Science 9 February 1990: Vol. 247. no. 4943, pp. 723 - 726 DOI: 10.1126/science.2154036

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Articles

Nhe1 is a luminal Na+/H+ exchanger in mouse choroid plexus and is targeted to the basolateral membrane in Ncbe/Nbcn2-null mice.

H. H. Damkier, V. Prasad, C. A. Hubner, and J. Praetorius (2009)
Am J Physiol Cell Physiol 296, C1291-C1300
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Mislocalized Scaffolding by the Na-H Exchanger NHE1 Dominantly Inhibits Fibronectin Production and TGF-{beta} Activation.

A. Karydis, M. Jimenez-Vidal, S. P. Denker, and D. L. Barber (2009)
Mol. Biol. Cell 20, 2327-2336
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Activation of Na+/H+ and K+/H+ exchange by calyculin A in Amphiuma tridactylum red blood cells: implications for the control of volume-induced ion flux activity.

A. Ortiz-Acevedo, R. R. Rigor, H. M. Maldonado, and P. M. Cala (2008)
Am J Physiol Cell Physiol 295, C1316-C1325
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Na+/H+ exchanger is required for hyperglycaemia-induced endothelial dysfunction via calcium-dependent calpain.

S. Wang, Q. Peng, J. Zhang, and L. Liu (2008)
Cardiovasc Res 80, 255-262
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Physical Interactions and Functional Coupling between Daxx and Sodium Hydrogen Exchanger 1 in Ischemic Cell Death.

Y.-S. Jung, H.-Y. Kim, J. Kim, M.-G. Lee, J. Pouyssegur, and E. Kim (2008)
J. Biol. Chem. 283, 1018-1025
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pH dependence of melanoma cell migration: protons extruded by NHE1 dominate protons of the bulk solution.

L. Stuwe, M. Muller, A. Fabian, J. Waning, S. Mally, J. Noel, A. Schwab, and C. Stock (2007)
J. Physiol. 585, 351-360
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Distribution of sodium transporters and aquaporin-1 in the human choroid plexus.

J. Praetorius and S. Nielsen (2006)
Am J Physiol Cell Physiol 291, C59-C67
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Roles of epidermal growth factor and Na+/H+ exchanger-1 in esophageal epithelial defense against acid-induced injury.

Y. Fujiwara, K. Higuchi, T. Takashima, M. Hamaguchi, T. Hayakawa, K. Tominaga, T. Watanabe, N. Oshitani, Y. Shimada, and T. Arakawa (2006)
Am J Physiol Gastrointest Liver Physiol 290, G665-G673
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Zinc finger transcription factor Egr-1 is involved in stimulation of NHE2 gene expression by phorbol 12-myristate 13-acetate.

J. Malakooti, R. Sandoval, V. C. Memark, P. K. Dudeja, and K. Ramaswamy (2005)
Am J Physiol Gastrointest Liver Physiol 289, G653-G663
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Eplerenone Blocks Nongenomic Effects of Aldosterone on the Na+/H+ Exchanger, Intracellular Ca2+ Levels, and Vasoconstriction in Mesenteric Resistance Vessels.

L. Michea, A. M. Delpiano, C. Hitschfeld, L. Lobos, S. Lavandero, and E. T. Marusic (2005)
Endocrinology 146, 973-980
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Na+/H+ exchanger NHE1 as plasma membrane scaffold in the assembly of signaling complexes.

M. Baumgartner, H. Patel, and D. L. Barber (2004)
Am J Physiol Cell Physiol 287, C844-C850
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Regulatory effects of G protein-coupled receptors on cardiac sarcolemmal Na+/H+ exchanger activity: signalling and significance.

M. Avkiran and R. S Haworth (2003)
Cardiovasc Res 57, 942-952
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Platelet-derived growth factor regulates K-Cl cotransport in vascular smooth muscle cells.

J. Zhang, P. K. Lauf, and N. C. Adragna (2003)
Am J Physiol Cell Physiol 284, C674-C680
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Regulation of Intracellular pH in Human Melanoma: Potential Therapeutic Implications.

M. L. Wahl, J. A. Owen, R. Burd, R. A. Herlands, S. S. Nogami, U. Rodeck, D. Berd, D. B. Leeper, and C. S. Owen (2002)
Mol. Cancer Ther. 1, 617-628
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Molecular cloning and functional analysis of the human Na+/H+ exchanger NHE3 promoter.

J. Malakooti, V. C. Memark, P. K. Dudeja, and K. Ramaswamy (2002)
Am J Physiol Gastrointest Liver Physiol 282, G491-G500
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Trophic Factor Withdrawal: p38 Mitogen-Activated Protein Kinase Activates NHE1, Which Induces Intracellular Alkalinization.

A. R. Khaled, A. N. Moor, A. Li, K. Kim, D. K. Ferris, K. Muegge, R. J. Fisher, L. Fliegel, and S. K. Durum (2001)
Mol. Cell. Biol. 21, 7545-7557
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Altered cardiac Na+/H+ exchange in phospholipase D-treated sarcolemmal vesicles.

D. P. Goel, A. Vecchini, V. Panagia, and G. N. Pierce (2000)
Am J Physiol Heart Circ Physiol 279, H1179-H1184
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A Novel Topology Model of the Human Na+/H+ Exchanger Isoform 1.

S. Wakabayashi, T. Pang, X. Su, and M. Shigekawa (2000)
J. Biol. Chem. 275, 7942-7949
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the formation of tumor cell pseudopodia by the Na(+)/H(+) exchanger NHE1.

A Lagana, J Vadnais, P. Le, T. Nguyen, R Laprade, I. Nabi, and J Noel (2000)
J. Cell Sci. 113, 3649-3662
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The Expanding Family of Eucaryotic Na+/H+ Exchangers.

L. Counillon and J. Pouyssegur (2000)
J. Biol. Chem. 275, 1-4
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Protein kinase D inhibits plasma membrane Na+/H+ exchanger activity.

R. S. Haworth, J. Sinnett-Smith, E. Rozengurt, and M. Avkiran (1999)
Am J Physiol Cell Physiol 277, C1202-C1209
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Na+/H+ exchange hyperactivity and myocardial hypertrophy: Are they linked phenomena?.

H. E. Cingolani (1999)
Cardiovasc Res 44, 462-467
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Targeted Disruption of the Nhe1 Gene Prevents Muscarinic Agonist-induced Up-regulation of Na+/H+ Exchange in Mouse Parotid Acinar Cells.

R. L. Evans, S. M. Bell, P. J. Schultheis, G. E. Shull, and J. E. Melvin (1999)
J. Biol. Chem. 274, 29025-29030
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Molecular cloning, tissue distribution, and functional expression of the human Na+/H+ exchanger NHE2.

J. Malakooti, R. Y. Dahdal, L. Schmidt, T. J. Layden, P. K. Dudeja, and K. Ramaswamy (1999)
Am J Physiol Gastrointest Liver Physiol 277, G383-G390
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Molecular Cloning of NHE3 from LLC-PK1 Cells and Localization in Pig Kidney.

C. A. SHUGRUE, N. OBERMÜLLER, S. BACHMANN, C. W. SLAYMAN, and R. F. REILLY (1999)
J. Am. Soc. Nephrol. 10, 1649-1657
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p90RSK Is a Serum-stimulated Na+/H+ Exchanger Isoform-1 Kinase. REGULATORY PHOSPHORYLATION OF SERINE 703 OF Na+/H+ EXCHANGER ISOFORM-1.

E. Takahashi, J.-i. Abe, B. Gallis, R. Aebersold, D. J. Spring, E. G. Krebs, and B. C. Berk (1999)
J. Biol. Chem. 274, 20206-20214
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ATP dependence is not an intrinsic property of Na+/H+ exchanger NHE1: requirement for an ancillary factor.

O. Aharonovitz, N. Demaurex, M. Woodside, and S. Grinstein (1999)
Am J Physiol Cell Physiol 276, C1303-C1311
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Physiological significance of volume-regulatory transporters.

W. C. O'Neill (1999)
Am J Physiol Cell Physiol 276, C995-C1011
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Acute regulation of Na/H exchanger NHE3 activity by protein kinase C: role of NHE3 phosphorylation.

M. R. Wiederkehr, H. Zhao, and O. W. Moe (1999)
Am J Physiol Cell Physiol 276, C1205-C1217
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ETB receptor activation leads to activation and phosphorylation of NHE3.

Y. Peng, O. W. Moe, T.-S. Chu, P. A. Preisig, M. Yanagisawa, and R. J. Alpern (1999)
Am J Physiol Cell Physiol 276, C938-C945
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A unique Na+/H+ exchanger, analogous to NHE1, in the chicken embryonic fibroblast.

S. G. Bhartur, L. J. Ballarin, M. W. Musch, C. Bookstein, E. B. Chang, and M. C. Rao (1999)
Am J Physiol Regulatory Integrative Comp Physiol 276, R838-R846
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Expression of multiple Na+/H+ exchanger isoforms in rat parotid acinar and ductal cells.

K. Park, J. A. Olschowka, L. A. Richardson, C. Bookstein, E. B. Chang, and J. E. Melvin (1999)
Am J Physiol Gastrointest Liver Physiol 276, G470-G478
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Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage.

L. D. Shrode, B. S. Gan, S. J. A. D'Souza, J. Orlowski, and S. Grinstein (1998)
Am J Physiol Cell Physiol 275, C431-C439
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Altered sodium-hydrogen exchange activity is a mechanism for acid-induced hyperproliferation in Barrett's esophagus.

R. C. Fitzgerald, M. B. Omary, and G. Triadafilopoulos (1998)
Am J Physiol Gastrointest Liver Physiol 275, G47-G55
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Hydrogen Peroxide Activates Mitogen-Activated Protein Kinases and Na+-H+ Exchange in Neonatal Rat Cardiac Myocytes.

A. Sabri, K. L. Byron, A. M. Samarel, J. Bell, and P. A. Lucchesi (1998)
Circ. Res. 82, 1053-1062
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PKC activation is required by EGF-stimulated Na+-H+ exchanger in human pleural mesothelial cells.

Y.-S. Liaw, P.-C. Yang, C.-J. Yu, S.-H. Kuo, K.-T. Luh, Y.-J. Lin, and M.-L. Wu (1998)
Am J Physiol Lung Cell Mol Physiol 274, L665-L672
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Role of Ion Channels and Exchangers in Mechanical Stretch–Induced Cardiomyocyte Hypertrophy.

T. Yamazaki, I. Komuro, S. Kudoh, Y. Zou, R. Nagai, R. Aikawa, H. Uozumi, and Y. Yazaki (1998)
Circ. Res. 82, 430-437
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Activity and Expression of Na+-H+ Exchanger Isoforms 1 and 3 in Kidney Proximal Tubules of Hypertensive Rats.

M. P. Kelly, P. A. Quinn, J. E. Davies, and L. L. Ng (1997)
Circ. Res. 80, 853-860
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Second Messengers, Trafficking-Related Proteins, and Amino Acid Residues that Contribute to the Functional Regulation of the Rat Brain GABA Transporter GAT1.

M. W. Quick, J. L. Corey, N. Davidson, and H. A.  Lester (1997)
J. Neurosci. 17, 2967-2979
 |  Abstract »  |  Full Text »  |  PDF »

The p42/p44 Mitogen-activated Protein Kinase Cascade Is Determinant in Mediating Activation of the Na+/H+ Exchanger (NHE1 Isoform) in Response to Growth Factors.

L. Bianchini, G. L'Allemain, and J. Pouyssegur (1997)
J. Biol. Chem. 272, 271-279
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Muscarinic Agonists Induce Phosphorylation-independent Activation of the NHE-1 Isoform of the Na+/H+ Antiporter in Salivary Acinar Cells.

M. A. Robertson, M. Woodside, J. K. Foskett, J. Orlowski, and S. Grinstein (1997)
J. Biol. Chem. 272, 287-294
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The Involvement of Protein Phosphatases in the Activation of ICE/CED-3 Protease, Intracellular Acidification, DNA Digestion, and Apoptosis.

S. J. Morana, C. M. Wolf, J. Li, J. E. Reynolds, M. K. Brown, and A. Eastman (1996)
J. Biol. Chem. 271, 18263-18271
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of Mitogen-activated Protein Kinase and Na+/H+ Exchanger in Human Platelets. DIFFERENTIAL EFFECT OF PHORBOL ESTER AND VASOPRESSIN.

O. Aharonovitz and Y. Granot (1996)
J. Biol. Chem. 271, 16494-16499
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Phorbol Ester Activation of the Rat Vascular Myocyte Na+-H+ Exchanger Isoform 1.

M. Siczkowski and L. L. Ng (1996)
Hypertension 27, 859-866
 |  Abstract »  |  Full Text »

Distinct Structural Domains Confer cAMP Sensitivity and ATP Dependence to the Na[IMAGE]/H[IMAGE] Exchanger NHE3 Isoform.

A. G. Cabado, F. H. Yu, A. Kapus, G. Lukacs, S. Grinstein, and J. Orlowski (1996)
J. Biol. Chem. 271, 3590-3599
 |  Abstract »  |  Full Text »  |  PDF »

Differential localization of Na+/H+ exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines.

J Noel, D Roux, and J Pouyssegur (1996)
J. Cell Sci. 109, 929-939
 |  Abstract »  |  PDF »

Plasma Membrane Na[IMAGE]/H[IMAGE] Exchanger Isoforms (NHE-1, -2, and -3) Are Differentially Responsive to Second Messenger Agonists of the Protein Kinase A and C Pathways.

R. A. Kandasamy, F. H. Yu, R. Harris, A. Boucher, J. W. Hanrahan, and J. Orlowski (1995)
J. Biol. Chem. 270, 29209-29216
 |  Abstract »  |  Full Text »  |  PDF »

pHi Regulation in Myocardium of the Spontaneously Hypertensive Rat : Compensated Enhanced Activity of the Na+-H+ Exchanger.

N. G. Perez, B. V. Alvarez, M. C. Camilion de Hurtado, and H. E. Cingolani (1995)
Circ. Res. 77, 1192-1200
 |  Abstract »  |  Full Text »

Sodium-Proton Exchange and Primary Hypertension : An Update.

W. Siffert and R. Dusing (1995)
Hypertension 26, 649-655
 |  Abstract »  |  Full Text »

Na+-H+ Exchanger Isoform 1 Phosphorylation in Normal Wistar-Kyoto andSpontaneously Hypertensive Rats.

M. Siczkowski, J. E. Davies, and L. L. Ng (1995)
Circ. Res. 76, 825-831
 |  Abstract »  |  Full Text »

Na+-H+ Antiporter Phenotype, Abundance, and Phosphorylation of Immortalized Lymphoblasts From Humans With Hypertension.

L. L. Ng, F. P. Sweeney, M. Siczkowski, J. E. Davies, P. A. Quinn, B. Krolewski, and A. S. Krolewski (1995)
Hypertension 25, 971-977
 |  Abstract »  |  Full Text »

Na+-H+ Exchange and Essential Hypertension : A New Approach.

J. P. Reeves and A. Aviv (1995)
Hypertension 25, 978-980
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Apoptosis in an Interleukin-2-dependent Cytotoxic T Lymphocyte Cell Line Is Associated with Intracellular Acidification.

J. Li and A. Eastman (1995)
J. Biol. Chem. 270, 3203-3211
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular acidification of gastrula ectoderm is important for posterior axial development in Xenopus.

D. Gutknecht, C. Koster, L. Tertoolen, S. de Laat, and A. Durston (1995)
Development 121, 1911-1925
 |  Abstract »  |  PDF »

The Yeast Na+/H+ Exchanger Nhx1 Is an N-Linked Glycoprotein. TOPOLOGICAL IMPLICATIONS.

K. M. Wells and R. Rao (2001)
J. Biol. Chem. 276, 3401-3407
 |  Abstract »  |  Full Text »  |  PDF »

14-3-3 Binding to Na+/H+ Exchanger Isoform-1 Is Associated with Serum-dependent Activation of Na+/H+ Exchange.

S. Lehoux, J.-i. Abe, J. A. Florian, and B. C. Berk (2001)
J. Biol. Chem. 276, 15794-15800
 |  Abstract »  |  Full Text »  |  PDF »

P-gp-induced modulation of regulatory volume increase occurs via PKC in mouse proximal tubule.

Y. Miyata, K. Okada, S. Ishibashi, Y. Asano, and S. Muto (2002)
Am J Physiol Renal Physiol 282, F65-F76
 |  Abstract »  |  Full Text »  |  PDF »

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