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Science 2 March 1990:
Vol. 247. no. 4946, pp. 1077 - 1079
DOI: 10.1126/science.2408148
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Articles

Science, Vol 247, Issue 4946, 1077-1079
Copyright © 1990 by American Association for the Advancement of Science

articles

Translation initiation and ribosomal biogenesis: involvement of a putative rRNA helicase and RPL46

AB Sachs and RW Davis

Department of Biochemistry, Stanford Medical Center, CA 94305.

Cold-sensitive mutations in the SPB genes (spb1-spb7) of Saccharomyces cerevisiae suppress the inhibition of translation initiation resulting from deletion of the poly(A)-binding protein gene (PAB1). The SPB4 protein belongs to a family of adenosine triphosphate (ATP)-dependent RNA helicases. The aberrant production of 25S ribosomal RNA (rRNA) occurring in spb4-1 mutants or the deletion of SPB2 (RPL46) permits the deletion of PAB1. These data suggest that mutations affecting different steps of 60S subunit formation can allow PAB-independent translation, and they indicate that further characterization of the spb mutations could lend insight into the biogenesis of the ribosome.


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S Zaffran, A Chartier, P Gallant, M Astier, N Arquier, D Doherty, D Gratecos, and M Semeriva (1998)
Development 125, 3571-3584
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RNA Recognition Motif 2 of Yeast Pab1p Is Required for Its Functional Interaction with Eukaryotic Translation Initiation Factor 4G.
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A common function for mRNA 5' and 3' ends in translation initiation in yeast..
S Z Tarun and A B Sachs (1995)
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Poly(A) Tail Length Control Is Caused by Termination of Processive Synthesis.
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The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency..
D R Gallie (1991)
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A cold-sensitive mRNA splicing mutant is a member of the RNA helicase gene family..
E J Strauss and C Guthrie (1991)
Genes & Dev. 5, 629-641
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Deadenylation of maternal mRNAs during Xenopus oocyte maturation does not require specific cis-sequences: a default mechanism for translational control..
S M Varnum and W M Wormington (1990)
Genes & Dev. 4, 2278-2286
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The Phosphorylation State of Poly(A)-binding Protein Specifies Its Binding to Poly(A) RNA and Its Interaction with Eukaryotic Initiation Factor (eIF) 4F, eIFiso4F, and eIF4B.
H. Le, K. S. Browning, and D. R. Gallie (2000)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)