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Science 18 May 1990:
Vol. 248. no. 4957, pp. 857 - 860
DOI: 10.1126/science.2188361
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Articles

Science, Vol 248, Issue 4957, 857-860
Copyright © 1990 by American Association for the Advancement of Science

articles

Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog

FB Gertler, JS Doctor, and FM Hoffmann

McArdle Laboratory for Cancer Research, University of Wisconsin, Madison 53706.

The Drosophila abelson (abl) gene encodes the homolog of the mammalian c-abl cytoplasmic tyrosine kinase and is an essential gene for the development of viable adult flies. Three second-site mutations that suppress the lethality caused by the absence of abl function have been isolated, and all three map to the gene enabled (ena). The mutations are recessive embryonic lethal mutations but act as dominant mutations to compensate for the neural defects of abl mutants. Thus, mutations in a specific gene can compensate for the absence of a tyrosine kinase.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Using Bcr-Abl to Examine Mechanisms by Which Abl Kinase Regulates Morphogenesis in Drosophila.
T. L. Stevens, E. M. Rogers, L. M. Koontz, D. T. Fox, C. C.F. Homem, S. H. Nowotarski, N. B. Artabazon, and M. Peifer (2008)
Mol. Biol. Cell 19, 378-393
   Abstract »    Full Text »    PDF »
Ena/VASP Proteins Can Regulate Distinct Modes of Actin Organization at Cadherin-adhesive Contacts.
J. A. Scott, A. M. Shewan, N. R. den Elzen, J. J. Loureiro, F. B. Gertler, and A. S. Yap (2006)
Mol. Biol. Cell 17, 1085-1095
   Abstract »    Full Text »    PDF »
Mena and Vasodilator-Stimulated Phosphoprotein Are Required for Multiple Actin-Dependent Processes That Shape the Vertebrate Nervous System.
A. S. Menzies, A. Aszodi, S. E. Williams, A. Pfeifer, A. M. Wehman, K. L. Goh, C. A. Mason, R. Fassler, and F. B. Gertler (2004)
J. Neurosci. 24, 8029-8038
   Abstract »    Full Text »    PDF »
Common Mechanism of Ligand Recognition by Group II/III WW Domains: REDEFINING THEIR FUNCTIONAL CLASSIFICATION.
Y. Kato, K. Nagata, M. Takahashi, L. Lian, J. J. Herrero, M. Sudol, and M. Tanokura (2004)
J. Biol. Chem. 279, 31833-31841
   Abstract »    Full Text »    PDF »
Caenorhabditis elegans WASP and Ena/VASP Proteins Play Compensatory Roles in Morphogenesis and Neuronal Cell Migration.
J. Withee, B. Galligan, N. Hawkins, and G. Garriga (2004)
Genetics 167, 1165-1176
   Abstract »    Full Text »    PDF »
Balancing different types of actin polymerization at distinct sites: roles for Abelson kinase and Enabled.
E. E. Grevengoed, D. T. Fox, J. Gates, and M. Peifer (2003)
J. Cell Biol. 163, 1267-1279
   Abstract »    Full Text »    PDF »
Interactions between the secreted protein Amalgam, its transmembrane receptor Neurotactin and the Abelson tyrosine kinase affect axon pathfinding.
E. C. Liebl, R. G. Rowe, D. J. Forsthoefel, A. L. Stammler, E. R. Schmidt, M. Turski, and M. A. Seeger (2003)
Development 130, 3217-3226
   Abstract »    Full Text »    PDF »
The Amyloid Precursor Protein and Its Regulatory Protein, FE65, in Growth Cones and Synapses In Vitro and In Vivo.
S. L. Sabo, A. F. Ikin, J. D. Buxbaum, and P. Greengard (2003)
J. Neurosci. 23, 5407-5415
   Abstract »    Full Text »    PDF »
Abl Interactor 1 Promotes Tyrosine 296 Phosphorylation of Mammalian Enabled (Mena) by c-Abl Kinase.
K. Tani, S. Sato, T. Sukezane, H. Kojima, H. Hirose, H. Hanafusa, and T. Shishido (2003)
J. Biol. Chem. 278, 21685-21692
   Abstract »    Full Text »    PDF »
The Ena/VASP enigma.
M. Krause, J. E. Bear, J. J. Loureiro, and F. B. Gertler (2003)
J. Cell Sci. 115, 4721-4726
   Abstract »    Full Text »    PDF »
Contribution of Ena/VASP Proteins to Intracellular Motility of Listeria Requires Phosphorylation and Proline-rich Core but Not F-Actin Binding or Multimerization.
M. Geese, J. J. Loureiro, J. E. Bear, J. Wehland, F. B. Gertler, and A. S. Sechi (2002)
Mol. Biol. Cell 13, 2383-2396
   Abstract »    Full Text »    PDF »
Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension.
P. J. Woodring, E. D. Litwack, D. D.M. O'Leary, G. R. Lucero, J. Y.J. Wang, and T. Hunter (2002)
J. Cell Biol. 156, 879-892
   Abstract »    Full Text »    PDF »
four-jointed interacts with dachs, abelson and enabled and feeds back onto the Notch pathway to affect growth and segmentation in the Drosophila leg.
G. R. Buckles, C. Rauskolb, J. L. Villano, and F. N. Katz (2001)
Development 128, 3533-3542
   Abstract »    Full Text »    PDF »
The Alzheimer Amyloid Precursor Protein (APP) and FE65, an APP-binding Protein, Regulate Cell Movement.
S. L. Sabo, A. F. Ikin, J. D. Buxbaum, and P. Greengard (2001)
J. Cell Biol. 153, 1403-1414
   Abstract »    Full Text »    PDF »
Role of Proteins of the Ena/VASP Family in Actin-based Motility of Listeria monocytogenes.
V. Laurent, T. P. Loisel, B. Harbeck, A. Wehman, L. Grobe, B. M. Jockusch, J. Wehland, F. B. Gertler, and M.-F. Carlier (1999)
J. Cell Biol. 144, 1245-1258
   Abstract »    Full Text »    PDF »
Mutations in Drosophila Enabled and Rescue by Human Vasodilator-stimulated Phosphoprotein (VASP) Indicate Important Functional Roles for Ena/VASP Homology Domain 1 (EVH1) and EVH2 Domains.
S. M. Ahern-Djamali, A. R. Comer, C. Bachmann, A. S. Kastenmeier, S. K. Reddy, M. C. Beckerle, U. Walter, and F. M. Hoffmann (1998)
Mol. Biol. Cell 9, 2157-2171
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A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A.
Y Chen, M. Riese, M. Killinger, and F. Hoffmann (1998)
Development 125, 1759-1768
   Abstract »    PDF »
Phosphorylation of Enabled by the Drosophila Abelson Tyrosine Kinase Regulates the In Vivo Function and Protein-Protein Interactions of Enabled.
A. R. Comer, S. M. Ahern-Djamali, J.-L. Juang, P. D. Jackson, and F. M. Hoffmann (1998)
Mol. Cell. Biol. 18, 152-160
   Abstract »    Full Text »
The WW Domain of Neural Protein FE65 Interacts with Proline-rich Motifs in Mena, the Mammalian Homolog of Drosophila Enabled.
K. S. Ermekova, N. Zambrano, H. Linn, G. Minopoli, F. Gertler, T. Russo, and M. Sudol (1997)
J. Biol. Chem. 272, 32869-32877
   Abstract »    Full Text »    PDF »
enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties..
F B Gertler, A R Comer, J L Juang, S M Ahern, M J Clark, E C Liebl, and F M Hoffmann (1995)
Genes & Dev. 9, 521-533
   Abstract »    PDF »
Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate..
F B Gertler, K K Hill, M J Clark, and F M Hoffmann (1993)
Genes & Dev. 7, 441-453
   Abstract »    PDF »
Increased levels of the Drosophila Abelson tyrosine kinase in nerves and muscles: subcellular localization and mutant phenotypes imply a role in cell-cell interactions.
R. L. Bennett and F. M. Hoffmann (1992)
Development 116, 953-966
   Abstract »    PDF »
Toward cloning and mapping the genome of Drosophila.
J Merriam, M Ashburner, D. Hartl, and F. Kafatos (1991)
Science 254, 221-225
   Abstract »    PDF »
cAMP-dependent Protein Kinase Phosphorylation of EVL, a Mena/VASP Relative, Regulates Its Interaction with Actin and SH3 Domains.
A. Lambrechts, A. V. Kwiatkowski, L. M. Lanier, J. E. Bear, J. Vandekerckhove, C. Ampe, and F. B. Gertler (2000)
J. Biol. Chem. 275, 36143-36151
   Abstract »    Full Text »    PDF »
The Orthologous Human and Murine Semaphorin 6A-1 Proteins (SEMA6A-1/Sema6A-1) Bind to the Enabled/Vasodilator-stimulated Phosphoprotein-like Protein (EVL) via a Novel Carboxyl-terminal Zyxin-like Domain.
A. Klostermann, B. Lutz, F. Gertler, and C. Behl (2000)
J. Biol. Chem. 275, 39647-39653
   Abstract »    Full Text »    PDF »
The beta -Amyloid Precursor Protein APP Is Tyrosine-phosphorylated in Cells Expressing a Constitutively Active Form of the Abl Protoncogene.
N. Zambrano, P. Bruni, G. Minopoli, R. Mosca, D. Molino, C. Russo, G. Schettini, M. Sudol, and T. Russo (2001)
J. Biol. Chem. 276, 19787-19792
   Abstract »    Full Text »    PDF »
Abelson kinase regulates epithelial morphogenesis in Drosophila.
E. E. Grevengoed, J. J. Loureiro, T. L. Jesse, and M. Peifer (2001)
J. Cell Biol. 155, 1185-1198
   Abstract »    Full Text »    PDF »
Modulation of the F-actin cytoskeleton by c-Abl tyrosine kinase in cell spreading and neurite extension.
P. J. Woodring, E. D. Litwack, D. D.M. O'Leary, G. R. Lucero, J. Y.J. Wang, and T. Hunter (2002)
J. Cell Biol. 156, 879-892
   Abstract »    Full Text »    PDF »


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