Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 2 March 1990:
Vol. 247. no. 4946, pp. 1088 - 1090
DOI: 10.1126/science.2309121
Prev | Table of Contents | Next

Articles

Science, Vol 247, Issue 4946, 1088-1090
Copyright © 1990 by American Association for the Advancement of Science

articles

Calcium-sensitive cross-bridge transitions in mammalian fast and slow skeletal muscle fibers

JM Metzger and RL Moss

Department of Physiology, School of Medicine, University of Wisconsin, Madison 53706.

The fundamental mechanism underlying the differing rates of tension development in fast and slow mammalian skeletal muscle is still unknown. Now, in skinned (membrane-permeabilized) single fibers it has been shown that the rate of formation of the strongly bound, force-producing cross-bridge between actin and myosin is calcium-sensitive in both fast and slow fibers and that the rate is markedly greater in fast fibers. The transition rates obtained at high calcium concentrations correlated with myosin isoform content, whereas at low calcium concentrations the thin filament regulatory proteins appeared to modulate the rate of tension development, especially in fast fibers. Fiber type-dependent differences in rates of cross-bridge transitions may account for the characteristic rates of tension development in mammalian fast and slow skeletal muscles.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Thin filament Ca2+ binding properties and regulatory unit interactions alter kinetics of tension development and relaxation in rabbit skeletal muscle.
K. L. Kreutziger, N. Piroddi, B. Scellini, C. Tesi, C. Poggesi, and M. Regnier (2008)
J. Physiol. 586, 3683-3700
   Abstract »    Full Text »    PDF »
The cross-bridge cycle and skeletal muscle fatigue.
R. H. Fitts (2008)
J Appl Physiol 104, 551-558
   Abstract »    Full Text »    PDF »
Thin-filament regulation of force redevelopment kinetics in rabbit skeletal muscle fibres.
A. Moreno-Gonzalez, T. E. Gillis, A. J. Rivera, P. B. Chase, D. A. Martyn, and M. Regnier (2007)
J. Physiol. 579, 313-326
   Abstract »    Full Text »    PDF »
Myofilament calcium sensitivity does not affect cross-bridge activation-relaxation kinetics.
P. P. de Tombe, A. Belus, N. Piroddi, B. Scellini, J. S. Walker, A. F. Martin, C. Tesi, and C. Poggesi (2007)
Am J Physiol Regulatory Integrative Comp Physiol 292, R1129-R1136
   Abstract »    Full Text »    PDF »
Aging, muscle fiber type, and contractile function in sprint-trained athletes.
M. T. Korhonen, A. Cristea, M. Alen, K. Hakkinen, S. Sipila, A. Mero, J. T. Viitasalo, L. Larsson, and H. Suominen (2006)
J Appl Physiol 101, 906-917
   Abstract »    Full Text »    PDF »
Contractile responses of the rat gastrocnemius and soleus muscles to isotonic resistance exercise.
K. M. Norenberg and R. H. Fitts (2004)
J Appl Physiol 97, 2322-2332
   Abstract »    Full Text »    PDF »
Contractile effects of the exchange of cardiac troponin for fast skeletal troponin in rabbit psoas single myofibrils.
N Piroddi, C Tesi, M A Pellegrino, L S Tobacman, E Homsher, and C Poggesi (2003)
J. Physiol. 552, 917-931
   Abstract »    Full Text »    PDF »
Increased rate of force development and neural drive of human skeletal muscle following resistance training.
P. Aagaard, E. B. Simonsen, J. L. Andersen, P. Magnusson, and P. Dyhre-Poulsen (2002)
J Appl Physiol 93, 1318-1326
   Abstract »    Full Text »    PDF »
Length-dependent activation in three striated muscle types of the rat.
J. P Konhilas, T. C Irving, and P. P de Tombe (2002)
J. Physiol. 544, 225-236
   Abstract »    Full Text »    PDF »
Isotonic force modulates force redevelopment rate of intact frog muscle fibres: evidence for cross-bridge induced thin filament activation.
R. Vandenboom, J. D Hannon, and G. C Sieck (2002)
J. Physiol. 543, 555-566
   Abstract »    Full Text »    PDF »
Load dependence of ventricular performance explained by model of calcium-myofilament interactions.
J. Shimizu, K. Todaka, and D. Burkhoff (2002)
Am J Physiol Heart Circ Physiol 282, H1081-H1091
   Abstract »    Full Text »    PDF »
Plasticity in Skeletal, Cardiac, and Smooth Muscle: Invited Review: Plasticity and energetic demands of contraction in skeletal and cardiac muscle.
G. C. Sieck and M. Regnier (2001)
J Appl Physiol 90, 1158-1164
   Abstract »    Full Text »    PDF »
Cross-bridge kinetics in rat myocardium: effect of sarcomere length and calcium activation.
T. Wannenburg, G. H. Heijne, J. H. Geerdink, H. W. Van den Dool, P. M. L. Janssen, and P. P. De Tombe (2000)
Am J Physiol Heart Circ Physiol 279, H779-H790
   Abstract »    Full Text »    PDF »
Ca2+ dependence of loaded shortening in rat skinned cardiac myocytes and skeletal muscle fibres.
K. S McDonald (2000)
J. Physiol. 525, 169-181
   Abstract »    Full Text »    PDF »
Regulation of Contraction in Striated Muscle.
A. M. Gordon, E. Homsher, and M. Regnier (2000)
Physiol Rev 80, 853-924
   Abstract »    Full Text »    PDF »
Force-calcium relationship depends on myosin heavy chain and troponin isoforms in rat diaphragm muscle fibers.
P. C. Geiger, M. J. Cody, and G. C. Sieck (1999)
J Appl Physiol 87, 1894-1900
   Abstract »    Full Text »    PDF »
Aging-dependent depression in the kinetics of force development in rat skinned myocardium.
D. P. Fitzsimons, J. R. Patel, and R. L. Moss (1999)
Am J Physiol Heart Circ Physiol 276, H1511-H1519
   Abstract »    Full Text »    PDF »
Role of myosin heavy chain composition in kinetics of force development and relaxation in rat myocardium.
D. P Fitzsimons, J. R Patel, and R. L Moss (1998)
J. Physiol. 513, 171-183
   Abstract »    Full Text »    PDF »
Ca2+ regulates the kinetics of tension development in intact cardiac muscle.
A. J. Baker, V. M. Figueredo, E. C. Keung, and S. A. Camacho (1998)
Am J Physiol Heart Circ Physiol 275, H744-H750
   Abstract »    Full Text »    PDF »
Roles of Ca2+ and Crossbridge Kinetics in Determining the Maximum Rates of Ca2+ Activation and Relaxation in Rat and Guinea Pig Skinned Trabeculae.
S. Palmer and J. C. Kentish (1998)
Circ. Res. 83, 179-186
   Abstract »    Full Text »    PDF »
Modulation of Contractile Activation in Skeletal Muscle by a Calcium-insensitive Troponin C Mutant.
C. A. Morris, L. S. Tobacman, and E. Homsher (2001)
J. Biol. Chem. 276, 20245-20251
   Abstract »    Full Text »    PDF »
Cooperative activation in cardiac muscle: impact of sarcomere length.
D. P. Dobesh, J. P. Konhilas, and P. P. de Tombe (2002)
Am J Physiol Heart Circ Physiol 282, H1055-H1062
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)