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Science 16 February 1990:
Vol. 247. no. 4944, pp. 852 - 854
DOI: 10.1126/science.2305257
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Articles

Science, Vol 247, Issue 4944, 852-854
Copyright © 1990 by American Association for the Advancement of Science

articles

Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels

S Amoroso, H Schmid-Antomarchi, M Fosset, and M Lazdunski

Institut de Pharmacologie Moleculaire et Cellulaire, UPR 411 du CNRS, Valbonne, France.

Sulfonylurea-sensitive adenosine triphosphate (ATP)-regulated potassium (KATP) channels are present in brain cells and play a role in neurosecretion at nerve terminals. KATP channels in substantia nigra, a brain region that shows high sulfonylurea binding, are inactivated by high glucose concentrations and by antidiabetic sulfonylureas and are activated by ATP depletion and anoxia. KATP channel inhibition leads to activation of gamma-aminobutyric acid (GABA) release, whereas KATP channel activation leads to inhibition of GABA release. These channels may be involved in the response of the brain to hyper- and hypoglycemia (in diabetes) and ischemia or anoxia.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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