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Science 8 June 1990:
Vol. 248. no. 4960, pp. 1234 - 1237
DOI: 10.1126/science.2190315
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Articles

Science, Vol 248, Issue 4960, 1234-1237
Copyright © 1990 by American Association for the Advancement of Science

articles

Induction of CD4+ human cytolytic T cells specific for HIV-infected cells by a gp160 subunit vaccine

RJ Orentas, JE Hildreth, E Obah, M Polydefkis, GE Smith, ML Clements, and RF Siliciano

Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Cytolytic T lymphocyte (CTL) responses were evaluated in humans immunized with recombinant human immunodeficiency virus type 1 (HIV) envelope glycoprotein gp160. Some vaccinees had gp160-specific CTLs that were shown by cloning to be CD4+. Although induced by exogenous antigen, most gp160-specific CTL clones also recognized gp160 synthesized endogenously in target cells. These clones lysed autologous CD4+ T lymphoblasts infected with HIV. Of particular interest were certain vaccine-induced clones that lysed HIV-infected cells, recognized gp160 from diverse HIV isolates, and did not participate in "innocent bystander" killing of noninfected CD4+ T cells that had bound gp120.


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