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Science 19 January 1990:
Vol. 247. no. 4940, pp. 332 - 336
DOI: 10.1126/science.2404338
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Articles

Science, Vol 247, Issue 4940, 332-336
Copyright © 1990 by American Association for the Advancement of Science

articles

Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells

SM Dymecki, JE Niederhuber, and SV Desiderio

Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

Several pathways of transmembrane signaling in lymphocytes involve protein-tyrosine phosphorylation. With the exception of p56lck, a tyrosine kinase specific to T lymphoid cells that associates with the T cell transmembrane proteins CD4 and CD8, the kinases that function in these pathways are unknown. A murine lymphocyte complementary DNA that represents a new member of the src family has now been isolated and characterized. This complementary DNA, termed blk (for B lymphoid kinase), specifies a polypeptide of 55 kilodaltons that is related to, but distinct from, previously identified retroviral or cellular tyrosine kinases. The protein encoded by blk exhibits tyrosine kinase activity when expressed in bacterial cells. In the mouse and among cell lines, blk is specifically expressed in the B cell lineage. The tyrosine kinase encoded by blk may function in a signal transduction pathway that is restricted to B lymphoid cells.


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