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Science 15 June 1990:
Vol. 248. no. 4961, pp. 1373 - 1379
DOI: 10.1126/science.2356469
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Articles
Science, Vol 248, Issue 4961, 1373-1379
Copyright © 1990 by American Association for the Advancement of Science
The need for central and peripheral tolerance in the B cell repertoire
CC Goodnow,
S Adelstein,
and
A Basten
Centenary Institute for Cancer Medicine and Cell Biology, University of Sydney, New South Wales, Australia.
The immune system normally avoids producing antibodies that react with autologous ("self") antigens by censoring self-reactive T and B cells. Unlike the T cell repertoire, antibody diversity is generated within the B cell repertoire in two phases; the first occurs by gene rearrangement in primary lymphoid organs, and the second phase involves antigen-driven hypermutation in peripheral lymphoid organs. The possibility that distinct cellular mechanisms may impose self tolerance at these two different phases of B cell diversification may explain recent findings in transgenic mouse models, in which self-reactive B cells appear to be silenced both by functional inactivation and by physical elimination.
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