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Science 20 April 1990:
Vol. 248. no. 4953, pp. 367 - 370
DOI: 10.1126/science.2326647
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Articles

Science, Vol 248, Issue 4953, 367-370
Copyright © 1990 by American Association for the Advancement of Science

articles

Defective presentation of endogenous antigen by a cell line expressing class I molecules

NA Hosken and MJ Bevan

Department of Immunology, Research Institute of Scripps Clinic, La Jolla, CA 92037.

Cytotoxic T lymphocytes (CTLs) recognize class I major histocompatibility complex (MHC) molecules associated with antigenic peptides derived from endogenously synthesized proteins. Binding to such peptides is a requirement for class I assembly in the endoplasmic reticulum (ER). A mutant human cell line, T2, assembles and transports to its surface some, but not all, class I MHC molecules. The class I molecules expressed on the surface of T2 do not present peptides derived from cytosolic antigens, although they can present exogenously added peptides to CTL. The transported class I molecules may interact weakly with an unknown retaining factor in the ER such that they can assemble despite the relative shortage of peptides.


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