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Science 19 January 1990:
Vol. 247. no. 4940, pp. 318 - 320
DOI: 10.1126/science.2296720
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Articles
Science, Vol 247, Issue 4940, 318-320
Copyright © 1990 by American Association for the Advancement of Science
Prenylated proteins: the structure of the isoprenoid group
HC Rilling,
E Breunger,
WW Epstein,
and
PF Crain
Department of Biochemistry, University of Utah, Salt Lake City 84112.
The mevalonate-derived portion of a prenylated protein from Chinese hamster ovary cells has been established as diterpenoid (C20). This group is linked to a carboxyl-terminal cysteine as a thioether. It was removed from the protein by hydrazinolysis followed by Raney nickel desulfurization, and the resulting hydrocarbon fraction was analyzed by gas chromatography-mass spectrometry.
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