Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 1 June 1990:
Vol. 248. no. 4959, pp. 1109 - 1112
DOI: 10.1126/science.2160735
Prev | Table of Contents | Next

Articles

Science, Vol 248, Issue 4959, 1109-1112
Copyright © 1990 by American Association for the Advancement of Science

articles

Induction of AIDS in rhesus monkeys by molecularly cloned simian immunodeficiency virus

H Kestler, T Kodama, D Ringler, M Marthas, N Pedersen, A Lackner, D Regier, P Sehgal, M Daniel, N King, and al. et

New England Regional Primate Research Center, Harvard Medical School, Southborough, MA 01772.

Better understanding of the pathogenesis of acquired immunodeficiency syndrome (AIDS) would be greatly facilitated by a relevant animal model that uses molecularly cloned virus of defined sequence to induce the disease. Such a system would also be of great value for AIDS vaccine research. An infectious molecular clone of simian immunodeficiency virus (SIV) was identified that induces AIDS in common rhesus monkeys in a time frame suitable for laboratory investigation. These results provide another strong link in the chain of evidence for the viral etiology of AIDS. More importantly, they define a system for molecular dissection of the determinants of AIDS pathogenesis.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Distribution, Persistence, and Efficacy of Adoptively Transferred Central and Effector Memory-Derived Autologous Simian Immunodeficiency Virus-Specific CD8+ T Cell Clones in Rhesus Macaques during Acute Infection.
J. T. Minang, M. T. Trivett, D. L. Bolton, C. M. Trubey, J. D. Estes, Y. Li, J. Smedley, R. Pung, M. Rosati, R. Jalah, et al. (2010)
J. Immunol. 184, 315-326
   Abstract »    Full Text »    PDF »
Trafficking, Persistence, and Activation State of Adoptively Transferred Allogeneic and Autologous Simian Immunodeficiency Virus-Specific CD8+ T Cell Clones during Acute and Chronic Infection of Rhesus Macaques.
D. L. Bolton, J. T. Minang, M. T. Trivett, K. Song, J. J. Tuscher, Y. Li, M. Piatak Jr, D. O'Connor, J. D. Lifson, M. Roederer, et al. (2010)
J. Immunol. 184, 303-314
   Abstract »    Full Text »    PDF »
Profound CD4+/CCR5+ T cell expansion is induced by CD8+ lymphocyte depletion but does not account for accelerated SIV pathogenesis.
A. Okoye, H. Park, M. Rohankhedkar, L. Coyne-Johnson, R. Lum, J. M. Walker, S. L. Planer, A. W. Legasse, A. W. Sylwester, M. Piatak Jr., et al. (2009)
J. Exp. Med. 206, 1575-1588
   Abstract »    Full Text »    PDF »
Two MHC Class I Molecules Associated with Elite Control of Immunodeficiency Virus Replication, Mamu-B*08 and HLA-B*2705, Bind Peptides with Sequence Similarity.
J. T. Loffredo, J. Sidney, A. T. Bean, D. R. Beal, W. Bardet, A. Wahl, O. E. Hawkins, S. Piaskowski, N. A. Wilson, W. H. Hildebrand, et al. (2009)
J. Immunol. 182, 7763-7775
   Abstract »    Full Text »    PDF »
Potent Antibody-Mediated Neutralization and Evolution of Antigenic Escape Variants of Simian Immunodeficiency Virus Strain SIVmac239 In Vivo.
S. Sato, E. Yuste, W. A. Lauer, E. H. Chang, J. S. Morgan, J. G. Bixby, J. D. Lifson, R. C. Desrosiers, and W. E. Johnson (2008)
J. Virol. 82, 9739-9752
   Abstract »    Full Text »    PDF »
Patterns of CD8+ Immunodominance May Influence the Ability of Mamu-B*08-Positive Macaques To Naturally Control Simian Immunodeficiency Virus SIVmac239 Replication.
J. T. Loffredo, A. T. Bean, D. R. Beal, E. J. Leon, G. E. May, S. M. Piaskowski, J. R. Furlott, J. Reed, S. K. Musani, E. G. Rakasz, et al. (2008)
J. Virol. 82, 1723-1738
   Abstract »    Full Text »    PDF »
Construction of a Doxycycline-Dependent Simian Immunodeficiency Virus Reveals a Nontranscriptional Function of Tat in Viral Replication.
A. T. Das, B. Klaver, A. Harwig, M. Vink, M. Ooms, M. Centlivre, and B. Berkhout (2007)
J. Virol. 81, 11159-11169
   Abstract »    Full Text »    PDF »
A Single Amino Acid of the Human Immunodeficiency Virus Type 2 Capsid Affects Its Replication in the Presence of Cynomolgus Monkey and Human TRIM5{alpha}s.
H. Song, E. E. Nakayama, M. Yokoyama, H. Sato, J. A. Levy, and T. Shioda (2007)
J. Virol. 81, 7280-7285
   Abstract »    Full Text »    PDF »
The Antiviral Efficacy of Simian Immunodeficiency Virus-Specific CD8+ T Cells Is Unrelated to Epitope Specificity and Is Abrogated by Viral Escape.
J. T. Loffredo, B. J. Burwitz, E. G. Rakasz, S. P. Spencer, J. J. Stephany, J. P. Giraldo Vela, S. R. Martin, J. Reed, S. M. Piaskowski, J. Furlott, et al. (2007)
J. Virol. 81, 2624-2634
   Abstract »    Full Text »    PDF »
Not All Cytokine-Producing CD8+ T Cells Suppress Simian Immunodeficiency Virus Replication.
C. Chung, W. Lee, J. T. Loffredo, B. Burwitz, T. C. Friedrich, J. P. Giraldo Vela, G. Napoe, E. G. Rakasz, N. A. Wilson, D. B. Allison, et al. (2007)
J. Virol. 81, 1517-1523
   Abstract »    Full Text »    PDF »
Loss of Naive Cells Accompanies Memory CD4+ T-Cell Depletion during Long-Term Progression to AIDS in Simian Immunodeficiency Virus-Infected Macaques.
Y. Nishimura, T. Igarashi, A. Buckler-White, C. Buckler, H. Imamichi, R. M. Goeken, W. R. Lee, B. A. P. Lafont, R. Byrum, H. C. Lane, et al. (2007)
J. Virol. 81, 893-902
   Abstract »    Full Text »    PDF »
Simian Immunodeficiency Virus (SIV)/Immunoglobulin G Immune Complexes in SIV-Infected Macaques Block Detection of CD16 but Not Cytolytic Activity of Natural Killer Cells..
Q. Wei, J. W. Stallworth, P. J. Vance, J. A. Hoxie, and P. N. Fultz (2006)
Clin. Vaccine Immunol. 13, 768-778
   Abstract »    Full Text »    PDF »
Comparative studies on mucosal and intravenous transmission of simian immunodeficiency virus (SIVsm): evolution of coreceptor use varies with pathogenic outcome..
A. Lauren, D. Vodros, R. Thorstensson, and E. M. Fenyo (2006)
J. Gen. Virol. 87, 581-594
   Abstract »    Full Text »    PDF »
Characterization and role of lentivirus-associated host proteins..
K. Kolegraff, P. Bostik, and A. A. Ansari (2006)
Experimental Biology and Medicine 231, 252-263
   Abstract »    Full Text »    PDF »
Tat28-35SL8-Specific CD8+ T Lymphocytes Are More Effective than Gag181-189CM9-Specific CD8+ T Lymphocytes at Suppressing Simian Immunodeficiency Virus Replication in a Functional In Vitro Assay.
J. T. Loffredo, E. G. Rakasz, J. P. Giraldo, S. P. Spencer, K. K. Grafton, S. R. Martin, G. Napoe, L. J. Yant, N. A. Wilson, and D. I. Watkins (2005)
J. Virol. 79, 14986-14991
   Abstract »    Full Text »    PDF »
The High Frequency Indian Rhesus Macaque MHC Class I Molecule, Mamu-B*01, Does Not Appear to Be Involved in CD8+ T Lymphocyte Responses to SIVmac239.
J. T. Loffredo, J. Sidney, S. Piaskowski, A. Szymanski, J. Furlott, R. Rudersdorf, J. Reed, B. Peters, H. D. Hickman-Miller, W. Bardet, et al. (2005)
J. Immunol. 175, 5986-5997
   Abstract »    Full Text »    PDF »
Use of Molecular Beacons for Rapid, Real-Time, Quantitative Monitoring of Cytotoxic T-Lymphocyte Epitope Mutations in Simian Immunodeficiency Virus.
F. W. Peyerl, D. H. Barouch, H. S. Bazick, E. Manuel, and N. L. Letvin (2005)
J. Clin. Microbiol. 43, 4773-4779
   Abstract »    Full Text »    PDF »
Primary Sooty Mangabey Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 2 nef Alleles Modulate Cell Surface Expression of Various Human Receptors and Enhance Viral Infectivity and Replication.
J. Munch, M. Schindler, S. Wildum, E. Rucker, N. Bailer, V. Knoop, F. J. Novembre, and F. Kirchhoff (2005)
J. Virol. 79, 10547-10560
   Abstract »    Full Text »    PDF »
Resting naive CD4+ T cells are massively infected and eliminated by X4-tropic simian-human immunodeficiency viruses in macaques.
Y. Nishimura, C. R. Brown, J. J. Mattapallil, T. Igarashi, A. Buckler-White, B. A. P. Lafont, V. M. Hirsch, M. Roederer, and M. A. Martin (2005)
PNAS 102, 8000-8005
   Abstract »    Full Text »    PDF »
ATP{gamma}S Disrupts Human Immunodeficiency Virus Type 1 Virion Core Integrity.
C. Gurer, A. Hoglund, S. Hoglund, and J. Luban (2005)
J. Virol. 79, 5557-5567
   Abstract »    Full Text »    PDF »
Phosphorylation and Proteolytic Cleavage of Gag Proteins in Budded Simian Immunodeficiency Virus.
S. M. Rue, J. W. Roos, P. M. Tarwater, J. E. Clements, and S. A. Barber (2005)
J. Virol. 79, 2484-2492
   Abstract »    Full Text »    PDF »
Fitness Costs Limit Viral Escape from Cytotoxic T Lymphocytes at a Structurally Constrained Epitope.
F. W. Peyerl, H. S. Bazick, M. H. Newberg, D. H. Barouch, J. Sodroski, and N. L. Letvin (2004)
J. Virol. 78, 13901-13910
   Abstract »    Full Text »    PDF »
Cell Tropism of Simian Immunodeficiency Virus in Culture Is Not Predictive of in Vivo Tropism or Pathogenesis.
J. T. Borda, X. Alvarez, I. Kondova, P. Aye, M. A. Simon, R. C. Desrosiers, and A. A. Lackner (2004)
Am. J. Pathol. 165, 2111-2122
   Abstract »    Full Text »    PDF »
Insufficient Production and Tissue Delivery of CD4+ Memory T Cells in Rapidly Progressive Simian Immunodeficiency Virus Infection.
L. J. Picker, S. I. Hagen, R. Lum, E. F. Reed-Inderbitzin, L. M. Daly, A. W. Sylwester, J. M. Walker, D. C. Siess, M. Piatak Jr., C. Wang, et al. (2004)
J. Exp. Med. 200, 1299-1314
   Abstract »    Full Text »    PDF »
Identification of Seventeen New Simian Immunodeficiency Virus-Derived CD8+ T Cell Epitopes Restricted by the High Frequency Molecule, Mamu-A*02, and Potential Escape from CTL Recognition.
J. T. Loffredo, J. Sidney, C. Wojewoda, E. Dodds, M. R. Reynolds, G. Napoe, B. R. Mothe, D. H. O'Connor, N. A. Wilson, D. I. Watkins, et al. (2004)
J. Immunol. 173, 5064-5076
   Abstract »    Full Text »    PDF »
Comprehensive Analysis of Nef Functions Selected in Simian Immunodeficiency Virus-Infected Macaques.
M. Schindler, J. Munch, M. Brenner, C. Stahl-Hennig, J. Skowronski, and F. Kirchhoff (2004)
J. Virol. 78, 10588-10597
   Abstract »    Full Text »    PDF »
Primary HIV-1 Infection Is Associated with Preferential Depletion of CD4+ T Lymphocytes from Effector Sites in the Gastrointestinal Tract.
S. Mehandru, M. A. Poles, K. Tenner-Racz, A. Horowitz, A. Hurley, C. Hogan, D. Boden, P. Racz, and M. Markowitz (2004)
J. Exp. Med. 200, 761-770
   Abstract »    Full Text »    PDF »
Highly pathogenic SHIVs and SIVs target different CD4+ T cell subsets in rhesus monkeys, explaining their divergent clinical courses.
Y. Nishimura, T. Igarashi, O. K. Donau, A. Buckler-White, C. Buckler, B. A. P. Lafont, R. M. Goeken, S. Goldstein, V. M. Hirsch, and M. A. Martin (2004)
PNAS 101, 12324-12329
   Abstract »    Full Text »    PDF »
Loss of virus-specific CD4+ T cells with increases in viral loads in the chronic phase after vaccine-based partial control of primary simian immunodeficiency virus replication in macaques.
W.-H. Lun, A. Takeda, H. Nakamura, M. Kano, K. Mori, T. Sata, Y. Nagai, and T. Matano (2004)
J. Gen. Virol. 85, 1955-1963
   Abstract »    Full Text »    PDF »
Modulation of Env Content in Virions of Simian Immunodeficiency Virus: Correlation with Cell Surface Expression and Virion Infectivity.
E. Yuste, J. D. Reeves, R. W. Doms, and R. C. Desrosiers (2004)
J. Virol. 78, 6775-6785
   Abstract »    Full Text »    PDF »
Amino Acid 324 in the Simian Immunodeficiency Virus SIVmac V3 Loop Can Confer CD4 Independence and Modulate the Interaction with CCR5 and Alternative Coreceptors.
S. Pohlmann, C. Davis, S. Meister, G. J. Leslie, C. Otto, J. D. Reeves, B. A. Puffer, A. Papkalla, M. Krumbiegel, A. Marzi, et al. (2004)
J. Virol. 78, 3223-3232
   Abstract »    Full Text »    PDF »
Molecular Evidence for Rhesus Lymphocryptovirus Infection of Epithelial Cells in Immunosuppressed Rhesus Macaques.
J. L. Kutok, S. Klumpp, M. Simon, J. J. MacKey, V. Nguyen, J. M. Middeldorp, J. C. Aster, and F. Wang (2004)
J. Virol. 78, 3455-3461
   Abstract »    Full Text »    PDF »
Specificity of Interaction of INI1/hSNF5 with Retroviral Integrases and Its Functional Significance.
E. Yung, M. Sorin, E.-J. Wang, S. Perumal, D. Ott, and G. V. Kalpana (2004)
J. Virol. 78, 2222-2231
   Abstract »    Full Text »    PDF »
Simian Immunodeficiency Virus Promoter Exchange Results in a Highly Attenuated Strain That Protects against Uncloned Challenge Virus.
P. Blancou, N. Chenciner, R. H. T. Fang, V. Monceaux, M.-C. Cumont, D. Guetard, B. Hurtrel, and S. Wain-Hobson (2004)
J. Virol. 78, 1080-1092
   Abstract »    Full Text »    PDF »
Multispecific Vaccine-Induced Mucosal Cytotoxic T Lymphocytes Reduce Acute-Phase Viral Replication but Fail in Long-Term Control of Simian Immunodeficiency Virus SIVmac239.
T. U. Vogel, M. R. Reynolds, D. H. Fuller, K. Vielhuber, T. Shipley, J. T. Fuller, K. J. Kunstman, G. Sutter, M. L. Marthas, V. Erfle, et al. (2003)
J. Virol. 77, 13348-13360
   Abstract »    Full Text »    PDF »
Simian-Human Immunodeficiency Virus Escape from Cytotoxic T-Lymphocyte Recognition at a Structurally Constrained Epitope.
F. W. Peyerl, D. H. Barouch, W. W. Yeh, H. S. Bazick, J. Kunstman, K. J. Kunstman, S. M. Wolinsky, and N. L. Letvin (2003)
J. Virol. 77, 12572-12578
   Abstract »    Full Text »    PDF »
The emergence and characterization of macrophage-tropic SIV/HIV chimeric viruses (SHIVs) present in CD4+ T cell-depleted rhesus monkeys.
T. Igarashi, H. Imamichi, C. R. Brown, V. M. Hirsch, and M. A. Martin (2003)
J. Leukoc. Biol. 74, 772-780
   Abstract »    Full Text »    PDF »
Early Control of Highly Pathogenic Simian Immunodeficiency Virus/Human Immunodeficiency Virus Chimeric Virus Infections in Rhesus Monkeys Usually Results in Long-Lasting Asymptomatic Clinical Outcomes.
T. Igarashi, Y. Endo, Y. Nishimura, C. Buckler, R. Sadjadpour, O. K. Donau, M.-J. Dumaurier, R. J. Plishka, A. Buckler-White, and M. A. Martin (2003)
J. Virol. 77, 10829-10840
   Abstract »    Full Text »    PDF »
Down-Modulation of Mature Major Histocompatibility Complex Class II and Up-Regulation of Invariant Chain Cell Surface Expression Are Well-Conserved Functions of Human and Simian Immunodeficiency Virus nef Alleles.
M. Schindler, S. Wurfl, P. Benaroch, T. C. Greenough, R. Daniels, P. Easterbrook, M. Brenner, J. Munch, and F. Kirchhoff (2003)
J. Virol. 77, 10548-10556
   Abstract »    Full Text »    PDF »
DNA vaccination of macaques by a full-genome simian/human immunodeficiency virus type 1 plasmid chimera that produces non-infectious virus particles.
W. Akahata, E. Ido, H. Akiyama, H. Uesaka, Y. Enose, R. Horiuchi, T. Kuwata, T. Goto, H. Takahashi, and M. Hayami (2003)
J. Gen. Virol. 84, 2237-2244
   Abstract »    Full Text »    PDF »
Hydrogen Bonding at a Conserved Threonine in Lentivirus Capsid Is Required for Virus Replication.
S. M. Rue, J. W. Roos, L. M. Amzel, J. E. Clements, and S. A. Barber (2003)
J. Virol. 77, 8009-8018
   Abstract »    Full Text »    PDF »
Determinants of Increased Replicative Capacity of Serially Passaged Simian Immunodeficiency Virus with nef Deleted in Rhesus Monkeys.
L. Alexander, P. O. Illyinskii, S. M. Lang, R. E. Means, J. Lifson, K. Mansfield, and R. C. Desrosiers (2003)
J. Virol. 77, 6823-6835
   Abstract »    Full Text »    PDF »
Expression of Simian Immunodeficiency Virus (SIV) Nef in Astrocytes during Acute and Terminal Infection and Requirement of Nef for Optimal Replication of Neurovirulent SIV In Vitro.
E. D. Overholser, G. D. Coleman, J. L. Bennett, R. J. Casaday, M. C. Zink, S. A. Barber, and J. E. Clements (2003)
J. Virol. 77, 6855-6866
   Abstract »    Full Text »    PDF »
Mutational analysis of two zinc-finger motifs in the nucleocapsid protein of simian immunodeficiency virus mac239.
W. Akahata, E. Ido, and M. Hayami (2003)
J. Gen. Virol. 84, 1641-1648
   Abstract »    Full Text »    PDF »
Unique Pattern of Convergent Envelope Evolution in Simian Immunodeficiency Virus-Infected Rapid Progressor Macaques: Association with CD4-Independent Usage of CCR5.
H. Dehghani, B. A. Puffer, R. W. Doms, and V. M. Hirsch (2003)
J. Virol. 77, 6405-6418
   Abstract »    Full Text »    PDF »
In Situ Hybridization AT-Tailing with Catalyzed Signal Amplification for Sensitive and Specific in Situ Detection of Human Immunodeficiency Virus-1 mRNA in Formalin-Fixed and Paraffin-Embedded Tissues.
N. Nakajima, P. Ionescu, Y. Sato, M. Hashimoto, T. Kuroita, H. Takahashi, H. Yoshikura, and T. Sata (2003)
Am. J. Pathol. 162, 381-389
   Abstract »    Full Text »    PDF »
Control of Viremia and Prevention of Simian-Human Immunodeficiency Virus-Induced Disease in Rhesus Macaques Immunized with Recombinant Vaccinia Viruses plus Inactivated Simian Immunodeficiency Virus and Human Immunodeficiency Virus Type 1 Particles.
R. L. Willey, R. Byrum, M. Piatak, Y. B. Kim, M. W. Cho, J. L. Rossio Jr., J. Bess Jr., T. Igarashi, Y. Endo, L. O. Arthur, et al. (2003)
J. Virol. 77, 1163-1174
   Abstract »    Full Text »    PDF »
Importance of B-Cell Responses for Immunological Control of Variant Strains of Simian Immunodeficiency Virus.
W. E. Johnson, J. D. Lifson, S. M. Lang, R. P. Johnson, and R. C. Desrosiers (2003)
J. Virol. 77, 375-381
   Abstract »    Full Text »    PDF »
Effects of Cytotoxic T Lymphocytes (CTL) Directed against a Single Simian Immunodeficiency Virus (SIV) Gag CTL Epitope on the Course of SIVmac239 Infection.
T. M. Allen, P. Jing, B. Calore, H. Horton, D. H. O'Connor, T. Hanke, M. Piekarczyk, R. Ruddersdorf, B. R. Mothe, C. Emerson, et al. (2002)
J. Virol. 76, 10507-10511
   Abstract »    Full Text »    PDF »
Primary replication of a recombinant Sendai virus vector in macaques.
M. Kano, T. Matano, A. Kato, H. Nakamura, A. Takeda, Y. Suzaki, Y. Ami, K. Terao, and Y. Nagai (2002)
J. Gen. Virol. 83, 1377-1386
   Abstract »    Full Text »    PDF »
CD4 Independence of Simian Immunodeficiency Virus Envs Is Associated with Macrophage Tropism, Neutralization Sensitivity, and Attenuated Pathogenicity.
B. A. Puffer, S. Pohlmann, A. L. Edinger, D. Carlin, M. D. Sanchez, J. Reitter, D. D. Watry, H. S. Fox, R. C. Desrosiers, and R. W. Doms (2002)
J. Virol. 76, 2595-2605
   Abstract »    Full Text »    PDF »
Rapid and Irreversible CD4+ T-Cell Depletion Induced by the Highly Pathogenic Simian/Human Immunodeficiency Virus SHIVDH12R Is Systemic and Synchronous.
T. Igarashi, C. R. Brown, R. A. Byrum, Y. Nishimura, Y. Endo, R. J. Plishka, C. Buckler, A. Buckler-White, G. Miller, V. M. Hirsch, et al. (2002)
J. Virol. 76, 379-391
   Abstract »    Full Text »    PDF »
Characteristics of a Pathogenic Molecular Clone of an End-Stage Serum-Derived Variant of Simian Immunodeficiency Virus (SIVF359).
L. Holterman, R. Dubbes, J. Mullins, G. Learn, H. Niphuis, W. Koornstra, G. Koopman, E.-M. Kuhn, A. Wade-Evans, B. Rosenwirth, et al. (2001)
J. Virol. 75, 9328-9338
   Abstract »    Full Text »    PDF »
Simian Immunodeficiency Virus in Which nef and U3 Sequences Do Not Overlap Replicates Efficiently In Vitro and In Vivo in Rhesus Macaques.
J. Munch, N. Adam, N. Finze, N. Stolte, C. Stahl-Hennig, D. Fuchs, P. Ten Haaft, J. L. Heeney, and F. Kirchhoff (2001)
J. Virol. 75, 8137-8146
   Abstract »    Full Text »    PDF »
Protection against Simian Immunodeficiency Virus Vaginal Challenge by Using Sabin Poliovirus Vectors.
S. Crotty, C. J. Miller, B. L. Lohman, M. R. Neagu, L. Compton, D. Lu, F. X.-S. Lu, L. Fritts, J. D. Lifson, and R. Andino (2001)
J. Virol. 75, 7435-7452
   Abstract »    Full Text »    PDF »
Induction of Disseminated Mycobacterium avium in Simian AIDS Is Dependent upon Simian Immunodeficiency Virus Strain and Defective Granuloma Formation.
K. G. Mansfield, R. S. Veazey, A. Hancock, A. Carville, M. Elliott, K.-C. Lin, and A. A. Lackner (2001)
Am. J. Pathol. 159, 693-702
   Abstract »    Full Text »
Primate and Feline Lentivirus Vector RNA Packaging and Propagation by Heterologous Lentivirus Virions.
M. T. Browning, R. D. Schmidt, K. A. Lew, and T. A. Rizvi (2001)
J. Virol. 75, 5129-5140
   Abstract »    Full Text »    PDF »
Construction and In Vitro Properties of a Series of Attenuated Simian Immunodeficiency Viruses with All Accessory Genes Deleted.
Y. Guan, J. B. Whitney, M. Detorio, and M. A. Wainberg (2001)
J. Virol. 75, 4056-4067
   Abstract »    Full Text »    PDF »
Ability of the V3 Loop of Simian Immunodeficiency Virus To Serve as a Target for Antibody-Mediated Neutralization: Correlation of Neutralization Sensitivity, Growth in Macrophages, and Decreased Dependence on CD4.
R. E. Means, T. Matthews, J. A. Hoxie, M. H. Malim, T. Kodama, and R. C. Desrosiers (2001)
J. Virol. 75, 3903-3915
   Abstract »    Full Text »    PDF »
Suboptimal Nucleotides in the Infectious, Pathogenic Simian Immunodeficiency Virus Clone SIVmac239.
L. Alexander, L. Denekamp, S. Czajak, and R. C. Desrosiers (2001)
J. Virol. 75, 4019-4022
   Abstract »    Full Text »    PDF »
Novel, Live Attenuated Simian Immunodeficiency Virus Constructs Containing Major Deletions in Leader RNA Sequences.
Y. Guan, J. B. Whitney, C. Liang, and M. A. Wainberg (2001)
J. Virol. 75, 2776-2785
   Abstract »    Full Text »    PDF »
Activation of NFAT-Dependent Gene Expression by Nef: Conservation among Divergent Nef Alleles, Dependence on SH3 Binding and Membrane Association, and Cooperation with Protein Kinase C-{theta}.
A. Manninen, P. Huotari, M. Hiipakka, G. H. Renkema, and K. Saksela (2001)
J. Virol. 75, 3034-3037
   Abstract »    Full Text »    PDF »
Identification of Enteropathogenic Escherichia coli in Simian Immunodeficiency Virus-Infected Infant and Adult Rhesus Macaques.
K. G. Mansfield, K.-C. Lin, J. Newman, D. Schauer, J. MacKey, A. A. Lackner, and A. Carville (2001)
J. Clin. Microbiol. 39, 971-976
   Abstract »    Full Text »    PDF »
In Vivo Attenuation of Simian Immunodeficiency Virus by Disruption of a Tyrosine-Dependent Sorting Signal in the Envelope Glycoprotein Cytoplasmic Tail.
P. N. Fultz, P. J. Vance, M. J. Endres, B. Tao, J. D. Dvorin, I. C. Davis, J. D. Lifson, D. C. Montefiori, M. Marsh, M. H. Malim, et al. (2001)
J. Virol. 75, 278-291
   Abstract »    Full Text »    PDF »
The Level of CD4 Expression Limits Infection of Primary Rhesus Monkey Macrophages by a T-Tropic Simian Immunodeficiency Virus and Macrophagetropic Human Immunodeficiency Viruses.
N. Bannert, D. Schenten, S. Craig, and J. Sodroski (2000)
J. Virol. 74, 10984-10993
   Abstract »    Full Text »    PDF »
Naturally Occurring V1-env Region Variants Mediate Simian Immunodeficiency Virus SIVmac Escape from High-Titer Neutralizing Antibodies Induced by a Protective Subunit Vaccine.
H. Petry, K. Pekrun, G. Hunsmann, E. Jurkiewicz, and W. Luke (2000)
J. Virol. 74, 11145-11152
   Abstract »    Full Text »    PDF »
Human T-Lymphotropic Virus Type 1 Open Reading Frame I p12I Is Required for Efficient Viral Infectivity in Primary Lymphocytes.
B. Albrecht, N. D. Collins, M. T. Burniston, J. W. Nisbet, L. Ratner, P. L. Green, and M. D. Lairmore (2000)
J. Virol. 74, 9828-9835
   Abstract »    Full Text »    PDF »
Leader Sequences Downstream of the Primer Binding Site Are Important for Efficient Replication of Simian Immunodeficiency Virus.
Y. Guan, J. B. Whitney, K. Diallo, and M. A. Wainberg (2000)
J. Virol. 74, 8854-8860
   Abstract »    Full Text »    PDF »
Induction of Mucosal Homing Virus-Specific CD8+ T Lymphocytes by Attenuated Simian Immunodeficiency Virus.
M. A. Cromwell, R. S. Veazey, J. D. Altman, K. G. Mansfield, R. Glickman, T. M. Allen, D. I. Watkins, A. A. Lackner, and R. P. Johnson (2000)
J. Virol. 74, 8762-8766
   Abstract »    Full Text »    PDF »
Mechanisms Associated with Thymocyte Apoptosis Induced by Simian Immunodeficiency Virus.
M. Rosenzweig, M. Connole, A. Forand-Barabasz, M.-P. Tremblay, R. P. Johnson, and A. A. Lackner (2000)
J. Immunol. 165, 3461-3468
   Abstract »    Full Text »    PDF »
Short- and Long-Term Clinical Outcomes in Rhesus Monkeys Inoculated with a Highly Pathogenic Chimeric Simian/Human Immunodeficiency Virus.
Y. Endo, T. Igarashi, Y. Nishimura, C. Buckler, A. Buckler-White, R. Plishka, D. S. Dimitrov, and M. A. Martin (2000)
J. Virol. 74, 6935-6945
   Abstract »    Full Text »    PDF »
Enhanced Infectivity of an R5-Tropic Simian/Human Immunodeficiency Virus Carrying Human Immunodeficiency Virus Type 1 Subtype C Envelope after Serial Passages in Pig-Tailed Macaques (Macaca nemestrina).
Z. Chen, Y. Huang, X. Zhao, E. Skulsky, D. Lin, J. Ip, A. Gettie, and D. D. Ho (2000)
J. Virol. 74, 6501-6510
   Abstract »    Full Text »    PDF »
Simian Immunodeficiency Virus Utilizes Human and Sooty Mangabey but Not Rhesus Macaque STRL33 for Efficient Entry.
S. Pohlmann, B. Lee, S. Meister, M. Krumbiegel, G. Leslie, R. W. Doms, and F. Kirchhoff (2000)
J. Virol. 74, 5075-5082
   Abstract »    Full Text »    PDF »
Simian Immunodeficiency Virus Containing Mutations in N-Terminal Tyrosine Residues and in the PxxP Motif in Nef Replicates Efficiently in Rhesus Macaques.
S. Carl, A. J. Iafrate, S. M. Lang, N. Stolte, C. Stahl-Hennig, K. Matz-Rensing, D. Fuchs, J. Skowronski, and F. Kirchhoff (2000)
J. Virol. 74, 4155-4164
   Abstract »    Full Text »    PDF »
Experimental Infection of Rhesus and Pig-Tailed Macaques with Macaque Rhadinoviruses.
K. G. Mansfield, S. V. Westmoreland, C. D. DeBakker, S. Czajak, A. A. Lackner, and R. C. Desrosiers (1999)
J. Virol. 73, 10320-10328
   Abstract »    Full Text »    PDF »
Mucosal Immunization of Cynomolgus Macaques with Two Serotypes of Live Poliovirus Vectors Expressing Simian Immunodeficiency Virus Antigens: Stimulation of Humoral, Mucosal, and Cellular Immunity.
S. Crotty, B. L. Lohman, F. X.-S. Lu, S. Tang, C. J. Miller, and R. Andino (1999)
J. Virol. 73, 9485-9495
   Abstract »    Full Text »    PDF »
Protection by Live, Attenuated Simian Immunodeficiency Virus against Heterologous Challenge.
M. S. Wyand, K. Manson, D. C. Montefiori, J. D. Lifson, R. P. Johnson, and R. C. Desrosiers (1999)
J. Virol. 73, 8356-8363
   Abstract »    Full Text »    PDF »
The Human Immunodeficiency Virus Type 1 nef Gene Can to a Large Extent Replace Simian Immunodeficiency Virus nef In Vivo.
F. Kirchhoff, J. Munch, S. Carl, N. Stolte, K. Matz-Rensing, D. Fuchs, P. Ten Haaft, J. L. Heeney, T. Swigut, J. Skowronski, et al. (1999)
J. Virol. 73, 8371-8383
   Abstract »    Full Text »    PDF »
Neuropathogenesis of Simian Immunodeficiency Virus in Neonatal Rhesus Macaques.
S. V. Westmoreland, K. C. Williams, M. A. Simon, M. E. Bahn, A. E. Rullkoetter, M. W. Elliott, C. D. deBakker, H. L. Knight, and A. A. Lackner (1999)
Am. J. Pathol. 155, 1217-1228
   Abstract »    Full Text »    PDF »
Effects of Soluble CD4 on Simian Immunodeficiency Virus Infection of CD4-Positive and CD4-Negative Cells.
D. Schenten, L. Marcon, G. B. Karlsson, C. Parolin, T. Kodama, N. Gerard, and J. Sodroski (1999)
J. Virol. 73, 5373-5380
   Abstract »    Full Text »    PDF »
Improved Mg2+-Based Reverse Transcriptase Assay for Detection of Primate Retroviruses.
J. F. Sears, R. Repaske, and A. S. Khan (1999)
J. Clin. Microbiol. 37, 1704-1708
   Abstract »    Full Text »    PDF »
Effect of the Attenuating Deletion and of Sequence Alterations Evolving In Vivo on Simian Immunodeficiency Virus C8-Nef Function.
S. Carl, A. J. Iafrate, J. Skowronski, C. Stahl-Hennig, and F. Kirchhoff (1999)
J. Virol. 73, 2790-2797
   Abstract »    Full Text »    PDF »
Association of Simian Virus 40 with a Central Nervous System Lesion Distinct from Progressive Multifocal Leukoencephalopathy in Macaques with AIDS.
M. A. Simon, P. O. Ilyinskii, G. B. Baskin, H. Y. Knight, D. R. Pauley, and A. A. Lackner (1999)
Am. J. Pathol. 154, 437-446
   Abstract »    Full Text »    PDF »
Diverse Host Responses and Outcomes following Simian Immunodeficiency Virus SIVmac239 Infection in Sooty Mangabeys and Rhesus Macaques.
A. Kaur, R. M. Grant, R. E. Means, H. McClure, M. Feinberg, and R. P. Johnson (1998)
J. Virol. 72, 9597-9611
   Abstract »    Full Text »    PDF »
Rhesus Macaques Infected with Macrophage-Tropic Simian Immunodeficiency Virus (SIVmacR71/17E) Exhibit Extensive Focal Segmental and Global Glomerulosclerosis.
E. B. Stephens, C. Tian, Z. Li, O. Narayan, and V. H. Gattone II (1998)
J. Virol. 72, 8820-8832
   Abstract »    Full Text »    PDF »
Inhibition of Simian Immunodeficiency Virus (SIV) Replication by CD8+ T Lymphocytes from Macaques Immunized with Live Attenuated SIV.
M.-C. Gauduin, R. L. Glickman, R. Means, and R. P. Johnson (1998)
J. Virol. 72, 6315-6324
   Abstract »    Full Text »    PDF »
Viral Genetic Evolution in Macaques Infected with Molecularly Cloned Simian Immunodeficiency Virus Correlates with the Extent of Persistent Viremia.
V. M. Hirsch, G. Dapolito, A. Hahn, J. Lifson, D. Montefiori, C. R. Brown, and R. Goeken (1998)
J. Virol. 72, 6482-6489
   Abstract »    Full Text »    PDF »
Neutralizing Antibodies in Sera from Macaques Immunized with Attenuated Simian Immunodeficiency Virus.
A. J. Langlois, R. C. Desrosiers, M. G. Lewis, V. N. KewalRamani, D. R. Littman, J. Y. Zhou, K. Manson, M. S. Wyand, D. P. Bolognesi, and D. C. Montefiori (1998)
J. Virol. 72, 6950-6955
   Abstract »    Full Text »    PDF »
Simian-Human Immunodeficiency Virus (SHIV) Containing the nef/Long Terminal Repeat Region of the Highly Virulent SIVsmmPBj14 Causes PBj-Like Activation of Cultured Resting Peripheral Blood Mononuclear Cells, but the Chimera Showed No Increase in Virulence.
E. B. Stephens, S. Mukherjee, Z. Q. Liu, D. Sheffer, R. Lamb-Wharton, K. Leung, W. Zhuge, S. V. Joag, Z. Li, L. Foresman, et al. (1998)
J. Virol. 72, 5207-5214
   Abstract »    Full Text »    PDF »
Early Regeneration of Thymic Progenitors in Rhesus Macaques Infected with Simian Immunodeficiency Virus.
J. J. Wykrzykowska, M. Rosenzweig, R. S. Veazey, M. A. Simon, K. Halvorsen, R. C. Desrosiers, R. P. Johnson, and A. A. Lackner (1998)
J. Exp. Med. 187, 1767-1778
   Abstract »    Full Text »    PDF »
Gastrointestinal Tract as a Major Site of CD4+ T Cell Depletion and Viral Replication in SIV Infection.
R. S. Veazey, M. DeMaria, L. V. Chalifoux, D. E. Shvetz, D. R. Pauley, H. L. Knight, M. Rosenzweig, R. P. Johnson, R. C. Desrosiers, and A. A. Lackner (1998)
Science 280, 427-431
   Abstract »    Full Text »    PDF »
In Vivo Replication Capacity Rather Than In Vitro Macrophage Tropism Predicts Efficiency of Vaginal Transmission of Simian Immunodeficiency Virus or Simian/Human Immunodeficiency Virus in Rhesus Macaques.
C. J. Miller, M. Marthas, J. Greenier, D. Lu, P. J. Dailey, and Y. Lu (1998)
J. Virol. 72, 3248-3258
   Abstract »    Full Text »    PDF »
The U3 Promoter and the nef Gene of Simian Immunodeficiency Virus (SIV) smmPBj1.9 Do Not Confer Acute Pathogenicity upon SIVagm.
S. Wagener, M. T. Dittmar, B. Beer, R. Konig, R. Plesker, S. Norley, R. Kurth, and K. Cichutek (1998)
J. Virol. 72, 3446-3450
   Abstract »    Full Text »    PDF »
Identification of Highly Attenuated Mutants of Simian Immunodeficiency Virus.
R. C. Desrosiers, J. D. Lifson, J. S. Gibbs, S. C. Czajak, A. Y. M. Howe, L. O. Arthur, and R. P. Johnson (1998)
J. Virol. 72, 1431-1437
   Abstract »    Full Text »    PDF »
Administration of an Anti-CD8 Monoclonal Antibody Interferes with the Clearance of Chimeric Simian/Human Immunodeficiency Virus during Primary Infections of Rhesus Macaques.
T. Matano, R. Shibata, C. Siemon, M. Connors, H. C. Lane, and M. A. Martin (1998)
J. Virol. 72, 164-169
   Abstract »    Full Text »    PDF »
A Lymph Node-Derived Cytopathic Simian Immunodeficiency Virus Mne Variant Replicates in Nonstimulated Peripheral Blood Mononuclear Cells.
J. T. Kimata, A. Mozaffarian, and J. Overbaugh (1998)
J. Virol. 72, 245-256
   Abstract »    Full Text »    PDF »
Evolution of a Simian Immunodeficiency Virus Pathogen.
P. Edmonson, M. Murphey-Corb, L. N. Martin, C. Delahunty, J. Heeney, H. Kornfeld, P. R. Donahue, G. H. Learn, L. Hood, and J. I. Mullins (1998)
J. Virol. 72, 405-414
   Abstract »    Full Text »    PDF »
Intracellular Immunization of Rhesus CD34+ Hematopoietic Progenitor Cells With a Hairpin Ribozyme Protects T Cells and Macrophages From Simian Immunodeficiency Virus Infection.
M. Rosenzweig, D. F. Marks, D. Hempel, M. Heusch, G. Kraus, F. Wong-Staal, and R. P. Johnson (1997)
Blood 90, 4822-4831
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)