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Science 25 May 1990:
Vol. 248. no. 4958, pp. 1016 - 1019
DOI: 10.1126/science.1693015
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Articles

Science, Vol 248, Issue 4958, 1016-1019
Copyright © 1990 by American Association for the Advancement of Science

articles

Shared human T cell receptor V beta usage to immunodominant regions of myelin basic protein

KW Wucherpfennig, K Ota, N Endo, JG Seidman, A Rosenzweig, HL Weiner, and DA Hafler

Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.

Multiple sclerosis (MS) may be an autoimmune disease mediated by T cells specific for a myelin protein. Investigations have demonstrated myelin basic protein (MBP)-reactive T cells that were activated in vivo in MS patients, suggesting that MBP may be a target antigen in MS. The variable (V) region of the T cell receptor (TCR) beta chain was examined among 83 T cell lines from both MS patients and healthy subjects that were reactive with the immunodominant region of human MBP (residues 84 to 102) or with a second immunodominant region of MBP (143 to 168). V beta 17 and to a lesser extent V beta 12 were frequently used in recognition of MBP(84-102) among different individuals. In contrast, V beta 17 was very infrequent among lines reactive with MBP (143-168). These data demonstrate shared TCR V beta gene usage for the recognition of immunodominant regions of the human autoantigen MBP. Such TCR structures may be used as targets for specific immunotherapy in MS.


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