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Science 12 January 1990:
Vol. 247. no. 4939, pp. 217 - 220
DOI: 10.1126/science.2294603
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Articles

Science, Vol 247, Issue 4939, 217-220
Copyright © 1990 by American Association for the Advancement of Science

articles

Target control of collateral extension and directional axon growth in the mammalian brain

CD Heffner, AG Lumsden, and DD O'Leary

Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110.

Individual neurons in the brain send their axons over considerable distances to multiple targets, but the mechanisms governing this process are unresolved. An amenable system for studying axon outgrowth, branching, and target selection is the mammalian corticopontine projection. This major connection develops from parent corticospinal axons that have already grown past the pons, by a delayed interstitial budding of collateral branches that then grow directly into their target, the basilar pons. When cocultured with explants of developing cortex in three-dimensional collagen matrices, the basilar pons elicits the formation and directional growth of cortical axon collaterals across the intervening matrix. This effect appears to be target-specific and selectively influences neurons in the appropriate cortical layer. These in vitro findings provide evidence that the basilar pons becomes innervated by controlling at a distance the budding and directed ingrowth of cortical axon collaterals through the release of a diffusible, chemotropic molecule.


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