Science 19 January 1990: Vol. 247. no. 4940, pp. 294 - 301 DOI: 10.1126/science.2153315

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Articles

Alterations in Gene Expression in Human Mesothelial Cells Correlate with Mineral Pathogenicity.

A. Shukla, M. B. MacPherson, J. Hillegass, M. E. Ramos-Nino, V. Alexeeva, P. M. Vacek, J. P. Bond, H. I. Pass, C. Steele, and B. T. Mossman (2009)
Am. J. Respir. Cell Mol. Biol. 41, 114-123
 |  Abstract »  |  Full Text »  |  PDF »

A Protein Kinase C{delta}-Dependent Protein Kinase D Pathway Modulates ERK1/2 and JNK1/2 Phosphorylation and Bim-Associated Apoptosis by Asbestos.

S. A. Buder-Hoffmann, A. Shukla, T. F. Barrett, M. B. MacPherson, K. M. Lounsbury, and B. T. Mossman (2009)
Am. J. Pathol. 174, 449-459
 |  Abstract »  |  Full Text »  |  PDF »

Airborne Concentrations of Asbestos Onboard Maritime Shipping Vessels (1978-1992).

D. M. Murbach, A. K. Madl, K. M. Unice, J. S. Knutsen, P. S. Chapman, J. L. Brown, and D. J. Paustenbach (2008)
Ann. Hyg. 52, 267-279
 |  Abstract »  |  Full Text »  |  PDF »

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica.

C. Dostert, V. Petrilli, R. Van Bruggen, C. Steele, B. T. Mossman, and J. Tschopp (2008)
Science 320, 674-677
 |  Abstract »  |  Full Text »  |  PDF »

Targeting the MEK1 Cascade in Lung Epithelium Inhibits Proliferation and Fibrogenesis by Asbestos.

C. B. Manning, T. Sabo-Attwood, R. F. Robledo, M. B. MacPherson, M. Rincon, P. Vacek, D. Hemenway, D. J. Taatjes, P. J. Lee, and B. T. Mossman (2008)
Am. J. Respir. Cell Mol. Biol. 38, 618-626
 |  Abstract »  |  Full Text »  |  PDF »

Toxic Potential of Mineral Dusts.

B. Fubini and I. Fenoglio (2007)
Elements 3, 407-414
 |  Abstract »  |  Full Text »  |  PDF »

Amphiboles: Environmental and Health Concerns.

M. E. Gunter, E. Belluso, and A. Mottana (2007)
Reviews in Mineralogy and Geochemistry 67, 453-516
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Potential role of ferritin heavy chain in oxidative stress and apoptosis in human mesothelial and mesothelioma cells: implications for asbestos-induced oncogenesis.

W. Aung, S. Hasegawa, T. Furukawa, and T. Saga (2007)
Carcinogenesis 28, 2047-2052
 |  Abstract »  |  Full Text »  |  PDF »

Asbestos-mediated CREB phosphorylation is regulated by protein kinase A and extracellular signal-regulated kinases 1/2.

C. A. Barlow, T. F. Barrett, A. Shukla, B. T. Mossman, and K. M. Lounsbury (2007)
Am J Physiol Lung Cell Mol Physiol 292, L1361-L1369
 |  Abstract »  |  Full Text »  |  PDF »

SV40 Oncoproteins Enhance Asbestos-Induced DNA Double-Strand Breaks and Abrogate Senescence in Murine Mesothelial Cells.

J. R. Pietruska and A. B. Kane (2007)
Cancer Res. 67, 3637-3645
 |  Abstract »  |  Full Text »  |  PDF »

Lung Cancer in Never Smokers: A Review.

J. Subramanian and R. Govindan (2007)
J. Clin. Oncol. 25, 561-570
 |  Abstract »  |  Full Text »  |  PDF »

The Geology of Asbestos in the United States and Its Practical Applications.

B. S VAN GOSEN (2007)
Environmental and Engineering Geoscience 13, 55-68
 |  Abstract »  |  Full Text »  |  PDF »

Airway Epithelial NF-{kappa}B Activation Modulates Asbestos-Induced Inflammation and Mucin Production In Vivo.

A. Haegens, T. F. Barrett, J. Gell, A. Shukla, M. MacPherson, P. Vacek, M. E. Poynter, K. J. Butnor, Y. M. Janssen-Heininger, C. Steele, et al. (2007)
J. Immunol. 178, 1800-1808
 |  Abstract »  |  Full Text »  |  PDF »

Asbestos-Induced Peribronchiolar Cell Proliferation and Cytokine Production Are Attenuated in Lungs of Protein Kinase C-{delta} Knockout Mice.

A. Shukla, K. M. Lounsbury, T. F. Barrett, J. Gell, M. Rincon, K. J. Butnor, D. J. Taatjes, G. S. Davis, P. Vacek, K. I. Nakayama, et al. (2007)
Am. J. Pathol. 170, 140-151
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylated Extracellular Signal-regulated Kinases Are Significantly Increased in Malignant Mesothelioma.

M. de Melo, M. W. Gerbase, J. Curran, and J.-C. Pache (2006)
J. Histochem. Cytochem. 54, 855-861
 |  Abstract »  |  Full Text »  |  PDF »

Nanotechnology and the occupational physician..

A. Seaton (2006)
Occup. Med. 56, 312-316
 |  Abstract »  |  Full Text »  |  PDF »

TNF-{alpha} inhibits asbestos-induced cytotoxicity via a NF-{kappa}B-dependent pathway, a possible mechanism for asbestos-induced oncogenesis.

H. Yang, M. Bocchetta, B. Kroczynska, A. G. Elmishad, Y. Chen, Z. Liu, C. Bubici, B. T. Mossman, H. I. Pass, J. R. Testa, et al. (2006)
PNAS 103, 10397-10402
 |  Abstract »  |  Full Text »  |  PDF »

Oxidants and Signaling by Mitogen-Activated Protein Kinases in Lung Epithelium.

B. T. Mossman, K. M. Lounsbury, and S. P. Reddy (2006)
Am. J. Respir. Cell Mol. Biol. 34, 666-669
 |  Abstract »  |  Full Text »  |  PDF »

Genetic predisposition to fiber carcinogenesis causes a mesothelioma epidemic in Turkey..

A. U. Dogan, Y. I. Baris, M. Dogan, S. Emri, I. Steele, A. G. Elmishad, and M. Carbone (2006)
Cancer Res. 66, 5063-5068
 |  Abstract »  |  Full Text »  |  PDF »

Asbestos-Induced Lung Inflammation and Epithelial Cell Proliferation Are Altered in Myeloperoxidase-Null Mice.

A. Haegens, A. van der Vliet, K. J. Butnor, N. Heintz, D. Taatjes, D. Hemenway, P. Vacek, B. A. Freeman, S. L. Hazen, M. L. Brennan, et al. (2005)
Cancer Res. 65, 9670-9677
 |  Abstract »  |  Full Text »  |  PDF »

Gene Expression Profiles Reveal Increased mClca3 (Gob5) Expression and Mucin Production in a Murine Model of Asbestos-Induced Fibrogenesis.

T. Sabo-Attwood, M. Ramos-Nino, J. Bond, K. J. Butnor, N. Heintz, A. D. Gruber, C. Steele, D. J. Taatjes, P. Vacek, and B. T. Mossman (2005)
Am. J. Pathol. 167, 1243-1256
 |  Abstract »  |  Full Text »  |  PDF »

Human mesothelioma cells exhibit tumor cell-specific differences in phosphatidylinositol 3-kinase/AKT activity that predict the efficacy of Onconase.

M. E. Ramos-Nino, G. Vianale, T. Sabo-Attwood, L. Mutti, C. Porta, N. Heintz, and B. T. Mossman (2005)
Mol. Cancer Ther. 4, 835-842
 |  Abstract »  |  Full Text »  |  PDF »

Asbestos-containing Floor Tile and Mastic Abatement: Is there Enough Exposure to Cause Asbestos-related Disease?.

J. H. Lange (2005)
Indoor and Built Environment 14, 83-88
 |  Abstract »  |  PDF »

The {gamma}-Glutamylcysteine Synthetase and Glutathione Regulate Asbestos-induced Expression of Activator Protein-1 Family Members and Activity.

A. Shukla, T. Flanders, K. M. Lounsbury, and B. T. Mossman (2004)
Cancer Res. 64, 7780-7786
 |  Abstract »  |  Full Text »  |  PDF »

The Duration of Nuclear Extracellular Signal-Regulated Kinase 1 and 2 Signaling during Cell Cycle Reentry Distinguishes Proliferation from Apoptosis in Response to Asbestos.

Z. Yuan, D. J. Taatjes, B. T. Mossman, and N. H. Heintz (2004)
Cancer Res. 64, 6530-6536
 |  Abstract »  |  Full Text »  |  PDF »

Asbestos and the Pleura: A Review.

D. W. Cugell and D. W. Kamp (2004)
Chest 125, 1103-1117
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Emergence of a New Policy for Asbestos: A Result of the World Trade Center Tragedy.

J. H. Lange (2004)
Indoor and Built Environment 13, 21-33
 |  Abstract »  |  PDF »

{alpha}7-Nicotinic Acetylcholine Receptors Affect Growth Regulation of Human Mesothelioma Cells: Role of Mitogen-Activated Protein Kinase Pathway.

S. Trombino, A. Cesario, S. Margaritora, P. Granone, G. Motta, C. Falugi, and P. Russo (2004)
Cancer Res. 64, 135-145
 |  Abstract »  |  Full Text »  |  PDF »

Asbestos induces mitochondrial DNA damage and dysfunction linked to the development of apoptosis.

A. Shukla, M. Jung, M. Stern, N. K. Fukagawa, D. J. Taatjes, D. Sawyer, B. Van Houten, and B. T. Mossman (2003)
Am J Physiol Lung Cell Mol Physiol 285, L1018-L1025
 |  Abstract »  |  Full Text »  |  PDF »

Asbestos-Induced Apoptosis Is Protein Kinase C{delta}-Dependent.

A. Shukla, M. Stern, K. M. Lounsbury, T. Flanders, and B. T. Mossman (2003)
Am. J. Respir. Cell Mol. Biol. 29, 198-205
 |  Abstract »  |  Full Text »  |  PDF »

Microarray Analysis and RNA Silencing Link fra-1 to cd44 and c-met Expression in Mesothelioma.

M. E. Ramos-Nino, L. Scapoli, M. Martinelli, S. Land, and B. T. Mossman (2003)
Cancer Res. 63, 3539-3545
 |  Abstract »  |  Full Text »  |  PDF »

Asbestos-Induced Pulmonary Toxicity: Role of DNA Damage and Apoptosis.

D. Upadhyay and D. W. Kamp (2003)
Experimental Biology and Medicine 228, 650-659
 |  Abstract »  |  Full Text »  |  PDF »

Persistent Localization of Activated Extracellular Signal-Regulated Kinases (ERK1/2) Is Epithelial Cell-Specific in an Inhalation Model of Asbestosis.

A. B. Cummins, C. Palmer, B. T. Mossman, and D. J. Taatjes (2003)
Am. J. Pathol. 162, 713-720
 |  Abstract »  |  Full Text »  |  PDF »

Surface and Passive Monitoring for Asbestos in an Industrial Facility.

J.H. Lange, K.W. Thomulka, R.J. Lee, and D.R. VanOrden (2002)
Indoor and Built Environment 11, 327-333
 |  Abstract »  |  PDF »

Mesothelial Cell Transformation Requires Increased AP-1 Binding Activity and ERK-dependent Fra-1 Expression.

M. E. Ramos-Nino, C. R. Timblin, and B. T. Mossman (2002)
Cancer Res. 62, 6065-6069
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Epidermal Growth Factor Receptor Signaling in Malignant Pleural Mesothelioma.

P. A. Janne, M. L. Taffaro, R. Salgia, and B. E. Johnson (2002)
Cancer Res. 62, 5242-5247
 |  Abstract »  |  Full Text »  |  PDF »

A Mutant Epidermal Growth Factor Receptor Targeted to Lung Epithelium Inhibits Asbestos-induced Proliferation and Proto-Oncogene Expression.

C. B. Manning, A. B. Cummins, M. W. Jung, I. Berlanger, C. R. Timblin, C. Palmer, D. J. Taatjes, D. Hemenway, P. Vacek, and B. T. Mossman (2002)
Cancer Res. 62, 4169-4175
 |  Abstract »  |  Full Text »  |  PDF »

Increased Localization and Substrate Activation of Protein Kinase C{delta} in Lung Epithelial Cells following Exposure to Asbestos.

K. M. Lounsbury, M. Stern, D. Taatjes, S. Jaken, and B. T. Mossman (2002)
Am. J. Pathol. 160, 1991-2000
 |  Abstract »  |  Full Text »  |  PDF »

Oxidant-Mediated Increases in Redox Factor-1 Nuclear Protein and Activator Protein-1 DNA Binding in Asbestos-Treated Macrophages.

D. M. Flaherty, M. M. Monick, A. B. Carter, M. W. Peterson, and G. W. Hunninghake (2002)
J. Immunol. 168, 5675-5681
 |  Abstract »  |  Full Text »  |  PDF »

SV40, Growth Factors, and Mesothelioma . Another Piece of the Puzzle.

B. T. Mossman and D. C. Gruenert (2002)
Am. J. Respir. Cell Mol. Biol. 26, 167-170
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Distinct Spectrum of Mutations Induced by Crocidolite Asbestos: Clue for 8-Hydroxydeoxyguanosine-dependent Mutagenesis in Vivo.

K. Unfried, C. Schurkes, and J. Abel (2002)
Cancer Res. 62, 99-104
 |  Abstract »  |  Full Text »  |  PDF »

Community health risk assessment after a fire with asbestos containing fallout.

S Bridgman (2001)
J Epidemiol Community Health 55, 921-927
 |  Abstract »  |  Full Text »  |  PDF »

Has the World Trade Center Tragedy Established a New Standard for Asbestos?.

J. H. Lange (2001)
Indoor and Built Environment 10, 346-349
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Health Risks from Exposures to Asbestos, Metals, and Various Chemicals due to Collapse of the World Trade Center: An Environmental Residential Survey with a Commentary Related to Ground Zero Workers.

E.B. Ilgren (2001)
Indoor and Built Environment 10, 361-383
 |  Abstract »  |  PDF »

Cancer Mortality among Workers Exposed to Amphibole-free Chrysotile Asbestos.

E. Yano, Z.-M. Wang, X.-R. Wang, M.-Z. Wang, and Y.-J. Lan (2001)
Am. J. Epidemiol. 154, 538-543
 |  Abstract »  |  Full Text »  |  PDF »

Airborne Asbestos Concentrations during Abatement of Floor Tile and Mastic: Evaluation of Two Different Containment Systems and Discussion of Regulatory Issues.

J. H. Lange (2001)
Indoor and Built Environment 10, 193-199
 |  Abstract »  |  PDF »

Silica-induced Activation of c-Jun-NH2-Terminal Amino Kinases, Protracted Expression of the Activator Protein-1 Proto-Oncogene, fra-1, and S-Phase Alterations Are Mediated via Oxidative Stress.

A. Shukla, C. R. Timblin, A. K. Hubbard, J. Bravman, and B. T. Mossman (2001)
Cancer Res. 61, 1791-1795
 |  Abstract »  |  Full Text »

Should Canadian health care professionals support the call for a worldwide ban on asbestos?.

J. Siemiatycki (2001)
Can. Med. Assoc. J. 164, 495-497
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Increased expression of epidermal growth factor receptor in rat pleural mesothelial cells correlates with carcinogenicity of mineral fibres.

S. P. Faux, C. E. Houghton, A. Hubbard, and G. Patrick (2000)
Carcinogenesis 21, 2275-2280
 |  Abstract »  |  Full Text »  |  PDF »

A Survey of Publicly Funded Asbestos Abatement Projects in the County of Erie, Pennsylvania, USA, during the Time Period 1996-1999.

J. H. Lange, M. Bules, J. Lindquist, M. Gray, and C. Ivarone (2000)
Indoor and Built Environment 9, 342-347
 |  Abstract »  |  PDF »

Differentially expressed genes in asbestos-induced tumorigenic human bronchial epithelial cells: implication for mechanism.

Y. L. Zhao, C. Q. Piao, L. J. Wu, M. Suzuki, and T. K. Hei (2000)
Carcinogenesis 21, 2005-2010
 |  Abstract »  |  Full Text »  |  PDF »

A Study of Area and Personal Airborne Asbestos Samples during Abatement in a Crawl Space.

J.H. Lange, B.D. Kuhn, K.W. Thomulka, and S.L.M. Sites (2000)
Indoor and Built Environment 9, 192-200
 |  Abstract »  |  PDF »

Cost and Distribution of Bids for Asbestos Abatement Projects in the Public Sector.

J. H. Lange (2000)
Indoor and Built Environment 9, 201-206
 |  Abstract »  |  PDF »

mRNA expression patterns in different stages of asbestos-induced carcinogenesis in rats.

H. Sandhu, W. Dehnen, M. Roller, J. Abel, and K. Unfried (2000)
Carcinogenesis 21, 1023-1029
 |  Abstract »  |  Full Text »  |  PDF »

Antioxidant defense mechanisms of human mesothelioma and lung adenocarcinoma cells.

K. Jarvinen, P. Pietarinen-Runtti, K. Linnainmaa, K. O. Raivio, C. M. Krejsa, T. Kavanagh, and V. L. Kinnula (2000)
Am J Physiol Lung Cell Mol Physiol 278, L696-L702
 |  Abstract »  |  Full Text »  |  PDF »

Role of Oxyradicals in Mutagenicity and DNA Damage Induced by Crocidolite Asbestos in Mammalian Cells.

A. Xu, L.-J. Wu, R. M. Santella, and T. K. Hei (1999)
Cancer Res. 59, 5922-5926
 |  Abstract »  |  Full Text »  |  PDF »

Asbestos-induced phosphorylation of epidermal growth factor receptor is linked to c-fos and apoptosis.

C. L. Zanella, C. R. Timblin, A. Cummins, M. Jung, J. Goldberg, R. Raabe, T. R. Tritton, and B. T. Mossman (1999)
Am J Physiol Lung Cell Mol Physiol 277, L684-L693
 |  Abstract »  |  Full Text »  |  PDF »

A Statistical Evaluation of Asbestos Air Concentrations.

J. H. Lange (1999)
Indoor and Built Environment 8, 293-303
 |  Abstract »  |  PDF »

The molecular basis of asbestos induced lung injury.

D. W Kamp and S. A Weitzman (1999)
Thorax 54, 638-652
 |  Full Text »

Lung Cancer and Past Occupational Exposure to Asbestos . Role of p53 and K-ras Mutations.

K. Husgafvel-Pursiainen, A. Karjalainen, A. Kannio, S. Anttila, T. Partanen, A. Ojajärvi, and H. Vainio (1999)
Am. J. Respir. Cell Mol. Biol. 20, 667-674
 |  Abstract »  |  Full Text »

Asbestos and DNA Double Strand Breaks.

R. Okayasu, S. Takahashi, S. Yamada, T. K. Hei, and R. L. Ullrich (1999)
Cancer Res. 59, 298-300
 |  Abstract »  |  Full Text »  |  PDF »

Deletions of Chromosome 4 at Multiple Sites Are Frequent in Malignant Mesothelioma and Small Cell Lung Carcinoma.

N. Shivapurkar, A. K. Virmani, I. I. Wistuba, S. Milchgrub, B. Mackay, J. D. Minna, and A. F. Gazdar (1999)
Clin. Cancer Res. 5, 17-23
 |  Abstract »  |  Full Text »  |  PDF »

Nonoccupational Exposure to Chrysotile Asbestos and the Risk of Lung Cancer.

M. Camus, J. Siemiatycki, and B. Meek (1998)
N. Engl. J. Med. 338, 1565-1571
 |  Abstract »  |  Full Text »  |  PDF »

Role of extracellular signal-regulated protein kinases in apoptosis by asbestos and H2O2.

L. A. Jimenez, C. Zanella, H. Fung, Y. M. W. Janssen, P. Vacek, C. Charland, J. Goldberg, and B. T. Mossman (1997)
Am J Physiol Lung Cell Mol Physiol 273, L1029-L1035
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms in the Pathogenesis of Asbestosis and Silicosis.

B. T. MOSSMAN and A. CHURG (1997)
Am. J. Respir. Crit. Care Med. 157, 1666-1680
 |  Full Text »

Phytic Acid, an Iron Chelator, Attenuates Pulmonary Inflammation and Fibrosis in Rats after Intratracheal Instillation of Asbestos.

D. W. Kamp, V. A. Israbian, A. V. Yeldandi, R. J. Panos, P. Graceffa, and S. A. Weitzman (1995)
Toxicol Pathol 23, 689-695
 |  Abstract »  |  PDF »

Mineral Fibre-Related Bronchial Lesions.

T. Kerenyi, B. Voss, and K.-M. Muller (1995)
Indoor and Built Environment 4, 151-156
 |  Abstract »  |  PDF »

No meeting of the minds on asbestos.

R Stone (1991)
Science 254, 928-931
 |  PDF »

The Environment and the Lung: Changing Perspectives.

J. M. Samet and M. J. Utell (1991)
JAMA 266, 670-675
 |  Abstract »  |  PDF »

Asbestos Removal, Health Hazards, and the EPA.

Council on Scientific Affairs, W. C. Scott, E. H. Estes Jr, Y. D. Coble Jr, A. B. Eisenbrey, M. S. Karlan, W. R. Kennedy, M. P. Moulton, P. J. Numann, W. D. Skelton, et al. (1991)
JAMA 266, 696-697
 |  Abstract »  |  PDF »

Development and Characterization of a Rapid-Onset Rodent Inhalation Model of Asbestosis for Disease Prevention*1.

B. T. Mossman, Y. M. Janssen, J. P. Marsh, A. Sesko, M. A. Shatos, J. Doherty, K. B. Adler, D. Piemenway, R. Mickey, P. Vacek, et al. (1991)
Toxicol Pathol 19, 412-418
 |  Abstract »  |  PDF »

The asbestos removal fiasco.

P. Abelson (1990)
Science 247, 1017
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Priority one: rescue the environment.

D. Koshland Jr (1990)
Science 247, 777
 |  PDF »

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