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Science 2 February 1990:
Vol. 247. no. 4942, pp. 564 - 566
DOI: 10.1126/science.2300816
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Articles

Science, Vol 247, Issue 4942, 564-566
Copyright © 1990 by American Association for the Advancement of Science

articles

Suppression of HIV infection in AZT-treated SCID-hu mice

JM McCune, R Namikawa, CC Shih, L Rabin, and H Kaneshima

HIV Group, SyStemix, Palo Alto, CA 94303.

The SCID-hu mouse, engrafted with human hematolymphoid organs, is permissive for infection with the human immunodeficiency virus (HIV). This mouse model was used to test compounds for antiviral efficacy. Two weeks after infection with HIV, 100 percent (40/40) of SCID-hu mice were positive for HIV by the polymerase chain reaction. When first treated with 3'-azido-3'-deoxythymidine (AZT), none (0/17) were HIV-positive by this assay. However, AZT-treated SCID-hu mice did have a few infected cells; after AZT treatment was stopped, viral spread was detected by polymerase chain reaction in such mice. Thus, the SCID-hu mouse provides a means to directly compare new antiviral compounds with AZT and to further improve antiviral efficacy.


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