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Science 9 March 1990:
Vol. 247. no. 4947, pp. 1225 - 1229
DOI: 10.1126/science.2156339
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Articles

Science, Vol 247, Issue 4947, 1225-1229
Copyright © 1990 by American Association for the Advancement of Science

articles

A T cell-specific transcriptional enhancer within the human T cell receptor delta locus

JM Redondo, S Hata, C Brocklehurst, and MS Krangel

Division of Tumor Virology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115.

The T cell antigen receptor (TCR) delta gene is located within the TCR alpha locus. A T cell-specific transcriptional enhancer, distinct from the TCR alpha enhancer, has been identified within the J delta 3-C delta intron of the human T cell receptor delta gene. This enhancer activates transcription from the V delta 1 and V delta 3 promoters as well as from heterologous promoters. Enhancer activity has been localized to a 250-bp region that contains multiple binding sites for nuclear proteins. Thus, transcriptional control of the TCR delta and TCR alpha genes is mediated by distinct regulatory elements.


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Chromosomal excision of TCR{delta} chain genes is dispensable for {alpha}{beta} T cell lineage commitment.
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Distinct Roles for c-Myb and Core Binding Factor/Polyoma Enhancer-Binding Protein 2 in the Assembly and Function of a Multiprotein Complex on the TCR {delta} Enhancer In Vivo.
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Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination.
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PNAS 96, 11970-11975
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Enhancer-Blocking Activity Within the DNase I Hypersensitive Site 2 to 6 Region Between the TCR {alpha} and Dad1 Genes.
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GATA-3 Dominant Negative Mutant.
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Embryonic expression and cloning of the murine GATA-3 gene.
K. M. George, M. W. Leonard, M. E. Roth, K. H. Lieuw, D. Kioussis, F. Grosveld, and J. D. Engel (1994)
Development 120, 2673-2686
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GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene.
Y. Ng, K. George, J. Engel, and D. Linzer (1994)
Development 120, 3257-3266
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The AML1 Gene in the 8;21 and 3;21 Translocations in Chronic and Acute Myeloid Leukemia.
G. Nucifora and J.D. Rowley (1994)
Cold Spring Harb Symp Quant Biol 59, 595-605
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The erythroid-specific protein cGATA-1 mediates distal enhancer activity through a specialized beta-globin TATA box..
T C Fong and B M Emerson (1992)
Genes & Dev. 6, 521-532
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A thymus-specific member of the HMG protein family regulates the human T cell receptor C alpha enhancer..
M L Waterman, W H Fischer, and K A Jones (1991)
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Differences and similarities in DNA-binding preferences of MyoD and E2A protein complexes revealed by binding site selection.
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Activity and tissue-specific expression of the transcription factor NF-E1 multigene family..
M Yamamoto, L J Ko, M W Leonard, H Beug, S H Orkin, and J D Engel (1990)
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