-{lambda} B Cells Are Unable to Complete All Developmental Programs.
- F. Martin, W.-J. Won, and J. F. Kearney (1998)
J. Immunol.
160, 3748-3758
| Abstract »
| Full Text »
| PDF »
- Premature Ovarian Failure and Ovarian Autoimmunity.
- A. Hoek, J. Schoemaker, and H. A. Drexhage (1997)
Endocr. Rev.
18, 107-134
| Abstract »
| Full Text »
- Peripheral deletion of rheumatoid factor B cells after abortive activation by IgG.
- H. Tighe, K. Warnatz, D. Brinson, M. Corr, W. O. Weigle, S. M. Baird, and D. A. Carson (1997)
PNAS
94, 646-651
| Abstract »
| Full Text »
| PDF »
- Sjogren's Syndrome: Immunobiology of Exocrine Gland Dysfunction.
- R.I. Fox (1996)
Advances in Dental Research
10, 35-40
| Abstract »
| PDF »
- Transactivation by AP-1 Is a Molecular Target of T Cell Clonal Anergy.
- S.-M. Kang, B. Beverly, A.-C. Tran, K. Brorson, R. H. Schwartz, and M. J. Lenardot (1992)
Science
257, 1134-1138
| Abstract »
| PDF »
- Autoimmune diseases: the failure of self tolerance.
- A. Sinha, M. Lopez, and H. McDevitt (1990)
Science
248, 1380-1388
| Abstract »
| PDF »
|
|
