Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 23 February 1990:
Vol. 247. no. 4945, pp. 967 - 969
DOI: 10.1126/science.2305264
Prev | Table of Contents | Next

Articles

Science, Vol 247, Issue 4945, 967-969
Copyright © 1990 by American Association for the Advancement of Science

articles

Mini-mouse: disruption of the pygmy locus in a transgenic insertional mutant

X Xiang, KF Benson, and K Chada

Department of Biochemistry, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854.

A founder transgenic mouse harbored two different integration patterns of a transgene at the same locus, each of which gave rise to a similar autosomal recessive mutation. Mice of the mutant phenotype were of small stature but had normal levels of growth hormone. The disrupted locus was cloned, and a genetic and molecular analysis showed that the insertional mutants were allelic to a spontaneous mutant, pygmy. The mice should be a useful model for the growth hormone-resistant human dwarf syndromes and could lead to a greater understanding of the pathways involved in growth and development.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of the Benign Mesenchymal Tumor Gene HMGA2 in Lymphangiomyomatosis.
J. D'Armiento, K. Imai, J. Schiltz, N. Kolesnekova, D. Sternberg, K. Benson, A. Pardo, M. Selman, T. Smolarek, M. Vundavalli, et al. (2007)
Cancer Res. 67, 1902-1909
   Abstract »    Full Text »    PDF »
Expression of Mesenchyme-Specific Gene HMGA2 in Squamous Cell Carcinomas of the Oral Cavity.
J. Miyazawa, A. Mitoro, S. Kawashiri, K. K. Chada, and K. Imai (2004)
Cancer Res. 64, 2024-2029
   Abstract »    Full Text »    PDF »
Molecular Characterization of the Mouse In(10)17Rk Inversion and Identification of a Novel Muscle-Specific Gene at the Proximal Breakpoint.
K. F. Benson and K. Chada (2002)
Genetics 160, 279-287
   Abstract »    Full Text »    PDF »
HMGI-C gene expression is not required for in vivo thyroid cell transformation.
S. Scala, G. Portella, D. Vitagliano, C. Ledent, G. Chiappetta, V. Giancotti, J. Dumont, and A. Fusco (2001)
Carcinogenesis 22, 251-256
   Abstract »    Full Text »    PDF »
Many Tumors and Many Genes : Genetics of Uterine Leiomyomata.
C. C. Morton (1998)
Am. J. Pathol. 153, 1015-1020
   Full Text »    PDF »
Use of a simplified single-site PCR to facilitate cloning of genomic DNA sequences flanking a transgene integration site..
G R MacGregor and P A Overbeek (1991)
Genome Res. 1, 129-135
   Abstract »    PDF »
Inactivation of a sperm motility gene by insertion of an epidermal growth factor receptor transgene whose product is overexpressed and compartmentalized during spermatogenesis..
G T Merlino, C Stahle, C Jhappan, R Linton, K A Mahon, and M C Willingham (1991)
Genes & Dev. 5, 1395-1406
   Abstract »    PDF »
Molecular basis of mouse developmental mutants..
A D Reith and A Bernstein (1991)
Genes & Dev. 5, 1115-1123
   PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)