Related Content
Search Google Scholar for:
|
|
Science 11 May 1990: Vol. 248. no. 4956, pp. 705 - 711 DOI: 10.1126/science.2185544
|
|
Articles
Science, Vol 248, Issue 4956, 705-711
Copyright © 1990 by American Association for the Advancement of Science
The staphylococcal enterotoxins and their relatives
P Marrack
and
J Kappler
Howard Hughes Medical Institute, Department of Medicine, Denver, CO.
Staphylococcal enterotoxins and a group of related proteins made by Streptococci cause food poisoning and shock in man and animals. These proteins share an ability to bind to human and mouse major histocompatibility complex proteins. The complex ligand so formed has specificity for a particular part of T cell receptors, V beta, and by engaging V beta can stimulate many T cells. It is likely that some or all of the pathological effects of these toxins are caused by their ability to activate quickly so many T cells. It is also possible that encounters with such toxins have caused mice, at least, to evolve mechanisms for varying their T cell V beta repertoires, such that they are less susceptible to attack by the toxins.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- The Cellular and Molecular Immune Response of the Weanling Piglet to Staphylococcal Enterotoxin B.
- S. Bi, R. Das, E. Zelazowska, S. Mani, R. Neill, G. D. Coleman, D. C. Yang, R. Hammamieh, J. W. Shupp, and M. Jett (2009)
Experimental Biology and Medicine
234, 1305-1315
| Abstract »
| Full Text »
| PDF »
- Diverse Enterotoxin Gene Profiles among Clonal Complexes of Staphylococcus aureus Isolates from the Bronx, New York.
- A. K. Varshney, J. R. Mediavilla, N. Robiou, A. Guh, X. Wang, P. Gialanella, M. H. Levi, B. N. Kreiswirth, and B. C. Fries (2009)
Appl. Envir. Microbiol.
75, 6839-6849
| Abstract »
| Full Text »
| PDF »
- Case 33-2009 -- A 35-Year-Old Woman with Fever, Abdominal Pain, and Hypotension after Cesarean Section.
- M. A. de Moya, M. G. del Carmen, R. M. Allain, R. E. Hirschberg, J.-A. O. Shepard, and R. L. Kradin (2009)
N. Engl. J. Med.
361, 1689-1697
| Full Text »
| PDF »
- Staphylococcus aureus Superantigens Elicit Redundant and Extensive Human V{beta} Patterns.
- D. Thomas, O. Dauwalder, V. Brun, C. Badiou, T. Ferry, J. Etienne, F. Vandenesch, and G. Lina (2009)
Infect. Immun.
77, 2043-2050
| Abstract »
| Full Text »
| PDF »
- Lipopolysaccharide Potentiates Effector T Cell Accumulation into Nonlymphoid Tissues through TRIF.
- J. P. McAleer, R. J. Rossi, and A. T. Vella (2009)
J. Immunol.
182, 5322-5330
| Abstract »
| Full Text »
| PDF »
- T helper 1 to T helper 2 shift in cytokine expression: an autoregulatory process in superantigen-associated psoriasis progression?.
- S. Jain, I. R. Kaur, S. Das, S. N. Bhattacharya, and A. Singh (2009)
J. Med. Microbiol.
58, 180-184
| Abstract »
| Full Text »
| PDF »
- Analysis of the early response to TSST-1 reveals V{beta}-unrestricted extravasation, compartmentalization of the response, and unresponsiveness but not anergy to TSST-1.
- M. Waclavicek, N. Stich, I. Rappan, H. Bergmeister, and M. M. Eibl (2009)
J. Leukoc. Biol.
85, 44-54
| Abstract »
| Full Text »
| PDF »
- Targeting Poly(I:C) to the TLR3-Independent Pathway Boosts Effector CD8 T Cell Differentiation through IFN-{alpha}/{beta}.
- S. M. Ngoi, M. G. Tovey, and A. T. Vella (2008)
J. Immunol.
181, 7670-7680
| Abstract »
| Full Text »
| PDF »
- Molecular Requirements for MHC Class II {alpha}-Chain Engagement and Allelic Discrimination by the Bacterial Superantigen Streptococcal Pyrogenic Exotoxin C.
- K. J. Kasper, W. Xi, A. K. M. Nur-ur Rahman, M. M. Nooh, M. Kotb, E. J. Sundberg, J. Madrenas, and J. K. McCormick (2008)
J. Immunol.
181, 3384-3392
| Abstract »
| Full Text »
| PDF »
- Syndecan-1 Is an in Vivo Suppressor of Gram-positive Toxic Shock.
- K. Hayashida, Y. Chen, A. H. Bartlett, and P. W. Park (2008)
J. Biol. Chem.
283, 19895-19903
| Abstract »
| Full Text »
| PDF »
- Commercial peptidoglycan preparations are contaminated with superantigen-like activity that stimulates IL-17 production.
- H. Li, M. M. Nooh, M. Kotb, and F. Re (2008)
J. Leukoc. Biol.
83, 409-418
| Abstract »
| Full Text »
| PDF »
- Structure and Biological Activities of Beta Toxin from Staphylococcus aureus.
- M. Huseby, K. Shi, C. K. Brown, J. Digre, F. Mengistu, K. S. Seo, G. A. Bohach, P. M. Schlievert, D. H. Ohlendorf, and C. A. Earhart (2007)
J. Bacteriol.
189, 8719-8726
| Abstract »
| Full Text »
| PDF »
- Bovine Luteal Cells Stimulate Proliferation of Major Histocompatibility Nonrestricted Gamma Delta T Cells.
- T. L Davis and J. L Pate (2007)
Biol Reprod
77, 914-922
| Abstract »
| Full Text »
| PDF »
- The Lipopolysaccharide Adjuvant Effect on T Cells Relies on Nonoverlapping Contributions from the MyD88 Pathway and CD11c+ Cells.
- J. P. McAleer, D. J. Zammit, L. Lefrancois, R. J. Rossi, and A. T. Vella (2007)
J. Immunol.
179, 6524-6535
| Abstract »
| Full Text »
| PDF »
- Chitosan Malate Inhibits Growth and Exotoxin Production of Toxic Shock Syndrome-Inducing Staphylococcus aureus Strains and Group A Streptococci.
- P. M. Schlievert (2007)
Antimicrob. Agents Chemother.
51, 3056-3062
| Abstract »
| Full Text »
| PDF »
- Cutting Edge: Evidence of Direct TCR {alpha}-Chain Interaction with Superantigen.
- N. Pumphrey, A. Vuidepot, B. Jakobsen, G. Forsberg, B. Walse, and K. Lindkvist-Petersson (2007)
J. Immunol.
179, 2700-2704
| Abstract »
| Full Text »
| PDF »
- Vaginal Staphylococcus aureus Superantigen Profile Shift from 1980 and 1981 to 2003, 2004, and 2005.
- P. M. Schlievert, L. C. Case, K. L. Strandberg, T. J. Tripp, Y.-C. Lin, and M. L. Peterson (2007)
J. Clin. Microbiol.
45, 2704-2707
| Abstract »
| Full Text »
| PDF »
- Atraumatic Compartment Syndrome: A Manifestation of Toxic Shock and Infectious Pyomyositis in a Child. A Case Report.
- S. Park, J. B. Shatsky, B. R. Pawel, and L. Wells (2007)
J. Bone Joint Surg. Am.
89, 1337-1342
| Full Text »
| PDF »
- Staphylococcal toxic-shock-syndrome-toxin-1 as a risk factor for disease relapse in Wegener's granulomatosis.
- E. R. Popa, C. A. Stegeman, W. H. Abdulahad, B. van der Meer, J. Arends, W. M. Manson, N. A. Bos, C. G. M. Kallenberg, and J.-W. Cohen Tervaert (2007)
Rheumatology
46, 1029-1033
| Abstract »
| Full Text »
| PDF »
- Molecular Basis of TCR Selectivity, Cross-Reactivity, and Allelic Discrimination by a Bacterial Superantigen: Integrative Functional and Energetic Mapping of the SpeC-Vbeta2.1 Molecular Interface.
- A. K. M. N.-u. Rahman, C. A. Herfst, B. Moza, S. R. Shames, L. A. Chau, C. Bueno, J. Madrenas, E. J. Sundberg, and J. K. McCormick (2006)
J. Immunol.
177, 8595-8603
| Abstract »
| Full Text »
| PDF »
- The TCR V{beta} signature of bacterial superantigens spreads with stimulus strength.
- M. Llewelyn, S. Sriskandan, N. Terrazzini, J. Cohen, and D. M. Altmann (2006)
Int. Immunol.
18, 1433-1441
| Abstract »
| Full Text »
| PDF »
- Staphylococcal Enterotoxin-Like Toxins U2 and V, Two New Staphylococcal Superantigens Arising from Recombination within the Enterotoxin Gene Cluster..
- D. Y. Thomas, S. Jarraud, B. Lemercier, G. Cozon, K. Echasserieau, J. Etienne, M.-L. Gougeon, G. Lina, and F. Vandenesch (2006)
Infect. Immun.
74, 4724-4734
| Abstract »
| Full Text »
| PDF »
- TCR trans-Rearrangements: Biological Significance in Antigen Recognition vs the Role as Lymphoma Biomarker.
- A. Allam and D. Kabelitz (2006)
J. Immunol.
176, 5707-5712
| Abstract »
| Full Text »
| PDF »
- Accessory Gene Regulator Locus of Staphylococcus intermedius..
- J. M. L. Sung, P. D. Chantler, and D. H. Lloyd (2006)
Infect. Immun.
74, 2947-2956
| Abstract »
| Full Text »
| PDF »
- Identification of novel th2-associated genes in T memory responses to allergens..
- A. Bosco, K. L. McKenna, C. J. Devitt, M. J. Firth, P. D. Sly, and P. G. Holt (2006)
J. Immunol.
176, 4766-4777
| Abstract »
| Full Text »
| PDF »
- Iodinated N-Acylvanillamines: Potential "Multiple-Target" Anti-Inflammatory Agents Acting via the Inhibition of T-Cell Activation and Antagonism at Vanilloid TRPV1 Channels.
- N. Marquez, L. De Petrocellis, F. J. Caballero, A. Macho, A. Schiano-Moriello, A. Minassi, G. Appendino, E. Munoz, and V. Di Marzo (2006)
Mol. Pharmacol.
69, 1373-1382
| Abstract »
| Full Text »
| PDF »
- CD4-Dependent Potentiation of a High Molecular Weight-Melanoma-Associated Antigen-Specific CTL Response Elicited in HLA-A2/Kb Transgenic Mice.
- L. Peng, E. Ko, W. Luo, X. Wang, P. A. Shrikant, and S. Ferrone (2006)
J. Immunol.
176, 2307-2315
| Abstract »
| Full Text »
| PDF »
- Dexamethasone Attenuates Staphylococcal Enterotoxin B-Induced Hypothermic Response and Protects Mice from Superantigen-Induced Toxic Shock.
- T. Krakauer and M. Buckley (2006)
Antimicrob. Agents Chemother.
50, 391-395
| Abstract »
| Full Text »
| PDF »
- Structure of a group A streptococcal phage-encoded virulence factor reveals a catalytically active triple-stranded {beta}-helix.
- N. L. Smith, E. J. Taylor, A.-M. Lindsay, S. J. Charnock, J. P. Turkenburg, E. J. Dodson, G. J. Davies, and G. W. Black (2005)
PNAS
102, 17652-17657
| Abstract »
| Full Text »
| PDF »
- Identification and antimicrobial susceptibility of micro-organisms recovered from cutaneous lesions of human American tegumentary leishmaniasis in Minas Gerais, Brazil.
- C. O Fontes, M. A. R Carvalho, J. R Nicoli, J. S Hamdan, W. Mayrink, O. Genaro, L. S Carmo, and L. M Farias (2005)
J. Med. Microbiol.
54, 1071-1076
| Abstract »
| Full Text »
| PDF »
- Persistence of Zinc-Binding Bacterial Superantigens at the Surface of Antigen-Presenting Cells Contributes to the Extreme Potency of These Superantigens as T-Cell Activators.
- D. D. Pless, G. Ruthel, E. K. Reinke, R. G. Ulrich, and S. Bavari (2005)
Infect. Immun.
73, 5358-5366
| Abstract »
| Full Text »
| PDF »
- Characterization of Novel Staphylococcal Enterotoxin-Like Toxin Type P.
- K. Omoe, K. Imanishi, D.-L. Hu, H. Kato, Y. Fugane, Y. Abe, S. Hamaoka, Y. Watanabe, A. Nakane, T. Uchiyama, et al. (2005)
Infect. Immun.
73, 5540-5546
| Abstract »
| Full Text »
| PDF »
- A Defective Viral Superantigen-Presenting Phenotype in HLA-DR Transfectants Is Corrected by CIITA.
- G. A. Azar, R.-P. Sekaly, and J. Thibodeau (2005)
J. Immunol.
174, 7548-7557
| Abstract »
| Full Text »
| PDF »
- Increased Sensitivity to Staphylococcal Enterotoxin B following Adenoviral Infection.
- T. O. Yarovinsky, M. P. Mohning, M. A. Bradford, M. M. Monick, and G. W. Hunninghake (2005)
Infect. Immun.
73, 3375-3384
| Abstract »
| Full Text »
| PDF »
- The Innate Immune System Is Activated by Stimulation of Vaginal Epithelial Cells with Staphylococcus aureus and Toxic Shock Syndrome Toxin 1.
- M. L. Peterson, K. Ault, M. J. Kremer, A. J. Klingelhutz, C. C. Davis, C. A. Squier, and P. M. Schlievert (2005)
Infect. Immun.
73, 2164-2174
| Abstract »
| Full Text »
| PDF »
- Staphylococcal enterotoxins condition cells of the innate immune system for Toll-like receptor 4 stimulation.
- R. J. Rossi, G. Muralimohan, J. R. Maxwell, and A. T. Vella (2004)
Int. Immunol.
16, 1751-1760
| Abstract »
| Full Text »
| PDF »
- Functional Piglet Model for the Clinical Syndrome and Postmortem Findings Induced by Staphylococcal Enterotoxin B.
- Y. A. van Gessel, S. Mani, S. Bi, R. Hammamieh, J. W. Shupp, R. Das, G. D. Coleman, and M. Jett (2004)
Experimental Biology and Medicine
229, 1061-1071
| Abstract »
| Full Text »
| PDF »
- Crystallographic and Mutational Data Show That the Streptococcal Pyrogenic Exotoxin J Can Use a Common Binding Surface for T-cell Receptor Binding and Dimerization.
- H. M. Baker, T. Proft, P. D. Webb, V. L. Arcus, J. D. Fraser, and E. N. Baker (2004)
J. Biol. Chem.
279, 38571-38576
| Abstract »
| Full Text »
| PDF »
- 4-1BB and OX40 Dual Costimulation Synergistically Stimulate Primary Specific CD8 T Cells for Robust Effector Function.
- S.-J. Lee, L. Myers, G. Muralimohan, J. Dai, Y. Qiao, Z. Li, R. S. Mittler, and A. T. Vella (2004)
J. Immunol.
173, 3002-3012
| Abstract »
| Full Text »
| PDF »
- Deficiency of CD11b or CD11d Results in Reduced Staphylococcal Enterotoxin-Induced T Cell Response and T Cell Phenotypic Changes.
- H. Wu, J. R. Rodgers, X.-Y. D. Perrard, J. L. Perrard, J. E. Prince, Y. Abe, B. K. Davis, G. Dietsch, C. W. Smith, and C. M. Ballantyne (2004)
J. Immunol.
173, 297-306
| Abstract »
| Full Text »
| PDF »
- In Vivo Cyclophosphamide and IL-2 Treatment Impedes Self-Antigen-Induced Effector CD4 Cell Tolerization: Implications for Adoptive Immunotherapy.
- M. A. Mihalyo, A. D. H. Doody, J. P. McAleer, E. C. Nowak, M. Long, Y. Yang, and A. J. Adler (2004)
J. Immunol.
172, 5338-5345
| Abstract »
| Full Text »
| PDF »
- Caffeic Acid Phenethyl Ester Inhibits T-Cell Activation by Targeting Both Nuclear Factor of Activated T-Cells and NF-{kappa}B Transcription Factors.
- N. Marquez, R. Sancho, A. Macho, M. A. Calzado, B. L. Fiebich, and E. Munoz (2004)
J. Pharmacol. Exp. Ther.
308, 993-1001
| Abstract »
| Full Text »
| PDF »
- Persistent and Selective Deficiency of CD4+ T Cell Immunity to Cytomegalovirus in Immunocompetent Young Children.
- W. Tu, S. Chen, M. Sharp, C. Dekker, A. M. Manganello, E. C. Tongson, H. T. Maecker, T. H. Holmes, Z. Wang, G. Kemble, et al. (2004)
J. Immunol.
172, 3260-3267
| Abstract »
| Full Text »
| PDF »
- HLA Class II Polymorphisms Determine Responses to Bacterial Superantigens.
- M. Llewelyn, S. Sriskandan, M. Peakman, D. R. Ambrozak, D. C. Douek, W. W. Kwok, J. Cohen, and D. M. Altmann (2004)
J. Immunol.
172, 1719-1726
| Abstract »
| Full Text »
| PDF »
- HIV-1-suppressive factors are secreted by CD4+ T cells during primary immune responses.
- S. F. Abdelwahab, F. Cocchi, K. C. Bagley, R. Kamin-Lewis, R. C. Gallo, A. DeVico, and G. K. Lewis (2003)
PNAS
100, 15006-15010
| Abstract »
| Full Text »
| PDF »
- Molecular basis of endothelial dysfunction in sepsis.
- K. Peters, R. E. Unger, J. Brunner, and C.J. Kirkpatrick (2003)
Cardiovasc Res
60, 49-57
| Abstract »
| Full Text »
| PDF »
- Detection of Staphylococcus aureus Enterotoxins A to D by Real-Time Fluorescence PCR Assay.
- M. Klotz, S. Opper, K. Heeg, and S. Zimmermann (2003)
J. Clin. Microbiol.
41, 4683-4687
| Abstract »
| Full Text »
| PDF »
- Functional Analysis of the TCR Binding Domain of Toxic Shock Syndrome Toxin-1 Predicts Further Diversity in MHC Class II/Superantigen/TCR Ternary Complexes.
- J. K. McCormick, T. J. Tripp, A. S. Llera, E. J. Sundberg, M. M. Dinges, R. A. Mariuzza, and P. M. Schlievert (2003)
J. Immunol.
171, 1385-1392
| Abstract »
| Full Text »
| PDF »
- A DNA Spiegelmer to staphylococcal enterotoxin B.
- W. G. Purschke, F. Radtke, F. Kleinjung, and S. Klussmann (2003)
Nucleic Acids Res.
31, 3027-3032
| Abstract »
| Full Text »
| PDF »
- Staphylococcal Enterotoxin B-Induced Acute Inflammation Is Inhibited by Dexamethasone: Important Role of CXC Chemokines KC and Macrophage Inflammatory Protein 2.
- R. Schramm and H. Thorlacius (2003)
Infect. Immun.
71, 2542-2547
| Abstract »
| Full Text »
| PDF »
- Staphylococcal Enterotoxin H Induces V{alpha}-Specific Expansion of T Cells.
- K. Petersson, H. Pettersson, N. J. Skartved, B. Walse, and G. Forsberg (2003)
J. Immunol.
170, 4148-4154
| Abstract »
| Full Text »
| PDF »
- Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor {kappa}B in Regulating Mature T Cell Survival and In Vivo Function.
- Y. Zheng, M. Vig, J. Lyons, L. Van Parijs, and A. A. Beg (2003)
J. Exp. Med.
197, 861-874
| Abstract »
| Full Text »
| PDF »
- Interaction of Mycoplasmas With Host Cells.
- S. Rottem (2003)
Physiol Rev
83, 417-432
| Abstract »
| Full Text »
| PDF »
- Two Novel Superantigens Found in Both Group A and Group C Streptococcus.
- T. Proft, P. D. Webb, V. Handley, and J. D. Fraser (2003)
Infect. Immun.
71, 1361-1369
| Abstract »
| Full Text »
| PDF »
- Synergistic and antagonistic interactions between LPS and superantigens.
- A. H. Dalpke and K. Heeg (2003)
Innate Immunity
9, 51-54
| Abstract »
| PDF »
- Comparative Molecular Analysis of Community- or Hospital-Acquired Methicillin-Resistant Staphylococcus aureus.
- P. D. Fey, B. Said-Salim, M. E. Rupp, S. H. Hinrichs, D. J. Boxrud, C. C. Davis, B. N. Kreiswirth, and P. M. Schlievert (2003)
Antimicrob. Agents Chemother.
47, 196-203
| Abstract »
| Full Text »
| PDF »
- Superantigenic activity is responsible for induction of coronary arteritis in mice: an animal model of Kawasaki disease.
- T. T. Duong, E. D. Silverman, M. V. Bissessar, and R. S. M. Yeung (2003)
Int. Immunol.
15, 79-89
| Abstract »
| Full Text »
| PDF »
- Characterization of Two Novel Pyrogenic Toxin Superantigens Made by an Acute Rheumatic Fever Clone of Streptococcus pyogenes Associated with Multiple Disease Outbreaks.
- L. M. Smoot, J. K. McCormick, J. C. Smoot, N. P. Hoe, I. Strickland, R. L. Cole, K. D. Barbian, C. A. Earhart, D. H. Ohlendorf, L. G. Veasy, et al. (2002)
Infect. Immun.
70, 7095-7104
| Abstract »
| Full Text »
| PDF »
- Staphylococcal enterotoxin B induces hepatic injury and lethal shock in endotoxin-resistant C3H/HeJ mice despite a deficient macrophage response.
- S. Yasuda, M. Nagaki, and H. Moriwaki (2002)
Innate Immunity
8, 253-261
| Abstract »
| PDF »
- Pirfenidone Blocks the In Vitro and In Vivo Effects of Staphylococcal Enterotoxin B.
- M. L. Hale, S. B. Margolin, T. Krakauer, C. J. Roy, and B. G. Stiles (2002)
Infect. Immun.
70, 2989-2994
| Abstract »
| Full Text »
| PDF »
- Mucosal Tolerance to a Bacterial Superantigen Indicates a Novel Pathway To Prevent Toxic Shock.
- L. V. Collins, K. Eriksson, R. G. Ulrich, and A. Tarkowski (2002)
Infect. Immun.
70, 2282-2287
| Abstract »
| Full Text »
| PDF »
- Characterization and Expression Analysis of Staphylococcus aureus Pathogenicity Island 3. IMPLICATIONS FOR THE EVOLUTION OF STAPHYLOCOCCAL PATHOGENICITY ISLANDS.
- J. M. Yarwood, J. K. McCormick, M. L. Paustian, P. M. Orwin, V. Kapur, and P. M. Schlievert (2002)
J. Biol. Chem.
277, 13138-13147
| Abstract »
| Full Text »
| PDF »
- Enterotoxigenic Potential of Staphylococcus intermedius.
- K. Becker, B. Keller, C. von Eiff, M. Bruck, G. Lubritz, J. Etienne, and G. Peters (2001)
Appl. Envir. Microbiol.
67, 5551-5557
| Abstract »
| Full Text »
| PDF »
- Toxin Genes and Other Characteristics of Staphylococcus aureus Isolates from Milk of Cows with Mastitis.
- O. Akineden, C. Annemuller, A. A. Hassan, C. Lammler, W. Wolter, and M. Zschock (2001)
Clin. Vaccine Immunol.
8, 959-964
| Abstract »
| Full Text »
| PDF »
- Role of Endogenous Interleukin-12 in Immune Response to Staphylococcal Enterotoxin B in Mice.
- F. N. Lauw, S. Florquin, P. Speelman, S. J. H. van Deventer, and T. van der Poll (2001)
Infect. Immun.
69, 5949-5952
| Abstract »
| Full Text »
| PDF »
- Differential Roles of Interleukin-18 (IL-18) and IL-12 for Induction of Gamma Interferon by Staphylococcal Cell Wall Components and Superantigens.
- R. J. L. Stuyt, M. G. Netea, S.-H. Kim, D. Novick, M. Rubinstein, B.-J. Kullberg, J. W. M. Van der Meer, and C. A. Dinarello (2001)
Infect. Immun.
69, 5025-5030
| Abstract »
| Full Text »
| PDF »
- Cardiac Myosin and the TH1/TH2 Paradigm in Autoimmune Myocarditis.
- M. W. Cunningham (2001)
Am. J. Pathol.
159, 5-12
| Full Text »
| PDF »
- Effects of Superantigen and Lipopolysaccharide on Induction of CD80 through Apoptosis of Human Monocytes.
- M. Takahashi, M. Takahashi, F. Shinohara, H. Takada, and H. Rikiishi (2001)
Infect. Immun.
69, 3652-3657
| Abstract »
| Full Text »
| PDF »
- Presence of Lpsd Mutation Influences Cytokine Regulation In Vivo by the Mycoplasma arthritidis Mitogen Superantigen and Lethal Toxicity in Mice Infected with M. arthritidis.
- H.-H. Mu, A. D. Sawitzke, and B. C. Cole (2001)
Infect. Immun.
69, 3837-3844
| Abstract »
| Full Text »
| PDF »
- Superantigen antagonist blocks Th1 cytokine gene induction and lethal shock.
- G. Arad, D. Hillman, R. Levy, and R. Kaempfer (2001)
J. Leukoc. Biol.
69, 921-927
| Abstract »
| Full Text »
| PDF »
- Immunological and Biochemical Characterization of Streptococcal Pyrogenic Exotoxins I and J (SPE-I and SPE-J) from Streptococcus pyogenes.
- T. Proft, V. L. Arcus, V. Handley, E. N. Baker, and J. D. Fraser (2001)
J. Immunol.
166, 6711-6719
| Abstract »
| Full Text »
| PDF »
- Chronic exposure to superantigen induces regulatory CD4+ T cells with IL-10-mediated suppressive activity.
- C. Noel, S. Florquin, M. Goldman, and M. Y. Braun (2001)
Int. Immunol.
13, 431-439
| Abstract »
| Full Text »
| PDF »
- Functional Characterization of Streptococcal Pyrogenic Exotoxin J, a Novel Superantigen.
- J. K. McCormick, A. A. Pragman, J. C. Stolpa, D. Y. M. Leung, and P. M. Schlievert (2001)
Infect. Immun.
69, 1381-1388
| Abstract »
| Full Text »
| PDF »
- Superantigens: The Good, the Bad, and the Ugly.
- B. A. Torres, S. Kominsky, G. Q. Perrin, A. C. Hobeika, and H. M. Johnson (2001)
Experimental Biology and Medicine
226, 164-176
| Abstract »
| Full Text »
- Human Antibodies to Bacterial Superantigens and Their Ability To Inhibit T-Cell Activation and Lethality.
- R. D. LeClaire and S. Bavari (2001)
Antimicrob. Agents Chemother.
45, 460-463
| Abstract »
| Full Text »
- Biochemical and Biological Properties of Staphylococcal Enterotoxin K.
- P. M. Orwin, D. Y. M. Leung, H. L. Donahue, R. P. Novick, and P. M. Schlievert (2001)
Infect. Immun.
69, 360-366
| Abstract »
| Full Text »
| PDF »
- Cutting Edge: The Related Molecules CD28 and Inducible Costimulator Deliver Both Unique and Complementary Signals Required for Optimal T Cell Activation.
- J.-A. Gonzalo, T. Delaney, J. Corcoran, A. Goodearl, J. C. Gutierrez-Ramos, and A. J. Coyle (2001)
J. Immunol.
166, 1-5
| Abstract »
| Full Text »
| PDF »
- egc, A Highly Prevalent Operon of Enterotoxin Gene, Forms a Putative Nursery of Superantigens in Staphylococcus aureus.
- S. Jarraud, M. A. Peyrat, A. Lim, A. Tristan, M. Bes, C. Mougel, J. Etienne, F. Vandenesch, M. Bonneville, and G. Lina (2001)
J. Immunol.
166, 669-677
| Abstract »
| Full Text »
| PDF »
- Modulation of Neutrophil Chemokine Receptors by Staphylococcus aureus Supernate.
- K. E. Veldkamp, H. C. J. M. Heezius, J. Verhoef, J. A. G. van Strijp, and K. P. M. van Kessel (2000)
Infect. Immun.
68, 5908-5913
| Abstract »
| Full Text »
| PDF »
- A Single Oral Dose of Thalidomide Enhances the Capacity of Lymphocytes to Secrete Gamma Interferon in Healthy Humans.
- A. Verbon, N. P. Juffermans, P. Speelman, S. J. H. van Deventer, I. J. M. ten Berge, H.-J. Guchelaar, and T. van der Poll (2000)
Antimicrob. Agents Chemother.
44, 2286-2290
| Abstract »
| Full Text »
- Toxoids of Streptococcal Pyrogenic Exotoxin A Are Protective in Rabbit Models of Streptococcal Toxic Shock Syndrome.
- M. Roggiani, J. A. Stoehr, S. B. Olmsted, Y. V. Matsuka, S. Pillai, D. H. Ohlendorf, and P. M. Schlievert (2000)
Infect. Immun.
68, 5011-5017
| Abstract »
| Full Text »
| PDF »
- Nuclear Factor of Activated T Cells Transcription Factor Nfatp Controls Superantigen-Induced Lethal Shock.
- A. V. Tsytsykova and A. E. Goldfeld (2000)
J. Exp. Med.
192, 581-586
| Abstract »
| Full Text »
| PDF »
- Antigen Triggering Selectively Increases TCRBV Gene Transcription.
- G. P. Lennon, J. E. Sillibourne, E. Furrie, M. J. Doherty, and R. A. Kay (2000)
J. Immunol.
165, 2020-2027
| Abstract »
| Full Text »
| PDF »
- Development of Streptococcal Pyrogenic Exotoxin C Vaccine Toxoids That Are Protective in the Rabbit Model of Toxic Shock Syndrome.
- J. K. McCormick, T. J. Tripp, S. B. Olmsted, Y. V. Matsuka, P. J. Gahr, D. H. Ohlendorf, and P. M. Schlievert (2000)
J. Immunol.
165, 2306-2312
| Abstract »
| Full Text »
| PDF »
- Identification of a Novel Gene Cluster Encoding Staphylococcal Exotoxin-Like Proteins: Characterization of the Prototypic Gene and Its Protein Product, SET1.
- R. J. Williams, J. M. Ward, B. Henderson, S. Poole, B. P. O'Hara, M. Wilson, and S. P. Nair (2000)
Infect. Immun.
68, 4407-4415
| Abstract »
| Full Text »
| PDF »
- Advances in our understanding of the bone and joint pathology caused by Staphylococcus aureus infection.
- S. P. Nair, R. J. Williams, and B. Henderson (2000)
Rheumatology
39, 821-834
| Full Text »
| PDF »
- Functional Analysis of the env Open Reading Frame in Human Endogenous Retrovirus IDDMK1,222 Encoding Superantigen Activity.
- M. Lapatschek, S. Dürr, R. Löwer, C. Magin, H. Wagner, and T. Miethke (2000)
J. Virol.
74, 6386-6393
| Abstract »
| Full Text »
- Molecular evidence for antigen-driven immune responses in cardiac lesions of rheumatic heart disease patients.
- L. Guilherme, N. Dulphy, C. Douay, V. Coelho, E. Cunha-Neto, S. E. Oshiro, R. V Assis, A. C. Tanaka, P. M. Alberto Pomerantzeff, D. Charron, et al. (2000)
Int. Immunol.
12, 1063-1074
| Abstract »
| Full Text »
| PDF »
- Inhibition of Staphylococcal Enterotoxin B-Induced Lymphocyte Proliferation and Tumor Necrosis Factor Alpha Secretion by MAb5, an Anti-Toxic Shock Syndrome Toxin 1 Monoclonal Antibody.
- L. T. Y. Pang, W. W. S. Kum, and A. W. Chow (2000)
Infect. Immun.
68, 3261-3268
| Abstract »
| Full Text »
| PDF »
- Pyrogenic Toxin Superantigen Site Specificity in Toxic Shock Syndrome and Food Poisoning in Animals.
- P. M. Schlievert, L. M. Jablonski, M. Roggiani, I. Sadler, S. Callantine, D. T. Mitchell, D. H. Ohlendorf, and G. A. Bohach (2000)
Infect. Immun.
68, 3630-3634
| Abstract »
| Full Text »
| PDF »
- Comparison of Pulsed-Field Gel Electrophoresis and Coagulase Gene Restriction Profile Analysis Techniques in the Molecular Typing of Staphylococcus aureus.
- C.-S. Chiou, H.-L. Wei, and L.-C. Yang (2000)
J. Clin. Microbiol.
38, 2186-2190
| Abstract »
| Full Text »
- T Cell Adoptive Immunotherapy of Newly Diagnosed Gliomas.
- G. E. Plautz, D. W. Miller, G. H. Barnett, G. H. J. Stevens, S. Maffett, J. Kim, P. A. Cohen, and S. Shu (2000)
Clin. Cancer Res.
6, 2209-2218
| Abstract »
| Full Text »
- The Streptococcal Superantigen Smez Exhibits Wide Allelic Variation, Mosaic Structure, and Significant Antigenic Variation.
- T. Proft, S. L. Moffatt, K. D. Weller, A. Paterson, D. Martin, and J. D. Fraser (2000)
J. Exp. Med.
191, 1765-1776
| Abstract »
| Full Text »
| PDF »
- Characterization of the Promoter Elements for the Staphylococcal Enterotoxin D Gene.
- S. Zhang and G. C. Stewart (2000)
J. Bacteriol.
182, 2321-2325
| Abstract »
| Full Text »
- Development of a Single-Reaction Multiplex PCR Toxin Typing Assay for Staphylococcus aureus Strains.
- N. K. Sharma, C. E. D. Rees, and C. E. R. Dodd (2000)
Appl. Envir. Microbiol.
66, 1347-1353
| Abstract »
| Full Text »
- Staphylococcal Enterotoxin A Acts through Nitric Oxide Synthase Mechanisms in Human Peripheral Blood Mononuclear Cells To Stimulate Synthesis of Pyrogenic Cytokines.
- S.-J. Won, W.-T. Huang, Y.-S. Lai, and M.-T. Lin (2000)
Infect. Immun.
68, 2003-2008
| Abstract »
| Full Text »
| PDF »
- Mapping the Energy of Superantigen Staphylococcus Enterotoxin C3 Recognition of an {alpha}/{beta} T Cell Receptor Using Alanine Scanning Mutagenesis.
- H. R.O. Churchill, P. S. Andersen, E. A. Parke, R. A. Mariuzza, and D. M. Kranz (2000)
J. Exp. Med.
191, 835-846
| Abstract »
| Full Text »
| PDF »
- Reduced Th1, but Not Th2, Cytokine Production by Lymphocytes after In Vivo Exposure of Healthy Subjects to Endotoxin.
- F. N. Lauw, T. ten Hove, P. E. P. Dekkers, E. de Jonge, S. J. H. van Deventer, and T. van der Poll (2000)
Infect. Immun.
68, 1014-1018
| Abstract »
| Full Text »
| PDF »
|
|