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Science 23 February 1990:
Vol. 247. no. 4945, pp. 975 - 978
DOI: 10.1126/science.2305266

Articles

Science, Vol 247, Issue 4945, 975-978
Copyright © 1990 by American Association for the Advancement of Science


articles

Transplanted suprachiasmatic nucleus determines circadian period

MR Ralph, RG Foster, FC Davis, and M Menaker

Department of Biology, University of Virginia, Charlottesville 22903.

The pacemaker role of the suprachiasmatic nucleus in a mammalian circadian system was tested by neural transplantation by using a mutant strain of hamster that shows a short circadian period. Small neural grafts from the suprachiasmatic region restored circadian rhythms to arrhythmic animals whose own nucleus had been ablated. The restored rhythms always exhibited the period of the donor genotype regardless of the direction of the transplant or genotype of the host. The basic period of the overt circadian rhythm therefore is determined by cells of the suprachiasmatic region.


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Resetting Central and Peripheral Circadian Oscillators in Transgenic Rats.
S. Yamazaki, R. Numano, M. Abe, A. Hida, R. Takahashi, M. Ueda, G. D. Block, Y. Sakaki, M. Menaker, and H. Tei (2000)
Science 288, 682-685
   Abstract »    Full Text »
Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau.
P. L. Lowrey, K. Shimomura, M. P. Antoch, S. Yamazaki, P. D. Zemenides, M. R. Ralph, M. Menaker, and J. S. Takahashi (2000)
Science 288, 483-491
   Abstract »    Full Text »
Relationship of atypical melatonin rhythm with two circadian clock outputs in B6D2F1 mice.
X.-M. Li, X.-H. Liu, E. Filipski, G. Metzger, P. Delagrange, J.-P. Jeanniot, and F. Levi (2000)
Am J Physiol Regulatory Integrative Comp Physiol 278, R924-R930
   Abstract »    Full Text »    PDF »
CLOCK, an essential pacemaker component, controls expression of the circadian transcription factor DBP.
J. A. Ripperger, L. P. Shearman, S. M. Reppert, and U. Schibler (2000)
Genes & Dev. 14, 679-689
   Abstract »    Full Text »
The Suprachiasmatic Nucleus in Organotypic Slice Cultures of the Common Vole (Microtus arvalis): Comparison of Development with Rat and Hamster and the Effect of Age.
E. A. Van der Zee, K. Jansen, and M. P. Gerkema (2000)
J Biol Rhythms 15, 37-47
   Abstract »    PDF »
Circadian rhythms in the chemoreflex control of breathing.
R. Stephenson, R. M. Mohan, J. Duffin, and T. M. Jarsky (2000)
Am J Physiol Regulatory Integrative Comp Physiol 278, R282-R286
   Abstract »    Full Text »    PDF »



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