Science 15 June 1990: Vol. 248. no. 4961, pp. 1349 - 1356 DOI: 10.1126/science.2113314

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Articles

Anti-CD40 Monoclonal Antibody Synergizes with CTLA4-Ig in Promoting Long-Term Graft Survival in Murine Models of Transplantation.

C. R. Gilson, Z. Milas, S. Gangappa, D. Hollenbaugh, T. C. Pearson, M. L. Ford, and C. P. Larsen (2009)
J. Immunol. 183, 1625-1635
 |  Abstract »  |  Full Text »  |  PDF »

Activation of T Cells: Releasing the Brakes by Proteolytic Elimination of Cbl-b.

M. L. Schmitz (2009)
Science Signaling 2, pe38
 |  Abstract »  |  Full Text »  |  PDF »

PD-1-Mediated Suppression of IL-2 Production Induces CD8+ T Cell Anergy In Vivo.

S. Chikuma, S. Terawaki, T. Hayashi, R. Nabeshima, T. Yoshida, S. Shibayama, T. Okazaki, and T. Honjo (2009)
J. Immunol. 182, 6682-6689
 |  Abstract »  |  Full Text »  |  PDF »

Antigen-independent adhesion and cell spreading by inducible costimulator engagement inhibits T cell migration in a PI-3K-dependent manner.

J. L. Franko and A. D. Levine (2009)
J. Leukoc. Biol. 85, 526-538
 |  Abstract »  |  Full Text »  |  PDF »

Human Cytomegalovirus Differentially Controls B Cell and T Cell Responses through Effects on Plasmacytoid Dendritic Cells.

S. Varani, M. Cederarv, S. Feld, C. Tammik, G. Frascaroli, M. P. Landini, and C. Soderberg-Naucler (2007)
J. Immunol. 179, 7767-7776
 |  Abstract »  |  Full Text »  |  PDF »

Effective Proliferation of Human Regulatory T Cells Requires a Strong Costimulatory CD28 Signal That Cannot Be Substituted by IL-2.

A. A. Hombach, D. Kofler, A. Hombach, G. Rappl, and H. Abken (2007)
J. Immunol. 179, 7924-7931
 |  Abstract »  |  Full Text »  |  PDF »

Co-stimulation with 4-1BB ligand allows extended T-cell proliferation, synergizes with CD80/CD86 and can reactivate anergic T cells.

M. Habib-Agahi, T. T. Phan, and P. F. Searle (2007)
Int. Immunol. 19, 1383-1394
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background.

Z. Illes, H. Waldner, J. Reddy, A. C. Anderson, R. A. Sobel, and V. K. Kuchroo (2007)
Int. Immunol. 19, 1235-1248
 |  Abstract »  |  Full Text »  |  PDF »

CD4+ T Cells from Simian Immunodeficiency Virus Disease-Resistant Sooty Mangabeys Produce More IL-2 Than Cells from Disease-Susceptible Species: Involvement of p300 and CREB at the Proximal IL-2 Promoter in IL-2 Up-Regulation.

P. Bostik, E. S. Noble, S. T. Stephenson, F. Villinger, and A. A. Ansari (2007)
J. Immunol. 178, 7720-7729
 |  Abstract »  |  Full Text »  |  PDF »

Legionella pneumophila Infection Up-Regulates Dendritic Cell Toll-Like Receptor 2 (TLR2)/TLR4 Expression and Key Maturation Markers.

J. Rogers, A. Hakki, I. Perkins, C. Newton, R. Widen, N. Burdash, T. Klein, and H. Friedman (2007)
Infect. Immun. 75, 3205-3208
 |  Abstract »  |  Full Text »  |  PDF »

Aberrant Regulation of Synovial T Cell Activation by Soluble Costimulatory Molecules in Rheumatoid Arthritis.

B. Wan, H. Nie, A. Liu, G. Feng, D. He, R. Xu, Q. Zhang, C. Dong, and J. Z. Zhang (2006)
J. Immunol. 177, 8844-8850
 |  Abstract »  |  Full Text »  |  PDF »

Modulatory Role of DR4- to DQ8-restricted CD4 T-Cell Responses and Type 1 Diabetes Susceptibility.

X. Ge, J. D. Piganelli, H. M. Tse, S. Bertera, C. E. Mathews, M. Trucco, L. Wen, and W. A. Rudert (2006)
Diabetes 55, 3455-3462
 |  Abstract »  |  Full Text »  |  PDF »

Amelioration of Mercury-Induced Autoimmunity by 4-1BB.

D. S. Vinay, J. D. Kim, and B. S. Kwon (2006)
J. Immunol. 177, 5708-5717
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of T cell homing by down-regulation of CD62L and the induction of a Th-2 response as a method to prevent acute allograft rejection in mice..

C. Stremmel, W. Sienel, S. Eggeling, B. Passlick, and A. Slavin (2006)
Eur. J. Cardiothorac. Surg. 30, 362-369
 |  Abstract »  |  Full Text »  |  PDF »

Ligation of CD28 by Its Natural Ligand CD86 in the Absence of TCR Stimulation Induces Lipid Raft Polarization in Human CD4 T Cells.

B. Kovacs, R. V. Parry, Z. Ma, E. Fan, D. K. Shivers, B. A. Freiberg, A. K. Thomas, R. Rutherford, C. A. Rumbley, J. L. Riley, et al. (2005)
J. Immunol. 175, 7848-7854
 |  Abstract »  |  Full Text »  |  PDF »

Autoimmunity Correlates With Tumor Regression in Patients With Metastatic Melanoma Treated With Anti-Cytotoxic T-Lymphocyte Antigen-4.

P. Attia, G. Q. Phan, A. V. Maker, M. R. Robinson, M. M. Quezado, J. C. Yang, R. M. Sherry, S. L. Topalian, U. S. Kammula, R. E. Royal, et al. (2005)
J. Clin. Oncol. 23, 6043-6053
 |  Abstract »  |  Full Text »  |  PDF »

Both Dendritic Cells and Macrophages Can Stimulate Naive CD8 T Cells In Vivo to Proliferate, Develop Effector Function, and Differentiate into Memory Cells.

L.-A. M. Pozzi, J. W. Maciaszek, and K. L. Rock (2005)
J. Immunol. 175, 2071-2081
 |  Abstract »  |  Full Text »  |  PDF »

T Cell Tolerance Induced by Cross-Reactive TCR Ligands Can Be Broken by Superagonist Resulting in Anti-Inflammatory T Cell Cytokine Production.

Z. Illes, H. Waldner, J. Reddy, E. Bettelli, L. B. Nicholson, and V. K. Kuchroo (2005)
J. Immunol. 175, 1491-1497
 |  Abstract »  |  Full Text »  |  PDF »

The Influence of the Major Histocompatibility Complex on Development of Autoimmune Diabetes in RIP-B7.1 Mice.

F. S. Wong, W. Du, I. J. Thomas, and L. Wen (2005)
Diabetes 54, 2032-2040
 |  Abstract »  |  Full Text »  |  PDF »

Plasticity in the positive selection of T cells: affinity of the selecting antigen and IL-7 affect T cell responsiveness.

R. L. Rubin and T. M. Hermanson (2005)
Int. Immunol. 17, 959-971
 |  Abstract »  |  Full Text »  |  PDF »

BAT mAb induces lymphopoiesis in nude mice.

B. Hardy, Y. Niv, L. Fadaeev, and A. Raiter (2005)
Int. Immunol. 17, 615-619
 |  Abstract »  |  Full Text »  |  PDF »

Down-regulation of normal human T cell blast activation: roles of APO2L/TRAIL, FasL, and c- FLIP, Bim, or Bcl-x isoform expression.

A. Bosque, J. Pardo, M{a} J. Martinez-Lorenzo, M. Iturralde, I. Marzo, A. Pineiro, M{a} A. Alava, J. Naval, and A. Anel (2005)
J. Leukoc. Biol. 77, 568-578
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Intercellular Adhesion Molecule-1/LFA-1 Interactions in the Generation of Tumor-Specific CD8+ T Cell Responses.

S. R. Jenkinson, N. A. Williams, and D. J. Morgan (2005)
J. Immunol. 174, 3401-3407
 |  Abstract »  |  Full Text »  |  PDF »

Transplantation Tolerance in NF-{kappa}B-Impaired Mice Is Not Due to Regulation but Is Prevented by Transgenic Expression of Bcl-xL.

P. Zhou, S. J. Balin, M. Mashayekhi, K. W. Hwang, D. A. Palucki, and M.-L. Alegre (2005)
J. Immunol. 174, 3447-3453
 |  Abstract »  |  Full Text »  |  PDF »

Influence of CD80, Interleukin-2, and Interleukin-7 Expression in Human Renal Cell Carcinoma on the Expansion, Function, and Survival of Tumor-Specific CTLs.

B. Frankenberger, H. Pohla, E. Noessner, G. Willimsky, B. Papier, A. Pezzutto, J. Kopp, R. Oberneder, T. Blankenstein, and D. J. Schendel (2005)
Clin. Cancer Res. 11, 1733-1742
 |  Abstract »  |  Full Text »  |  PDF »

Indefinite Survival of Neonatal Porcine Islet Xenografts by Simultaneous Targeting of LFA-1 and CD154 or CD45RB.

G. R. Rayat and R. G. Gill (2005)
Diabetes 54, 443-451
 |  Abstract »  |  Full Text »  |  PDF »

Differential Control of CD28-Regulated In Vivo Immunity by the E3 Ligase Cbl-b.

C. M. Krawczyk, R. G. Jones, A. Atfield, K. Bachmaier, S. Arya, B. Odermatt, P. S. Ohashi, and J. M. Penninger (2005)
J. Immunol. 174, 1472-1478
 |  Abstract »  |  Full Text »  |  PDF »

Role of CD28 in Polyclonal and Specific T and B Cell Responses Required for Protection against Blood Stage Malaria.

R. M. Elias, L. R. Sardinha, K. R. B. Bastos, C. A. Zago, A. P. F. da Silva, J. M. Alvarez, and M. R. D. Lima (2005)
J. Immunol. 174, 790-799
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 Overcomes the Unresponsiveness but Fails to Reverse the Regulatory Function of Antigen-Induced T Regulatory Cells.

P. O. Anderson, A. Sundstedt, Z. Yazici, S. Minaee, R. Woolf, K. Nicolson, N. Whitley, L. Li, S. Li, D. C. Wraith, et al. (2005)
J. Immunol. 174, 310-319
 |  Abstract »  |  Full Text »  |  PDF »

CD63 as an Activation-Linked T Cell Costimulatory Element.

K. Pfistershammer, O. Majdic, J. Stockl, G. Zlabinger, S. Kirchberger, P. Steinberger, and W. Knapp (2004)
J. Immunol. 173, 6000-6008
 |  Abstract »  |  Full Text »  |  PDF »

Adoptive Transfer of Paternal Antigen-Hyporesponsive T Cells Induces Maternal Tolerance to the Allogeneic Fetus in Abortion-Prone Matings.

L.-P. Jin, D.-J. Li, J.-P. Zhang, M.-Y. Wang, X.-Y. Zhu, Y. Zhu, Y. Meng, and M.-M. Yuan (2004)
J. Immunol. 173, 3612-3619
 |  Abstract »  |  Full Text »  |  PDF »

Complement Activation Regulates the Capacity of Proximal Tubular Epithelial Cell to Stimulate Alloreactive T Cell Response.

K. Li, H. Patel, C. A. Farrar, R. E.G. Hargreaves, S. H. Sacks, and W. Zhou (2004)
J. Am. Soc. Nephrol. 15, 2414-2422
 |  Abstract »  |  Full Text »  |  PDF »

Naive T Cells Are Resistant to Anergy Induction by Anti-CD3 Antibodies.

F. Andris, S. Denanglaire, F. de Mattia, J. Urbain, and O. Leo (2004)
J. Immunol. 173, 3201-3208
 |  Abstract »  |  Full Text »  |  PDF »

Selective Cytoplasmic Translocation of HuR and Site-specific Binding to the Interleukin-2 mRNA Are Not Sufficient for CD28-mediated Stabilization of the mRNA.

Y. Seko, H. Azmi, R. Fariss, and J. A. Ragheb (2004)
J. Biol. Chem. 279, 33359-33367
 |  Abstract »  |  Full Text »  |  PDF »

Cyclic AMP Modulates the Functional Plasticity of Immature Dendritic Cells by Inhibiting Src-like Kinases through Protein Kinase A-mediated Signaling.

M. Galgani, V. De Rosa, S. De Simone, A. Leonardi, U. D'Oro, G. Napolitani, A. M. Masci, S. Zappacosta, and L. Racioppi (2004)
J. Biol. Chem. 279, 32507-32514
 |  Abstract »  |  Full Text »  |  PDF »

Association of rapamycin and co-stimulation blockade using anti-B7 antibodies in renal allotransplantation in baboons.

G. Boulday, J. Ashton-Chess, P. Bernard, G. Karam, H. Vie, A. Moreau, D. Minault, K. Lorre, J.-P. Soulillou, and G. Blancho (2004)
Nephrol. Dial. Transplant. 19, 1752-1760
 |  Abstract »  |  Full Text »  |  PDF »

Different Costimulatory and Growth Factor Requirements for CD4+ and CD8+ T Cell-Mediated Rejection.

M. D. Vu, F. Amanullah, Y. Li, G. Demirci, M. H. Sayegh, and X. C. Li (2004)
J. Immunol. 173, 214-221
 |  Abstract »  |  Full Text »  |  PDF »

Artificial antigen-presenting constructs efficiently stimulate minor histocompatibility antigen-specific cytotoxic T lymphocytes.

L. E. M. Oosten, E. Blokland, A. G. S. van Halteren, J. Curtsinger, M. F. Mescher, J. H. F. Falkenburg, T. Mutis, and E. Goulmy (2004)
Blood 104, 224-226
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for Donor and Recipient CD40 Expression in Cardiac Allograft Rejection: Induction of Th1 Responses and Influence of Donor-Derived Dendritic Cells.

M. J. Nathan, J. E. Mold, S. C. Wood, K. Csencsits, G. Lu, E. J. Eichwald, and D. K. Bishop (2004)
J. Immunol. 172, 6626-6633
 |  Abstract »  |  Full Text »  |  PDF »

CD4-CD8 and CD28 Expression in T Cells Infiltrating the Vitreous Fluid in Patients With Proliferative Diabetic Retinopathy: A Flow Cytometric Analysis.

A. Canton, E. M. Martinez-Caceres, C. Hernandez, C. Espejo, J. Garcia-Arumi, and R. Simo (2004)
Arch Ophthalmol 122, 743-749
 |  Abstract »  |  Full Text »  |  PDF »

Up-regulation of IL-4 production by the activated cAMP/cAMP-dependent protein kinase (protein kinase A) pathway in CD3/CD28-stimulated naive T cells.

K. Tokoyoda, K. Tsujikawa, H. Matsushita, Y. Ono, T. Hayashi, Y. Harada, R. Abe, M. Kubo, and H. Yamamoto (2004)
Int. Immunol. 16, 643-653
 |  Abstract »  |  Full Text »  |  PDF »

Cathepsin-Dependent Apoptosis Triggered by Supraoptimal Activation of T Lymphocytes: A Possible Mechanism of High Dose Tolerance.

M.-C. Michallet, F. Saltel, M. Flacher, J.-P. Revillard, and L. Genestier (2004)
J. Immunol. 172, 5405-5414
 |  Abstract »  |  Full Text »  |  PDF »

A deficiency of CD4+ CD25+ T cells permits the development of spontaneous lupus-like disease in mice, and can be reversed by induction of mucosal tolerance to histone peptide autoantigen.

H Y Wu and N A Staines (2004)
Lupus 13, 192-200
 |  Abstract »  |  PDF »

Bcl-3 and NF{kappa}B p50-p50 Homodimers Act as Transcriptional Repressors in Tolerant CD4+ T Cells.

S. Grundstrom, P. Anderson, P. Scheipers, and A. Sundstedt (2004)
J. Biol. Chem. 279, 8460-8468
 |  Abstract »  |  Full Text »  |  PDF »

Dependency of Direct Pathway CD4+ T Cells on CD40-CD154 Costimulation Is Determined by Nature and Microenvironment of Primary Contact with Alloantigen.

A. van Maurik, B. F. de St. Groth, K. J. Wood, and N. D. Jones (2004)
J. Immunol. 172, 2163-2170
 |  Abstract »  |  Full Text »  |  PDF »

B7 Expression on T Cells Down-Regulates Immune Responses through CTLA-4 Ligation via R-T Interactions.

P. A. Taylor, C. J. Lees, S. Fournier, J. P. Allison, A. H. Sharpe, and B. R. Blazar (2004)
J. Immunol. 172, 34-39
 |  Abstract »  |  Full Text »  |  PDF »

Human Cytomegalovirus Inhibits Differentiation of Monocytes into Dendritic Cells with the Consequence of Depressed Immunological Functions.

S. Gredmark and C. Soderberg-Naucler (2003)
J. Virol. 77, 10943-10956
 |  Abstract »  |  Full Text »  |  PDF »

T Cell Costimulatory Molecule Function Determines Susceptibility to Infection with Pneumocystis carinii in Mice.

J. M. Beck, M. B. Blackmon, C. M. Rose, S. L. Kimzey, A. M. Preston, and J. M. Green (2003)
J. Immunol. 171, 1969-1977
 |  Abstract »  |  Full Text »  |  PDF »

Rat Corneal Allograft Survival Prolonged by the Superantigen Staphylococcal Enterotoxin B.

Z. Pan, Y. Chen, W. Zhang, Y. Jie, N. Li, and Y. Wu (2003)
Invest. Ophthalmol. Vis. Sci. 44, 3346-3351
 |  Abstract »  |  Full Text »  |  PDF »

Protection of Mice against Philadelphia Chromosome-positive Acute Lymphoblastic Leukemia by Cell-based Vaccination Using Nonviral, Minimalistic Expression Vectors and Immunomodulatory Oligonucleotides.

J. Kochling, S. A. Konig-Merediz, R. Stripecke, D. Buchwald, A. Korte, H. G. von Einsiedel, F. Sack, G. Henze, K. Seeger, B. Wittig, et al. (2003)
Clin. Cancer Res. 9, 3142-3149
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Polyclonal T Cell Responses by an MHC Anchor-Substituted Variant of Myelin Oligodendrocyte Glycoprotein 35-55.

M. L. Ford and B. D. Evavold (2003)
J. Immunol. 171, 1247-1254
 |  Abstract »  |  Full Text »  |  PDF »

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma.

G. Q. Phan, J. C. Yang, R. M. Sherry, P. Hwu, S. L. Topalian, D. J. Schwartzentruber, N. P. Restifo, L. R. Haworth, C. A. Seipp, L. J. Freezer, et al. (2003)
PNAS 100, 8372-8377
 |  Abstract »  |  Full Text »  |  PDF »

Thy-1 Signaling in the Context of Costimulation Provided by Dendritic Cells Provides Signal 1 for T Cell Proliferation and Cytotoxic Effector Molecule Expression, but Fails to Trigger Delivery of the Lethal Hit.

S. M. M. Haeryfar, M. M. Al-alwan, J. S. Mader, G. Rowden, K. A. West, and D. W. Hoskin (2003)
J. Immunol. 171, 69-77
 |  Abstract »  |  Full Text »  |  PDF »

Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Renders Influenza Virus-Specific CD8+ T Cells Hyporesponsive to Antigen.

K. A. Mitchell and B. P. Lawrence (2003)
Toxicol. Sci. 74, 74-84
 |  Abstract »  |  Full Text »  |  PDF »

Topological Requirements and Signaling Properties of T Cell-activating, Anti-CD28 Antibody Superagonists.

F. Luhder, Y. Huang, K. M. Dennehy, C. Guntermann, I. Muller, E. Winkler, T. Kerkau, S. Ikemizu, S. J. Davis, T. Hanke, et al. (2003)
J. Exp. Med. 197, 955-966
 |  Abstract »  |  Full Text »  |  PDF »

CD4+ T Cells Pass Through an Effector Phase During the Process of In Vivo Tolerance Induction.

C.-T. Huang, D. L. Huso, Z. Lu, T. Wang, G. Zhou, E. P. Kennedy, C. G. Drake, D. J. Morgan, L. A. Sherman, A. D. Higgins, et al. (2003)
J. Immunol. 170, 3945-3953
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of T Cell Activation and Tolerance by Phospholipase C{gamma}-1-Dependent Integrin Avidity Modulation.

A. D. Wells, Q.-H. Liu, B. Hondowicz, J. Zhang, L. A. Turka, and B. D. Freedman (2003)
J. Immunol. 170, 4127-4133
 |  Abstract »  |  Full Text »  |  PDF »

Vav-1 and the IKK{alpha} Subunit of I{kappa}B Kinase Functionally Associate to Induce NF-{kappa}B Activation in Response to CD28 Engagement.

E. Piccolella, F. Spadaro, C. Ramoni, B. Marinari, A. Costanzo, M. Levrero, L. Thomson, R. T. Abraham, and L. Tuosto (2003)
J. Immunol. 170, 2895-2903
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of CD40-Mediated Signaling Is Sufficient for Inducing Islet But Not Skin Transplantation Tolerance.

N. E. Phillips, T. G. Markees, J. P. Mordes, D. L. Greiner, and A. A. Rossini (2003)
J. Immunol. 170, 3015-3023
 |  Abstract »  |  Full Text »  |  PDF »

Clinical advances in therapies targeting the interleukin-2 receptor.

A.C. Church (2003)
QJM 96, 91-102
 |  Full Text »  |  PDF »

Transfer of TCR Genes into Mature T Cells Is Accompanied by the Maintenance of Parental T Cell Avidity.

M. P. Rubinstein, A. N. Kadima, M. L. Salem, C. L. Nguyen, W. E. Gillanders, M. I. Nishimura, and D. J. Cole (2003)
J. Immunol. 170, 1209-1217
 |  Abstract »  |  Full Text »  |  PDF »

Normal Tissue Depresses While Tumor Tissue Enhances Human T Cell Responses In Vivo to a Novel Self/Tumor Melanoma Antigen, OA1.

C. E. Touloukian, W. W. Leitner, R. E. Schnur, P. F. Robbins, Y. Li, S. Southwood, A. Sette, S. A. Rosenberg, and N. P. Restifo (2003)
J. Immunol. 170, 1579-1585
 |  Abstract »  |  Full Text »  |  PDF »

CD28 Costimulation Is Required for In Vivo Induction of Peripheral Tolerance in CD8 T Cells.

M. S. Vacchio and R. J. Hodes (2003)
J. Exp. Med. 197, 19-26
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Programmed Death 1 Ligands by Murine T Cells and APC.

T. Yamazaki, H. Akiba, H. Iwai, H. Matsuda, M. Aoki, Y. Tanno, T. Shin, H. Tsuchiya, D. M. Pardoll, K. Okumura, et al. (2002)
J. Immunol. 169, 5538-5545
 |  Abstract »  |  Full Text »  |  PDF »

Chimeric Co-stimulatory Molecules That Selectively Act through CD28 or CTLA-4 on Human T Cells.

S. Lazetic, S. R. Leong, J. C-C. Chang, R. Ong, G. Dawes, and J. Punnonen (2002)
J. Biol. Chem. 277, 38660-38668
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Costimulation Pathway Via the 4C8 Antigen for the Induction of CD4+ Regulatory T Cells.

J.-i. Masuyama, S. Kaga, S. Kano, and S. Minota (2002)
J. Immunol. 169, 3710-3716
 |  Abstract »  |  Full Text »  |  PDF »

The Poststimulation Program of CD4 Versus CD8 T Cells (Death Versus Activation-Induced Nonresponsiveness).

E. L. Tham and M. F. Mescher (2002)
J. Immunol. 169, 1822-1828
 |  Abstract »  |  Full Text »  |  PDF »

Cancer Vaccines.

I. Espinoza-Delgado (2002)
Oncologist 7, 20-33
 |  Abstract »  |  Full Text »  |  PDF »

Renal Tubular Epithelial Expression of the Costimulatory Molecule B7RP-1 (Inducible Costimulator Ligand).

P. Wahl, R. Schoop, G. Bilic, J. Neuweiler, M. Le Hir, S. K. Yoshinaga, and R. P. Wuthrich (2002)
J. Am. Soc. Nephrol. 13, 1517-1526
 |  Abstract »  |  Full Text »  |  PDF »

Tolerance induction of alloreactive T cells via ex vivo blockade of the CD40:CD40L costimulatory pathway results in the generation of a potent immune regulatory cell.

P. A. Taylor, T. M. Friedman, R. Korngold, R. J. Noelle, and B. R. Blazar (2002)
Blood 99, 4601-4609
 |  Abstract »  |  Full Text »  |  PDF »

Antigen challenge leads to in vivo activation and elimination of highly polarized TH1 memory T cells.

N. Hayashi, D. Liu, B. Min, S. Z. Ben-Sasson, and W. E. Paul (2002)
PNAS 99, 6187-6191
 |  Abstract »  |  Full Text »  |  PDF »

Abnormal Priming of CD4+ T Cells by Dendritic Cells Expressing Hepatitis C Virus Core and E1 Proteins.

P. Sarobe, J. J. Lasarte, N. Casares, A. Lopez-Diaz de Cerio, E. Baixeras, P. Labarga, N. Garcia, F. Borras-Cuesta, and J. Prieto (2002)
J. Virol. 76, 5062-5070
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanisms Underlying Differential Contribution of CD28 Versus Non-CD28 Costimulatory Molecules to IL-2 Promoter Activation.

X.-Y. Zhou, Y. Yashiro-Ohtani, M. Nakahira, W. R. Park, R. Abe, T. Hamaoka, M. Naramura, H. Gu, and H. Fujiwara (2002)
J. Immunol. 168, 3847-3854
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Administration of CTLA4-Ig as Protein or cDNA on Corneal Allograft Survival.

R. M. Comer, W. J. King, N. Ardjomand, S. Theoharis, A. J. T. George, and D. F. P. Larkin (2002)
Invest. Ophthalmol. Vis. Sci. 43, 1095-1103
 |  Abstract »  |  Full Text »  |  PDF »

CD40-expressing Carcinoma Cells Induce Down-Regulation of CD40 Ligand (CD154) and Impair T-Cell Functions.

R. Batrla, M. Linnebacher, W. Rudy, S. Stumm, D. Wallwiener, and B. Guckel (2002)
Cancer Res. 62, 2052-2057
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance.

L. T. Nguyen, A. R. Elford, K. Murakami, K. M. Garza, S. P. Schoenberger, B. Odermatt, D. E. Speiser, and P. S. Ohashi (2002)
J. Exp. Med. 195, 423-435
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Peripheral Tolerance to a Nuclear Autoantigen: Dendritic Cells Expressing a Nuclear Autoantigen Lead to Persistent Anergic State of CD4+ Autoreactive T Cells After Proliferation.

K. Kawahata, Y. Misaki, M. Yamauchi, S. Tsunekawa, K. Setoguchi, J.-i. Miyazaki, and K. Yamamoto (2002)
J. Immunol. 168, 1103-1112
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Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?.

R. K. Burt, S. Slavin, W. H. Burns, and A. M. Marmont (2002)
Blood 99, 768-784
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CTLA4-IgG Reverses Asthma Manifestations in a Mild but Not in a More ""Severe"" Ongoing Murine Model.

D. T. Deurloo, B. C.A.M. van Esch, C. L. Hofstra, F. P. Nijkamp, and A. J.M. van Oosterhout (2001)
Am. J. Respir. Cell Mol. Biol. 25, 751-760
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Norepinephrine and beta 2-Adrenergic Receptor Stimulation Regulate CD4+ T and B Lymphocyte Function in Vitro and in Vivo.

A. P. Kohm and V. M. Sanders (2001)
Pharmacol. Rev. 53, 487-525
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Differential Role of CD80 and CD86 Molecules in the Induction and the Effector Phases of Allergic Rhinitis in Mice.

M. OKANO, M. AZUMA, T. YOSHINO, H. HATTORI, M. NAKADA, A. R. SATOSKAR, D. A. HARN Jr, E. NAKAYAMA, T. AKAGI, and K. NISHIZAKI (2001)
Am. J. Respir. Crit. Care Med. 164, 1501-1507
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Role of CD47 in the Induction of Human Naive T Cell Anergy.

M.-N. Avice, M. Rubio, M. Sergerie, G. Delespesse, and M. Sarfati (2001)
J. Immunol. 167, 2459-2468
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Longevity of Antigen Presentation and Activation Status of APC Are Decisive Factors in the Balance Between CTL Immunity Versus Tolerance.

A. Th. den Boer, L. Diehl, G. J. D. van Mierlo, E. I. H. van der Voort, M. F. Fransen, P. Krimpenfort, C. J. M. Melief, R. Offringa, and R. E. M. Toes (2001)
J. Immunol. 167, 2522-2528
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Signaling Alterations in Activation-Induced Nonresponsive CD8 T Cells.

E. L. Tham and M. F. Mescher (2001)
J. Immunol. 167, 2040-2048
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Rejection of Mouse Cardiac Allografts by Costimulation in trans.

D. A. Mandelbrot23, K. Kishimoto, H. Auchincloss Jr., A. H. Sharpe, and M. H. Sayegh (2001)
J. Immunol. 167, 1174-1178
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The Art of the Probable: System Control in the Adaptive Immune System.

R. N. Germain (2001)
Science 293, 240-245
 |  Abstract »  |  Full Text »

Cd4+Cd25+ Immune Regulatory Cells Are Required for Induction of Tolerance to Alloantigen via Costimulatory Blockade.

P. A. Taylor, R. J. Noelle, and B. R. Blazar (2001)
J. Exp. Med. 193, 1311-1318
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Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood.

D. Dieckmann, H. Plottner, S. Berchtold, T. Berger, and G. Schuler (2001)
J. Exp. Med. 193, 1303-1310
 |  Abstract »  |  Full Text »  |  PDF »

T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3.

N. A. Glavas, C. Ostenson, J. B. Schaefer, V. Vasta, and J. A. Beavo (2001)
PNAS 98, 6319-6324
 |  Abstract »  |  Full Text »  |  PDF »

CD28 and CTLA4 Coordinately Regulate Airway Inflammatory Cell Recruitment and T-Helper Cell Differentiation after Inhaled Allergen.

J. S. Burr, S. L. Kimzey, D. R. Randolph, and J. M. Green (2001)
Am. J. Respir. Cell Mol. Biol. 24, 563-568
 |  Abstract »  |  Full Text »

Glandular and extraglandular expression of costimulatory molecules in patients with Sjogren's syndrome.

R Matsumura, K Umemiya, T Goto, T Nakazawa, M Kagami, H Tomioka, E Tanabe, T Sugiyama, and M Sueishi (2001)
Ann Rheum Dis 60, 473-482
 |  Abstract »  |  Full Text »  |  PDF »

Multiple co-stimulatory signals are required for triggering proliferation of T cells from human secondary lymphoid tissue.

S. G. Agrawal, J. Marquet, J. Plumas, H. Rouard, M.-H. Delfau-Larue, P. Gaulard, L. Boumsell, F. Reyes, A. Bensussan, and J.-P. Farcet (2001)
Int. Immunol. 13, 441-450
 |  Abstract »  |  Full Text »  |  PDF »

Molecular motors involved in T cell receptor clusterings.

C. Krawczyk and J. M. Penninger (2001)
J. Leukoc. Biol. 69, 317-330
 |  Abstract »  |  Full Text »

Prolonged Islet Graft Survival in NOD Mice by Blockade of the CD40-CD154 Pathway of T-Cell Costimulation.

R. D. Molano, T. Berney, H. Li, P. Cattan, A. Pileggi, C. Vizzardelli, N. S. Kenyon, C. Ricordi, L. C. Burkly, and L. Inverardi (2001)
Diabetes 50, 270-276
 |  Abstract »  |  Full Text »

Allogeneic chimerism with low-dose irradiation, antigen presensitization, and costimulator blockade in H-2 mismatched mice.

P. J. Quesenberry, S. Zhong, H. Wang, and M. Stewart (2001)
Blood 97, 557-564
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: The Related Molecules CD28 and Inducible Costimulator Deliver Both Unique and Complementary Signals Required for Optimal T Cell Activation.

J.-A. Gonzalo, T. Delaney, J. Corcoran, A. Goodearl, J. C. Gutierrez-Ramos, and A. J. Coyle (2001)
J. Immunol. 166, 1-5
 |  Abstract »  |  Full Text »  |  PDF »

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