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Science 2 February 1990:
Vol. 247. no. 4942, pp. 571 - 574
DOI: 10.1126/science.2154034

Articles

Science, Vol 247, Issue 4942, 571-574
Copyright © 1990 by American Association for the Advancement of Science


articles

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia

MJ Sheardown, EO Nielsen, AJ Hansen, P Jacobsen, and T Honore

A/S Ferrosan, CNS Division, Soeborg, Denmark.

2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline (NBQX) is an analog of the quinoxalinedione antagonists to the non-N-methyl-D-aspartate (non-NMDA) glutamate receptor. NBQX is a potent and selective inhibitor of binding to the quisqualate subtype of the glutamate receptor, with no activity at the NMDA and glycine sites. NBQX protects against global ischemia, even when administered 2 hours after an ischemic challenge.


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