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Science 26 January 1990:
Vol. 247. no. 4941, pp. 451 - 454
DOI: 10.1126/science.2300805
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Articles

Science, Vol 247, Issue 4941, 451-454
Copyright © 1990 by American Association for the Advancement of Science

articles

Identification of fructose 3-phosphate in the lens of diabetic rats

BS Szwergold, F Kappler, and TR Brown

Department of Nuclear Magnetic Resonance and Medical Spectroscopy, Fox Chase Cancer Center, Philadelphia, PA 19111.

Fructose 3-phosphate, a novel monosaccharide phosphate, has been identified in the lens of diabetic rats. This compound, which is not present in normal lenses, is a protein glycosylating agent and enzyme inactivator. In addition, because of its structural features, this metabolite is relatively labile and undergoes hydrolysis to yield inorganic phosphate and the potent glycosylating agent, 3-deoxyglucosone. The increase in the concentration of fructose 3-phosphate in the lens of diabetic rats suggests that it and its hydrolysis product, 3-deoxyglucosone, may be responsible in part for the development of some diabetic complications in the lens.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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S. P. Baba, O. A. Barski, Y. Ahmed, T. E. O'Toole, D. J. Conklin, A. Bhatnagar, and S. Srivastava (2009)
Diabetes 58, 2486-2497
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The Internalization and Metabolism of 3-Deoxyglucosone in Human Umbilical Vein Endothelial Cells.
H. Sakiyama, M. Takahashi, T. Yamamoto, T. Teshima, S. H. Lee, Y. Miyamoto, Y. Misonou, and N. Taniguchi (2006)
J. Biochem. 139, 245-253
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Relation Between Serum 3-Deoxyglucosone and Development of Diabetic Microangiopathy.
H. Kusunoki, S. Miyata, T. Ohara, B.-F. Liu, A. Uriuhara, H. Kojima, K. Suzuki, H. Miyazaki, Y. Yamashita, K. Inaba, et al. (2003)
Diabetes Care 26, 1889-1894
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Identification in Human Atherosclerotic Lesions of GA-pyridine, a Novel Structure Derived from Glycolaldehyde-modified Proteins.
R. Nagai, C. M. Hayashi, L. Xia, M. Takeya, and S. Horiuchi (2002)
J. Biol. Chem. 277, 48905-48912
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Human Fructosamine-3-Kinase: Purification, Sequencing, Substrate Specificity, and Evidence of Activity In Vivo.
B. S. Szwergold, S. Howell, and P. J. Beisswenger (2001)
Diabetes 50, 2139-2147
   Abstract »    Full Text »    PDF »
{alpha}-Dicarbonyls Increase in the Postprandial Period and Reflect the Degree of Hyperglycemia.
P. J. Beisswenger, S. K. Howell, R. M. O’Dell, M. E. Wood, A. D. Touchette, and B. S. Szwergold (2001)
Diabetes Care 24, 726-732
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