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Science 30 March 1990:
Vol. 247. no. 4950, pp. 1581 - 1584
DOI: 10.1126/science.2321018
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Articles

Science, Vol 247, Issue 4950, 1581-1584
Copyright © 1990 by American Association for the Advancement of Science

articles

A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter

HC Liou, MR Boothby, PW Finn, R Davidon, N Nabavi, NJ Zeleznik-Le, JP Ting, and LH Glimcher

Department of Cancer Biology, Harvard School of Public Health, Boston, MA 02115.

Several mutants derived from transformed human B cell lines are defective in expressing major histocompatibility complex (MHC) class II genes. The failure to express a class II gene in at least one such mutant line has been mapped to the MHC class II X box, a conserved transcriptional element in the promoter region. A complementary DNA encoding a DNA-binding protein (human X box binding protein, hXBP-1) whose target is the human DR alpha X box and the 3' flanking region has now been cloned. This complementary DNA encoded a protein with structural similarities to the c-jun proto-oncogene product, and its target sequence was closely related to the palindromic target sequence of c-jun. Mutation of the hXBP-1 DNA target sequence decreased DR alpha promoter activity in vivo. These studies suggest that the hXBP-1 protein acts as a transcription factor in B cells.


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