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Science 2 March 1990:
Vol. 247. no. 4946, pp. 1082 - 1084
DOI: 10.1126/science.2309119
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Articles

Science, Vol 247, Issue 4946, 1082-1084
Copyright © 1990 by American Association for the Advancement of Science

articles

HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene

KT Jeang, SG Widen, OJ Semmes 4th, and SH Wilson

Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.

Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the expression of human beta-polymerase (hu beta-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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Human T-Cell Lymphotropic Virus Type 1 Infection of CD34+ Hematopoietic Progenitor Cells Induces Cell Cycle Arrest by Modulation of p21cip1/waf1 and Survivin.
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Cross Talk between Expression of the Human T-Cell Leukemia Virus Type 1 Tax Transactivator and the Oncogenic bHLH Transcription Factor TAL1.
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Human T-cell Leukemia Virus Type 1 Tax Oncoprotein Prevents DNA Damage-induced Chromatin Egress of Hyperphosphorylated Chk2.
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BCL3 Acts as a Negative Regulator of Transcription from the Human T-cell Leukemia Virus Type 1 Long Terminal Repeat through Interactions with TORC3.
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Negative regulation of the SH2-homology containing protein-tyrosine phosphatase-1 (SHP-1) P2 promoter by the HTLV-1 Tax oncoprotein.
J. Cheng, A. R. Kydd, K. Nakase, K. M. Noonan, A. Murakami, H. Tao, M. Dwyer, C. Xu, Q. Zhu, and W. A. Marasco (2007)
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Evidence for Cooperative Transforming Activity of the Human Pituitary Tumor Transforming Gene and Human T-Cell Leukemia Virus Type 1 Tax.
S. V. Sheleg, J.-M. Peloponese, Y.-H. Chi, Y. Li, M. Eckhaus, and K.-T. Jeang (2007)
J. Virol. 81, 7894-7901
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Human T-Cell Leukemia Virus Oncoprotein Tax Represses Nuclear Receptor-Dependent Transcription by Targeting Coactivator TAX1BP1.
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Induction of Cell Cycle Arrest by Human T-Cell Lymphotropic Virus Type 1 Tax in Hematopoietic Progenitor (CD34+) Cells: Modulation of p21cip1/waf1 and p27kip1 Expression.
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J. Virol. 79, 14069-14078
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The bZIP Transcription Factor ATFx Binds Human T-Cell Leukemia Virus Type 1 (HTLV-1) Tax and Represses HTLV-1 Long Terminal Repeat-Mediated Transcription.
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J.-M. Peloponese Jr., H. Iha, V. R. K. Yedavalli, A. Miyazato, Y. Li, K. Haller, M. Benkirane, and K.-T. Jeang (2004)
J. Virol. 78, 11686-11695
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Transcriptional activation of hTERT through the NF-{kappa}B pathway in HTLV-I-transformed cells.
U. Sinha-Datta, I. Horikawa, E. Michishita, A. Datta, J. C. Sigler-Nicot, M. Brown, M. Kazanji, J. C. Barrett, and C. Nicot (2004)
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Human T-Cell Leukemia Virus Type 1 (HTLV-1) and HTLV-2 Tax Oncoproteins Modulate Cell Cycle Progression and Apoptosis.
M. Sieburg, A. Tripp, J.-W. Ma, and G. Feuer (2004)
J. Virol. 78, 10399-10409
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Life, Death, and Tax: Role of HTLV-I Oncoprotein in Genetic Instability and Cellular Transformation.
K.-T. Jeang, C.-z. Giam, F. Majone, and M. Aboud (2004)
J. Biol. Chem. 279, 31991-31994
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Deregulated expression in Ph+ human leukemias of AHI-1, a gene activated by insertional mutagenesis in mouse models of leukemia.
X. Jiang, Y. Zhao, W.-Y. Chan, S. Vercauteren, E. Pang, S. Kennedy, F. Nicolini, A. Eaves, and C. Eaves (2004)
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J Natl Cancer Inst 95, 1846-1859
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Functional Domain Structure of Human T-Cell Leukemia Virus Type 2 Rex.
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J. Virol. 77, 12829-12840
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Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Suppression of Multilineage Hematopoiesis of CD34+ Cells In Vitro.
A. Tripp, Y. Liu, M. Sieburg, J. Montalbano, S. Wrzesinski, and G. Feuer (2003)
J. Virol. 77, 12152-12164
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Human T-cell Leukemia Virus-I Tax Oncoprotein Functionally Targets a Subnuclear Complex Involved in Cellular DNA Damage-Response.
A. Haoudi, R. C. Daniels, E. Wong, G. Kupfer, and O. J. Semmes (2003)
J. Biol. Chem. 278, 37736-37744
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p53 facilitates degradation of human T-cell leukaemia virus type I Tax-binding protein through a proteasome-dependent pathway.
I. H. Chowdhury, M. Radonovich, R. Mahieux, C. Pise-Masison, S. Muralidhar, and J. N. Brady (2003)
J. Gen. Virol. 84, 897-906
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Differential Requirements for Activation of Integrated and Transiently Transfected Human T-Cell Leukemia Virus Type 1 Long Terminal Repeat.
M. Okada and K.-T. Jeang (2002)
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Human T-Cell Leukemia Virus Type 2 (HTLV-2) Tax Protein Transforms a Rat Fibroblast Cell Line but Less Efficiently than HTLV-1 Tax.
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CREB/ATF-Dependent Repression of Cyclin A by Human T-Cell Leukemia Virus Type 1 Tax Protein.
K. V. Kibler and K.-T. Jeang (2001)
J. Virol. 75, 2161-2173
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Genetic Evidence of a Role for ATM in Functional Interaction between Human T-Cell Leukemia Virus Type 1 Tax and p53.
P. L. Van, K.-W. Yim, D.-Y. Jin, G. Dapolito, A. Kurimasa, and K.-T. Jeang (2001)
J. Virol. 75, 396-407
   Abstract »    Full Text »
Bcl-XL is up-regulated by HTLV-I and HTLV-II in vitro and in ex vivo ATLL samples.
C. Nicot, R. Mahieux, S. Takemoto, and G. Franchini (2000)
Blood 96, 275-281
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Initiation of translation by non-AUG codons in human T-cell lymphotropic virus type I mRNA encoding both Rex and Tax regulatory proteins.
S. Corcelette, T. Masse, and J.-J. Madjar (2000)
Nucleic Acids Res. 28, 1625-1634
   Abstract »    Full Text »    PDF »
The Human T Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein Represses MyoD-dependent Transcription by Inhibiting MyoD-binding to the KIX Domain of p300. A POTENTIAL MECHANISM FOR Tax-MEDIATED REPRESSION OF THE TRANSCRIPTIONAL ACTIVITY OF BASIC HELIX-LOOP-HELIX FACTORS.
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Human T-Cell Leukemia Virus Type 1 Tax Shuttles between Functionally Discrete Subcellular Targets.
M. Burton, C. D. Upadhyaya, B. Maier, T. J. Hope, and O. J. Semmes (2000)
J. Virol. 74, 2351-2364
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Increasing Methylation of the CDKN2A Gene Is Associated with the Progression of Adult T-Cell Leukemia.
K. Nosaka, M. Maeda, S. Tamiya, T. Sakai, H. Mitsuya, and M. Matsuoka (2000)
Cancer Res. 60, 1043-1048
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Assessment of Bovine Leukemia Virus Transcripts In Vivo.
J. Rovnak and J. W. Casey (1999)
J. Virol. 73, 8890-8897
   Abstract »    Full Text »    PDF »
Role of Adapter Function in Oncoprotein-mediated Activation of NF-kappa B. HUMAN T-CELL LEUKEMIA VIRUS TYPE I Tax INTERACTS DIRECTLY WITH Ikappa B KINASE gamma.
D.-Y. Jin, V. Giordano, K. V. Kibler, H. Nakano, and K.-T. Jeang (1999)
J. Biol. Chem. 274, 17402-17405
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Taxing the Cellular Capacity for Repair: Human T-Cell Leukemia Virus Type 1, DNA Damage, and Adult T-Cell Leukemia.
K. V. Kibler and K.-T. Jeang (1999)
J Natl Cancer Inst 91, 903-904
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Defective DNA Repair in Cells With Human T-Cell Leukemia/Bovine Leukemia Viruses: Role of tax Gene.
S. M. Philpott and G. C. Buehring (1999)
J Natl Cancer Inst 91, 933-942
   Abstract »    Full Text »    PDF »
Immortalization of CD4+ and CD8+ T Lymphocytes by Human T-Cell Leukemia Virus Type 1 Tax Mutants Expressed in a Functional Molecular Clone.
M. D. Robek and L. Ratner (1999)
J. Virol. 73, 4856-4865
   Abstract »    Full Text »
Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I.
P. Hollsberg (1999)
Microbiol. Mol. Biol. Rev. 63, 308-333
   Abstract »    Full Text »    PDF »
Disruption of Nucleotide Excision Repair by the Human T-Cell Leukemia Virus Type 1 Tax Protein.
S.-Y. Kao and S. J. Marriott (1999)
J. Virol. 73, 4299-4304
   Abstract »    Full Text »
Human T-Cell Leukemia Virus Type 1 Tax Protein Abrogates Interleukin-2 Dependence in a Mouse T-Cell Line.
Y. Iwanaga, T. Tsukahara, T. Ohashi, Y. Tanaka, M. Arai, M. Nakamura, K. Ohtani, Y. Koya, M. Kannagi, N. Yamamoto, et al. (1999)
J. Virol. 73, 1271-1277
   Abstract »    Full Text »
SFA-1/PETA-3 (CD151), a Member of the Transmembrane 4 Superfamily, Associates Preferentially with {alpha}5{beta}1 Integrin and Regulates Adhesion of Human T Cell Leukemia Virus Type 1-Infected T Cells to Fibronectin.
H. Hasegawa, T. Nomura, K. Kishimoto, K. Yanagisawa, and S. Fujita (1998)
J. Immunol. 161, 3087-3095
   Abstract »    Full Text »    PDF »
Activation of E2F-mediated Transcription by Human T-cell Leukemia Virus Type I Tax Protein in a p16INK4A-negative T-cell Line.
I. Lemasson, S. Thebault, C. Sardet, C. Devaux, and J.-M. Mesnard (1998)
J. Biol. Chem. 273, 23598-23604
   Abstract »    Full Text »    PDF »
An Exposed KID-Like Domain in Human T-Cell Lymphotropic Virus Type 1 Tax Is Responsible for the Recruitment of Coactivators CBP/p300.
R. Harrod, Y. Tang, C. Nicot, H. S. Lu, A. Vassilev, Y. Nakatani, and C.-Z. Giam (1998)
Mol. Cell. Biol. 18, 5052-5061
   Abstract »    Full Text »
Human T-Cell Leukemia Virus Type 1 Tax and Cell Cycle Progression: Role of Cyclin D-cdk and p110Rb.
C. Neuveut, K. G. Low, F. Maldarelli, I. Schmitt, F. Majone, R. Grassmann, and K.-T. Jeang (1998)
Mol. Cell. Biol. 18, 3620-3632
   Abstract »    Full Text »
Factors Secreted by Human T Lymphotropic Virus Type I (HTLV-I)-infected Cells Can Enhance or Inhibit Replication of HIV-1 in HTLV-I-uninfected Cells: Implications for In Vivo Coinfection with HTLV-I and HIV-1.
H. Moriuchi, M. Moriuchi, and A. S. Fauci (1998)
J. Exp. Med. 187, 1689-1697
   Abstract »    Full Text »    PDF »
Stimulation of Cyclin-Dependent Kinase Activity and G1- to S-Phase Transition in Human Lymphocytes by the Human T-Cell Leukemia/Lymphotropic Virus Type 1 Tax Protein.
I. Schmitt, O. Rosin, P. Rohwer, M. Gossen, and R. Grassmann (1998)
J. Virol. 72, 633-640
   Abstract »    Full Text »    PDF »
The Tax Protein of Human T-cell Leukemia Virus Type 1 Mediates the Transactivation of the c-sis/Platelet-derived Growth Factor-B Promoter through Interactions with the Zinc Finger Transcription Factors Sp1 and NGFI-A/Egr-1.
S. R. Trejo, W. E. Fahl, and L. Ratner (1997)
J. Biol. Chem. 272, 27411-27421
   Abstract »    Full Text »    PDF »
A Human Suppressor of c-Jun N-terminal Kinase 1 Activation by Tumor Necrosis Factor alpha.
D.-Y. Jin, H. Teramoto, C.-Z. Giam, R. F. Chun, J. S. Gutkind, and K.-T. Jeang (1997)
J. Biol. Chem. 272, 25816-25823
   Abstract »    Full Text »    PDF »
Finkel-Biskis-Reilly Mouse Osteosarcoma Virus v-fos Inhibits the Cellular Response to Ionizing Radiation in a Myristoylation-dependent Manner.
D. W. Abbott and J. T. Holt (1997)
J. Biol. Chem. 272, 14005-14008
   Abstract »    Full Text »    PDF »
Transcriptional Repression of p53 by Human T-cell Leukemia Virus Type I Tax Protein.
M. N. Uittenbogaard, H. A. Giebler, D. Reisman, and J. K. Nyborg (1995)
J. Biol. Chem. 270, 28503-28506
   Abstract »    Full Text »    PDF »
Identification of HTLV-I tax trans-activator mutants exhibiting novel transcriptional phenotypes..
M R Smith and W C Greene (1990)
Genes & Dev. 4, 1875-1885
   Abstract »    PDF »
Clastogenic Effect of the Human T-cell Leukemia Virus Type I Tax Oncoprotein Correlates with Unstabilized DNA Breaks.
F. Majone and K.-T. Jeang (2000)
J. Biol. Chem. 275, 32906-32910
   Abstract »    Full Text »    PDF »
Suppression of DNA Repair by Human T Cell Leukemia Virus Type 1 Tax Is Rescued by a Functional p53 Signaling Pathway.
S.-Y. Kao, F. J. Lemoine, and S. J. Marriott (2000)
J. Biol. Chem. 275, 35926-35931
   Abstract »    Full Text »    PDF »


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