Science 23 March 1990: Vol. 247. no. 4949, pp. 1446 - 1451 DOI: 10.1126/science.2321006

Prev | Table of Contents | Next

Articles

The Skin as a Neurotrophic Organ.

K. M. Albers and B. M. Davis (2007)
Neuroscientist 13, 371-382
 |  Abstract »  |  PDF »

The Function of Neurotrophic Factor Receptors Expressed by the Developing Adductor Motor Pool In Vivo.

T. W. Gould and R. W. Oppenheim (2004)
J. Neurosci. 24, 4668-4682
 |  Abstract »  |  Full Text »  |  PDF »

Target-derived BMP signaling limits sensory neuron number and the extent of peripheral innervation in vivo.

U. Guha, W. A. Gomes, J. Samanta, M. Gupta, F. L. Rice, and J. A. Kessler (2004)
Development 131, 1175-1186
 |  Abstract »  |  Full Text »  |  PDF »

Accelerated dendritic development of rat cortical pyramidal cells and interneurons after biolistic transfection with BDNF and NT4/5.

M. J. Wirth, A. Brun, J. Grabert, S. Patz, and P. Wahle (2003)
Development 130, 5827-5838
 |  Abstract »  |  Full Text »  |  PDF »

Neurotrophin-3 inhibits HCO3- absorption via a cAMP-dependent pathway in renal thick ascending limb.

D. W. Good and T. George (2001)
Am J Physiol Cell Physiol 281, C1804-C1811
 |  Abstract »  |  Full Text »  |  PDF »

Neurotrophic Factors and Receptors in the Immature and Adult Spinal Cord after Mechanical Injury or Kainic Acid.

J. Widenfalk, K. Lundstromer, M. Jubran, S. Brene, and L. Olson (2001)
J. Neurosci. 21, 3457-3475
 |  Abstract »  |  Full Text »  |  PDF »

Lack of Neurotrophin-4 Causes Selective Structural and Chemical Deficits in Sympathetic Ganglia and Their Preganglionic Innervation.

A. Roosen, A. Schober, J. Strelau, M. Bottner, J. Faulhaber, G. Bendner, S. L. McIlwrath, H. Seller, H. Ehmke, G. R. Lewin, et al. (2001)
J. Neurosci. 21, 3073-3084
 |  Abstract »  |  Full Text »  |  PDF »

Ephrin-B3 is the midline barrier that prevents corticospinal tract axons from recrossing, allowing for unilateral motor control.

K. Kullander, S. D. Croll, M. Zimmer, L. Pan, J. McClain, V. Hughes, S. Zabski, T. M. DeChiara, R. Klein, G. D. Yancopoulos, et al. (2001)
Genes & Dev. 15, 877-888
 |  Abstract »  |  Full Text »

The role of retinoic acid receptors in neurite outgrowth from different populations of embryonic mouse dorsal root ganglia.

J Corcoran, B Shroot, J Pizzey, and M Maden (2000)
J. Cell Sci. 113, 2567-2574
 |  Abstract »  |  PDF »

Neurotrophin-3 Levels in Cerebrospinal Fluid From Children With Bacterial Meningitis, Viral Meningitis, or Encephalitis.

Y. Mizuno, H. Takada, K. Urakami, K. Ihara, R. Kira, A. Suminoe, S. Ohga, T. Aoki, and T. Hara (2000)
J Child Neurol 15, 19-21
 |  Abstract »  |  PDF »

Differential Expression of Brain-Derived Neurotrophic Factor, Neurotrophin-3, and Neurotrophin-4/5 in the Adult Rat Spinal Cord: Regulation by the Glutamate Receptor Agonist Kainic Acid.

I. A. Scarisbrick, P. J. Isackson, and A. J. Windebank (1999)
J. Neurosci. 19, 7757-7769
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Brain-Derived Neurotrophic Factor Enhances Sensory Innervation and Selectively Increases Neuron Number.

A. M. LeMaster, R. F. Krimm, B. M. Davis, T. Noel, M. E. Forbes, J. E. Johnson, and K. M. Albers (1999)
J. Neurosci. 19, 5919-5931
 |  Abstract »  |  Full Text »  |  PDF »

Functionally Antagonistic Interactions between the TrkA and p75 Neurotrophin Receptors Regulate Sympathetic Neuron Growth and Target Innervation.

J. Kohn, R. S. Aloyz, J. G. Toma, M. Haak-Frendscho, and F. D. Miller (1999)
J. Neurosci. 19, 5393-5408
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Synaptic Function by Neurotrophic Factors in Vertebrates and Invertebrates: Implications for Development and Learning.

S. E. McKay, A. L. Purcell, and T. J. Carew (1999)
Learn. Mem. 6, 193-215
 |  Abstract »  |  Full Text »

Brain-Derived Neurotrophic Factor and Neurotrophin-3 Enhance Somatostatin Gene Expression through a Likely Direct Effect on Hypothalamic Somatostatin Neurons.

F. Rage, B. Riteau, G. Alonso, and L. Tapia-Arancibia (1999)
Endocrinology 140, 909-916
 |  Abstract »  |  Full Text »

Activity-dependent Release of Brain-derived Neurotrophic Factor Underlies the Neuroprotective Effect of N-Methyl-D-aspartate.

A. M. Marini, S. J. Rabin, R. H. Lipsky, and I. Mocchetti (1998)
J. Biol. Chem. 273, 29394-29399
 |  Abstract »  |  Full Text »  |  PDF »

Lampetra fluviatilis Neurotrophin Homolog, Descendant of a Neurotrophin Ancestor, Discloses the Early Molecular Evolution of Neurotrophins in the Vertebrate Subphylum.

F. Hallbook, L.-G. Lundin, and K. Kullander (1998)
J. Neurosci. 18, 8700-8711
 |  Abstract »  |  Full Text »  |  PDF »

Endogenous Neurotrophin-3 Regulates Short-Term Plasticity at Lateral Perforant Path-Granule Cell Synapses.

M. Kokaia, F. Asztely, K. Olofsdotter, C. B. Sindreu, D. M. Kullmann, and O. Lindvall (1998)
J. Neurosci. 18, 8730-8739
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Nerve Growth Factor and trkA After Transient Focal Cerebral Ischemia in Rats • Editorial Comment.

T.-H. Lee, H. Kato, S.-T. Chen, K. Kogure, Y. Itoyama, and C. D. Kontos (1998)
Stroke 29, 1687-1697
 |  Abstract »  |  Full Text »  |  PDF »

Neurexophilins Form a Conserved Family of Neuropeptide-Like Glycoproteins.

M. Missler and T. C. Sudhof (1998)
J. Neurosci. 18, 3630-3638
 |  Abstract »  |  Full Text »  |  PDF »

Brain-Derived Neurotrophic Factor, Neurotrophin-3, and Neurotrophin-4 Complement and Cooperate with Each Other Sequentially during Visceral Neuron Development.

W. M. ElShamy and P. Ernfors (1997)
J. Neurosci. 17, 8667-8675
 |  Abstract »  |  Full Text »  |  PDF »

Cellular Delivery of Neurotrophin-3 Promotes Corticospinal Axonal Growth and Partial Functional Recovery after Spinal Cord Injury.

R. Grill, K. Murai, A. Blesch, F. H. Gage, and M. H. Tuszynski (1997)
J. Neurosci. 17, 5560-5572
 |  Abstract »  |  Full Text »  |  PDF »

Activity-Dependent Expression of NT-3 in Muscle Cells in Culture: Implications in the Development of Neuromuscular Junctions.

K. Xie, T. Wang, P. Olafsson, K. Mizuno, and B. Lu (1997)
J. Neurosci. 17, 2947-2958
 |  Abstract »  |  Full Text »  |  PDF »

5-HT2A Receptor-Mediated Regulation of Brain-Derived Neurotrophic Factor mRNA in the Hippocampus and the Neocortex.

V. A. Vaidya, G. J. Marek, G. K. Aghajanian, and R. S. Duman (1997)
J. Neurosci. 17, 2785-2795
 |  Abstract »  |  Full Text »  |  PDF »

Hepatocyte Growth Factor Promotes Motor Neuron Survival and Synergizes with Ciliary Neurotrophic Factor.

V. Wong, D. J. Glass, R. Arriaga, G. D. Yancopoulos, R. M. Lindsay, and G. Conn (1997)
J. Biol. Chem. 272, 5187-5191
 |  Abstract »  |  Full Text »  |  PDF »

Two Peptides Derived from the Nerve Growth Factor Precursor Are Biologically Active.

E. Dicou, B. Pflug, M. Magazin, T. Lehy, D. Djakiew, P. Ferrara, V. Nerriere, and D. Harvie (1997)
J. Cell Biol. 136, 389-398
 |  Abstract »  |  Full Text »  |  PDF »

The Regulated Secretion and Vectorial Targeting of Neurotrophins in Neuroendocrine and Epithelial Cells.

J. V. Heymach Jr., A. Kruttgen, U. Suter, and E. M. Shooter (1996)
J. Biol. Chem. 271, 25430-25437
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Histidine Residues Essential for Receptor Binding and Activity of Nerve Growth Factor.

S. B. Woo and K. E. Neet (1996)
J. Biol. Chem. 271, 24433-24441
 |  Abstract »  |  Full Text »  |  PDF »

Upregulation of BDNF mRNA Expression in the Barrel Cortex of Adult Mice after Sensory Stimulation.

N. Rocamora, E. Welker, M. Pascual, and E. Soriano (1996)
J. Neurosci. 16, 4411-4419
 |  Abstract »  |  Full Text »  |  PDF »

Neurotrophin-3 Increases Intracellular Calcium in a Rat Insulin-secreting Cell Line through Its Action on a Functional TrkC Receptor.

A. Tazi, S. Le Bras, H. O. Lamghitnia, J. D. Vincent, P. Czernichow, and R. Scharfmann (1996)
J. Biol. Chem. 271, 10154-10160
 |  Abstract »  |  Full Text »  |  PDF »

Binding of Neurotrophin-3 to p75[IMAGE], TrkA, and TrkB Mediated by a Single Functional Epitope Distinct from That Recognized by TrkC.

M. Rydén and C. F. Ibáñez (1996)
J. Biol. Chem. 271, 5623-5627
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of neurotrophin-3 for the survival of proliferating trigeminal ganglion progenitor cells.

W. elshamy and P Ernfors (1996)
Development 122, 2405-2414
 |  Abstract »  |  PDF »

Prenatal and postnatal requirements of NT-3 for sympathetic neuroblast survival and innervation of specific targets.

W. ElShamy, S Linnarsson, K. Lee, R Jaenisch, and P Ernfors (1996)
Development 122, 491-500
 |  Abstract »  |  PDF »

The expression of trkB and p75 and the role of BDNF in the developing neuromuscular system of the chick embryo.

S. McKay, a Garner, J Caldero, R. Tucker, T Large, and R. Oppenheim (1996)
Development 122, 715-724
 |  Abstract »  |  PDF »

In vivo effects of neurotrophin-3 during sensory neurogenesis.

M Ockel, G. Lewin, and Y. Barde (1996)
Development 122, 301-307
 |  Abstract »  |  PDF »

Structural Determinants of Neurotrophin Action.

N. Q. McDonald and M. V. Chao (1995)
J. Biol. Chem. 270, 19669-19672
 |  Full Text »  |  PDF »

Peripheral Neuropathies: Will Growth Factors Be Effective as Therapies?.

S. C. Apfel and J. A. Kessler (1995)
Neuroscientist 1, 176-182
 |  Abstract »  |  PDF »

Alteration of NH(2)-terminal Residues of Nerve Growth Factor Affects Activity and Trk Binding without Affecting Stability or Conformation.

S. B. Woo, D. E. Timm, and K. E. Neet (1995)
J. Biol. Chem. 270, 6278-6285
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of ocular dominance column formation by infusion of NT-4/5 or BDNF.

R. Cabelli, A Hohn, and C. Shatz (1995)
Science 267, 1662-1666
 |  Abstract »  |  PDF »

Muscle sensory neurons require neurotrophin-3 from peripheral tissues during the period of normal cell death.

R. Oakley, A. Garner, T. Large, and E Frank (1995)
Development 121, 1341-1350
 |  Abstract »  |  PDF »

The treatment of Alzheimer's disease.

N.H.P. Allen and A. Burns (1995)
J Psychopharmacol 9, 43-56
 |  PDF »

Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity.

S Davis, N. Gale, T. Aldrich, P. Maisonpierre, V Lhotak, T Pawson, M Goldfarb, and G. Yancopoulos (1994)
Science 266, 816-819
 |  Abstract »  |  PDF »

Dependence on p75 for innervation of some sympathetic targets.

K. Lee, K Bachman, S Landis, and R Jaenisch (1994)
Science 263, 1447-1449
 |  Abstract »  |  PDF »

The survival of NGF-dependent but not BDNF-dependent cranial sensory neurons is promoted by several different neurotrophins early in their development.

A Buj-Bello, L. Pinon, and A. Davies (1994)
Development 120, 1573-1580
 |  Abstract »  |  PDF »

Role of transforming growth factor-beta isoforms in regulating the expression of nerve growth factor and neurotrophin-3 mRNA levels in embryonic cutaneous cells at different stages of development.

V. Buchman, M Sporn, and A. Davies (1994)
Development 120, 1621-1629
 |  Abstract »  |  PDF »

p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF.

K. Lee, A. Davies, and R Jaenisch (1994)
Development 120, 1027-1033
 |  Abstract »  |  PDF »

Differential expression of neurotrophin receptors during renal development.

M. Durbeej, S. Soderstrom, T. Ebendal, C. Birchmeier, and P. Ekblom (1993)
Development 119, 977-989
 |  Abstract »  |  PDF »

Repair and Replacement to Restore Sight: Report From the Panel on Ganglion Cell/Connectivity.

C. J. Shatz, D. D. M. O'Leary, and Panel on Ganglion Cell/Connectivity (1993)
Arch Ophthalmol 111, 472-477
 |  Abstract »  |  PDF »

Sympathetic neuroblasts undergo a developmental switch in trophic dependence.

S. Birren, L Lo, and D. Anderson (1993)
Development 119, 597-610
 |  Abstract »  |  PDF »

Stem cell factor induces outgrowth of c-kit-positive neurites and supports the survival of c-kit-positive neurons in dorsal root ganglia of mouse embryos.

T Hirata, E Morii, M Morimoto, T Kasugai, T Tsujimura, S Hirota, Y Kanakura, S Nomura, and Y Kitamura (1993)
Development 119, 49-56
 |  Abstract »  |  PDF »

Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons.

V. Buchman and A. Davies (1993)
Development 118, 989-1001
 |  Abstract »  |  PDF »

trkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues.

L Tessarollo, P Tsoulfas, D Martin-Zanca, D. Gilbert, N. Jenkins, N. Copeland, and L. Parada (1993)
Development 118, 463-475
 |  Abstract »  |  PDF »

Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion.

C. Ibanez, P Ernfors, T Timmusk, N. Ip, E Arenas, G. Yancopoulos, and H Persson (1993)
Development 117, 1345-1353
 |  Abstract »  |  PDF »

BHK-21-derived cell lines that produce basic fibroblast growth factor, but not parental BHK-21 cells, initiate neuronal differentiation of neural crest progenitors.

G Brill, N Vaisman, G Neufeld, and C Kalcheim (1992)
Development 115, 1059-1069
 |  Abstract »  |  PDF »

The Trk Family of Tyrosine Kinases: Receptors for NGF-related Neurotrophins.

L.F. Parada, P. Tsoulfas, L. Tessarollo, J. Blair, S.W. Reid, and D. Soppet (1992)
Cold Spring Harb Symp Quant Biol 57, 43-51
 |  Abstract »  |  PDF »

Cloning and Analysis of Neurotrophic Factor Receptors Using Function-based Strategies.

D.J. Glass, D.R. Gies, T. Stitt, S. Davis, P. Hantzopoulos, N.Y. Ip, M. Goldfarb, and G.D. Yancopoulos (1992)
Cold Spring Harb Symp Quant Biol 57, 53-62
 |  Abstract »  |  PDF »

Dependence of kidney morphogenesis on the expression of nerve growth factor receptor.

H Sariola, M Saarma, K Sainio, U Arumae, J Palgi, A Vaahtokari, I Thesleff, and A Karavanov (1991)
Science 254, 571-573
 |  Abstract »  |  PDF »

The receptor for ciliary neurotrophic factor.

S Davis, T. Aldrich, D. Valenzuela, V. Wong, M. Furth, S. Squinto, and G. Yancopoulos (1991)
Science 253, 59-63
 |  Abstract »  |  PDF »

Intraputaminal Infusion of Nerve Growth Factor to Support Adrenal Medullary Autografts in Parkinson's Disease: One-Year Follow-up of First Clinical Trial.

L. Olson, E.-O. Backlund, T. Ebendal, R. Freedman, B. Hamberger, P. Hansson, B. Hoffer, U. Lindblom, B. Meyerson, I. Stromberg, et al. (1991)
Arch Neurol 48, 373-381
 |  Abstract »  |  PDF »

Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor.

R. Oppenheim, D Prevette, Q. Yin, F Collins, and J MacDonald (1991)
Science 251, 1616-1618
 |  Abstract »  |  PDF »

Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity.

Y. Li, P. Milner, A. Chauhan, M. Watson, R. Hoffman, C. Kodner, J Milbrandt, and T. Deuel (1990)
Science 250, 1690-1694
 |  Abstract »  |  PDF »

Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons.

H. Phillips, J. Hains, G. Laramee, A Rosenthal, and J. Winslow (1990)
Science 250, 290-294
 |  Abstract »  |  PDF »

An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control.

T. Boulton, G. Yancopoulos, J. Gregory, C Slaughter, C Moomaw, J Hsu, and M. Cobb (1990)
Science 249, 64-67
 |  Abstract »  |  PDF »

Neurotrophic Factors, Their Receptors, and the Signal Transduction Pathways They Activate.

G.D. Yancopoulos, P.C. Maisonpierre, N.Y. Ip, T.H. Aldrich, L. Belluscio, T.G. Boulton, M.H. Cobb, S.R Squinto, and M.E. Furth (1990)
Cold Spring Harb Symp Quant Biol 55, 371-379
 |  Abstract »  |  PDF »

Pioneer Neurons and Target Selection in Cerebral Cortical Development.

C.J. Shatz, A. Ghosh, S.K. McConnell, K.L. Allendoerfer, E. Friauf, and A. Antonini (1990)
Cold Spring Harb Symp Quant Biol 55, 469-480
 |  Abstract »  |  PDF »

p75 Reduces TrkB Tyrosine Autophosphorylation in Response to Brain-derived Neurotrophic Factor and Neurotrophin 4/5.

J. Vesa, A. Kruttgen, and E. M. Shooter (2000)
J. Biol. Chem. 275, 24414-24420
 |  Abstract »  |  Full Text »  |  PDF »

Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene.

C.-W. Xie, D. Sayah, Q.-S. Chen, W.-Z. Wei, D. Smith, and X. Liu (2000)
PNAS 97, 8116-8121
 |  Abstract »  |  Full Text »  |  PDF »

Inaugural Article: Neurotrophins are key mediators of the myelination program in the peripheral nervous system.

J. R. Chan, J. M. Cosgaya, Y. J. Wu, and E. M. Shooter (2001)
PNAS 98, 14661-14668
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products