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Science 9 March 1990:
Vol. 247. no. 4947, pp. 1225 - 1229
DOI: 10.1126/science.2156339
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Articles

Science, Vol 247, Issue 4947, 1225-1229
Copyright © 1990 by American Association for the Advancement of Science

articles

A T cell-specific transcriptional enhancer within the human T cell receptor delta locus

JM Redondo, S Hata, C Brocklehurst, and MS Krangel

Division of Tumor Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.

The T cell antigen receptor (TCR) delta gene is located within the TCR alpha locus. A T cell-specific transcriptional enhancer, distinct from the TCR alpha enhancer, has been identified within the J delta 3-C delta intron of the human T cell receptor delta gene. This enhancer activates transcription from the V delta 1 and V delta 3 promoters as well as from heterologous promoters. Enhancer activity has been localized to a 250-bp region that contains multiple binding sites for nuclear proteins. Thus, transcriptional control of the TCR delta and TCR alpha genes is mediated by distinct regulatory elements.


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