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Science 8 June 1990:
Vol. 248. no. 4960, pp. 1227 - 1230
DOI: 10.1126/science.2112266

Articles

Science, Vol 248, Issue 4960, 1227-1230
Copyright © 1990 by American Association for the Advancement of Science


articles

Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells

BH Koller, P Marrack, JW Kappler, and O Smithies

Department of Pathology, University of North Carolina, Chapel Hill 27599-7525.

Major histocompatibility class I proteins display viral and self antigens to potentially responsive cells and are important for the maturation of T cells; beta 2-microglobulin (beta 2M) is required for their normal expression. Mouse chimeras derived from embryonic stem cells with a disrupted beta 2M gene transmitted the inactivated gene to their progeny. Animals homozygous for the mutated beta 2M gene were obtained at expected frequencies after further breeding. The homozygotes appeared normal, although no class I antigens could be detected on their cells and the animals are grossly deficient in CD4- CD8+ T cells, which normally mediate cytotoxic T cell function.


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J. Virol. 74, 9083-9089
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Premature Expression of T Cell Receptor (TCR){alpha}{beta} Suppresses TCR{gamma}{delta} Gene Rearrangement but Permits Development of {gamma}{delta} Lineage T Cells.
K. Terrence, C. P. Pavlovich, E. O. Matechak, and B.J. Fowlkes (2000)
J. Exp. Med. 192, 537-548
   Abstract »    Full Text »    PDF »
Response of Murine {gamma}{delta} T Cells to the Synthetic Polypeptide Poly-Glu50Tyr50 1.
C. T. Cady, M. Lahn, M. Vollmer, M. Tsuji, S. J. Seo, C. L. Reardon, R. L. O'Brien, and W. K. Born (2000)
J. Immunol. 165, 1790-1798
   Abstract »    Full Text »    PDF »
{alpha}{beta}TCR+ Cells Are a Minimal Fraction of Peripheral CD8+ Pool in MHC Class I-Deficient Mice.
D. Nesic, F. R. Santori, and S. Vukmanovic (2000)
J. Immunol. 165, 1896-1901
   Abstract »    Full Text »    PDF »
Programming for cytotoxic effector function occurs concomitantly with CD4 extinction during CD8+ T cell differentiation in the thymus.
A. Bhandoola, B. Kithiganahalli, L. Granger, and A. Singer (2000)
Int. Immunol. 12, 1035-1040
   Abstract »    Full Text »    PDF »
Relative contributions of distinct MHC class I-dependent cell populations in protection to tuberculosis infection in mice.
A. O. Sousa, R. J. Mazzaccaro, R. G. Russell, F. K. Lee, O. C. Turner, S. Hong, L. Van Kaer, and B. R. Bloom (2000)
PNAS 97, 4204-4208
   Abstract »    Full Text »    PDF »
Positive Selection Is Limited by Available Peptide-Dependent MHC Conformations.
H. E. Stefanski, S. C. Jameson, and K. A. Hogquist (2000)
J. Immunol. 164, 3519-3526
   Abstract »    Full Text »    PDF »
Crucial Role of TNF-{alpha} in CD8 T Cell-Mediated Elimination of 3LL-A9 Lewis Lung Carcinoma Cells In Vivo.
A. Prevost-Blondel, E. Roth, F. M. Rosenthal, and H. Pircher (2000)
J. Immunol. 164, 3645-3651
   Abstract »    Full Text »    PDF »
Recombinant Adeno-Associated Virus Expressing Human Papillomavirus Type 16 E7 Peptide DNA Fused with Heat Shock Protein DNA as a Potential Vaccine for Cervical Cancer.
D.-W. Liu, Y.-P. Tsao, J. T. Kung, Y.-A. Ding, H.-K. Sytwu, X. Xiao, and S.-L. Chen (2000)
J. Virol. 74, 2888-2894
   Abstract »    Full Text »
Recognition of a Sequestered Self Peptide by Influenza Virus-Specific CD8+ Cytolytic T Lymphocytes.
R. Fan, S. S. Tykodi, and T. J. Braciale (2000)
J. Immunol. 164, 1669-1680
   Abstract »    Full Text »    PDF »
Annexin V Binds to Viable B Cells and Colocalizes with a Marker of Lipid Rafts upon B Cell Receptor Activation.
S. R. Dillon, M. Mancini, A. Rosen, and M. S. Schlissel (2000)
J. Immunol. 164, 1322-1332
   Abstract »    Full Text »    PDF »
Tetracycline-controllable Selection of CD4+ T Cells: Half-Life and Survival Signals in the Absence of Major Histocompatibility Complex Class II Molecules.
D. Witherden, N. van Oers, C. Waltzinger, A. Weiss, C. Benoist, and D. Mathis (2000)
J. Exp. Med. 191, 355-364
   Abstract »    Full Text »    PDF »
Comparative Contribution of CD1 on the Development of CD4+ and CD8+ T Cell Compartments.
B. Wang, T. Chun, and C.-R. Wang (2000)
J. Immunol. 164, 739-745
   Abstract »    Full Text »    PDF »
Thymocyte Maturation Is Regulated by the Activity of the Helix-Loop-Helix Protein, E47.
G. Bain, M. W. Quong, R. S. Soloff, S. M. Hedrick, and C. Murre (1999)
J. Exp. Med. 190, 1605-1616
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Regulation of Lineage Commitment Distinct from Positive Selection.
R. Keefe, V. Dave, D. Allman, D. Wiest, and D. J. Kappes (1999)
Science 286, 1149-1153
   Abstract »    Full Text »
Expression of the Bcl-2 family member A1 is developmentally regulated in T cells.
M. M. Tomayko, J. A. Punt, J. M. Bolcavage, S. L. Levy, D. M. Allman, and M. P. Cancro (1999)
Int. Immunol. 11, 1753-1761
   Abstract »    Full Text »    PDF »
Role of CD4+ T Cells in Immunobiology of Orthotopic Corneal Transplants in Mice.
J. Yamada, I. Kurimoto, and J. W. Streilein (1999)
Invest. Ophthalmol. Vis. Sci. 40, 2614-2621
   Abstract »    Full Text »    PDF »



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