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Science 1 June 1990:
Vol. 248. no. 4959, pp. 1115 - 1118
DOI: 10.1126/science.2188366
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Articles

Science, Vol 248, Issue 4959, 1115-1118
Copyright © 1990 by American Association for the Advancement of Science

articles

Cell interactions in the sea urchin embryo studied by fluorescence photoablation

CA Ettensohn

Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213.

In many organisms, interactions between cells play a critical role in the specification of cell fates. In the sea urchin embryo, primary mesenchyme cells (PMCs) regulate the developmental program of a subpopulation of secondary mesenchyme cells (SMCs). The timing of this cell interaction was analyzed by means of a fluorescence photoablation technique, which was used to specifically ablate PMCs at various stages of development. In addition, the PMCs were microinjected into PMC-depleted recipient embryos at different developmental stages and their effect on SMC fate was examined. The critical interaction between PMCs and SMCs was brief and took place late in gastrulation. Before that time, SMCs were insensitive to the suppressive signals transmitted by the PMCs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis and regulate gastrulation during sea urchin development.
E. Rottinger, A. Saudemont, V. Duboc, L. Besnardeau, D. McClay, and T. Lepage (2008)
Development 135, 353-365
   Abstract »    Full Text »    PDF »
Gene regulatory networks and developmental plasticity in the early sea urchin embryo: alternative deployment of the skeletogenic gene regulatory network.
C. A. Ettensohn, C. Kitazawa, M. S. Cheers, J. D. Leonard, and T. Sharma (2007)
Development 134, 3077-3087
   Abstract »    Full Text »    PDF »
Dynamics of thin filopodia during sea urchin gastrulation.
J Miller, S. Fraser, and D McClay (1995)
Development 121, 2501-2511
   Abstract »    PDF »
A complete second gut induced by transplanted micromeres in the sea urchin embryo.
A Ransick and E. Davidson (1993)
Science 259, 1134-1138
   Abstract »    PDF »
Size regulation and morphogenesis: a cellular analysis of skeletogenesis in the sea urchin embryo.
C. Ettensohn and K. Malinda (1993)
Development 119, 155-167
   Abstract »    PDF »
Mesodermal cell interactions in the sea urchin embryo: properties of skeletogenic secondary mesenchyme cells.
C. Ettensohn and S. Ruffins (1993)
Development 117, 1275-1285
   Abstract »    PDF »


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