Science 1 June 1990: Vol. 248. no. 4959, pp. 1124 - 1126 DOI: 10.1126/science.2111584

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Articles

Independent Effects of Intra- and Extracellular A{beta} on Learning-Related Gene Expression.

B. M. Wegenast-Braun, A. Fulgencio Maisch, D. Eicke, R. Radde, M. C. Herzig, M. Staufenbiel, M. Jucker, and M. E. Calhoun (2009)
Am. J. Pathol. 175, 271-282
 |  Abstract »  |  Full Text »  |  PDF »

A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis.

G. Di Fede, M. Catania, M. Morbin, G. Rossi, S. Suardi, G. Mazzoleni, M. Merlin, A. R. Giovagnoli, S. Prioni, A. Erbetta, et al. (2009)
Science 323, 1473-1477
 |  Abstract »  |  Full Text »  |  PDF »

Invited Article: The Alzheimer disease-frontotemporal lobar degeneration spectrum.

J. van der Zee, K. Sleegers, and C. V. Broeckhoven (2008)
Neurology 71, 1191-1197
 |  Abstract »  |  Full Text »  |  PDF »

Serum cystatin C and the risk of Alzheimer disease in elderly men.

J. Sundelof, J. Arnlov, E. Ingelsson, J. Sundstrom, S. Basu, B. Zethelius, A. Larsson, M. C. Irizarry, V. Giedraitis, E. Ronnemaa, et al. (2008)
Neurology 71, 1072-1079
 |  Abstract »  |  Full Text »  |  PDF »

Tg-SwDI Transgenic Mice Exhibit Novel Alterations in A{beta}PP Processing, A{beta} Degradation, and Resilient Amyloid Angiopathy.

G. D. Van Vickle, C. L. Esh, I. D. Daugs, T. A. Kokjohn, W. M. Kalback, R. L. Patton, D. C. Luehrs, D. G. Walker, L.-F. Lue, T. G. Beach, et al. (2008)
Am. J. Pathol. 173, 483-493
 |  Abstract »  |  Full Text »  |  PDF »

Human Apolipoprotein E Redistributes Fibrillar Amyloid Deposition in Tg-SwDI Mice.

F. Xu, M. P. Vitek, C. A. Colton, M. L. Previti, N. Gharkholonarehe, J. Davis, and W. E. Van Nostrand (2008)
J. Neurosci. 28, 5312-5320
 |  Abstract »  |  Full Text »  |  PDF »

Clinical and Neuropathological Features of the Arctic APP Gene Mutation Causing Early-Onset Alzheimer Disease.

H. Basun, N. Bogdanovic, M. Ingelsson, O. Almkvist, J. Naslund, K. Axelman, T. D. Bird, D. Nochlin, G. D. Schellenberg, L.-O. Wahlund, et al. (2008)
Arch Neurol 65, 499-505
 |  Abstract »  |  Full Text »  |  PDF »

Familial Alzheimer's disease mutations alter the stability of the amyloid beta-protein monomer folding nucleus.

M. A. Grant, N. D. Lazo, A. Lomakin, M. M. Condron, H. Arai, G. Yamin, A. C. Rigby, and D. B. Teplow (2007)
PNAS 104, 16522-16527
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Familial Cerebral Amyloid Angiopathy Mutant Amyloid beta-Protein Fibril Assembly by Myelin Basic Protein.

M. D. Hoos, M. Ahmed, S. O. Smith, and W. E. Van Nostrand (2007)
J. Biol. Chem. 282, 9952-9961
 |  Abstract »  |  Full Text »  |  PDF »

Minocycline Reduces Microglial Activation and Improves Behavioral Deficits in a Transgenic Model of Cerebral Microvascular Amyloid.

R. Fan, F. Xu, M. L. Previti, J. Davis, A. M. Grande, J. K. Robinson, and W. E. Van Nostrand (2007)
J. Neurosci. 27, 3057-3063
 |  Abstract »  |  Full Text »  |  PDF »

A Ganglioside-induced Toxic Soluble Abeta Assembly: ITS ENHANCED FORMATION FROM AbetaBEARING THE ARCTIC MUTATION.

N. Yamamoto, E. Matsubara, S. Maeda, H. Minagawa, A. Takashima, W. Maruyama, M. Michikawa, and K. Yanagisawa (2007)
J. Biol. Chem. 282, 2646-2655
 |  Abstract »  |  Full Text »  |  PDF »

A Century of Alzheimer's Disease.

M. Goedert and M. G. Spillantini (2006)
Science 314, 777-781
 |  Abstract »  |  Full Text »  |  PDF »

Phenotype associated with APP duplication in five families.

L. Cabrejo, L. Guyant-Marechal, A. Laquerriere, M. Vercelletto, F. De La Fourniere, C. Thomas-Anterion, C. Verny, F. Letournel, F. Pasquier, A. Vital, et al. (2006)
Brain 129, 2966-2976
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's centennial legacy: prospects for rational therapeutic intervention targeting the A{beta} amyloid pathway.

C. L. Masters and K. Beyreuther (2006)
Brain 129, 2823-2839
 |  Abstract »  |  Full Text »  |  PDF »

Recommendations of the National Heart, Lung, and Blood Institute Working Group on Cerebrovascular Biology and Disease.

C. Iadecola, S. S. Goldman, D. R. Harder, D. D. Heistad, Z. S. Katusic, M. A. Moskowitz, J. M. Simard, M. A. Sloan, R. J. Traystman, and P. A. Velletri (2006)
Stroke 37, 1578-1581
 |  Abstract »  |  Full Text »  |  PDF »

The Effect of A{beta} Conformation on the Metal Affinity and Aggregation Mechanism Studied by Circular Dichroism Spectroscopy..

Y.R. Chen, H.B. Huang, C.L. Chyan, M.S. Shiao, T.H. Lin, and Y.C. Chen (2006)
J. Biochem. 139, 733-740
 |  Abstract »  |  Full Text »  |  PDF »

Genetics of Vascular Cognitive Impairment: The Opportunity and the Challenges.

G. G. Leblanc, J. F. Meschia, D. T. Stuss, and V. Hachinski (2006)
Stroke 37, 248-255
 |  Abstract »  |  Full Text »  |  PDF »

The Absence of ABCA1 Decreases Soluble ApoE Levels but Does Not Diminish Amyloid Deposition in Two Murine Models of Alzheimer Disease.

V. Hirsch-Reinshagen, L. F. Maia, B. L. Burgess, J.-F. Blain, K. E. Naus, S. A. McIsaac, P. F. Parkinson, J. Y. Chan, G. H. Tansley, M. R. Hayden, et al. (2005)
J. Biol. Chem. 280, 43243-43256
 |  Abstract »  |  Full Text »  |  PDF »

Solvent and mutation effects on the nucleation of amyloid {beta}-protein folding.

L. Cruz, B. Urbanc, J. M. Borreguero, N. D. Lazo, D. B. Teplow, and H. E. Stanley (2005)
PNAS 102, 18258-18263
 |  Abstract »  |  Full Text »  |  PDF »

The soluble epoxide hydrolase gene harbors sequence variation associated with susceptibility to and protection from incident ischemic stroke.

M. Fornage, C. R. Lee, P. A. Doris, M. S. Bray, G. Heiss, D. C. Zeldin, and E. Boerwinkle (2005)
Hum. Mol. Genet. 14, 2829-2837
 |  Abstract »  |  Full Text »  |  PDF »

Cerebral Microvascular Amyloid {beta} Protein Deposition Induces Vascular Degeneration and Neuroinflammation in Transgenic Mice Expressing Human Vasculotropic Mutant Amyloid {beta} Precursor Protein.

J. Miao, F. Xu, J. Davis, I. Otte-Holler, M. M. Verbeek, and W. E. Van Nostrand (2005)
Am. J. Pathol. 167, 505-515
 |  Abstract »  |  Full Text »  |  PDF »

Reducing Cerebral Microvascular Amyloid-{beta} Protein Deposition Diminishes Regional Neuroinflammation in Vasculotropic Mutant Amyloid Precursor Protein Transgenic Mice.

J. Miao, M. P. Vitek, F. Xu, M. L. Previti, J. Davis, and W. E. Van Nostrand (2005)
J. Neurosci. 25, 6271-6277
 |  Abstract »  |  Full Text »  |  PDF »

A multigenerational pedigree of late-onset Alzheimer's disease implies new genetic causes.

A. Jimenez-Escrig, E. Gomez-Tortosa, M. Baron, A. Rabano, M. Arcos-Burgos, L. G. Palacios, A. Yusta, P. Anta, I. Perez, M. Hierro, et al. (2005)
Brain 128, 1707-1715
 |  Abstract »  |  Full Text »  |  PDF »

GM1 Ganglioside and the Seeding of Amyloid in Alzheimer's Disease: Endogenous Seed for Alzheimer Amyloid.

K. Yanagisawa (2005)
Neuroscientist 11, 250-260
 |  Abstract »  |  PDF »

Insulin-degrading Enzyme in Brain Microvessels: PROTEOLYSIS OF AMYLOID {beta} VASCULOTROPIC VARIANTS AND REDUCED ACTIVITY IN CEREBRAL AMYLOID ANGIOPATHY.

L. Morelli, R. E. Llovera, I. Mathov, L.-F. Lue, B. Frangione, J. Ghiso, and E. M. Castano (2004)
J. Biol. Chem. 279, 56004-56013
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of the Secondary Structure of {beta}-Amyloid (A{beta}42) Fibrils by Systematic Proline Replacement.

A. Morimoto, K. Irie, K. Murakami, Y. Masuda, H. Ohigashi, M. Nagao, H. Fukuda, T. Shimizu, and T. Shirasawa (2004)
J. Biol. Chem. 279, 52781-52788
 |  Abstract »  |  Full Text »  |  PDF »

Hemorrhage is uncommon in new Alzheimer family with Flemish amyloid precursor protein mutation.

W. S. Brooks, J. B.J. Kwok, G. M. Halliday, A. K. Godbolt, M. N. Rossor, H. Creasey, A. O. Jones, and P. R. Schofield (2004)
Neurology 63, 1613-1617
 |  Abstract »  |  Full Text »  |  PDF »

A family with Alzheimer disease and strokes associated with A713T mutation of the APP gene.

G. Rossi, G. Giaccone, R. Maletta, M. Morbin, R. Capobianco, M. Mangieri, A. R. Giovagnoli, A. Bizzi, C. Tomaino, M. Perri, et al. (2004)
Neurology 63, 910-912
 |  Abstract »  |  Full Text »  |  PDF »

Hereditary dementia with intracerebral hemorrhages and cerebral amyloid angiopathy.

A. M. Remes, S. Finnila, H. Mononen, H. Tuominen, R. Takalo, R. Herva, and K. Majamaa (2004)
Neurology 63, 234-240
 |  Abstract »  |  Full Text »  |  PDF »

Novel amyloid precursor protein gene missense mutation (D678N) in probable familial Alzheimer's disease.

Y Wakutani, K Watanabe, Y Adachi, K Wada-Isoe, K Urakami, H Ninomiya, T C Saido, T Hashimoto, T Iwatsubo, and K Nakashima (2004)
J. Neurol. Neurosurg. Psychiatry 75, 1039-1042
 |  Abstract »  |  Full Text »  |  PDF »

Early-onset and Robust Cerebral Microvascular Accumulation of Amyloid {beta}-Protein in Transgenic Mice Expressing Low Levels of a Vasculotropic Dutch/Iowa Mutant Form of Amyloid {beta}-Protein Precursor.

J. Davis, F. Xu, R. Deane, G. Romanov, M. L. Previti, K. Zeigler, B. V. Zlokovic, and W. E. Van Nostrand (2004)
J. Biol. Chem. 279, 20296-20306
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer Disease: Mechanistic Understanding Predicts Novel Therapies.

D. J. Selkoe (2004)
Ann Intern Med 140, 627-638
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Neurotoxicity and Physicochemical Properties of A{beta} Mutant Peptides from Cerebral Amyloid Angiopathy: IMPLICATION FOR THE PATHOGENESIS OF CEREBRAL AMYLOID ANGIOPATHY AND ALZHEIMER'S DISEASE.

K. Murakami, K. Irie, A. Morimoto, H. Ohigashi, M. Shindo, M. Nagao, T. Shimizu, and T. Shirasawa (2003)
J. Biol. Chem. 278, 46179-46187
 |  Abstract »  |  Full Text »  |  PDF »

Elucidation of Primary Structure Elements Controlling Early Amyloid {beta}-Protein Oligomerization.

G. Bitan, S. S. Vollers, and D. B. Teplow (2003)
J. Biol. Chem. 278, 34882-34889
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E Markedly Facilitates Age-Dependent Cerebral Amyloid Angiopathy and Spontaneous Hemorrhage in Amyloid Precursor Protein Transgenic Mice.

J. D. Fryer, J. W. Taylor, R. B. DeMattos, K. R. Bales, S. M. Paul, M. Parsadanian, and D. M. Holtzman (2003)
J. Neurosci. 23, 7889-7896
 |  Abstract »  |  Full Text »  |  PDF »

Differential Degradation of Amyloid {beta} Genetic Variants Associated with Hereditary Dementia or Stroke by Insulin-degrading Enzyme.

L. Morelli, R. Llovera, S. A. Gonzalez, J. L. Affranchino, F. Prelli, B. Frangione, J. Ghiso, and E. M. Castano (2003)
J. Biol. Chem. 278, 23221-23226
 |  Abstract »  |  Full Text »  |  PDF »

Specific Compositions of Amyloid-{beta} Peptides as the Determinant of Toxic {beta}-Aggregation.

Y. Yoshiike, D.-H. Chui, T. Akagi, N. Tanaka, and A. Takashima (2003)
J. Biol. Chem. 278, 23648-23655
 |  Abstract »  |  Full Text »  |  PDF »

Early onset familial Alzheimer's disease: Mutation frequency in 31 families.

J.C. Janssen, J.A. Beck, T.A. Campbell, A. Dickinson, N.C. Fox, R.J. Harvey, H. Houlden, M.N. Rossor, and J. Collinge (2003)
Neurology 60, 235-239
 |  Abstract »  |  Full Text »  |  PDF »

Explaining the Cause of the Amyloid Burden in Alzheimer Disease.

R. N. Rosenberg (2002)
Arch Neurol 59, 1367-1368
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Oligomeric and Fibrillar Species of Amyloid-beta Peptides Differentially Affect Neuronal Viability.

K. N. Dahlgren, A. M. Manelli, W. B. Stine Jr., L. K. Baker, G. A. Krafft, and M. J. LaDu (2002)
J. Biol. Chem. 277, 32046-32053
 |  Abstract »  |  Full Text »  |  PDF »

Dense-Core Senile Plaques in the Flemish Variant of Alzheimer's Disease Are Vasocentric.

S. Kumar-Singh, P. Cras, R. Wang, J. M. Kros, J. van Swieten, U. Lubke, C. Ceuterick, S. Serneels, K.'l Vennekens, J.-P. Timmermans, et al. (2002)
Am. J. Pathol. 161, 507-520
 |  Abstract »  |  Full Text »  |  PDF »

Vitamin E But Not 17beta -Estradiol Protects against Vascular Toxicity Induced by beta -Amyloid Wild Type and the Dutch Amyloid Variant.

F. J. Munoz, C. Opazo, G. Gil-Gomez, G. Tapia, V. Fernandez, M. A. Valverde, and N. C. Inestrosa (2002)
J. Neurosci. 22, 3081-3089
 |  Abstract »  |  Full Text »  |  PDF »

Advances in the genetics of cerebrovascular disease and stroke.

G.J. Hademenos, M.J. Alberts, I. Awad, M. Mayberg, T. Shephard, A. Jagoda, R.E. Latchaw, H.W. Todd, K. Viste, R. Starke, et al. (2001)
Neurology 56, 997-1008
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Disease: Genes, Proteins, and Therapy.

D. J. Selkoe (2001)
Physiol Rev 81, 741-766
 |  Abstract »  |  Full Text »  |  PDF »

Spontaneous Hemorrhagic Stroke in a Mouse Model of Cerebral Amyloid Angiopathy.

D. T. Winkler, L. Bondolfi, M. C. Herzig, L. Jann, M. E. Calhoun, K.-H. Wiederhold, M. Tolnay, M. Staufenbiel, and M. Jucker (2001)
J. Neurosci. 21, 1619-1627
 |  Abstract »  |  Full Text »  |  PDF »

Presentation of amyloidosis in carriers of the codon 692 mutation in the amyloid precursor protein gene (APP692).

G. Roks, F. Van Harskamp, I. De Koning, M. Cruts, C. De Jonghe, S. Kumar-Singh, A. Tibben, H. Tanghe, M. F. Niermeijer, A. Hofman, et al. (2000)
Brain 123, 2130-2140
 |  Abstract »  |  Full Text »  |  PDF »

Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons.

J. Van Dorpe, L. Smeijers, I. Dewachter, D. Nuyens, K. Spittaels, C. Van den Haute, M. Mercken, D. Moechars, I. Laenen, C. Kuiperi, et al. (2000)
Am. J. Pathol. 157, 1283-1298
 |  Abstract »  |  Full Text »  |  PDF »

The molecular and genetic basis of AD: The end of the beginning: The 2000 Wartenberg lecture.

R. N. Rosenberg (2000)
Neurology 54, 2045-2054
 |  Full Text »  |  PDF »

Protein aging hypothesis of Alzheimer disease.

J. ORPISZEWSKI, N. SCHORMANN, B. KLUVE-BECKERMAN, J. J. LIEPNIEKS, and M. D. BENSON (2000)
FASEB J 14, 1255-1263
 |  Abstract »  |  Full Text »

Variant Alzheimer's disease with spastic paraparesis: Clinical characterization.

A. Verkkoniemi, M. Somer, J. O. Rinne, L. Myllykangas, R. Crook, J. Hardy, M. Viitanen, H. Kalimo, and M. Haltia (2000)
Neurology 54, 1103-1109
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid.

M. E. Calhoun, P. Burgermeister, A. L. Phinney, M. Stalder, M. Tolnay, K.-H. Wiederhold, D. Abramowski, C. Sturchler-Pierrat, B. Sommer, M. Staufenbiel, et al. (1999)
PNAS 96, 14088-14093
 |  Abstract »  |  Full Text »  |  PDF »

The Gene Encoding Atrial Natriuretic Peptide and the Risk of Human Stroke.

S. Rubattu, P. Ridker, M. J. Stampfer, M. Volpe, C. H. Hennekens, and K. Lindpaintner (1999)
Circulation 100, 1722-1726
 |  Abstract »  |  Full Text »  |  PDF »

The impact of different presenilin 1 andpresenilin 2 mutations on amyloid deposition, neurofibrillary changes and neuronal loss in the familial Alzheimer's disease brain: Evidence for other phenotype-modifying factors.

T. Gomez-Isla, W. B. Growdon, M. J. McNamara, D. Nochlin, T. D. Bird, J. C. Arango, F. Lopera, K. S. Kosik, P. L. Lantos, N. J. Cairns, et al. (1999)
Brain 122, 1709-1719
 |  Abstract »  |  Full Text »  |  PDF »

Oculoleptomeningeal Amyloidosis Associated With a New Transthyretin Variant Ser64.

T. Uemichi, R. J. Uitti, A. H. Koeppen, J. R. Donat, and M. D. Benson (1999)
Arch Neurol 56, 1152-1155
 |  Abstract »  |  Full Text »  |  PDF »

Role of Phosphorylation of Alzheimer's Amyloid Precursor Protein during Neuronal Differentiation.

K. Ando, M. Oishi, S. Takeda, K.-i. Iijima, T. Isohara, A. C. Nairn, Y. Kirino, P. Greengard, and T. Suzuki (1999)
J. Neurosci. 19, 4421-4427
 |  Abstract »  |  Full Text »  |  PDF »

Recurrent cerebral haemorrhage in a 65 year old man: advanced clinical neurology course, Edinburgh, 1997.

N. U Weir, J. van Gijn, G A. Lammie, J. M Wardlaw, and C. P Warlow (1999)
J. Neurol. Neurosurg. Psychiatry 66, 104-110
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Propagating structure of Alzheimer's beta -amyloid(10-35) is parallel beta -sheet with residues in exact register.

T. L. S. Benzinger, D. M. Gregory, T. S. Burkoth, H. Miller-Auer, D. G. Lynn, R. E. Botto, and S. C. Meredith (1998)
PNAS 95, 13407-13412
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid beta -Peptide Possesses a Transforming Growth Factor-beta Activity.

S. S. Huang, F. W. Huang, J. Xu, S. Chen, C. Y. Hsu, and J. S. Huang (1998)
J. Biol. Chem. 273, 27640-27644
 |  Abstract »  |  Full Text »  |  PDF »

Cerebral Amyloid Angiopathy : Amyloid ß Accumulates in Putative Interstitial FluidDrainage Pathways in Alzheimer's Disease.

R. O. Weller, A. Massey, T. A. Newman, M. Hutchings, Y.-M. Kuo, and A. E. Roher (1998)
Am. J. Pathol. 153, 725-733
 |  Abstract »  |  Full Text »  |  PDF »

Introduction of Hereditary Disease-Associated Mutations into the beta -Amyloid Precursor Protein Gene of Mouse Embryonic Stem Cells: a Comparison of Homologous Recombination Methods.

M. Gschwind and G. Huber (1998)
Mol. Cell. Biol. 18, 4651-4658
 |  Abstract »  |  Full Text »

Microvasculopathy Is Associated With the Number of Cerebrovascular Lesions in Hereditary Cerebral Hemorrhage With Amyloidosis, Dutch Type.

R. Natte, H. V. Vinters, M. L. C. Maat-Schieman, M. Bornebroek, J. Haan, R. A. C. Roos, and S. G. van Duinen (1998)
Stroke 29, 1588-1594
 |  Abstract »  |  Full Text »  |  PDF »

Structural Transitions Associated with the Interaction of Alzheimer beta -Amyloid Peptides with Gangliosides.

J. McLaurin, T. Franklin, P. E. Fraser, and A. Chakrabartty (1998)
J. Biol. Chem. 273, 4506-4515
 |  Abstract »  |  Full Text »  |  PDF »

Heparin-binding Properties of the Amyloidogenic Peptides Abeta and Amylin. DEPENDENCE ON AGGREGATION STATE AND INHIBITION BY CONGO RED.

D. J. Watson, A. D. Lander, and D. J. Selkoe (1997)
J. Biol. Chem. 272, 31617-31624
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid beta -Protein Fibrillogenesis. DETECTION OF A PROTOFIBRILLAR INTERMEDIATE.

D. M. Walsh, A. Lomakin, G. B. Benedek, M. M. Condron, and D. B. Teplow (1997)
J. Biol. Chem. 272, 22364-22372
 |  Abstract »  |  Full Text »  |  PDF »

Clinical Features of Early-Onset Alzheimer Disease in a Large Kindred With an E280A Presenilin-1 Mutation.

F. Lopera, A. Ardilla, A. Martinez, L. Madrigal, J. C. Arango-Viana, C. A. Lemere, J. C. Arango-Lasprilla, L. Hincapie, M. Arcos-Burgos, J. E. Ossa, et al. (1997)
JAMA 277, 793-799
 |  Abstract »  |  PDF »

The length of Amyloid-beta in Hereditary Cerebral Hemorrhage with Amyloidosis, Dutch Type. IMPLICATIONS FOR THE ROLE OF AMYLOID-beta 1-42 IN ALZHEIMER'S DISEASE.

E. M. Castano, F. Prelli, C. Soto, R. Beavis, E. Matsubara, M. Shoji, and B. Frangione (1996)
J. Biol. Chem. 271, 32185-32191
 |  Abstract »  |  Full Text »  |  PDF »

Cystatin C: Icelandic-Like Mutation in an Animal Model of Cerebrovascular ß-Amyloidosis.

L. Wei, L. C. Walker, E. Levy, and W. I. Rosenblum (1996)
Stroke 27, 2080-2085
 |  Abstract »  |  Full Text »

Amyloid beta -Protein and the Genetics of Alzheimer's Disease.

D. J. Selkoe and D. J. Selkoe (1996)
J. Biol. Chem. 271, 18295-18298
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Immune Reactions Associated With Cerebral Amyloid Angiopathy.

M. Yamada, Y. Itoh, M. Shintaku, J. Kawamura, O. Jensson, L. Thorsteinsson, N. Suematsu, M. Matsushita, and E. Otomo (1996)
Stroke 27, 1155-1162
 |  Abstract »  |  Full Text »

The Interaction between Apolipoprotein E and Alzheimer's Amyloid beta-Peptide Is Dependent on beta-Peptide Conformation.

A. A. Golabek, C. Soto, T. Vogel, and T. Wisniewski (1996)
J. Biol. Chem. 271, 10602-10606
 |  Abstract »  |  Full Text »  |  PDF »

Amyloids beta[IMAGE] and beta[IMAGE] Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation.

R. S. Turner, N. Suzuki, A. S. C. Chyung, S. G. Younkin, and V. M.-Y. Lee (1996)
J. Biol. Chem. 271, 8966-8970
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Amyloid Protein Precursor (APP) Binding to Collagen and Mapping of the Binding Sites on APP and Collagen Type I.

D. Beher, L. Hesse, C. L. Masters, and G. Multhaup (1996)
J. Biol. Chem. 271, 1613-1620
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Biology and Genetics of Prion Diseases.

S.B. Prusiner (1996)
Cold Spring Harb Symp Quant Biol 61, 473-493
 |  Abstract »  |  PDF »

The Role of Presenilin 1 in the Genetics of Alzheimer's Disease.

R.F. Clark, M. Hutton, C. Talbot, M. Wragg, C. Lendon, F. Busfield, S.W. Han, J. Perez-Tur, M. Adams, R. Fuldner, et al. (1996)
Cold Spring Harb Symp Quant Biol 61, 551-558
 |  Abstract »  |  PDF »

Two Homologous Genes Causing Early-onset Familial Alzheimer's Disease.

P.H. St. George-Hyslop, G. Levesque, L. Levesque, J. Rommens, D. Westaway, and P.E. Fraser (1996)
Cold Spring Harb Symp Quant Biol 61, 559-564
 |  Abstract »  |  PDF »

Neuronal Sorting and Processing of Amyloid Precursor Protein: Implications for Alzheimer's Disease.

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The alpha-Helical to beta-Strand Transition in the Amino-terminal Fragment of the Amyloid beta-Peptide Modulates Amyloid Formation.

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Molecular Genetics of Alzheimer's Disease.

R. F. Clark and A. M. Goate (1993)
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Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism.

L. Goldfarb, R. Petersen, M Tabaton, P Brown, A. LeBlanc, P Montagna, P Cortelli, J Julien, C Vital, W. Pendelbury, et al. (1992)
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Alzheimer's disease: a cell biological perspective.

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Alzheimer's disease: the amyloid cascade hypothesis.

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Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues.

D. Selkoe (1990)
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Pathogenic Effects of D23N Iowa Mutant Amyloid beta -Protein.

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BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein.

M. Farzan, C. E. Schnitzler, N. Vasilieva, D. Leung, and H. Choe (2000)
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Abeta amyloid fibrils possess a core structure highly resistant to hydrogen exchange.

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