Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 15 June 1990:
Vol. 248. no. 4961, pp. 1369 - 1373
DOI: 10.1126/science.1972594
Prev | Table of Contents | Next

Articles

Science, Vol 248, Issue 4961, 1369-1373
Copyright © 1990 by American Association for the Advancement of Science

articles

Self-nonself discrimination by T cells

H von Boehmer and P Kisielow

Basel Institute for Immunology, Switzerland.

The alpha beta T cell receptor (TCR) recognizes antigens that are presented by major histocompatibility complex (MHC)-encoded cell surface molecules by binding to both the antigen and the MHC molecules. Discrimination of self from nonself antigens and MHC molecules is achieved by negative and positive selection of T cells in the thymus: potentially harmful T cells with receptors that bind to self antigens plus self MHC molecules are deleted before they can mount immune responses. In contrast, the maturation of useful T cells with receptors that bind foreign antigens plus self MHC molecules requires the binding of their receptor to MHC molecules on thymic epithelium in the absence of foreign antigen. The binding of the TCR to either class I or class II MHC molecules directs differentiation of the selected cells into either CD4-8+ (killer) or CD4+8- (helper) T cells, respectively.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The specificity of T cell regulation that enables self-nonself discrimination in the periphery.
Y. Wu, Z. Zheng, Y. Jiang, L. Chess, and H. Jiang (2009)
PNAS 106, 534-539
   Abstract »    Full Text »    PDF »
Regulation of immune responses by T cells..
H. Jiang and L. Chess (2006)
N. Engl. J. Med. 354, 1166-1176
   Full Text »    PDF »
Expression of Preproinsulin-2 Gene Shapes the Immune Response to Preproinsulin in Normal Mice.
B. Faideau, J.-P. Briand, C. Lotton, I. Tardivel, P. Halbout, J. Jami, J. F. Elliott, P. Krief, S. Muller, C. Boitard, et al. (2004)
J. Immunol. 172, 25-33
   Abstract »    Full Text »    PDF »
Transgenic models of tolerance and autoimmunity: with special reference to systemic lupus erythematosus.
C T Ravirajan and D A Isenberg (2002)
Lupus 11, 843-849
   Abstract »    PDF »
Overcoming Immune Tolerance to Cancer by Heat Shock Protein Vaccines.
B. Liu, A. M. DeFilippo, and Z. Li (2002)
Mol. Cancer Ther. 1, 1147-1151
   Abstract »    Full Text »    PDF »
Progress in cancer vaccines by enhanced self-presentation.
S. R. Riddell (2001)
PNAS 98, 8933-8935
   Full Text »    PDF »
Possible Involvement of Cyclophilin B and Caspase-Activated Deoxyribonuclease in the Induction of Chromosomal DNA Degradation in TCR-Stimulated Thymocytes.
T. Nagata, H. Kishi, Q. L. Liu, T. Yoshino, T. Matsuda, Z. X. Jin, K. Murayama, K. Tsukada, and A. Muraguchi (2000)
J. Immunol. 165, 4281-4289
   Abstract »    Full Text »    PDF »
Vigorous Allograft Rejection in the Absence of Danger.
A. W. Bingaman, J. Ha, S.-Y. Waitze, M. M. Durham, H. R. Cho, C. Tucker-Burden, R. Hendrix, S. R. Cowan, T. C. Pearson, and C. P. Larsen (2000)
J. Immunol. 164, 3065-3071
   Abstract »    Full Text »    PDF »
In Vivo CD4+ T Cell Tolerance Induction Versus Priming Is Independent of the Rate and Number of Cell Divisions.
A. J. Adler, C.-T. Huang, G. S. Yochum, D. W. Marsh, and D. M. Pardoll (2000)
J. Immunol. 164, 649-655
   Abstract »    Full Text »    PDF »
Dual MHC Class I and Class II Restriction of a Single T Cell Receptor: Distinct Modes of Tolerance Induction by Two Classes of Autoantigens.
I. Arsov and S. Vukmanovic (1999)
J. Immunol. 162, 2008-2015
   Abstract »    Full Text »    PDF »
The Molecular and Functional Characterization of a Dominant Minor H Antigen, H60.
S. Malarkannan, P. P. Shih, P. A. Eden, T. Horng, A. R. Zuberi, G. Christianson, D. Roopenian, and N. Shastri (1998)
J. Immunol. 161, 3501-3509
   Abstract »    Full Text »    PDF »
CD4+ T Cell Tolerance to Parenchymal Self-Antigens Requires Presentation by Bone Marrow-derived Antigen-presenting Cells.
A. J. Adler, D. W. Marsh, G. S. Yochum, J. L. Guzzo, A. Nigam, W. G. Nelson, and D. M. Pardoll (1998)
J. Exp. Med. 187, 1555-1564
   Abstract »    Full Text »    PDF »
Cytokine Gene Expression during Ontogeny in Murine Thymus on Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin.
Z.-W. Lai, C. Hundeiker, E. Gleichmann, and C. Esser (1997)
Mol. Pharmacol. 52, 30-37
   Abstract »    Full Text »
The Interferon-[IMAGE]-inducible 11 S Regulator (PA28) and the LMP2/LMP7 Subunits Govern the Peptide Production by the 20 S Proteasome in Vitro.
M. Groettrup, T. Ruppert, L. Kuehn, M. Seeger, S. Standera, U. Koszinowski, and P. M. Kloetzel (1995)
J. Biol. Chem. 270, 23808-23815
   Abstract »    Full Text »    PDF »
Requirement for positive selection of gamma delta receptor-bearing T cells.
F. Wells, S. Gahm, S. Hedrick, J. Bluestone, A Dent, and L. Matis (1991)
Science 253, 903-905
   Abstract »    PDF »
Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking.
L. Turka, D. Schatz, M. Oettinger, J. Chun, C Gorka, K Lee, W. McCormack, and C. Thompson (1991)
Science 253, 778-781
   Abstract »    PDF »
Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance.
F Ramsdell and B. Fowlkes (1990)
Science 248, 1342-1348
   Abstract »    PDF »
Regulatory function of in vivo anergized CD4+ T cells.
K. Jooss, B. Gjata, O. Danos, H. von Boehmer, and A. Sarukhan (2001)
PNAS 98, 8738-8743
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)