Science 1 June 1990: Vol. 248. no. 4959, pp. 1122 - 1124 DOI: 10.1126/science.2111583

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Articles

Dynein Dysfunction Induces Endocytic Pathology Accompanied by an Increase in Rab GTPases: A POTENTIAL MECHANISM UNDERLYING AGE-DEPENDENT ENDOCYTIC DYSFUNCTION.

N. Kimura, M. Inoue, S. Okabayashi, F. Ono, and T. Negishi (2009)
J. Biol. Chem. 284, 31291-31302
 |  Abstract »  |  Full Text »  |  PDF »

Induced Dimerization of the Amyloid Precursor Protein Leads to Decreased Amyloid-{beta} Protein Production.

S. Eggert, B. Midthune, B. Cottrell, and E. H. Koo (2009)
J. Biol. Chem. 284, 28943-28952
 |  Abstract »  |  Full Text »  |  PDF »

Up-regulation of the {alpha}-secretase ADAM10 by retinoic acid receptors and acitretin.

F. Tippmann, J. Hundt, A. Schneider, K. Endres, and F. Fahrenholz (2009)
FASEB J 23, 1643-1654
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A{beta}PP/APLP2 Family of Kunitz Serine Proteinase Inhibitors Regulate Cerebral Thrombosis.

F. Xu, M. L. Previti, M. T. Nieman, J. Davis, A. H. Schmaier, and W. E. Van Nostrand (2009)
J. Neurosci. 29, 5666-5670
 |  Abstract »  |  Full Text »  |  PDF »

The Catalytic Domain of Insulin-degrading Enzyme Forms a Denaturant-resistant Complex with Amyloid {beta} Peptide: IMPLICATIONS FOR ALZHEIMER DISEASE PATHOGENESIS.

R. E. Llovera, M. de Tullio, L. G. Alonso, M. A. Leissring, S. B. Kaufman, A. E. Roher, G. de Prat Gay, L. Morelli, and E. M. Castano (2008)
J. Biol. Chem. 283, 17039-17048
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Identification of Amino Acid Residues of the Matrix Metalloproteinase-2 Essential for Its Selective Inhibition by {beta}-Amyloid Precursor Protein-derived Inhibitor.

S. Higashi and K. Miyazaki (2008)
J. Biol. Chem. 283, 10068-10078
 |  Abstract »  |  Full Text »  |  PDF »

Homophilic Interactions of the Amyloid Precursor Protein (APP) Ectodomain Are Regulated by the Loop Region and Affect {beta}-Secretase Cleavage of APP.

D. Kaden, L.-M. Munter, M. Joshi, C. Treiber, C. Weise, T. Bethge, P. Voigt, M. Schaefer, M. Beyermann, B. Reif, et al. (2008)
J. Biol. Chem. 283, 7271-7279
 |  Abstract »  |  Full Text »  |  PDF »

RNA Interference Silencing of the Adaptor Molecules ShcC and Fe65 Differentially Affect Amyloid Precursor Protein Processing and Abeta Generation.

Z. Xie, Y. Dong, U. Maeda, W. Xia, and R. E. Tanzi (2007)
J. Biol. Chem. 282, 4318-4325
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic approaches to Alzheimer's disease.

H.-W. Klafki, M. Staufenbiel, J. Kornhuber, and J. Wiltfang (2006)
Brain 129, 2840-2855
 |  Abstract »  |  Full Text »  |  PDF »

Protease nexin-2/amyloid {beta}-protein precursor limits cerebral thrombosis.

F. Xu, J. Davis, J. Miao, M. L. Previti, G. Romanov, K. Ziegler, and W. E. Van Nostrand (2005)
PNAS 102, 18135-18140
 |  Abstract »  |  Full Text »  |  PDF »

Implications of the serine protease HtrA1 in amyloid precursor protein processing.

S. Grau, A. Baldi, R. Bussani, X. Tian, R. Stefanescu, M. Przybylski, P. Richards, S. A. Jones, V. Shridhar, T. Clausen, et al. (2005)
PNAS 102, 6021-6026
 |  Abstract »  |  Full Text »  |  PDF »

RNA Interference-mediated Silencing of X11{alpha} and X11{beta} Attenuates Amyloid {beta}-Protein Levels via Differential Effects on {beta}-Amyloid Precursor Protein Processing.

Z. Xie, D. M. Romano, and R. E. Tanzi (2005)
J. Biol. Chem. 280, 15413-15421
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid-{beta} Protein Precursor (A{beta}PP) Intracellular Domain-associated Protein-1 Proteins Bind to A{beta}PP and Modulate Its Processing in an Isoform-specific Manner.

E. Ghersi, C. Noviello, and L. D'Adamio (2004)
J. Biol. Chem. 279, 49105-49112
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The Proteolytic Processing of the Amyloid Precursor Protein Gene Family Members APLP-1 and APLP-2 Involves {alpha}-, {beta}-, {gamma}-, and {epsilon}-Like Cleavages: MODULATION OF APLP-1 PROCESSING BY N-GLYCOSYLATION.

S. Eggert, K. Paliga, P. Soba, G. Evin, C. L. Masters, A. Weidemann, and K. Beyreuther (2004)
J. Biol. Chem. 279, 18146-18156
 |  Abstract »  |  Full Text »  |  PDF »

Increased Expression and Processing of the Alzheimer Amyloid Precursor Protein in Pancreatic Cancer May Influence Cellular Proliferation.

D. E. Hansel, A. Rahman, S. Wehner, V. Herzog, C. J. Yeo, and A. Maitra (2003)
Cancer Res. 63, 7032-7037
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid {beta}-Protein Stimulates the Expression of Urokinase-type Plasminogen Activator (uPA) and Its Receptor (uPAR) in Human Cerebrovascular Smooth Muscle Cells.

J. Davis, M. R. Wagner, W. Zhang, F. Xu, and W. E. Van Nostrand (2003)
J. Biol. Chem. 278, 19054-19061
 |  Abstract »  |  Full Text »  |  PDF »

Endoproteolysis of beta -Secretase (beta -Site Amyloid Precursor Protein-cleaving Enzyme) within Its Catalytic Domain. A POTENTIAL MECHANISM FOR REGULATION.

J. T. Huse, D. Byant, Y. Yang, D. S. Pijak, I. D'Souza, J. J. Lah, V. M.-Y. Lee, R. W. Doms, and D. G. Cook (2003)
J. Biol. Chem. 278, 17141-17149
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Region of beta -Amyloid Precursor Protein Essential for Its Gelatinase A Inhibitory Activity.

S. Higashi and K. Miyazaki (2003)
J. Biol. Chem. 278, 14020-14028
 |  Abstract »  |  Full Text »  |  PDF »

Secretion and Intracellular Generation of Truncated Abeta in beta -Site Amyloid-beta Precursor Protein-cleaving Enzyme Expressing Human Neurons.

E. B. Lee, D. M. Skovronsky, F. Abtahian, R. W. Doms, and V. M.-Y. Lee (2003)
J. Biol. Chem. 278, 4458-4466
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The Extracellular N Terminus of the Endothelin B (ETB) Receptor Is Cleaved by a Metalloprotease in an Agonist-dependent Process.

E. Grantcharova, J. Furkert, H. P. Reusch, H.-W. Krell, G. Papsdorf, M. Beyermann, R. Schulein, W. Rosenthal, and A. Oksche (2002)
J. Biol. Chem. 277, 43933-43941
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Localization of a Fibrillar Amyloid beta -Protein Binding Domain on Its Precursor.

W. E. Van Nostrand, J. P. Melchor, D. M. Keane, S. M. Saporito-Irwin, G. Romanov, J. Davis, and F. Xu (2002)
J. Biol. Chem. 277, 36392-36398
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Amyloid Precursor Protein, Presenilins, and alpha -Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer's Disease.

Y.-H. Suh and F. Checler (2002)
Pharmacol. Rev. 54, 469-525
 |  Abstract »  |  Full Text »  |  PDF »

The gamma Secretase-generated Carboxyl-terminal Domain of the Amyloid Precursor Protein Induces Apoptosis via Tip60 in H4 Cells.

A. Kinoshita, C. M. Whelan, O. Berezovska, and B. T. Hyman (2002)
J. Biol. Chem. 277, 28530-28536
 |  Abstract »  |  Full Text »  |  PDF »

beta -Secretase Processing in the Trans-Golgi Network Preferentially Generates Truncated Amyloid Species That Accumulate in Alzheimer's Disease Brain.

J. T. Huse, K. Liu, D. S. Pijak, D. Carlin, V. M.-Y. Lee, and R. W. Doms (2002)
J. Biol. Chem. 277, 16278-16284
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Cholesterol Is an Important Factor Affecting the Membrane Insertion of beta -Amyloid Peptide (Abeta 1-40), Which May Potentially Inhibit the Fibril Formation.

S.-R. Ji, Y. Wu, and S.-f. Sui (2002)
J. Biol. Chem. 277, 6273-6279
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A Portrait of Alzheimer Secretases--New Features and Familiar Faces.

W. P. Esler and M. S. Wolfe (2001)
Science 293, 1449-1454
 |  Abstract »  |  Full Text »  |  PDF »

Generation of Aggregated {beta}-Amyloid in the Rat Hippocampus Impairs Synaptic Transmission and Plasticity and Causes Memory Deficits.

A. Stephan, S. Laroche, and S. Davis (2001)
J. Neurosci. 21, 5703-5714
 |  Abstract »  |  Full Text »  |  PDF »

A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells.

K.-P. Xu, D. Zoukhri, J. D. Zieske, D. A. Dartt, C. Sergheraert, E. Loing, and F.-S. X. Yu (2001)
Am J Physiol Cell Physiol 281, C603-C614
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Alzheimer's Disease: Genes, Proteins, and Therapy.

D. J. Selkoe (2001)
Physiol Rev 81, 741-766
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Recombinant, Soluble {beta}-Secretase from an Insect Cell Expression System.

W. D. Mallender, D. Yager, L. Onstead, M. R. Nichols, C. Eckman, K. Sambamurti, L. M. Kopcho, J. Marcinkeviciene, R. A. Copeland, and T. L. Rosenberry (2001)
Mol. Pharmacol. 59, 619-626
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Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility.

J. Theuns and C. Van Broeckhoven (2000)
Hum. Mol. Genet. 9, 2383-2394
 |  Abstract »  |  Full Text »  |  PDF »

Human bleomycin hydrolase regulates the secretion of amyloid precursor protein.

I. M. LEFTEROV, R. P. KOLDAMOVA, and J. S. LAZO (2000)
FASEB J 14, 1837-1847
 |  Abstract »  |  Full Text »

Carboxyl-terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity.

H.-S. KIM, C. H. PARK, S. H. CHA, J.-H. LEE, S. LEE, Y. KIM, J.-C. RAH, S.-J. JEONG, and Y.-H. SUH (2000)
FASEB J 14, 1508-1517
 |  Abstract »  |  Full Text »

Alzheimer's Disease, {beta}-Amyloid Protein and Zinc.

X. Huang, M. P. Cuajungco, C. S. Atwood, R. D. Moir, R. E. Tanzi, and A. I. Bush (2000)
J. Nutr. 130, 1488S-1492
 |  Abstract »  |  Full Text »

Regulation of Amyloid Precursor Protein Processing by Presenilin 1 (PS1) and PS2 in PS1 Knockout Cells.

J. J. Palacino, B. E. Berechid, P. Alexander, C. Eckman, S. Younkin, J. S. Nye, and B. Wolozin (2000)
J. Biol. Chem. 275, 215-222
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Proteolytic processing and cell biological functions of the amyloid precursor protein.

B De Strooper and W Annaert (2000)
J. Cell Sci. 113, 1857-1870
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Cognitive changes and modified processing of amyloid precursor protein in the cortical and hippocampal system after cholinergic synapse loss and muscarinic receptor activation.

L. Lin, B. Georgievska, A. Mattsson, and O. Isacson (1999)
PNAS 96, 12108-12113
 |  Abstract »  |  Full Text »  |  PDF »

Cellular mechanisms of beta -amyloid production and secretion.

S. Sinha and I. Lieberburg (1999)
PNAS 96, 11049-11053
 |  Abstract »  |  Full Text »  |  PDF »

{gamma}-Secretase, Evidence for Multiple Proteolytic Activities and Influence of Membrane Positioning of Substrate on Generation of Amyloid {beta} Peptides of Varying Length.

M. P. Murphy, L. J. Hickman, C. B. Eckman, S. N. Uljon, R. Wang, and T. E. Golde (1999)
J. Biol. Chem. 274, 11914-11923
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Constitutive and regulated alpha -secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease.

S. Lammich, E. Kojro, R. Postina, S. Gilbert, R. Pfeiffer, M. Jasionowski, C. Haass, and F. Fahrenholz (1999)
PNAS 96, 3922-3927
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of beta -Amyloid Secretion by FE65, an Amyloid Protein Precursor-binding Protein.

S. L. Sabo, L. M. Lanier, A. F. Ikin, O. Khorkova, S. Sahasrabudhe, P. Greengard, and J. D. Buxbaum (1999)
J. Biol. Chem. 274, 7952-7957
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Competition of Aß amyloid peptide and apolipoprotein E for receptor-mediated endocytosis.

K. Winkler, H. Scharnagl, U. Tisljar, H. Hoschützky, I. Friedrich, M. M. Hoffmann, M. Hüttinger, H. Wieland, and W. März (1999)
J. Lipid Res. 40, 447-455
 |  Abstract »  |  Full Text »

Prostaglandin E2 Stimulates Amyloid Precursor Protein Gene Expression: Inhibition by Immunosuppressants.

R. K. K. Lee, S. Knapp, and R. J. Wurtman (1999)
J. Neurosci. 19, 940-947
 |  Abstract »  |  Full Text »  |  PDF »

The Neurobiology and Pharmacotherapy of Alzheimer's Disease.

O. Felician and T. A. Sandson (1999)
J Neuropsychiatry Clin Neurosci 11, 19-31
 |  Abstract »  |  Full Text »

Transgenic Mice Over-Expressing the C-99 Fragment of ßPP with an {alpha}-Secretase Site Mutation Develop a Myopathy Similar to Human Inclusion Body Myositis.

L.-W. Jin, M. G. Hearn, C. E. Ogburn, N. Dang, D. Nochlin, W. C. Ladiges, and G. M. Martin (1998)
Am. J. Pathol. 153, 1679-1686
 |  Abstract »  |  Full Text »  |  PDF »

Evidence That Tumor Necrosis Factor alpha  Converting Enzyme Is Involved in Regulated alpha -Secretase Cleavage of the Alzheimer Amyloid Protein Precursor.

J. D. Buxbaum, K.-N. Liu, Y. Luo, J. L. Slack, K. L. Stocking, J. J. Peschon, R. S. Johnson, B. J. Castner, D. P. Cerretti, and R. A. Black (1998)
J. Biol. Chem. 273, 27765-27767
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A role for the beta -amyloid precursor protein in memory?.

S. S. Sisodia and M. Gallagher (1998)
PNAS 95, 12074-12076
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Memory-enhancing effects of secreted forms of the beta -amyloid precursor protein in normal and amnestic mice.

H. Meziane, J.-C. Dodart, C. Mathis, S. Little, J. Clemens, S. M. Paul, and A. Ungerer (1998)
PNAS 95, 12683-12688
 |  Abstract »  |  Full Text »  |  PDF »

Serine Proteases in Rodent Hippocampus.

B. J. Davies, B. S. Pickard, M. Steel, R. G. M. Morris, and R. Lathe (1998)
J. Biol. Chem. 273, 23004-23011
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Products of the Alzheimer's disease amyloid precursor protein generated by,{beta}-secretase are present in human platelets, and secreted upon degranulation.

Q.-X. Li, R. Cappai, G. Evin, J. E. Tanner, C. W. Gray, K. Beyreuther, and C. L. Masters (1998)
American Journal of Alzheimer's Disease and Other Dementias 13, 236-244
 |  Abstract »  |  PDF »

X11 Interaction with beta -Amyloid Precursor Protein Modulates Its Cellular Stabilization and Reduces Amyloid beta -Protein Secretion.

M. Sastre, R. S. Turner, and E. Levy (1998)
J. Biol. Chem. 273, 22351-22357
 |  Abstract »  |  Full Text »  |  PDF »

A Basic Amino Acid in the Cytoplasmic Domain of Alzheimer's beta -Amyloid Precursor Protein (APP) Is Essential for Cleavage of APP at the alpha -Site.

S. Tomita, Y. Kirino, and T. Suzuki (1998)
J. Biol. Chem. 273, 19304-19310
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Secreted beta -Amyloid Precursor Protein and Amyloid beta -Peptide in Brain by Cholesterol.

D. S. Howland, S. P. Trusko, M. J. Savage, A. G. Reaume, D. M. Lang, J. D. Hirsch, N. Maeda, R. Siman, B. D. Greenberg, R. W. Scott, et al. (1998)
J. Biol. Chem. 273, 16576-16582
 |  Abstract »  |  Full Text »  |  PDF »

Thyroid Hormones Regulate {beta}-Amyloid Gene Splicing and Protein Secretion in Neuroblastoma Cells.

M. J. Latasa, B. Belandia, and A. Pascual (1998)
Endocrinology 139, 2692-2698
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Amyloid Precursor Protein Secretion by Glutamate Receptors in Human Ntera 2 Neurons (NT2N).

C. Jolly-Tornetta, Z.-y. Gao, V. M.-Y. Lee, and B. A. Wolf (1998)
J. Biol. Chem. 273, 14015-14021
 |  Abstract »  |  Full Text »  |  PDF »

Degeneration In Vivo of Rat Hippocampal Neurons by Wild-Type Alzheimer Amyloid Precursor Protein Overexpressed by Adenovirus-Mediated Gene Transfer.

I. Nishimura, T. Uetsuki, S. U. Dani, Y. Ohsawa, I. Saito, H. Okamura, Y. Uchiyama, and K. Yoshikawa (1998)
J. Neurosci. 18, 2387-2398
 |  Abstract »  |  Full Text »  |  PDF »

Cleavage of Alzheimer's Amyloid Precursor Protein (APP) by Secretases Occurs after O-Glycosylation of APP in the Protein Secretory Pathway. IDENTIFICATION OF INTRACELLULAR COMPARTMENTS IN WHICH APP CLEAVAGE OCCURS WITHOUT USING TOXIC AGENTS THAT INTERFERE WITH PROTEIN METABOLISM.

S. Tomita, Y. Kirino, and T. Suzuki (1998)
J. Biol. Chem. 273, 6277-6284
 |  Abstract »  |  Full Text »  |  PDF »

Relative Increase in Alzheimer's Disease of Soluble Forms of Cerebral Abeta Amyloid Protein Precursor Containing the Kunitz Protease Inhibitory Domain.

R. D. Moir, T. Lynch, A. I. Bush, S. Whyte, A. Henry, S. Portbury, G. Multhaup, D. H. Small, R. E. Tanzi, K. Beyreuther, et al. (1998)
J. Biol. Chem. 273, 5013-5019
 |  Abstract »  |  Full Text »  |  PDF »

Structural Transitions Associated with the Interaction of Alzheimer beta -Amyloid Peptides with Gangliosides.

J. McLaurin, T. Franklin, P. E. Fraser, and A. Chakrabartty (1998)
J. Biol. Chem. 273, 4506-4515
 |  Abstract »  |  Full Text »  |  PDF »

Signal-dependent Trafficking of beta -Amyloid Precursor Protein-Transferrin Receptor Chimeras in Madin-Darby Canine Kidney Cells.

A. Lai, A. Gibson, C. R. Hopkins, and I. S. Trowbridge (1998)
J. Biol. Chem. 273, 3732-3739
 |  Abstract »  |  Full Text »  |  PDF »

The WW Domain of Neural Protein FE65 Interacts with Proline-rich Motifs in Mena, the Mammalian Homolog of Drosophila Enabled.

K. S. Ermekova, N. Zambrano, H. Linn, G. Minopoli, F. Gertler, T. Russo, and M. Sudol (1997)
J. Biol. Chem. 272, 32869-32877
 |  Abstract »  |  Full Text »  |  PDF »

Differential Effects of the Swedish Mutant Amyloid Precursor Protein on beta -Amyloid Accumulation and Secretion in Neurons and Nonneuronal Cells.

M. S. Forman, D. G. Cook, S. Leight, R. W. Doms, and V. M.-Y. Lee (1997)
J. Biol. Chem. 272, 32247-32253
 |  Abstract »  |  Full Text »  |  PDF »

Zinc-induced Alzheimer's Abeta 1-40 Aggregation Is Mediated by Conformational Factors.

X. Huang, C. S. Atwood, R. D. Moir, M. A. Hartshorn, J.-P. Vonsattel, R. E. Tanzi, and A. I. Bush (1997)
J. Biol. Chem. 272, 26464-26470
 |  Abstract »  |  Full Text »  |  PDF »

Late Compartments of Amyloid Precursor Protein Transport in SY5Y Cells Are Involved in beta -Amyloid Secretion.

G. C. Peraus, C. L. Masters, and K. Beyreuther (1997)
J. Neurosci. 17, 7714-7724
 |  Abstract »  |  Full Text »  |  PDF »

Zyme, a Novel and Potentially Amyloidogenic Enzyme cDNA Isolated from Alzheimer's Disease Brain.

S. P. Little, E. P. Dixon, F. Norris, W. Buckley, G. W. Becker, M. Johnson, J. R. Dobbins, T. Wyrick, J. R. Miller, W. MacKellar, et al. (1997)
J. Biol. Chem. 272, 25135-25142
 |  Abstract »  |  Full Text »  |  PDF »

Novel {beta}-Secretase Cleavage of {beta}-Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells.

A. S.C. Chyung, B. D. Greenberg, D. G. Cook, R. W. Doms, and V. M.-Y. Lee (1997)
J. Cell Biol. 138, 671-680
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of amyloid precursor protein synthesis by adrenergic receptors coupled to cAMP formation.

R. K. K. Lee, W. Araki, and R. J. Wurtman (1997)
PNAS 94, 5422-5426
 |  Abstract »  |  Full Text »  |  PDF »

Disaggregation of Alzheimer beta -amyloid by site-directed mAb.

B. Solomon, R. Koppel, D. Frankel, and E. Hanan-Aharon (1997)
PNAS 94, 4109-4112
 |  Abstract »  |  Full Text »  |  PDF »

Metabotropic Glutamate Receptor Agonists Increase Release of Soluble Amyloid Precursor Protein Derivatives from Rat Brain Cortical and Hippocampal Slices.

I. H. Ulus and R. J. Wurtman (1997)
J. Pharmacol. Exp. Ther. 281, 149-154
 |  Abstract »  |  Full Text »

Exploring the Etiology of Alzheimer Disease Using Molecular Genetics.

C. L. Lendon, F. Ashall, and A. M. Goate (1997)
JAMA 277, 825-831
 |  Abstract »  |  PDF »

Amyloid precursor protein processing and Abeta 42 deposition in a transgenic mouse model of Alzheimer disease.

K. Johnson-Wood, M. Lee, R. Motter, K. Hu, G. Gordon, R. Barbour, K. Khan, M. Gordon, H. Tan, D. Games, et al. (1997)
PNAS 94, 1550-1555
 |  Abstract »  |  Full Text »  |  PDF »

Cell Surface Amyloid beta -Protein Precursor Colocalizes with beta 1 Integrins at Substrate Contact Sites in Neural Cells.

T. Yamazaki, E. H. Koo, and D. J. Selkoe (1997)
J. Neurosci. 17, 1004-1010
 |  Abstract »  |  Full Text »  |  PDF »

Generation of Alzheimer Amyloid beta Peptide through Nonspecific Proteolysis.

L. O. Tjernberg, J. Naslund, J. Thyberg, S. E. Gandy, L. Terenius, and C. Nordstedt (1997)
J. Biol. Chem. 272, 1870-1875
 |  Abstract »  |  Full Text »  |  PDF »

Ectodomain Phosphorylation of beta -Amyloid Precursor Protein at Two Distinct Cellular Locations.

J. Walter, A. Capell, A. Y. Hung, H. Langen, M. Schnolzer, G. Thinakaran, S. S. Sisodia, D. J. Selkoe, and C. Haass (1997)
J. Biol. Chem. 272, 1896-1903
 |  Abstract »  |  Full Text »  |  PDF »

Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-beta Peptide (1-40).

J. R. Backstrom, G. P. Lim, M. J. Cullen, and Z. A. Tokes (1996)
J. Neurosci. 16, 7910-7919
 |  Abstract »  |  Full Text »  |  PDF »

Processing of beta -Amyloid Precursor Protein by Cathepsin D.

J. Higaki, R. Catalano, A. W. Guzzetta, D. Quon, J.-F. Nave, C. Tarnus, H. D'Orchymont, and B. Cordell (1996)
J. Biol. Chem. 271, 31885-31893
 |  Abstract »  |  Full Text »  |  PDF »

beta -Secretase Processing of the beta -Amyloid Precursor Protein in Transgenic Mice Is Efficient in Neurons but Inefficient in Astrocytes.

J. Zhao, L. Paganini, L. Mucke, M. Gordon, L. Refolo, M. Carman, S. Sinha, T. Oltersdorf, I. Lieberburg, and L. McConlogue (1996)
J. Biol. Chem. 271, 31407-31411
 |  Abstract »  |  Full Text »  |  PDF »

The Alternatively Spliced Kunitz Protease Inhibitor Domain Alters Amyloid beta Protein Precursor Processing and Amyloid beta Protein Production in Cultured Cells.

L. Ho, K.-i. Fukuchi, and StevenG. Younkin (1996)
J. Biol. Chem. 271, 30929-30934
 |  Abstract »  |  Full Text »  |  PDF »

The Carboxyl Termini of beta -Amyloid Peptides 1-40 and 1-42 Are Generated by Distinct gamma -Secretase Activities.

H.-W. Klafki, D. Abramowski, R. Swoboda, P.A. Paganetti, and M. Staufenbiel (1996)
J. Biol. Chem. 271, 28655-28659
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Amyloidogenic Processing of Human Amyloid Precursor Protein in Hippocampal Neurons Devoid of Cathepsin D.

P. Saftig, C. Peters, K. von Figura, K. Craessaerts, F. Van Leuven, and B. De Strooper (1996)
J. Biol. Chem. 271, 27241-27244
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Membrane Disruption by Alzheimer beta -Amyloid Peptides Mediated through Specific Binding to Either Phospholipids or Gangliosides. IMPLICATIONS FOR NEUROTOXICITY.

J. McLaurin and A. Chakrabartty (1996)
J. Biol. Chem. 271, 26482-26489
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Enhanced Amyloidogenic Processing of the beta -Amyloid Precursor Protein in Gene-targeted Mice Bearing the Swedish Familial Alzheimer's Disease Mutations and a ``Humanized'' Abeta Sequence.

A. G. Reaume, D. S. Howland, S. P. Trusko, M. J. Savage, D. M. Lang, B. D. Greenberg, R. Siman, and R. W. Scott (1996)
J. Biol. Chem. 271, 23380-23388
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Analysis of Heterogeneous beta A4 Peptides in Human Cerebrospinal Fluid and Blood by a Newly Developed Sensitive Western Blot Assay.

N. Ida, T. Hartmann, J. Pantel, J. Schroder, R. Zerfass, H. Forstl, R. Sandbrink, C. L. Masters, and K. Beyreuther (1996)
J. Biol. Chem. 271, 22908-22914
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Amyloid beta -Protein and the Genetics of Alzheimer's Disease.

D. J. Selkoe and D. J. Selkoe (1996)
J. Biol. Chem. 271, 18295-18298
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Metabolism of the ``Swedish'' Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells.

G. Thinakaran, D. B. Teplow, R. Siman, B. Greenberg, and S. S. Sisodia (1996)
J. Biol. Chem. 271, 9390-9397
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Arrest of beta-Amyloid Fibril Formation by a Pentapeptide Ligand.

L. O. Tjernberg, J. Näslund, F. Lindqvist, J. Johansson, A. R. Karlström, J. Thyberg, L. Terenius, and C. Nordstedt (1996)
J. Biol. Chem. 271, 8545-8548
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Amyloids beta[IMAGE] and beta[IMAGE] Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation.

R. S. Turner, N. Suzuki, A. S. C. Chyung, S. G. Younkin, and V. M.-Y. Lee (1996)
J. Biol. Chem. 271, 8966-8970
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Enhanced Release of Amyloid beta-Protein from Codon 670/671 ``Swedish'' Mutant beta-Amyloid Precursor Protein Occurs in Both Secretory and Endocytic Pathways.

R. G. Perez, S. L. Squazzo, and E. H. Koo (1996)
J. Biol. Chem. 271, 9100-9107
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Serotonin 5-HT2a and 5-HT2c Receptors Stimulate Amyloid Precursor Protein Ectodomain Secretion.

R. M. Nitsch, M. Deng, J. H. Growdon, and R. J. Wurtman (1996)
J. Biol. Chem. 271, 4188-4194
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Cholesterol Modulates alpha-Secretase Cleavage of Amyloid Precursor Protein.

S. Bodovitz and W. L. Klein (1996)
J. Biol. Chem. 271, 4436-4440
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Differential Effects of a Rab6 Mutant on Secretory Versus Amyloidogenic Processing of Alzheimer's beta-Amyloid Precursor Protein.

L. McConlogue, F. Castellano, C. deWit, D. Schenk, and W. A. Maltese (1996)
J. Biol. Chem. 271, 1343-1348
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Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody.

E. Koo, S. Squazzo, D. Selkoe, and C. Koo (1996)
J. Cell Sci. 109, 991-998
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Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization.

T Yamazaki, E. Koo, and D. Selkoe (1996)
J. Cell Sci. 109, 999-1008
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The Role of Presenilin 1 in the Genetics of Alzheimer's Disease.

R.F. Clark, M. Hutton, C. Talbot, M. Wragg, C. Lendon, F. Busfield, S.W. Han, J. Perez-Tur, M. Adams, R. Fuldner, et al. (1996)
Cold Spring Harb Symp Quant Biol 61, 551-558
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Neurodegenerative Diseases and Model Systems.

D.L. Price, D.R. Borchelt, P.C. Wong, C.A. Pardo, G. Thinakaran, M.K. Lee, D.W. Cleveland, and S.S. Sisodia (1996)
Cold Spring Harb Symp Quant Biol 61, 725-738
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Coagulation Factor XIa Cleaves the RHDS Sequence and Abolishes the Cell Adhesive Properties of the Amyloid beta-Protein.

S. M. Saporito-Irwin and W. E. Van Nostrand (1995)
J. Biol. Chem. 270, 26265-26269
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Amino-terminal Deletions Enhance Aggregation of beta-Amyloid Peptides in Vitro.

C. J. Pike, M. J. Overman, and C. W. Cotman (1995)
J. Biol. Chem. 270, 23895-23898
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Amyloid beta-Protein Aggregation Nullifies Its Pathologic Properties in Cultured Cerebrovascular Smooth Muscle Cells.

J. Davis-Salinas and W. E. Van Nostrand (1995)
J. Biol. Chem. 270, 20887-20890
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Amyloid beta-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro.

L. Gregori, C. Fuchs, M. E. Figueiredo-Pereira, W. E. Van Nostrand, and D. Goldgaber (1995)
J. Biol. Chem. 270, 19702-19708
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Generation of Amyloidogenic C-terminal Fragments during Rapid Axonal Transport in Vivo of [IMAGE]-Amyloid Precursor Protein in the Optic Nerve.

A. Amaratunga and R. E. Fine (1995)
J. Biol. Chem. 270, 17268-17272
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