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Science 8 June 1990: Vol. 248. no. 4960, pp. 1230 - 1234 DOI: 10.1126/science.2161559
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Articles
Science, Vol 248, Issue 4960, 1230-1234
Copyright © 1990 by American Association for the Advancement of Science
Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI
KW Moore,
P Vieira,
DF Fiorentino,
ML Trounstine,
TA Khan,
and
TR Mosmann
Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304.
Complementary DNA clones encoding mouse cytokine synthesis inhibitory factor (CSIF; interleukin-10), which inhibits cytokine synthesis by TH1 helper T cells, were isolated and expressed. The predicted protein sequence shows extensive homology with an uncharacterized open reading frame, BCRFI, in the Epstein-Barr virus genome, suggesting the possibility that this herpes virus exploits the biological activity of a captured cytokine gene to enhance its survival in the host.
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