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Science 23 February 1990:
Vol. 247. no. 4945, pp. 964 - 967
DOI: 10.1126/science.1968289
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Articles

Science, Vol 247, Issue 4945, 964-967
Copyright © 1990 by American Association for the Advancement of Science

articles

Requirement for cotolerogenic gene products in the clonal deletion of I-E reactive T cells

D Woodland, MP Happ, J Bill, and E Palmer

Division of Basic Sciences, National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206.

T cells that express the T cell receptor V beta 5.2 domain react with the class II major histocompatibility complex (MHC) molecule I-E, and V beta 5.2+ T cells are deleted in mouse strains that express I-E glycoproteins. By examination of genetically defined recombinant inbred (RI) mouse strains, it was found that the deletion was dependent on the expression of I-E and one of a limited number of non-MHC gene products (cotolerogens). The gene encoding one of these cotolerogens maps to chromosome 12 and is linked to the endogenous provirus Mtv-9. These observations suggest that the I-E-mediated and minor lymphocyte-stimulating antigen (Mls)-mediated deletions of alpha beta T cells from the repertoire are similar; both require the expression of a class II MHC glycoprotein and a second non-MHC gene product.


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