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Science 9 March 1990:
Vol. 247. no. 4947, pp. 1219 - 1222
DOI: 10.1126/science.1690453
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Articles

Science, Vol 247, Issue 4947, 1219-1222
Copyright © 1990 by American Association for the Advancement of Science

articles

PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily

PJ Newman, MC Berndt, J Gorski, GC White 2nd, S Lyman, C Paddock, and WA Muller

The Blood Center of Southeastern Wisconsin, Milwaukee 53233.

An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell protein that is enriched at intercellular junctions. This antibody identified a complementary DNA clone from an endothelial cell library. The 130-kilodalton translated sequence contained six extracellular immunoglobulin (Ig)-like domains and was most similar to the cell adhesion molecule (CAM) subgroup of the Ig superfamily. This is the only known member of the CAM family on platelets. Its cell surface distribution suggests participation in cellular recognition events.


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J. Biol. Chem. 273, 28332-28340
   Abstract »    Full Text »    PDF »
Evidence That CD31, CD49b, and CD62L Are Immunodominant Minor Histocompatibility Antigens in HLA Identical Sibling Bone Marrow Transplants.
E. Maruya, H. Saji, S. Seki, Y. Fujii, K. Kato, S. Kai, A. Hiraoka, K. Kawa, Y. Hoshi, K. Ito, et al. (1998)
Blood 92, 2169-2176
   Abstract »    Full Text »    PDF »
Regulation of Mouse PECAM-1 Tyrosine Phosphorylation by the Src and Csk Families of Protein-tyrosine Kinases.
M. Y. Cao, M. Huber, N. Beauchemin, J. Famiglietti, S. M. Albelda, and A. Veillette (1998)
J. Biol. Chem. 273, 15765-15772
   Abstract »    Full Text »    PDF »
Down-Regulation of Platelet Endothelial Cell Adhesion Molecule-1 Results in Thrombospondin-1 Expression and Concerted Regulation of Endothelial Cell Phenotype.
N. Sheibani and W. A. Frazier (1998)
Mol. Biol. Cell 9, 701-713
   Abstract »    Full Text »
Leishmania Lipophosphoglycan Reduces Monocyte Transendothelial Migration: Modulation of Cell Adhesion Molecules, Intercellular Junctional Proteins, and Chemoattractants.
S. K. Lo, L. Bovis, R. Matura, B. Zhu, S. He, H. Lum, S. J. Turco, and J. L. Ho (1998)
J. Immunol. 160, 1857-1865
   Abstract »    Full Text »    PDF »
Platelet/Endothelial Cell Adhesion Molecule-1 Serves as a Costimulatory Agonist Receptor That Modulates Integrin-Dependent Adhesion and Aggregation of Human Platelets.
D. Varon, D. E. Jackson, B. Shenkman, R. Dardik, I. Tamarin, N. Savion, and P. J. Newman (1998)
Blood 91, 500-507
   Abstract »    Full Text »    PDF »
VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions.
A. Kowalczyk, P Navarro, E Dejana, E. Bornslaeger, K. Green, D. Kopp, and J. Borgwardt (1998)
J. Cell Sci. 111, 3045-3057
   Abstract »    PDF »
Human CD38 (ADP-Ribosyl Cyclase) Is a Counter-Receptor of CD31, an Ig Superfamily Member.
S. Deaglio, M. Morra, R. Mallone, C. M. Ausiello, E. Prager, G. Garbarino, U. Dianzani, H. Stockinger, and F. Malavasi (1998)
J. Immunol. 160, 395-402
   Abstract »    Full Text »    PDF »
Role of cadherins and plakoglobin in interendothelial adhesion under resting conditions and shear stress.
H.-J. Schnittler, B. Puschel, and D. Drenckhahn (1997)
Am J Physiol Heart Circ Physiol 273, H2396-H2405
   Abstract »    Full Text »    PDF »
Characterization of Phosphotyrosine Binding Motifs in the Cytoplasmic Domain of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Are Required for the Cellular Association and Activation of the Protein-tyrosine Phosphatase, SHP-2.
D. E. Jackson, K. R. Kupcho, and Peter. J. Newman (1997)
J. Biol. Chem. 272, 24868-24875
   Abstract »    Full Text »    PDF »
Tyrosine Residue in Exon 14 of the Cytoplasmic Domain of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1/CD31) Regulates Ligand Binding Specificity.
J. Famiglietti, J. Sun, H. M. DeLisser, and S. M. Albelda (1997)
J. Cell Biol. 138, 1425-1435
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Residues on Both Faces of the First Immunoglobulin Fold Contribute to Homophilic Binding Sites of PECAM-1/CD31.
J. P. Newton, C. D. Buckley, E. Y. Jones, and D. L. Simmons (1997)
J. Biol. Chem. 272, 20555-20563
   Abstract »    Full Text »    PDF »
A General Strategy for Isolation of Endothelial Cells From Murine Tissues : Characterization of Two Endothelial Cell Lines From the Murine Lung and Subcutaneous Sponge Implants.
Q. G. Dong, S. Bernasconi, S. Lostaglio, R. Wainstok De Calmanovici, I. Martin-Padura, F. Breviario, C. Garlanda, S. Ramponi, A. Mantovani, and A. Vecchi (1997)
Arterioscler. Thromb. Vasc. Biol. 17, 1599-1604
   Abstract »    Full Text »
Platelet Endothelial Cell Adhesion Molecule-1 Is Phosphorylatable by c-Src, Binds Src-Src homology 2 Domain, and Exhibits Immunoreceptor Tyrosine-based Activation Motif-like Properties.
T. T. Lu, M. Barreuther, S. Davis, and J. A. Madri (1997)
J. Biol. Chem. 272, 14442-14446
   Abstract »    Full Text »    PDF »


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