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Science 13 April 1990: Vol. 248. no. 4952, pp. 220 - 223 DOI: 10.1126/science.2326636
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Articles
Science, Vol 248, Issue 4952, 220-223
Copyright © 1990 by American Association for the Advancement of Science
A class I antigen, HLA-G, expressed in human trophoblasts
S Kovats,
EK Main,
C Librach,
M Stubblebine,
SJ Fisher,
and
R DeMars
Department of Human Oncology, University of Wisconsin, Madison 53706.
The alpha chain of the human histocompatibility antigen HLA-G was identified as an array of five 37- to 39-kilodalton isoforms by the use of two-dimensional gel electrophoresis. Both cell-associated and secreted HLA-G antigens are prominent in first trimester villous cytotrophoblasts and are greatly reduced in third trimester cytotrophoblasts. Allelic variation was not detected, an indication that HLA-G is not obviously polymorphic in cytotrophoblasts. Among the following choriocarcinoma cell lines studied, HLA-G is expressed in JEG but not in Jar or BeWo. Expression of endogenous HLA-G genes has not been found in normal lymphoid cells. Thus, HLA-G is subject to both cell type-specific and developmental regulation and is expressed in early gestation human cytotrophoblasts.
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- Th1- and Th2-like cytokine production by first trimester decidual large granular lymphocytes is influenced by HLA-G and HLA-E.
- L. Rieger, V. Hofmeister, C. Probe, J. Dietl, E.H. Weiss, T. Steck, and U. Kammerer (2002)
Mol. Hum. Reprod.
8, 255-261
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- HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage.
- C.L. Aldrich, M.D. Stephenson, T. Karrison, R.R. Odem, D.W. Branch, J.R. Scott, J.R. Schreiber, and C. Ober (2001)
Mol. Hum. Reprod.
7, 1167-1172
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- Cell-free Fetal DNA Is Increased in Plasma of Women with Hyperemesis Gravidarum.
- A. Sekizawa, Y. Sugito, M. Iwasaki, A. Watanabe, M. Jimbo, S. Hoshi, H. Saito, and T. Okai (2001)
Clin. Chem.
47, 2164-2165
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- Chemokine Ligand and Receptor Expression in the Pregnant Uterus : Reciprocal Patterns in Complementary Cell Subsets Suggest Functional Roles.
- K. Red-Horse, P. M. Drake, M. D. Gunn, and S. J. Fisher (2001)
Am. J. Pathol.
159, 2199-2213
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- Implantation and the Survival of Early Pregnancy.
- E. R. Norwitz, D. J. Schust, and S. J. Fisher (2001)
N. Engl. J. Med.
345, 1400-1408
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- Human Placental Cytotrophoblasts Attract Monocytes and Cd56bright Natural Killer Cells via the Actions of Monocyte Inflammatory Protein 1{alpha}.
- P. M. Drake, M. D. Gunn, I. F. Charo, C.-L. Tsou, Y. Zhou, L. Huang, and S. J. Fisher (2001)
J. Exp. Med.
193, 1199-1212
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- Human Trophoblast Invasion and Spiral Artery Transformation : The Role of PECAM-1 in Normal Pregnancy, Preeclampsia, and Fetal Growth Restriction.
- F. Lyall, J. N. Bulmer, E. Duffie, F. Cousins, A. Theriault, and S. C. Robson (2001)
Am. J. Pathol.
158, 1713-1721
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- HLA-G2, -G3, and -G4 Isoforms Expressed as Nonmature Cell Surface Glycoproteins Inhibit NK and Antigen-Specific CTL Cytolysis.
- B. Riteau, N. Rouas-Freiss, C. Menier, P. Paul, J. Dausset, and E. D. Carosella (2001)
J. Immunol.
166, 5018-5026
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- Cellular localization of human relaxin-like factor in the cyclic endometrium and placenta.
- S. Hombach-Klonisch, S. Seeger, G. Tscheudschilsuren, J. Buchmann, B. Huppertz, G. Seliger, B. Fischer, and T. Klonisch (2001)
Mol. Hum. Reprod.
7, 349-356
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- The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion.
- K.A. Pfeiffer, R. Fimmers, G. Engels, H. van der Ven, and K. van der Ven (2001)
Mol. Hum. Reprod.
7, 373-378
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- Cutting Edge: Regulation of Uterine NKT Cells by a Fetal Class I Molecule Other Than CD1.
- Y. Dang and K. D. Heyborne (2001)
J. Immunol.
166, 3641-3644
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- Maturation of antigen-presenting cells is compromised in HLA-G transgenic mice.
- A. Horuzsko, F. Lenfant, D. H. Munn, and A. L. Mellor (2001)
Int. Immunol.
13, 385-394
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- Soluble HLA-G influences the release of cytokines from allogeneic peripheral blood mononuclear cells in culture.
- T. Kanai, T. Fujii, S. Kozuma, T. Yamashita, A. Miki, A. Kikuchi, and Y. Taketani (2001)
Mol. Hum. Reprod.
7, 195-200
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- HLA-G1 co-expression boosts the HLA class I-mediated NK lysis inhibition.
- B. Riteau, C. Menier, I. Khalil-Daher, S. Martinozzi, M. Pla, J. Dausset, E. D. Carosella, and N. Rouas-Freiss (2001)
Int. Immunol.
13, 193-201
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- Trophoblast Cell-Specific Carcinoembryonic Antigen Cell Adhesion Molecule 9 Is Not Required for Placental Development or a Positive Outcome of Allotypic Pregnancies.
- D. Finkenzeller, B. Fischer, J. McLaughlin, H. Schrewe, B. Ledermann, and W. Zimmermann (2000)
Mol. Cell. Biol.
20, 7140-7145
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- A Repertoire of Cell Cycle Regulators Whose Expression Is Coordinated with Human Cytotrophoblast Differentiation.
- O. Genbacev, M. T. McMaster, and S. J. Fisher (2000)
Am. J. Pathol.
157, 1337-1351
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- Class II Transactivator: Mastering the Art of Major Histocompatibility Complex Expression.
- J. A. Harton and J. P.-Y. Ting (2000)
Mol. Cell. Biol.
20, 6185-6194
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- Human Cytomegalovirus Infection of Placental Cytotrophoblasts In Vitro and In Utero: Implications for Transmission and Pathogenesis.
- S. Fisher, O. Genbacev, E. Maidji, and L. Pereira (2000)
J. Virol.
74, 6808-6820
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- HLA-G expression in extravillous trophoblasts is an intrinsic property of cell differentiation: a lesson learned from ectopic pregnancies.
- D. S. Goldman-Wohl, I. Ariel, C. Greenfield, J. Hanoch, and S. Yagel (2000)
Mol. Hum. Reprod.
6, 535-540
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- Posttranscriptional Regulation of Human Leukocyte Antigen G During Human Extravillous Cytotrophoblast Differentiation.
- J. Copeman, R. N.N. Han, I. Caniggia, M. McMaster, S. J. Fisher, and J. C. Cross (2000)
Biol Reprod
62, 1543-1550
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- Interferon-Tau Stimulates Granulocyte-Macrophage Colony-Stimulating Factor Gene Expression in Bovine Lymphocytes and Endometrial Stromal Cells.
- V. Emond, E. Asselin, M. A. Fortier, B. D. Murphy, and R. D. Lambert (2000)
Biol Reprod
62, 1728-1737
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- Extracellular Matrix Composition and Hypoxia Regulate the Expression of HLA-G and Integrins in a Human Trophoblast Cell Line.
- B. A. Kilburn, J. Wang, Z. M. Duniec-Dmuchkowski, R. E. Leach, R. Romero, and D. R. Armant (2000)
Biol Reprod
62, 739-747
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