Science 27 April 1990: Vol. 248. no. 4954, pp. 492 - 495 DOI: 10.1126/science.1691865

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Articles

Identification of Amino Acid Residues of the Matrix Metalloproteinase-2 Essential for Its Selective Inhibition by {beta}-Amyloid Precursor Protein-derived Inhibitor.

S. Higashi and K. Miyazaki (2008)
J. Biol. Chem. 283, 10068-10078
 |  Abstract »  |  Full Text »  |  PDF »

Homophilic Interactions of the Amyloid Precursor Protein (APP) Ectodomain Are Regulated by the Loop Region and Affect {beta}-Secretase Cleavage of APP.

D. Kaden, L.-M. Munter, M. Joshi, C. Treiber, C. Weise, T. Bethge, P. Voigt, M. Schaefer, M. Beyermann, B. Reif, et al. (2008)
J. Biol. Chem. 283, 7271-7279
 |  Abstract »  |  Full Text »  |  PDF »

Mice Lacking Protease Nexin-1 Show Delayed Structural and Functional Recovery after Sciatic Nerve Crush.

M. M. Lino, S. Atanasoski, M. Kvajo, B. Fayard, E. Moreno, H. R. Brenner, U. Suter, and D. Monard (2007)
J. Neurosci. 27, 3677-3685
 |  Abstract »  |  Full Text »  |  PDF »

RNA Interference Silencing of the Adaptor Molecules ShcC and Fe65 Differentially Affect Amyloid Precursor Protein Processing and Abeta Generation.

Z. Xie, Y. Dong, U. Maeda, W. Xia, and R. E. Tanzi (2007)
J. Biol. Chem. 282, 4318-4325
 |  Abstract »  |  Full Text »  |  PDF »

Therapeutic approaches to Alzheimer's disease.

H.-W. Klafki, M. Staufenbiel, J. Kornhuber, and J. Wiltfang (2006)
Brain 129, 2840-2855
 |  Abstract »  |  Full Text »  |  PDF »

High {beta}-Secretase Activity Elicits Neurodegeneration in Transgenic Mice Despite Reductions in Amyloid-{beta} Levels: IMPLICATIONS FOR THE TREATMENT OF ALZHEIMER DISEASE.

E. Rockenstein, M. Mante, M. Alford, A. Adame, L. Crews, M. Hashimoto, L. Esposito, L. Mucke, and E. Masliah (2005)
J. Biol. Chem. 280, 32957-32967
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Glycosphingolipid Biosynthesis Reduces Secretion of the {beta}-Amyloid Precursor Protein and Amyloid {beta}-Peptide.

I. Y. Tamboli, K. Prager, E. Barth, M. Heneka, K. Sandhoff, and J. Walter (2005)
J. Biol. Chem. 280, 28110-28117
 |  Abstract »  |  Full Text »  |  PDF »

RNA Interference-mediated Silencing of X11{alpha} and X11{beta} Attenuates Amyloid {beta}-Protein Levels via Differential Effects on {beta}-Amyloid Precursor Protein Processing.

Z. Xie, D. M. Romano, and R. E. Tanzi (2005)
J. Biol. Chem. 280, 15413-15421
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Inaugural Article: Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule.

B. J. Blanchard, A. Chen, L. M. Rozeboom, K. A. Stafford, P. Weigele, and V. M. Ingram (2004)
PNAS 101, 14326-14332
 |  Abstract »  |  Full Text »  |  PDF »

The Proteolytic Processing of the Amyloid Precursor Protein Gene Family Members APLP-1 and APLP-2 Involves {alpha}-, {beta}-, {gamma}-, and {epsilon}-Like Cleavages: MODULATION OF APLP-1 PROCESSING BY N-GLYCOSYLATION.

S. Eggert, K. Paliga, P. Soba, G. Evin, C. L. Masters, A. Weidemann, and K. Beyreuther (2004)
J. Biol. Chem. 279, 18146-18156
 |  Abstract »  |  Full Text »  |  PDF »

Increased Expression and Processing of the Alzheimer Amyloid Precursor Protein in Pancreatic Cancer May Influence Cellular Proliferation.

D. E. Hansel, A. Rahman, S. Wehner, V. Herzog, C. J. Yeo, and A. Maitra (2003)
Cancer Res. 63, 7032-7037
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Region of beta -Amyloid Precursor Protein Essential for Its Gelatinase A Inhibitory Activity.

S. Higashi and K. Miyazaki (2003)
J. Biol. Chem. 278, 14020-14028
 |  Abstract »  |  Full Text »  |  PDF »

Secretion and Intracellular Generation of Truncated Abeta in beta -Site Amyloid-beta Precursor Protein-cleaving Enzyme Expressing Human Neurons.

E. B. Lee, D. M. Skovronsky, F. Abtahian, R. W. Doms, and V. M.-Y. Lee (2003)
J. Biol. Chem. 278, 4458-4466
 |  Abstract »  |  Full Text »  |  PDF »

Platelet Microparticles as Carriers of Soluble Alzheimer's Amyloid {beta} (sA{beta}).

E. MATSUBARA, M. SHOJI, T. MURAKAMI, K. ABE, B. FRANGIONE, and J. GHISO (2002)
Ann. N.Y. Acad. Sci. 977, 340-348
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The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for {alpha}-secretase activity in fibroblasts.

D. Hartmann, B. de Strooper, L. Serneels, K. Craessaerts, A. Herreman, W. Annaert, L. Umans, T. Lubke, A. Lena Illert, K. von Figura, et al. (2002)
Hum. Mol. Genet. 11, 2615-2624
 |  Abstract »  |  Full Text »  |  PDF »

Amyloid Precursor Protein, Presenilins, and alpha -Synuclein: Molecular Pathogenesis and Pharmacological Applications in Alzheimer's Disease.

Y.-H. Suh and F. Checler (2002)
Pharmacol. Rev. 54, 469-525
 |  Abstract »  |  Full Text »  |  PDF »

The gamma Secretase-generated Carboxyl-terminal Domain of the Amyloid Precursor Protein Induces Apoptosis via Tip60 in H4 Cells.

A. Kinoshita, C. M. Whelan, O. Berezovska, and B. T. Hyman (2002)
J. Biol. Chem. 277, 28530-28536
 |  Abstract »  |  Full Text »  |  PDF »

Differential Roles of JIP Scaffold Proteins in the Modulation of Amyloid Precursor Protein Metabolism.

H. Taru, Y. Kirino, and T. Suzuki (2002)
J. Biol. Chem. 277, 27567-27574
 |  Abstract »  |  Full Text »  |  PDF »

Progressive Neuronal and Motor Dysfunction in Mice Overexpressing the Serine Protease Inhibitor Protease Nexin-1 in Postmitotic Neurons.

M. Meins, P. Piosik, N. Schaeren-Wiemers, S. Franzoni, E. Troncoso, J. Z. Kiss, C. Brosamle, M. E. Schwab, Z. Molnar, and D. Monard (2001)
J. Neurosci. 21, 8830-8841
 |  Abstract »  |  Full Text »  |  PDF »

A Portrait of Alzheimer Secretases--New Features and Familiar Faces.

W. P. Esler and M. S. Wolfe (2001)
Science 293, 1449-1454
 |  Abstract »  |  Full Text »  |  PDF »

A role for MAP kinase in regulating ectodomain shedding of APLP2 in corneal epithelial cells.

K.-P. Xu, D. Zoukhri, J. D. Zieske, D. A. Dartt, C. Sergheraert, E. Loing, and F.-S. X. Yu (2001)
Am J Physiol Cell Physiol 281, C603-C614
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Disease: Genes, Proteins, and Therapy.

D. J. Selkoe (2001)
Physiol Rev 81, 741-766
 |  Abstract »  |  Full Text »  |  PDF »

Amyloidogenesis in Familial British Dementia Is Associated with a Genetic Defect on Chromosome 13.

J. GHISO, R. VIDAL, A. ROSTAGNO, L. MIRAVALLE, J. L. HOLTON, S. MEAD, T. REVESZ, G. PLANT, and B. FRANGIONE (2000)
Ann. N.Y. Acad. Sci. 920, 84-92
 |  Abstract »  |  Full Text »  |  PDF »

The Value of Transgenic Models for the Study of Neurodegenerative Diseases.

D. L. PRICE, P. C. WONG, A. L. MARKOWSKA, M. K. LEE, G. THINAKAREN, D. W. CLEVELAND, S. S. SISODIA, and D. R. BORCHELT (2000)
Ann. N.Y. Acad. Sci. 920, 179-191
 |  Abstract »  |  Full Text »  |  PDF »

Nonfibrillar diffuse amyloid deposition due to a {gamma}42-secretase site mutation points to an essential role for N-truncated A{beta}42 in Alzheimer's disease.

S. Kumar-Singh, C. De Jonghe, M. Cruts, R. Kleinert, R. Wang, M. Mercken, B. De Strooper, H. Vanderstichele, A. Lofgren, I. Vanderhoeven, et al. (2000)
Hum. Mol. Genet. 9, 2589-2598
 |  Abstract »  |  Full Text »  |  PDF »

Early-Onset Alzheimer Disease Caused by a New Mutation (V717L) in the Amyloid Precursor Protein Gene.

J. R. Murrell, A. M. Hake, K. A. Quaid, M. R. Farlow, and B. Ghetti (2000)
Arch Neurol 57, 885-887
 |  Abstract »  |  Full Text »  |  PDF »

Insulin regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway.

D. C. SOLANO, M. SIRONI, C. BONFINI, S. B. SOLERTE, S. GOVONI, and M. RACCHI (2000)
FASEB J 14, 1015-1022
 |  Abstract »  |  Full Text »

Regulation of Amyloid Precursor Protein Processing by Presenilin 1 (PS1) and PS2 in PS1 Knockout Cells.

J. J. Palacino, B. E. Berechid, P. Alexander, C. Eckman, S. Younkin, J. S. Nye, and B. Wolozin (2000)
J. Biol. Chem. 275, 215-222
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Proteolytic processing and cell biological functions of the amyloid precursor protein.

B De Strooper and W Annaert (2000)
J. Cell Sci. 113, 1857-1870
 |  Abstract »  |  PDF »

Regulation of Cytokine Secretion and Amyloid Precursor Protein Processing by Proinflammatory Amyloid Beta (A{beta}).

B. D. GITTER, L. N. BOGGS, P. C. MAY, D. L. CZILLI, and C. D. CARLSON (2000)
Ann. N.Y. Acad. Sci. 917, 154-164
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Caveolins, Liquid-Ordered Domains, and Signal Transduction.

E. J. Smart, G. A. Graf, M. A. McNiven, W. C. Sessa, J. A. Engelman, P. E. Scherer, T. Okamoto, and M. P. Lisanti (1999)
Mol. Cell. Biol. 19, 7289-7304
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Caveolin-3 Upregulation Activates beta -Secretase-Mediated Cleavage of the Amyloid Precursor Protein in Alzheimer's Disease.

K. Nishiyama, B. D. Trapp, T. Ikezu, R. M. Ransohoff, T. Tomita, T. Iwatsubo, I. Kanazawa, K. K. Hsiao, M. P. Lisanti, and T. Okamoto (1999)
J. Neurosci. 19, 6538-6548
 |  Abstract »  |  Full Text »  |  PDF »

Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis.

X. Xu, D. Yang, T. Wyss-Coray, J. Yan, L. Gan, Y. Sun, and L. Mucke (1999)
PNAS 96, 7547-7552
 |  Abstract »  |  Full Text »  |  PDF »

{gamma}-Secretase, Evidence for Multiple Proteolytic Activities and Influence of Membrane Positioning of Substrate on Generation of Amyloid {beta} Peptides of Varying Length.

M. P. Murphy, L. J. Hickman, C. B. Eckman, S. N. Uljon, R. Wang, and T. E. Golde (1999)
J. Biol. Chem. 274, 11914-11923
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Competition of Aß amyloid peptide and apolipoprotein E for receptor-mediated endocytosis.

K. Winkler, H. Scharnagl, U. Tisljar, H. Hoschützky, I. Friedrich, M. M. Hoffmann, M. Hüttinger, H. Wieland, and W. März (1999)
J. Lipid Res. 40, 447-455
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Prostaglandin E2 Stimulates Amyloid Precursor Protein Gene Expression: Inhibition by Immunosuppressants.

R. K. K. Lee, S. Knapp, and R. J. Wurtman (1999)
J. Neurosci. 19, 940-947
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Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path.

J. D. Buxbaum, G. Thinakaran, V. Koliatsos, J. O'Callahan, H. H. Slunt, D. L. Price, and S. S. Sisodia (1998)
J. Neurosci. 18, 9629-9637
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Neurodegenerative Diseases: The Human Illness and Transgenic Models.

D. L. Price, S. S. Sisodia, and D. R. Borchelt (1998)
Science 282, 1079-1083
 |  Abstract »  |  Full Text »

A role for the beta -amyloid precursor protein in memory?.

S. S. Sisodia and M. Gallagher (1998)
PNAS 95, 12074-12076
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Products of the Alzheimer's disease amyloid precursor protein generated by,{beta}-secretase are present in human platelets, and secreted upon degranulation.

Q.-X. Li, R. Cappai, G. Evin, J. E. Tanner, C. W. Gray, K. Beyreuther, and C. L. Masters (1998)
American Journal of Alzheimer's Disease and Other Dementias 13, 236-244
 |  Abstract »  |  PDF »

X11 Interaction with beta -Amyloid Precursor Protein Modulates Its Cellular Stabilization and Reduces Amyloid beta -Protein Secretion.

M. Sastre, R. S. Turner, and E. Levy (1998)
J. Biol. Chem. 273, 22351-22357
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Proteolytic imbalance in Alzheimer fibroblasts as potential pathological trait of disease.

F. Paoletti and D. Tombaccini (1998)
FASEB J 12, 925-927
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Modulation of Secreted beta -Amyloid Precursor Protein and Amyloid beta -Peptide in Brain by Cholesterol.

D. S. Howland, S. P. Trusko, M. J. Savage, A. G. Reaume, D. M. Lang, J. D. Hirsch, N. Maeda, R. Siman, B. D. Greenberg, R. W. Scott, et al. (1998)
J. Biol. Chem. 273, 16576-16582
 |  Abstract »  |  Full Text »  |  PDF »

Thyroid Hormones Regulate {beta}-Amyloid Gene Splicing and Protein Secretion in Neuroblastoma Cells.

M. J. Latasa, B. Belandia, and A. Pascual (1998)
Endocrinology 139, 2692-2698
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Amyloid Precursor Protein Secretion by Glutamate Receptors in Human Ntera 2 Neurons (NT2N).

C. Jolly-Tornetta, Z.-y. Gao, V. M.-Y. Lee, and B. A. Wolf (1998)
J. Biol. Chem. 273, 14015-14021
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's-specific effects of soluble beta -amyloid on protein kinase C-alpha and -gamma degradation in human fibroblasts.

A. Favit, M. Grimaldi, T. J. Nelson, and D. L. Alkon (1998)
PNAS 95, 5562-5567
 |  Abstract »  |  Full Text »  |  PDF »

Post-translational Processing and Turnover Kinetics of Presynaptically Targeted Amyloid Precursor Superfamily Proteins in the Central Nervous System.

A. W. Lyckman, A. M. Confaloni, G. Thinakaran, S. S. Sisodia, and K. L. Moya (1998)
J. Biol. Chem. 273, 11100-11106
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Caveolae, Plasma Membrane Microdomains for alpha -Secretase-mediated Processing of the Amyloid Precursor Protein.

T. Ikezu, B. D. Trapp, K. S. Song, A. Schlegel, M. P. Lisanti, and T. Okamoto (1998)
J. Biol. Chem. 273, 10485-10495
 |  Abstract »  |  Full Text »  |  PDF »

Cleavage of Alzheimer's Amyloid Precursor Protein (APP) by Secretases Occurs after O-Glycosylation of APP in the Protein Secretory Pathway. IDENTIFICATION OF INTRACELLULAR COMPARTMENTS IN WHICH APP CLEAVAGE OCCURS WITHOUT USING TOXIC AGENTS THAT INTERFERE WITH PROTEIN METABOLISM.

S. Tomita, Y. Kirino, and T. Suzuki (1998)
J. Biol. Chem. 273, 6277-6284
 |  Abstract »  |  Full Text »  |  PDF »

Relative Increase in Alzheimer's Disease of Soluble Forms of Cerebral Abeta Amyloid Protein Precursor Containing the Kunitz Protease Inhibitory Domain.

R. D. Moir, T. Lynch, A. I. Bush, S. Whyte, A. Henry, S. Portbury, G. Multhaup, D. H. Small, R. E. Tanzi, K. Beyreuther, et al. (1998)
J. Biol. Chem. 273, 5013-5019
 |  Abstract »  |  Full Text »  |  PDF »

Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans.

D Levitan and I Greenwald (1998)
Development 125, 3599-3606
 |  Abstract »  |  PDF »

Differential Effects of the Swedish Mutant Amyloid Precursor Protein on beta -Amyloid Accumulation and Secretion in Neurons and Nonneuronal Cells.

M. S. Forman, D. G. Cook, S. Leight, R. W. Doms, and V. M.-Y. Lee (1997)
J. Biol. Chem. 272, 32247-32253
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Amyloid Precursor Protein Catabolism Involves the Mitogen-Activated Protein Kinase Signal Transduction Pathway.

J. Mills, D. Laurent Charest, F. Lam, K. Beyreuther, N. Ida, S. L. Pelech, and P. B. Reiner (1997)
J. Neurosci. 17, 9415-9422
 |  Abstract »  |  Full Text »  |  PDF »

Zinc-induced Alzheimer's Abeta 1-40 Aggregation Is Mediated by Conformational Factors.

X. Huang, C. S. Atwood, R. D. Moir, M. A. Hartshorn, J.-P. Vonsattel, R. E. Tanzi, and A. I. Bush (1997)
J. Biol. Chem. 272, 26464-26470
 |  Abstract »  |  Full Text »  |  PDF »

Novel beta -Secretase Cleavage of beta -Amyloid Precursor Protein in the Endoplasmic Reticulum/Intermediate Compartment of NT2N Cells.

A. S.C. Chyung, B. D. Greenberg, D. G. Cook, R. W. Doms, and V. M.-Y. Lee (1997)
J. Cell Biol. 138, 671-680
 |  Abstract »  |  Full Text »  |  PDF »

Role of the Juxtamembrane Domains of the Transforming Growth Factor-alpha Precursor and the beta -Amyloid Precursor Protein in Regulated Ectodomain Shedding.

J. Arribas, F. Lopez-Casillas, and J. Massague (1997)
J. Biol. Chem. 272, 17160-17165
 |  Abstract »  |  Full Text »  |  PDF »

Generation of Alzheimer beta -amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation.

H. Xu, D. Sweeney, R. Wang, G. Thinakaran, A. C. Y. Lo, S. S. Sisodia, P. Greengard, and S. Gandy (1997)
PNAS 94, 3748-3752
 |  Abstract »  |  Full Text »  |  PDF »

Metabotropic Glutamate Receptor Agonists Increase Release of Soluble Amyloid Precursor Protein Derivatives from Rat Brain Cortical and Hippocampal Slices.

I. H. Ulus and R. J. Wurtman (1997)
J. Pharmacol. Exp. Ther. 281, 149-154
 |  Abstract »  |  Full Text »

Ectodomain Phosphorylation of beta -Amyloid Precursor Protein at Two Distinct Cellular Locations.

J. Walter, A. Capell, A. Y. Hung, H. Langen, M. Schnolzer, G. Thinakaran, S. S. Sisodia, D. J. Selkoe, and C. Haass (1997)
J. Biol. Chem. 272, 1896-1903
 |  Abstract »  |  Full Text »  |  PDF »

Trafficking of Cell-Surface beta -Amyloid Precursor Protein: Evidence that a Sorting Intermediate Participates in Synaptic Vesicle Recycling.

N. R. Marquez-Sterling, A. C. Y. Lo, S. S. Sisodia, and E. H. Koo (1997)
J. Neurosci. 17, 140-151
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Matrix Metalloproteinase-9 (MMP-9) Is Synthesized in Neurons of the Human Hippocampus and Is Capable of Degrading the Amyloid-beta Peptide (1-40).

J. R. Backstrom, G. P. Lim, M. J. Cullen, and Z. A. Tokes (1996)
J. Neurosci. 16, 7910-7919
 |  Abstract »  |  Full Text »  |  PDF »

Processing of beta -Amyloid Precursor Protein by Cathepsin D.

J. Higaki, R. Catalano, A. W. Guzzetta, D. Quon, J.-F. Nave, C. Tarnus, H. D'Orchymont, and B. Cordell (1996)
J. Biol. Chem. 271, 31885-31893
 |  Abstract »  |  Full Text »  |  PDF »

Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F beta -Amyloid Precursor Protein and Alzheimer's Disease.

E. Masliah, A. Sisk, M. Mallory, L. Mucke, D. Schenk, and D. Games (1996)
J. Neurosci. 16, 5795-5811
 |  Abstract »  |  Full Text »  |  PDF »

Structural Requirements for the Ectodomain Cleavage of Human Cell Surface Macrophage Colony-stimulating Factor.

P. Deng, C. W. Rettenmier, and P. K. Pattengale (1996)
J. Biol. Chem. 271, 16338-16343
 |  Abstract »  |  Full Text »  |  PDF »

Metabolism of the ``Swedish'' Amyloid Precursor Protein Variant in Neuro2a (N2a) Cells.

G. Thinakaran, D. B. Teplow, R. Siman, B. Greenberg, and S. S. Sisodia (1996)
J. Biol. Chem. 271, 9390-9397
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Release of Amyloid beta-Protein from Codon 670/671 ``Swedish'' Mutant beta-Amyloid Precursor Protein Occurs in Both Secretory and Endocytic Pathways.

R. G. Perez, S. L. Squazzo, and E. H. Koo (1996)
J. Biol. Chem. 271, 9100-9107
 |  Abstract »  |  Full Text »  |  PDF »

Serotonin 5-HT2a and 5-HT2c Receptors Stimulate Amyloid Precursor Protein Ectodomain Secretion.

R. M. Nitsch, M. Deng, J. H. Growdon, and R. J. Wurtman (1996)
J. Biol. Chem. 271, 4188-4194
 |  Abstract »  |  Full Text »  |  PDF »

Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody.

E. Koo, S. Squazzo, D. Selkoe, and C. Koo (1996)
J. Cell Sci. 109, 991-998
 |  Abstract »  |  PDF »

Trafficking of cell-surface amyloid beta-protein precursor. II. Endocytosis, recycling and lysosomal targeting detected by immunolocalization.

T Yamazaki, E. Koo, and D. Selkoe (1996)
J. Cell Sci. 109, 999-1008
 |  Abstract »  |  PDF »

Generation of Amyloidogenic C-terminal Fragments during Rapid Axonal Transport in Vivo of [IMAGE]-Amyloid Precursor Protein in the Optic Nerve.

A. Amaratunga and R. E. Fine (1995)
J. Biol. Chem. 270, 17268-17272
 |  Abstract »  |  Full Text »  |  PDF »

Novel Regulation of Chondroitin Sulfate Glycosaminoglycan Modification of Amyloid Precursor Protein and Its Homologue, APLP2.

G. Thinakaran, H. H. Slunt, and S. S. Sisodia (1995)
J. Biol. Chem. 270, 16522-16525
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular A[IMAGE]1-42 Aggregates Stimulate the Accumulation of Stable, Insoluble Amyloidogenic Fragments of the Amyloid Precursor Protein in Transfected Cells.

A. J. Yang, M. Knauer, D. A. Burdick, and C. Glabe (1995)
J. Biol. Chem. 270, 14786-14792
 |  Abstract »  |  Full Text »  |  PDF »

Proteolytic Processing of Alzheimer's Disease [IMAGE]A4 Amyloid Precursor Protein in Human Platelets.

Q.-X. Li, G.èv. Evin, D. H. Small, G. Multhaup, K. Beyreuther, and C. L. Masters (1995)
J. Biol. Chem. 270, 14140-14147
 |  Abstract »  |  Full Text »  |  PDF »

Metabolism of the Amyloid Precursor-like Protein 2 in MDCK Cells.

A. C. Y. Lo, G. Thinakaran, H. H. Slunt, and S. S. Sisodia (1995)
J. Biol. Chem. 270, 12641-12645
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine Phosphorylation-dependent Stimulation of Amyloid Precursor Protein Secretion by the m3 Muscarinic Acetylcholine Receptor.

B. E. Slack, J. Breu, M. A. Petryniak, K. Srivastava, and R. J. Wurtman (1995)
J. Biol. Chem. 270, 8337-8344
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Matrix Influences the Biogenesis of Amyloid Precursor Protein in Microglial Cells.

U. Mönning, R. Sandbrink, A. Weidemann, R. B. Banati, C. L. Masters, and K. Beyreuther (1995)
J. Biol. Chem. 270, 7104-7110
 |  Abstract »  |  Full Text »  |  PDF »

Muscarinic Regulation of Alzheimer's Disease Amyloid Precursor Protein Secretion and Amyloid beta-Protein Production in Human Neuronal NT2N Cells.

B. A. Wolf, A. M. Wertkin, Y. C. Jolly, R. P. Yasuda, B. B. Wolfe, R. J. Konrad, D. Manning, S. Ravi, J. R. Williamson, and V. M.-Y. Lee (1995)
J. Biol. Chem. 270, 4916-4922
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Sorting Signals in the beta-Amyloid Precursor Protein Cytoplasmic Domain.

A. Lai, S. S. Sisodia, and I. S. Trowbridge (1995)
J. Biol. Chem. 270, 3565-3573
 |  Abstract »  |  Full Text »  |  PDF »

Soluble beta-amyloid induction of Alzheimer's phenotype for human fibroblast K+ channels.

R Etcheberrigaray, E Ito, C. Kim, and D. Alkon (1994)
Science 264, 276-279
 |  Abstract »  |  PDF »

Release of excess amyloid beta protein from a mutant amyloid beta protein precursor.

X. Cai, T. Golde, and S. Younkin (1993)
Science 259, 514-516
 |  Abstract »  |  PDF »

Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors.

R. Nitsch, B. Slack, R. Wurtman, and J. Growdon (1992)
Science 258, 304-307
 |  Abstract »  |  PDF »

Production of the Alzheimer amyloid beta protein by normal proteolytic processing.

M Shoji, T. Golde, J Ghiso, T. Cheung, S Estus, L. Shaffer, X. Cai, D. McKay, R Tintner, B Frangione, et al. (1992)
Science 258, 126-129
 |  Abstract »  |  PDF »

Alzheimer's disease: a cell biological perspective.

K. Kosik (1992)
Science 256, 780-783
 |  Abstract »  |  PDF »

Alzheimer's disease: the amyloid cascade hypothesis.

J. Hardy and G. Higgins (1992)
Science 256, 184-185
 |  PDF »

Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor.

S Estus, T. Golde, T Kunishita, D Blades, D Lowery, M Eisen, M Usiak, X. Qu, T Tabira, B. Greenberg, et al. (1992)
Science 255, 726-728
 |  Abstract »  |  PDF »

Processing of the amyloid protein precursor to potentially amyloidogenic derivatives.

T. Golde, S Estus, L. Younkin, D. Selkoe, and S. Younkin (1992)
Science 255, 728-730
 |  Abstract »  |  PDF »

Deposits of amyloid beta protein in the central nervous system of transgenic mice.

D. Wirak, R Bayney, T. Ramabhadran, R. Fracasso, J. Hart, P. Hauer, P Hsiau, S. Pekar, G. Scangos, B. Trapp, et al. (1991)
Science 253, 323-325
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Solution structures of beta peptide and its constituent fragments: relation to amyloid deposition.

C. Barrow and M. Zagorski (1991)
Science 253, 179-182
 |  Abstract »  |  PDF »

Deciphering Alzheimer's disease: the amyloid precursor protein yields new clues.

D. Selkoe (1990)
Science 248, 1058-1060
 |  PDF »

Apolipoprotein E4 Stimulates cAMP Response Element-binding Protein Transcriptional Activity through the Extracellular S