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Science 26 January 1990: Vol. 247. no. 4941, pp. 467 - 470 DOI: 10.1126/science.2105528
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Articles
Science, Vol 247, Issue 4941, 467-470
Copyright © 1990 by American Association for the Advancement of Science
Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif
P Henthorn,
M Kiledjian,
and
T Kadesch
Howard Hughes Medical Institute, Philadelphia, PA.
Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins. Two complementary DNAs were isolated that encode proteins, denoted ITF-1 and ITF-2, that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers. The complementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar. The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation.
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J. Biol. Chem.
276, 27424-27431
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- A Dynamic Role for HDAC7 in MEF2-mediated Muscle Differentiation.
- U. Dressel, P. J. Bailey, S-C. M. Wang, M. Downes, R. M. Evans, and G. E. O. Muscat (2001)
J. Biol. Chem.
276, 17007-17013
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