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Science 11 May 1990:
Vol. 248. no. 4956, pp. 705 - 711
DOI: 10.1126/science.2185544

Articles

Science, Vol 248, Issue 4956, 705-711
Copyright © 1990 by American Association for the Advancement of Science


articles

The staphylococcal enterotoxins and their relatives

P Marrack and J Kappler

Howard Hughes Medical Institute, Department of Medicine, Denver, CO.

Staphylococcal enterotoxins and a group of related proteins made by Streptococci cause food poisoning and shock in man and animals. These proteins share an ability to bind to human and mouse major histocompatibility complex proteins. The complex ligand so formed has specificity for a particular part of T cell receptors, V beta, and by engaging V beta can stimulate many T cells. It is likely that some or all of the pathological effects of these toxins are caused by their ability to activate quickly so many T cells. It is also possible that encounters with such toxins have caused mice, at least, to evolve mechanisms for varying their T cell V beta repertoires, such that they are less susceptible to attack by the toxins.


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   Abstract »    Full Text »    PDF »
Nuclear Factor of Activated T Cells Transcription Factor Nfatp Controls Superantigen-Induced Lethal Shock.
A. V. Tsytsykova and A. E. Goldfeld (2000)
J. Exp. Med. 192, 581-586
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Antigen Triggering Selectively Increases TCRBV Gene Transcription.
G. P. Lennon, J. E. Sillibourne, E. Furrie, M. J. Doherty, and R. A. Kay (2000)
J. Immunol. 165, 2020-2027
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Development of Streptococcal Pyrogenic Exotoxin C Vaccine Toxoids That Are Protective in the Rabbit Model of Toxic Shock Syndrome.
J. K. McCormick, T. J. Tripp, S. B. Olmsted, Y. V. Matsuka, P. J. Gahr, D. H. Ohlendorf, and P. M. Schlievert (2000)
J. Immunol. 165, 2306-2312
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Identification of a Novel Gene Cluster Encoding Staphylococcal Exotoxin-Like Proteins: Characterization of the Prototypic Gene and Its Protein Product, SET1.
R. J. Williams, J. M. Ward, B. Henderson, S. Poole, B. P. O'Hara, M. Wilson, and S. P. Nair (2000)
Infect. Immun. 68, 4407-4415
   Abstract »    Full Text »    PDF »
Advances in our understanding of the bone and joint pathology caused by Staphylococcus aureus infection.
S. P. Nair, R. J. Williams, and B. Henderson (2000)
Rheumatology 39, 821-834
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Functional Analysis of the env Open Reading Frame in Human Endogenous Retrovirus IDDMK1,222 Encoding Superantigen Activity.
M. Lapatschek, S. Dürr, R. Löwer, C. Magin, H. Wagner, and T. Miethke (2000)
J. Virol. 74, 6386-6393
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Molecular evidence for antigen-driven immune responses in cardiac lesions of rheumatic heart disease patients.
L. Guilherme, N. Dulphy, C. Douay, V. Coelho, E. Cunha-Neto, S. E. Oshiro, R. V Assis, A. C. Tanaka, P. M. Alberto Pomerantzeff, D. Charron, et al. (2000)
Int. Immunol. 12, 1063-1074
   Abstract »    Full Text »    PDF »
Inhibition of Staphylococcal Enterotoxin B-Induced Lymphocyte Proliferation and Tumor Necrosis Factor Alpha Secretion by MAb5, an Anti-Toxic Shock Syndrome Toxin 1 Monoclonal Antibody.
L. T. Y. Pang, W. W. S. Kum, and A. W. Chow (2000)
Infect. Immun. 68, 3261-3268
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Pyrogenic Toxin Superantigen Site Specificity in Toxic Shock Syndrome and Food Poisoning in Animals.
P. M. Schlievert, L. M. Jablonski, M. Roggiani, I. Sadler, S. Callantine, D. T. Mitchell, D. H. Ohlendorf, and G. A. Bohach (2000)
Infect. Immun. 68, 3630-3634
   Abstract »    Full Text »    PDF »
Comparison of Pulsed-Field Gel Electrophoresis and Coagulase Gene Restriction Profile Analysis Techniques in the Molecular Typing of Staphylococcus aureus.
C.-S. Chiou, H.-L. Wei, and L.-C. Yang (2000)
J. Clin. Microbiol. 38, 2186-2190
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T Cell Adoptive Immunotherapy of Newly Diagnosed Gliomas.
G. E. Plautz, D. W. Miller, G. H. Barnett, G. H. J. Stevens, S. Maffett, J. Kim, P. A. Cohen, and S. Shu (2000)
Clin. Cancer Res. 6, 2209-2218
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The Streptococcal Superantigen Smez Exhibits Wide Allelic Variation, Mosaic Structure, and Significant Antigenic Variation.
T. Proft, S. L. Moffatt, K. D. Weller, A. Paterson, D. Martin, and J. D. Fraser (2000)
J. Exp. Med. 191, 1765-1776
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Characterization of the Promoter Elements for the Staphylococcal Enterotoxin D Gene.
S. Zhang and G. C. Stewart (2000)
J. Bacteriol. 182, 2321-2325
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Development of a Single-Reaction Multiplex PCR Toxin Typing Assay for Staphylococcus aureus Strains.
N. K. Sharma, C. E. D. Rees, and C. E. R. Dodd (2000)
Appl. Envir. Microbiol. 66, 1347-1353
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Staphylococcal Enterotoxin A Acts through Nitric Oxide Synthase Mechanisms in Human Peripheral Blood Mononuclear Cells To Stimulate Synthesis of Pyrogenic Cytokines.
S.-J. Won, W.-T. Huang, Y.-S. Lai, and M.-T. Lin (2000)
Infect. Immun. 68, 2003-2008
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Mapping the Energy of Superantigen Staphylococcus Enterotoxin C3 Recognition of an {alpha}/{beta} T Cell Receptor Using Alanine Scanning Mutagenesis.
H. R.O. Churchill, P. S. Andersen, E. A. Parke, R. A. Mariuzza, and D. M. Kranz (2000)
J. Exp. Med. 191, 835-846
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Reduced Th1, but Not Th2, Cytokine Production by Lymphocytes after In Vivo Exposure of Healthy Subjects to Endotoxin.
F. N. Lauw, T. ten Hove, P. E. P. Dekkers, E. de Jonge, S. J. H. van Deventer, and T. van der Poll (2000)
Infect. Immun. 68, 1014-1018
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