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Science 25 May 1990: Vol. 248. no. 4958, pp. 1009 - 1012 DOI: 10.1126/science.2343305
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Articles
Science, Vol 248, Issue 4958, 1009-1012
Copyright © 1990 by American Association for the Advancement of Science
Localization of PDGF-B protein in macrophages in all phases of atherogenesis
R Ross,
J Masuda,
EW Raines,
AM Gown,
S Katsuda,
M Sasahara,
LT Malden,
H Masuko,
and
H Sato
Department of Pathology, University of Washington, Seattle 98195.
Lesions of atherosclerosis occur in the innermost layer of the artery wall and consist primarily of proliferated smooth muscle cells surrounded by large amounts of connective tissue, numerous lipid-laden macrophages, and varying numbers of lymphocytes. Growth-regulatory molecules may be involved in intimal accumulation and proliferation of smooth muscle cells responsible for the occlusive lesions of atherosclerosis. Platelet-derived growth factor (PDGF) B-chain protein was found within macrophages in all stages of lesion development in both human and nonhuman primate atherosclerosis. Thus macrophages may play a critical role in the disease by providing PDGF, a potent chemotactic and growth-stimulatory molecule, to the intimal smooth muscle cells.
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