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Science 8 June 1990:
Vol. 248. no. 4960, pp. 1230 - 1234
DOI: 10.1126/science.2161559

Articles

Science, Vol 248, Issue 4960, 1230-1234
Copyright © 1990 by American Association for the Advancement of Science


articles

Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI

KW Moore, P Vieira, DF Fiorentino, ML Trounstine, TA Khan, and TR Mosmann

Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.

Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.


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