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Science 13 April 1990:
Vol. 248. no. 4952, pp. 220 - 223
DOI: 10.1126/science.2326636

Articles

Science, Vol 248, Issue 4952, 220-223
Copyright © 1990 by American Association for the Advancement of Science


articles

A class I antigen, HLA-G, expressed in human trophoblasts

S Kovats, EK Main, C Librach, M Stubblebine, SJ Fisher, and R DeMars

Department of Human Oncology, University of Wisconsin, Madison 53706.

The alpha chain of the human histocompatibility antigen HLA-G was identified as an array of five 37- to 39-kilodalton isoforms by the use of two-dimensional gel electrophoresis. Both cell-associated and secreted HLA-G antigens are prominent in first trimester villous cytotrophoblasts and are greatly reduced in third trimester cytotrophoblasts. Allelic variation was not detected, an indication that HLA-G is not obviously polymorphic in cytotrophoblasts. Among the following choriocarcinoma cell lines studied, HLA-G is expressed in JEG but not in Jar or BeWo. Expression of endogenous HLA-G genes has not been found in normal lymphoid cells. Thus, HLA-G is subject to both cell type-specific and developmental regulation and is expressed in early gestation human cytotrophoblasts.


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P. M. Drake, M. D. Gunn, I. F. Charo, C.-L. Tsou, Y. Zhou, L. Huang, and S. J. Fisher (2001)
J. Exp. Med. 193, 1199-1212
   Abstract »    Full Text »    PDF »
Human Trophoblast Invasion and Spiral Artery Transformation : The Role of PECAM-1 in Normal Pregnancy, Preeclampsia, and Fetal Growth Restriction.
F. Lyall, J. N. Bulmer, E. Duffie, F. Cousins, A. Theriault, and S. C. Robson (2001)
Am. J. Pathol. 158, 1713-1721
   Abstract »    Full Text »    PDF »
HLA-G2, -G3, and -G4 Isoforms Expressed as Nonmature Cell Surface Glycoproteins Inhibit NK and Antigen-Specific CTL Cytolysis.
B. Riteau, N. Rouas-Freiss, C. Menier, P. Paul, J. Dausset, and E. D. Carosella (2001)
J. Immunol. 166, 5018-5026
   Abstract »    Full Text »    PDF »
Cellular localization of human relaxin-like factor in the cyclic endometrium and placenta.
S. Hombach-Klonisch, S. Seeger, G. Tscheudschilsuren, J. Buchmann, B. Huppertz, G. Seliger, B. Fischer, and T. Klonisch (2001)
Mol. Hum. Reprod. 7, 349-356
   Abstract »    Full Text »    PDF »
The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion.
K.A. Pfeiffer, R. Fimmers, G. Engels, H. van der Ven, and K. van der Ven (2001)
Mol. Hum. Reprod. 7, 373-378
   Abstract »    Full Text »    PDF »
Cutting Edge: Regulation of Uterine NKT Cells by a Fetal Class I Molecule Other Than CD1.
Y. Dang and K. D. Heyborne (2001)
J. Immunol. 166, 3641-3644
   Abstract »    Full Text »    PDF »
Maturation of antigen-presenting cells is compromised in HLA-G transgenic mice.
A. Horuzsko, F. Lenfant, D. H. Munn, and A. L. Mellor (2001)
Int. Immunol. 13, 385-394
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Soluble HLA-G influences the release of cytokines from allogeneic peripheral blood mononuclear cells in culture.
T. Kanai, T. Fujii, S. Kozuma, T. Yamashita, A. Miki, A. Kikuchi, and Y. Taketani (2001)
Mol. Hum. Reprod. 7, 195-200
   Abstract »    Full Text »    PDF »
HLA-G1 co-expression boosts the HLA class I-mediated NK lysis inhibition.
B. Riteau, C. Menier, I. Khalil-Daher, S. Martinozzi, M. Pla, J. Dausset, E. D. Carosella, and N. Rouas-Freiss (2001)
Int. Immunol. 13, 193-201
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Trophoblast Cell-Specific Carcinoembryonic Antigen Cell Adhesion Molecule 9 Is Not Required for Placental Development or a Positive Outcome of Allotypic Pregnancies.
D. Finkenzeller, B. Fischer, J. McLaughlin, H. Schrewe, B. Ledermann, and W. Zimmermann (2000)
Mol. Cell. Biol. 20, 7140-7145
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A Repertoire of Cell Cycle Regulators Whose Expression Is Coordinated with Human Cytotrophoblast Differentiation.
O. Genbacev, M. T. McMaster, and S. J. Fisher (2000)
Am. J. Pathol. 157, 1337-1351
   Abstract »    Full Text »    PDF »
Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression.
J. A. Harton and J. P.-Y. Ting (2000)
Mol. Cell. Biol. 20, 6185-6194
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Human Cytomegalovirus Infection of Placental Cytotrophoblasts In Vitro and In Utero: Implications for Transmission and Pathogenesis.
S. Fisher, O. Genbacev, E. Maidji, and L. Pereira (2000)
J. Virol. 74, 6808-6820
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HLA-G expression in extravillous trophoblasts is an intrinsic property of cell differentiation: a lesson learned from ectopic pregnancies.
D. S. Goldman-Wohl, I. Ariel, C. Greenfield, J. Hanoch, and S. Yagel (2000)
Mol. Hum. Reprod. 6, 535-540
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Posttranscriptional Regulation of Human Leukocyte Antigen G During Human Extravillous Cytotrophoblast Differentiation.
J. Copeman, R. N.N. Han, I. Caniggia, M. McMaster, S. J. Fisher, and J. C. Cross (2000)
Biol Reprod 62, 1543-1550
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Interferon-Tau Stimulates Granulocyte-Macrophage Colony-Stimulating Factor Gene Expression in Bovine Lymphocytes and Endometrial Stromal Cells.
V. Emond, E. Asselin, M. A. Fortier, B. D. Murphy, and R. D. Lambert (2000)
Biol Reprod 62, 1728-1737
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Extracellular Matrix Composition and Hypoxia Regulate the Expression of HLA-G and Integrins in a Human Trophoblast Cell Line.
B. A. Kilburn, J. Wang, Z. M. Duniec-Dmuchkowski, R. E. Leach, R. Romero, and D. R. Armant (2000)
Biol Reprod 62, 739-747
   Abstract »    Full Text »



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