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Science 9 March 1990:
Vol. 247. no. 4947, pp. 1216 - 1219
DOI: 10.1126/science.2180064
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Articles

Science, Vol 247, Issue 4947, 1216-1219
Copyright © 1990 by American Association for the Advancement of Science

articles

Control of the interferon-induced 68-kilodalton protein kinase by the HIV-1 tat gene product

S Roy, MG Katze, NT Parkin, I Edery, AG Hovanessian, and N Sonenberg

Department of Biochemistry, McGill University, Montreal, Canada.

The tat-responsive region (TAR) of the human immunodeficiency virus-1 (HIV-1) exhibits a trans-inhibitory effect on translation in vitro by activating the interferon-induced 68-kilodalton protein kinase (p68 kinase). Productive infection by HIV-1 was shown to result in a significant decrease in the amount of cellular p68 kinase. The steady-state amount of p68 kinase was also reduced in interferon-treated HeLa cell lines stably expressing tat, as compared to the amount of the kinase in interferon-treated control HeLa cells. Thus, the potential translational inhibitory effects of the TAR RNA region mediated by activation of p68 kinase may be downregulated by tat during productive HIV-1 infection.


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The Highly Conserved, Coregulated SNO and SNZ Gene Families in Saccharomyces cerevisiae Respond to Nutrient Limitation.
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The Interferon-inducible Protein Kinase PKR Modulates the Transcriptional Activation of Immunoglobulin kappa Gene.
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Analysis of arginine-rich peptides from the HIV Tat protein reveals unusual features of RNA-protein recognition..
B J Calnan, S Biancalana, D Hudson, and A D Frankel (1991)
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Straightening of bulged RNA by the double-stranded RNA-binding domain from the protein kinase PKR.
X. Zheng and P. C. Bevilacqua (2000)
PNAS 97, 14162-14167
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