Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 26 January 1990:
Vol. 247. no. 4941, pp. 456 - 459
DOI: 10.1126/science.1967851

Articles

Science, Vol 247, Issue 4941, 456-459
Copyright © 1990 by American Association for the Advancement of Science


articles

Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma

CD Wegner, RH Gundel, P Reilly, N Haynes, LG Letts, and R Rothlein

Department of Pharmacology, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877.

Airway eosinophilia, epithelial desquamation, and hyperresponsiveness are characteristics of the airway inflammation underlying bronchial asthma. The contribution of intercellular adhesion molecule-1 (ICAM-1) to eosinophil migration and airway responsiveness was studied. ICAM-1 partially mediated eosinophil adhesion to to endothelium in vitro and was upregulated on inflamed bronchial endothelium in vivo. ICAM-1 expression was also upregulated on inflamed airway epithelium in vitro and in vivo. In a primate model of asthma, a monoclonal antibody to ICAM-1 attenuated airway eosinophilia and hyperresponsiveness. Thus, antagonism of ICAM-1 may provide a therapeutic approach to reducing airway inflammation, hyperresponsiveness, and asthma symptoms.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Transepithelial Migration of Neutrophils: Mechanisms and Implications for Acute Lung Injury.
R. L. Zemans, S. P. Colgan, and G. P. Downey (2009)
Am. J. Respir. Cell Mol. Biol. 40, 519-535
   Abstract »    Full Text »    PDF »
Adenovirus E1A regulates lung epithelial ICAM-1 expression by interacting with transcriptional regulators at its promoter.
K. Morimoto, J. Gosselink, A. Kartono, J. C. Hogg, S. Hayashi, and E. Ogawa (2009)
Am J Physiol Lung Cell Mol Physiol 296, L361-L371
   Abstract »    Full Text »    PDF »
Neutrophils in cystic fibrosis.
D G Downey, S C Bell, and J S Elborn (2009)
Thorax 64, 81-88
   Abstract »    Full Text »    PDF »
Diminished ICAM-1 Expression and Impaired Pulmonary Clearance of Nontypeable Haemophilus influenzae in a Mouse Model of Chronic Obstructive Pulmonary Disease/Emphysema.
B. Pang, W. Hong, S. L. West-Barnette, N. D. Kock, and W. E. Swords (2008)
Infect. Immun. 76, 4959-4967
   Abstract »    Full Text »    PDF »
Proline-Rich Tyrosine Kinase 2 Regulates Spreading and Migration of Eosinophils after {beta}2-Integrin Adhesion.
X. Zhu, E. Boetticher, L. Wang, Y. Duan, J. Learoyd, and A. R. Leff (2008)
Am. J. Respir. Cell Mol. Biol. 39, 263-269
   Abstract »    Full Text »    PDF »
Cross-Talk between ICAM-1 and GM-CSF Receptor Signaling Modulates Eosinophil Survival and Activation.
K. Pazdrak, T. W. Young, S. Stafford, B. Olszewska-Pazdrak, C. Straub, V. Starosta, A. Brasier, and A. Kurosky (2008)
J. Immunol. 180, 4182-4190
   Abstract »    Full Text »    PDF »
Is Airway Smooth Muscle the "Missing Link" Modulating Airway Inflammation in Asthma?.
O. Tliba, Y. Amrani, and R. A. Panettieri Jr (2008)
Chest 133, 236-242
   Abstract »    Full Text »    PDF »
Inhibition of phosphoinositide 3-kinase {delta} attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model.
K. S. Lee, H. K. Lee, J. S. Hayflick, Y. C. Lee, and K. D. Puri (2006)
FASEB J 20, 455-465
   Abstract »    Full Text »    PDF »
TNF-Related Activation-Induced Cytokine Enhances Leukocyte Adhesiveness: Induction of ICAM-1 and VCAM-1 via TNF Receptor-Associated Factor and Protein Kinase C-Dependent NF-{kappa}B Activation in Endothelial Cells.
J.-K. Min, Y.-M. Kim, S. W. Kim, M.-C. Kwon, Y.-Y. Kong, I. K. Hwang, M. H. Won, J. Rho, and Y.-G. Kwon (2005)
J. Immunol. 175, 531-540
   Abstract »    Full Text »    PDF »
Nonhuman primate models of asthma.
R. L. Coffman and E. M. Hessel (2005)
J. Exp. Med. 201, 1875-1879
   Abstract »    Full Text »    PDF »
A3 Adenosine Receptor Signaling Contributes to Airway Inflammation and Mucus Production in Adenosine Deaminase-Deficient Mice.
H. W. J. Young, J. G. Molina, D. Dimina, H. Zhong, M. Jacobson, L.-N. L. Chan, T.-S. Chan, J. J. Lee, and M. R. Blackburn (2004)
J. Immunol. 173, 1380-1389
   Abstract »    Full Text »    PDF »
Inflammatory Responses in Allergic Rhinitis: Traditional Approaches and Novel Treatment Strategies.
S. A. Quraishi, M. J. Davies, and T. J. Craig (2004)
J Am Osteopath Assoc 104, 7S-15S
   Abstract »    Full Text »    PDF »
Additive blockade of {beta}2-integrin adhesion of eosinophils by salmeterol and fluticasone propionate.
S. Myo, X. Zhu, S. Myou, A.Y. Meliton, J. Liu, E. Boetticher, A.T. Lambertino, C. Xu, N.M. Munoz, and A.R. Leff (2004)
Eur. Respir. J. 23, 511-517
   Abstract »    Full Text »    PDF »
Regulation of Leukocyte Transmigration: Cell Surface Interactions and Signaling Events.
Y. Liu, S. K. Shaw, S. Ma, L. Yang, F. W. Luscinskas, and C. A. Parkos (2004)
J. Immunol. 172, 7-13
   Full Text »    PDF »
A Monoclonal Antibody to {alpha}1{beta}1 Blocks Antigen-induced Airway Responses in Sheep.
W. M. Abraham, A. Ahmed, I. Serebriakov, A. N. Carmillo, J. Ferrant, A. R. de Fougerolles, E. A. Garber, P. J. Gotwals, V. E. Koteliansky, F. Taylor, et al. (2004)
Am. J. Respir. Crit. Care Med. 169, 97-104
   Abstract »    Full Text »    PDF »
Inflammatory cytokines can enhance CD44-mediated airway epithelial cell adhesion independently of CD44 expression.
S.-H. Leir, S. T. Holgate, and P. M. Lackie (2003)
Am J Physiol Lung Cell Mol Physiol 285, L1305-L1311
   Abstract »    Full Text »    PDF »
Endothelial cells modulate eosinophil surface markers and mediator release.
M-J. Dallaire, C. Ferland, N. Page, S. Lavigne, F. Davoine, and M. Laviolette (2003)
Eur. Respir. J. 21, 918-924
   Abstract »    Full Text »    PDF »
Platelets Promote Eosinophil Adhesion of Patients with Asthma to Endothelium under Flow Conditions.
L. H. Ulfman, D. P. H. Joosten, C. W. van Aalst, J.-W. J. Lammers, E. A. van de Graaf, L. Koenderman, and J. J. Zwaginga (2003)
Am. J. Respir. Cell Mol. Biol. 28, 512-519
   Abstract »    Full Text »    PDF »
c-Src-dependent Tyrosine Phosphorylation of IKKbeta Is Involved in Tumor Necrosis Factor-alpha -induced Intercellular Adhesion Molecule-1 Expression.
W.-C. Huang, J.-J. Chen, and C.-C. Chen (2003)
J. Biol. Chem. 278, 9944-9952
   Abstract »    Full Text »    PDF »
Oral N-acetylcysteine attenuates the rat pulmonary inflammatory response to antigen.
S. Blesa, J. Cortijo, M. Mata, A. Serrano, D. Closa, F. Santangelo, J.M. Estrela, J. Suchankova, and E.J. Morcillo (2003)
Eur. Respir. J. 21, 394-400
   Abstract »    Full Text »    PDF »
Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1.
E. Ohga, T. Tomita, H. Wada, H. Yamamoto, T. Nagase, and Y. Ouchi (2003)
J Appl Physiol 94, 179-184
   Abstract »    Full Text »    PDF »
Recombinant alpha 1-proteinase inhibitor blocks antigen- and mediator-induced airway responses in sheep.
M. Scuri, Y. Botvinnikova, I. T. Lauredo, and W. M. Abraham (2002)
J Appl Physiol 93, 1900-1906
   Abstract »    Full Text »    PDF »
Functional Expression and Characterization of Macaque C-C Chemokine Receptor 3 (CCR3) and Generation of Potent Antagonistic Anti-macaque CCR3 Monoclonal Antibodies.
L. Zhang, M. P. Soares, Y. Guan, S. Matheravidathu, R. Wnek, K. E. Johnson, A. Meisher, S. A. Iliff, J. S. Mudgett, M. S. Springer, et al. (2002)
J. Biol. Chem. 277, 33799-33810
   Abstract »    Full Text »    PDF »
Blockade of Focal Clustering and Active Conformation in {beta}2-Integrin-Mediated Adhesion of Eosinophils to Intercellular Adhesion Molecule-1 Caused by Transduction of HIV TAT-Dominant Negative Ras.
S. Myou, X. Zhu, E. Boetticher, S. Myo, A. Meliton, A. Lambertino, N. M. Munoz, and A. R. Leff (2002)
J. Immunol. 169, 2670-2676
   Abstract »    Full Text »    PDF »
Role of alveolar epithelial ICAM-1 in lipopolysaccharide-induced lung inflammation.
B. Beck-Schimmer, C. Madjdpour, S. Kneller, U. Ziegler, T. Pasch, R.P. Wuthrich, P.A. Ward, and R.C. Schimmer (2002)
Eur. Respir. J. 19, 1142-1150
   Abstract »    Full Text »    PDF »
Fast Flowing Eosinophils . Signals for Stopping and Stepping Out of Blood Vessels.
D. Broide (2002)
Am. J. Respir. Cell Mol. Biol. 26, 637-640
   Full Text »    PDF »
Interferon-gamma -induced Epithelial ICAM-1 Expression and Monocyte Adhesion. INVOLVEMENT OF PROTEIN KINASE C-DEPENDENT c-Src TYROSINE KINASE ACTIVATION PATHWAY.
Y.-J. Chang, M. J. Holtzman, and C.-C. Chen (2002)
J. Biol. Chem. 277, 7118-7126
   Abstract »    Full Text »    PDF »
Stimulant-Dependent Modulation of Cytokines and Chemokines by Airway Epithelial Cells: Cross Talk between Pulmonary Epithelial and Peripheral Blood Mononuclear Cells.
T. Krakauer (2002)
Clin. Vaccine Immunol. 9, 126-131
   Abstract »    Full Text »    PDF »
Immunity, Inflammation, and Remodeling in the Airway Epithelial Barrier: Epithelial-Viral-Allergic Paradigm.
M. J. Holtzman, J. D. Morton, L. P. Shornick, J. W. Tyner, M. P. O'Sullivan, A. Antao, M. Lo, M. Castro, and M. J. Walter (2002)
Physiol Rev 82, 19-46
   Abstract »    Full Text »    PDF »
Vessels: new targets for asthma treatment.
J W WILSON and X LI (2001)
Thorax 56, 899-900
   Full Text »    PDF »
Eosinophil Tissue Recruitment to Sites of Allergic Inflammation in the Lung Is Platelet Endothelial Cell Adhesion Molecule Independent.
M. Miller, K.-L. P. Sung, W. A. Muller, J. Y. Cho, M. Roman, D. Castaneda, J. Nayar, T. Condon, J. Kim, P. Sriramarao, et al. (2001)
J. Immunol. 167, 2292-2297
   Abstract »    Full Text »    PDF »
Interferon-gamma Stimulates Fractalkine Expression in Human Bronchial Epithelial Cells and Regulates Mononuclear Cell Adherence.
K. Fujimoto, T. Imaizumi, H. Yoshida, S. Takanashi, K. Okumura, and K. Satoh (2001)
Am. J. Respir. Cell Mol. Biol. 25, 233-238
   Abstract »    Full Text »    PDF »
Distinct Roles for PECAM-1, ICAM-1, and VCAM-1 in Recruitment of Neutrophils and Eosinophils to the Cornea in Ocular Onchocerciasis (River Blindness).
J. T. Kaifi, E. Diaconu, and E. Pearlman (2001)
J. Immunol. 166, 6795-6801
   Abstract »    Full Text »    PDF »
Mechanism of cooperative effects of rhinovirus and atopic sensitization on airway responsiveness.
M. M. Grunstein, H. Hakonarson, R. L. Hodinka, N. Maskeri, C. Kim, and S. Chuang (2001)
Am J Physiol Lung Cell Mol Physiol 280, L229-L238
   Abstract »    Full Text »    PDF »
Role of leukotrienes in bronchial hyperresponsiveness and cellular responses in airways.
A. R Leff (2000)
Thorax 55, 32S-37
   Full Text »
Soluble Intercellular Adhesion Molecule-1 (sICAM-1) and Interferon-Gamma in Bronchoalveolar Lavage Fluid from Children with Airway Diseases.
C. MARGUET, T. P. DEAN, and J. O. WARNER (2000)
Am. J. Respir. Crit. Care Med. 162, 1016-1022
   Abstract »    Full Text »
Effects of TNF-alpha on Expression of ICAM-1 in Human Airway Epithelial Cells In Vitro . Signaling Pathways Controlling Surface and Gene Expression.
T. M. Krunkosky, B. M. Fischer, L. D. Martin, N. Jones, N. J. Akley, and K. B. Adler (2000)
Am. J. Respir. Cell Mol. Biol. 22, 685-692
   Abstract »    Full Text »
Increased CD44 expression in human bronchial epithelial repair after damage or plating at low cell densities.
S.-H. Leir, J. E. Baker, S. T. Holgate, and P. M. Lackie (2000)
Am J Physiol Lung Cell Mol Physiol 278, L1129-L1137
   Abstract »    Full Text »    PDF »
Intrinsic ICAM-1/LFA-1 activation mediates altered responsiveness of atopic asthmatic airway smooth muscle.
M. M. Grunstein, H. Hakonarson, N. Maskeri, C. Kim, and S. Chuang (2000)
Am J Physiol Lung Cell Mol Physiol 278, L1154-L1163
   Abstract »    Full Text »    PDF »
Role of Leukotrienes in Bronchial Hyperresponsiveness and Cellular Responses in Airways.
A. R. LEFF (2000)
Am. J. Respir. Crit. Care Med. 161, S125-132
   Full Text »    PDF »
Neutrophils enhance clearance of necrotic epithelial cells in ozone-induced lung injury in rhesus monkeys.
D. M. Hyde, L. A. Miller, R. J. McDonald, M. Y. Stovall, V. Wong, K. E. Pinkerton, C. D. Wegner, R. Rothlein, and C. G. Plopper (1999)
Am J Physiol Lung Cell Mol Physiol 277, L1190-L1198
   Abstract »    Full Text »    PDF »
Eosinophilic arthritis.
C.-H. Tay (1999)
Rheumatology 38, 1188-1194
   Abstract »    Full Text »    PDF »
Cytosolic Phospholipase A2 Activation Is Essential for {beta}1 and {beta}2 Integrin-Dependent Adhesion of Human Eosinophils.
X. Zhu, N. M. Munoz, K. P. Kim, H. Sano, W. Cho, and A. R. Leff (1999)
J. Immunol. 163, 3423-3429
   Abstract »    Full Text »    PDF »
Picornavirus Receptor Down-Regulation by Plasminogen Activator Inhibitor Type 2.
D. R. Shafren, J. Gardner, V. H. Mann, T. M. Antalis, and A. Suhrbier (1999)
J. Virol. 73, 7193-7198
   Abstract »    Full Text »
Up-Regulation of ICAM-1 by Cytokines in Human Tracheal Smooth Muscle Cells Involves an NF-{kappa}B-Dependent Signaling Pathway That Is Only Partially Sensitive to Dexamethasone.
Y. Amrani, A. L. Lazaar, and R. A. Panettieri Jr. (1999)
J. Immunol. 163, 2128-2134
   Abstract »    Full Text »    PDF »
Increased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome.
E. Ohga, T. Nagase, T. Tomita, S. Teramoto, T. Matsuse, H. Katayama, and Y. Ouchi (1999)
J Appl Physiol 87, 10-14
   Abstract »    Full Text »    PDF »
Rhinovirus-mediated changes in airway smooth muscle responsiveness: induced autocrine role of interleukin-1beta.
H. Hakonarson, C. Carter, N. Maskeri, R. Hodinka, and M. M. Grunstein (1999)
Am J Physiol Lung Cell Mol Physiol 277, L13-L21
   Abstract »    Full Text »    PDF »
IL-4 induces ICAM-1 expression in human bronchial epithelial cells and potentiates TNF-alpha.
I. Striz, T. Mio, Y. Adachi, P. Heires, R. A. Robbins, J. R. Spurzem, M. J. Illig, D. J. Romberger, and S. I. Rennard (1999)
Am J Physiol Lung Cell Mol Physiol 277, L58-L64
   Abstract »    Full Text »    PDF »
Characterization of Eosinophil Adhesion to TNF-{alpha}-Activated Endothelium Under Flow Conditions: {alpha}4 Integrins Mediate Initial Attachment, and E-Selectin Mediates Rolling.
L. H. Ulfman, P. H. M. Kuijper, J. A. M. van der Linden, J.-W. J. Lammers, J. J. Zwaginga, and L. Koenderman (1999)
J. Immunol. 163, 343-350
   Abstract »    Full Text »    PDF »
Rhinovirus Infection Induces Expression of Its Own Receptor Intercellular Adhesion Molecule 1 (ICAM-1) via Increased NF-kappa B-mediated Transcription.
A. Papi and S. L. Johnston (1999)
J. Biol. Chem. 274, 9707-9720
   Abstract »    Full Text »    PDF »
Selectin Blockade Prevents Antigen-induced Late Bronchial Responses and Airway Hyperresponsiveness in Allergic Sheep.
W. M. ABRAHAM, A. AHMED, J. R. SABATER, I. T. LAUREDO, Y. BOTVINNIKOVA, R. J. BJERCKE, X. HU, B. M. REVELLE, T. P. KOGAN, I. L. SCOTT, et al. (1999)
Am. J. Respir. Crit. Care Med. 159, 1205-1214
   Abstract »    Full Text »    PDF »
Differential Effects of Endogenous and Exogenous Interferon-gamma on Immunoglobulin E, Cellular Infiltration, and Airway Responsiveness in a Murine Model of Allergic Asthma.
C. L. Hofstra, I. Van Ark, G. Hofman, F. P. Nijkamp, P. M. Jardieu, and A. J. M. Van Oosterhout (1998)
Am. J. Respir. Cell Mol. Biol. 19, 826-835
   Abstract »    Full Text »
Increased Endothelial Cell Expression of Platelet-Endothelial Cell Adhesion Molecule-1 during Hyperoxic Lung Injury.
B. Piedboeuf, M. Gamache, J. Frenette, S. Horowitz, H. Scott Baldwin, and P. Petrov (1998)
Am. J. Respir. Cell Mol. Biol. 19, 543-553
   Abstract »    Full Text »
A CD18/ICAM-1-dependent Pathway Mediates Eosinophil Adhesion to Human Bronchial Epithelial Cells.
A. Burke-Gaffney and P. G. Hellewell (1998)
Am. J. Respir. Cell Mol. Biol. 19, 408-418
   Abstract »    Full Text »
Involvement of Lymphocyte Function-Associated Antigen-1 and Intercellular Adhesion Molecule-1 in Osteoclastogenesis: A Possible Role in Direct Interaction between Osteoclast Precursors.
H. Harada, T. Kukita, A. Kukita, Y. Iwamoto, and T. Iijima (1998)
Endocrinology 139, 3967-3975
   Abstract »    Full Text »    PDF »
Differential Regulation of Eosinophil Adhesion and Transmigration by Pulmonary Microvascular Endothelial Cells.
H. Yamamoto, J. B. Sedgwick, and W. W. Busse (1998)
J. Immunol. 161, 971-977
   Abstract »    Full Text »    PDF »
Granulocyte Macrophage Colony-stimulating Factor Augments ICAM-1 and VCAM-1 Activation of Eosinophil Function.
M. Nagata, J. B. Sedgwick, H. Kita, and W. W. Busse (1998)
Am. J. Respir. Cell Mol. Biol. 19, 158-166
   Abstract »    Full Text »
Effects of Rhinovirus Infection on Hydrogen Peroxide- induced Alterations of Barrier Function in the Cultured Human Tracheal Epithelium.
T. OHRUI, M. YAMAYA, K. SEKIZAWA, N. YAMADA, T. SUZUKI, M. TERAJIMA, S. OKINAGA, and H. SASAKI (1998)
Am. J. Respir. Crit. Care Med. 158, 241-248
   Abstract »    Full Text »    PDF »
Reduction of Antigen-induced Airway Hyperreactivity and Eosinophilia in ICAM-1-deficient Mice.
W. W. Wolyniec, G. T. De Sanctis, G. Nabozny, C. Torcellini, N. Haynes, A. Joetham, E. W. Gelfand, J. M. Drazen, and T. C. Noonan (1998)
Am. J. Respir. Cell Mol. Biol. 18, 777-785
   Abstract »    Full Text »
Eosinophilia.
M. E. Rothenberg (1998)
N. Engl. J. Med. 338, 1592-1600
   Full Text »    PDF »
Respiratory Syncytial Virus-Infected Pulmonary Epithelial Cells Induce Eosinophil Degranulation by a CD18-Mediated Mechanism.
B. Olszewska-Pazdrak, K. Pazdrak, P. L. Ogra, and R. P. Garofalo (1998)
J. Immunol. 160, 4889-4895
   Abstract »    Full Text »    PDF »
Acetylcholine and substance P stimulate bronchial epithelial cells to release eosinophil chemotactic activity.
S. Koyama, E. Sato, H. Nomura, K. Kubo, S. Nagai, and T. Izumi (1998)
J Appl Physiol 84, 1528-1534
   Abstract »    Full Text »    PDF »
Inhibition of Eosinophil Rolling and Recruitment in P-Selectin- and Intracellular Adhesion Molecule-1-Deficient Mice.
D. H. Broide, D. Humber, and P. Sriramarao (1998)
Blood 91, 2847-2856
   Abstract »    Full Text »    PDF »
Circulating Adhesion Molecules in Cystic Fibrosis.
V. DE ROSE, A. OLIVA, B. MESSORE, B. GROSSO, C. MOLLAR, and E. POZZI (1998)
Am. J. Respir. Crit. Care Med. 157, 1234-1239
   Abstract »    Full Text »    PDF »
Asthma.
J. A. NADEL and W. W. BUSSE (1998)
Am. J. Respir. Crit. Care Med. 157, S130-S138
   Full Text »    PDF »
Human Eotaxin Induces {alpha}4 and {beta}2 Integrin-Dependent Eosinophil Accumulation in Rat Skin In Vivo: Delayed Generation of Eotaxin in Response to IL-4.
M.-J. Sanz, P. D. Ponath, C. R. Mackay, W. Newman, M. Miyasaka, T. Tamatani, B. F. Flanagan, R. R. Lobb, T. J. Williams, S. Nourshargh, et al. (1998)
J. Immunol. 160, 3569-3576
   Abstract »    Full Text »    PDF »
Regulation of Allergic Inflammation and Eosinophil Recruitment in Mice Lacking the Transcription Factor NFAT1: Role of Interleukin-4 (IL-4) and IL-5.
J. P.B. Viola, A. Kiani, P. T. Bozza, and A. Rao (1998)
Blood 91, 2223-2230
   Abstract »    Full Text »    PDF »
Essential Roles of NF-kappa B and C/EBP in the Regulation of Intercellular Adhesion Molecule-1 after Respiratory Syncytial Virus Infection of Human Respiratory Epithelial Cell Cultures.
B. A. Chini, M. A. Fiedler, L. Milligan, T. Hopkins, and J. M. Stark (1998)
J. Virol. 72, 1623-1626
   Abstract »    Full Text »    PDF »
Involvement of Intercellular Adhesion Molecule-1 in the Antigen-induced Infiltration of Eosinophils and Lymphocytes into the Airways in a Murine Model of Pulmonary Inflammation.
J. E. Chin, G. E. Winterrowd, C. A. Hatfield, J. R. Brashler, R. L. Griffin, S. L. Vonderfecht, K. P. Kolbasa, S. F. Fidler, K. L. Shull, R. F. Krzesicki, et al. (1998)
Am. J. Respir. Cell Mol. Biol. 18, 158-167
   Abstract »    Full Text »
Inhibition of Pulmonary Eosinophilia in P-Selectin- and ICAM-1-deficient Mice.
D. H. Broide, S. Sullivan, T. Gifford, and P. Sriramarao (1998)
Am. J. Respir. Cell Mol. Biol. 18, 218-225
   Abstract »    Full Text »
Allergen Exposure Induces the Expression of Endothelial Adhesion Molecules in Passively Sensitized Human Bronchus: Time Course and the Role of Cytokines.
N. Hirata, H. Kohrogi, H. Iwagoe, E. Goto, J. Hamamoto, K. Fujii, T. Yamaguchi, O. Kawano, and M. Ando (1998)
Am. J. Respir. Cell Mol. Biol. 18, 12-20
   Abstract »    Full Text »
Clinical Role of Soluble Adhesion Molecules During Immunotherapy for Perennial Allergic Rhinitis.
Y. Ohashi, Y. Nakai, A. Tanaka, Y. Kakinoki, Y. Ohno, T. Masamoto, H. Sakamoto, A. Kato, Y. Washio, K. Yamada, et al. (1998)
Arch Otolaryngol Head Neck Surg 124, 41-45
   Abstract »    Full Text »    PDF »
Immunopharmacology: Immunomodulation and Immunotherapy.
M. Ballow and R. Nelson (1997)
JAMA 278, 2008-2017
   Abstract »    PDF »
Pneumocystis carinii induces ICAM-1 expression in lung epithelial cells through a TNF-alpha -mediated mechanism.
M. L. Yu and A. H. Limper (1997)
Am J Physiol Lung Cell Mol Physiol 273, L1103-L1111
   Abstract »    Full Text »    PDF »
Determination of airway and tissue resistances after antigen and methacholine in nonhuman primates.
J. B. Madwed and A. C. Jackson (1997)
J Appl Physiol 83, 1690-1696
   Abstract »    Full Text »    PDF »
Phenotyping and Cytokine Regulation of the BEAS-2B Human Bronchial Epithelial Cell: Demonstration of Inducible Expression of the Adhesion Molecules VCAM-1 and ICAM-1.
J. Atsuta, S. A. Sterbinsky, J. Plitt, L. M. Schwiebert, B. S. Bochner, and R. P. Schleimer (1997)
Am. J. Respir. Cell Mol. Biol. 17, 571-582
   Abstract »    Full Text »
Rhinovirus infection of primary cultures of human tracheal epithelium: role of ICAM-1 and IL-1beta.
M. Terajima, M. Yamaya, K. Sekizawa, S. Okinaga, T. Suzuki, N. Yamada, K. Nakayama, T. Ohrui, T. Oshima, Y. Numazaki, et al. (1997)
Am J Physiol Lung Cell Mol Physiol 273, L749-L759
   Abstract »    Full Text »    PDF »
Phase I Safety and Pharmacokinetic Profile of an Intercellular Adhesion Molecule-1 Antisense Oligodeoxynucleotide (ISIS 2302).
J. M. Glover, J. M. Leeds, T. G. K. Mant, D. Amin, D. L. Kisner, J. E. Zuckerman, R. S. Geary, A. A. Levin, and W. R. Shanahan Jr. (1997)
J. Pharmacol. Exp. Ther. 282, 1173-1180
   Abstract »    Full Text »
PGE1, dexamethasone, U-74389G, or Bt2-cAMP as an additive to promote protection by UW solution in I/R injury.
C.-H. Chiang, K. Hsu, H.-C. Yan, H.-J. Harn, and D.-M. Chang (1997)
J Appl Physiol 83, 583-590
   Abstract »    Full Text »    PDF »
Immunological responses to respiratory syncytial virus infection in infancy.
R L Smyth, J N Fletcher, H M Thomas, and C A Hart (1997)
Arch. Dis. Child. 76, 210-214
   Abstract »    Full Text »
An ICAM-1 Antisense Oligonucleotide Prevents and Reverses Dextran Sulfate Sodium-Induced Colitis in Mice.
C. F. Bennett, D. Kornbrust, S. Henry, K. Stecker, R. Howard, S. Cooper, S. Dutson, W. Hall, and H. I. Jacoby (1997)
J. Pharmacol. Exp. Ther. 280, 988-1000
   Abstract »    Full Text »
Inhibition of Stimulus-Induced Endothelial Cell Intercellular Adhesion Molecule-1, E-Selectin, and Vascular Cellular Adhesion Molecule-1 Expression by Arachidonic Acid and Its Hydroxy and Hydroperoxy Derivatives.
Z. H. Huang, E. J. Bates, J. V. Ferrante, C. S.T. Hii, A. Poulos, B. S. Robinson, and A. Ferrante (1997)
Circ. Res. 80, 149-158
   Abstract »    Full Text »
Cell Adhesion Molecules in Inflammation and Immunity: Relevance to Periodontal Diseases.
J. M. Crawford and K. Watanabe (1994)
Critical Reviews in Oral Biology & Medicine 5, 91-123
   Abstract »    Full Text »    PDF »
Eosinophilic Pustular Folliculitis (Ofuji's Disease) Immunohistochemical Analysis.
Y. Teraki, I. Konohana, T. Shiohara, M. Nagashima, and T. Nishikawa (1993)
Arch Dermatol 129, 1015-1019
   Abstract »    PDF »
New Concepts about the Mast Cell.
S. J. Galli (1993)
N. Engl. J. Med. 328, 257-265
   Full Text »
Cytokine-Induced Changes in the Leukon.
T. D. Anderson (1993)
Toxicol Pathol 21, 147-157
   Abstract »    PDF »
Rhinitis and Asthma.
M. Kaliner and R. Lemanske (1992)
JAMA 268, 2807-2829
   Abstract »    PDF »
AN ADHESION MOLECULE MAY PLAY A CENTRAL ROLE IN ASTHMA.
(1990)
Journal Watch (General) 1990, 4
   Full Text »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)