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Science 4 May 1990:
Vol. 248. no. 4955, pp. 588 - 591
DOI: 10.1126/science.2110381
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Articles
Science, Vol 248, Issue 4955, 588-591
Copyright © 1990 by American Association for the Advancement of Science
Expression of a zinc finger gene in HTLV-I- and HTLV-II-transformed cells
JJ Wright,
KC Gunter,
H Mitsuya,
SG Irving,
K Kelly,
and
U Siebenlist
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Gene products encoded by the human T cell leukemia virus (HTLV) types I and II mediate transformation by the transactivation of cellular genes necessary for proliferation, probably including transcriptional regulatory factors. By searching for factors that may control proliferation, a zinc finger gene (225) was identified that was constitutively expressed in all HTLV-I- or HTLV-II-transformed cell lines examined, whereas in normal T cells it was only transiently expressed after mitogenic stimulation. The 225 gene was also constitutively expressed in two HTLV-I-transformed helper T cell clones, but not in the parental cell lines. Thus this putative cellular transcriptional factor, which was abnormally expressed in retrovirus-infected cells, may have a role in transformation.
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