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Science 25 May 1990:
Vol. 248. no. 4958, pp. 1019 - 1023
DOI: 10.1126/science.2160731

Articles

Science, Vol 248, Issue 4958, 1019-1023
Copyright © 1990 by American Association for the Advancement of Science


articles

A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins

CA Smith, T Davis, D Anderson, L Solam, MP Beckmann, R Jerzy, SK Dower, D Cosman, and RG Goodwin

Immunex Corporation, Seattle, WA 98101.

Tumor necrosis factor alpha and beta (TNF-alpha and TNF-beta) bind surface receptors on a variety of cell types to mediate a wide range of immunological responses, inflammatory reactions, and anti-tumor effects. A cDNA clone encoding an integral membrane protein of 461 amino acids was isolated from a human lung fibroblast library by direct expression screening with radiolabeled TNF-alpha. The encoded receptor was also able to bind TNF-beta. The predicted cysteine-rich extracellular domain has extensive sequence similarity with five proteins, including nerve growth factor receptor and a transcriptionally active open reading frame from Shope fibroma virus, and thus defines a family of receptors.


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Affinity and Kinetics of the Interaction between Soluble Trimeric OX40 Ligand, a Member of the Tumor Necrosis Factor Superfamily, and Its Receptor OX40 on Activated T Cells.
A. Al-Shamkhani, S. Mallett, M. H. Brown, W. James, and A. N. Barclay (1997)
J. Biol. Chem. 272, 5275-5282
   Abstract »    Full Text »    PDF »
Inhibition of p75 Tumor Necrosis Factor Receptor by Antisense Oligonucleotides Increases Hypoxic Injury and beta -Amyloid Toxicity in Human Neuronal Cell Line.
Y. Shen, R. Li, and K. Shiosaki (1997)
J. Biol. Chem. 272, 3550-3553
   Abstract »    Full Text »    PDF »
The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex.
H.-B. Shu, M. Takeuchi, and D. V. Goeddel (1996)
PNAS 93, 13973-13978
   Abstract »    Full Text »    PDF »
Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic Region.
T. Ishida, S.-i. Mizushima, S. Azuma, N. Kobayashi, T. Tojo, K. Suzuki, S. Aizawa, T. Watanabe, G. Mosialos, E. Kieff, et al. (1996)
J. Biol. Chem. 271, 28745-28748
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor Receptors (Tnfr) in Mouse Fibroblasts Deficient in Tnfr1 or Tnfr2 are Signaling Competent and Activate the Mitogen-activated Protein Kinase Pathway with Differential Kinetics.
A. Kalb, H. Bluethmann, M. W. Moore, and W. Lesslauer (1996)
J. Biol. Chem. 271, 28097-28104
   Abstract »    Full Text »    PDF »
Characterization of Histidine Residues Essential for Receptor Binding and Activity of Nerve Growth Factor.
S. B. Woo and K. E. Neet (1996)
J. Biol. Chem. 271, 24433-24441
   Abstract »    Full Text »    PDF »
Human Tumor Necrosis Factor Receptor p75/80 (CD120b) Gene Structure and Promoter Characterization.
S. M. Santee and L. B. Owen-Schaub (1996)
J. Biol. Chem. 271, 21151-21159
   Abstract »    Full Text »    PDF »
Fibroblast Growth Factor-2 Suppression of Tumor Necrosis Factor alpha -Mediated Apoptosis Requires Ras and the Activation of Mitogen-activated Protein Kinase.
A. M. Gardner and G. L. Johnson (1996)
J. Biol. Chem. 271, 14560-14566
   Abstract »    Full Text »    PDF »
Interaction between the mRNA of the 55-kDa Tumor Necrosis Factor Receptor and Cellular Proteins. POSSIBLE INVOLVEMENT IN POST-TRANSCRIPTIONAL REGULATION OF RECEPTOR EXPRESSION.
R. Winzen, S. Kafert, B. P. H. A. Mylius-Spencker, K. Resch, and H. Holtmann (1996)
J. Biol. Chem. 271, 13461-13467
   Abstract »    Full Text »    PDF »
Cytokines and viral anti-immune genes.
C. Evans (1996)
Stem Cells 14, 177-184
   Abstract »
Expression and Functional Significance of Tumor Necrosis Factor Receptors in Human Myocardium.
G. Torre-Amione, S. Kapadia, J. Lee, R. D. Bies, R. Lebovitz, and D. L. Mann (1995)
Circulation 92, 1487-1493
   Abstract »    Full Text »
Epitopic Regions for Antibodies against Tumor Necrosis Factor alpha.
K. Yone, S. Bajard, N. Tsunekawa, and J. Suzuki (1995)
J. Biol. Chem. 270, 19509-19515
   Abstract »    Full Text »    PDF »
Cross-linking of the p55 Tumor Necrosis Factor Receptor Cytoplasmic Domain by a Dimeric Ligand Induces Nuclear Factor-[IMAGE]B and Mediates Cell Death.
D. Adam, D. Adam, and M. Krönke (1995)
J. Biol. Chem. 270, 17482-17487
   Abstract »    Full Text »    PDF »
Vaccinia Virus B18R Gene Encodes a Type I Interferon-binding Protein That Blocks Interferon [IMAGE] Transmembrane Signaling.
O. R. Colamonici, P. Domanski, S. M. Sweitzer, A. Larner, and R. M. L. Buller (1995)
J. Biol. Chem. 270, 15974-15978
   Abstract »    Full Text »    PDF »
Soluble tumor necrosis factor receptors are released independent of TNF in endotoxemia.
F. Otto, A. Seiz, C. Galanos, R. Mertelsmann, and R. Engelhardt (1995)
Innate Immunity 2, 85-89
   Abstract »    PDF »
Alteration of NH(2)-terminal Residues of Nerve Growth Factor Affects Activity and Trk Binding without Affecting Stability or Conformation.
S. B. Woo, D. E. Timm, and K. E. Neet (1995)
J. Biol. Chem. 270, 6278-6285
   Abstract »    Full Text »    PDF »
Identification of a Protein with Homology to hsp90 That Binds the Type 1 Tumor Necrosis Factor Receptor.
H. Y. Song, J. D. Dunbar, Y. X. Zhang, D. Guo, and D. B. Donner (1995)
J. Biol. Chem. 270, 3574-3581
   Abstract »    Full Text »    PDF »
Self-association of the ``Death Domains'' of the p55 Tumor Necrosis Factor (TNF) Receptor and Fas/APO1 Prompts Signaling for TNF and Fas/APO1 Effects.
M. P. Boldin, I. L. Mett, E. E. Varfolomeev, I. Chumakov, Y. Shemer-Avni, J. H. Camonis, and D. Wallach (1995)
J. Biol. Chem. 270, 387-391
   Abstract »    Full Text »    PDF »
Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor.
R. Dobrowsky, M. Werner, A. Castellino, M. Chao, and Y. Hannun (1994)
Science 265, 1596-1599
   Abstract »    PDF »
A lymphotoxin-beta-specific receptor.
P. Crowe, T. VanArsdale, B. Walter, C. Ware, C Hession, B Ehrenfels, J. Browning, W. Din, R. Goodwin, and C. Smith (1994)
Science 264, 707-710
   Abstract »    PDF »
Mapping the lectin-like activity of tumor necrosis factor.
R Lucas, S Magez, R De Leys, L Fransen, J. Scheerlinck, M Rampelberg, E Sablon, and P De Baetselier (1994)
Science 263, 814-817
   Abstract »    PDF »
An antiviral soluble form of the LDL receptor induced by interferon.
D. Fischer, N Tal, D Novick, S Barak, and M Rubinstein (1993)
Science 262, 250-253
   Abstract »    PDF »



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