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Science 26 January 1990:
Vol. 247. no. 4941, pp. 467 - 470
DOI: 10.1126/science.2105528

Articles

Science, Vol 247, Issue 4941, 467-470
Copyright © 1990 by American Association for the Advancement of Science


articles

Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif

P Henthorn, M Kiledjian, and T Kadesch

Howard Hughes Medical Institute, Philadelphia, PA.

Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins. Two complementary DNAs were isolated that encode proteins, denoted ITF-1 and ITF-2, that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers. The complementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar. The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation.


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