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Science 15 June 1990:
Vol. 248. no. 4961, pp. 1342 - 1348
DOI: 10.1126/science.1972593
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Articles

Science, Vol 248, Issue 4961, 1342-1348
Copyright © 1990 by American Association for the Advancement of Science

articles

Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance

F Ramsdell and BJ Fowlkes

Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

During development in the thymus, T cells are rendered tolerant to self antigens. It is now apparent that thymocytes bearing self-reactive T cell receptors can be tolerized by processes that result in physical elimination (clonal deletion) or functional inactivation (clonal anergy). As these mechanisms have important clinical implications for transplantation and autoimmunity, current investigations are focused on understanding the cellular and molecular interactions that generate these forms of tolerance.


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