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Science 20 April 1990:
Vol. 248. no. 4953, pp. 361 - 364
DOI: 10.1126/science.1691527
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Articles

Science, Vol 248, Issue 4953, 361-364
Copyright © 1990 by American Association for the Advancement of Science

articles

Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice

T Moriyama, S Guilhot, K Klopchin, B Moss, CA Pinkert, RD Palmiter, RL Brinster, O Kanagawa, and FV Chisari

Research Institute of Scripps Clinic, La Jolla, CA 92037.

The role of the immune response to hepatitis B virus (HBV)-encoded antigens in the pathogenesis of liver cell injury has not been defined because of the absence of appropriate experimental models. HBV envelope transgenic mice were used to show that HBV-encoded antigens are expressed at the hepatocyte surface in a form recognizable by major histocompatibility complex (MHC) class I-restricted, CD8+ cytotoxic T lymphocytes specific for a dominant T cell epitope within the major envelope polypeptide and by envelope-specific antibodies. Both interactions led to the death of the hepatocyte in vivo, providing direct evidence that hepatocellular injury in human HBV infection may also be immunologically mediated.


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(1990)
Journal Watch (General) 1990, 5
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