Related Content
Search Google Scholar for:
|
|
Science 5 January 1990: Vol. 247. no. 4938, pp. 77 - 79 DOI: 10.1126/science.1688470
|
|
Articles
Science, Vol 247, Issue 4938, 77-79
Copyright © 1990 by American Association for the Advancement of Science
Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides
TE Maione,
GS Gray,
J Petro,
AJ Hunt,
AL Donner,
SI Bauer,
HF Carson,
and
RJ Sharpe
Repligen Corporation, Cambridge, MA 02139.
Recombinant human platelet factor-4 (rhPF4), purified from Escherichia coli, inhibited blood vessel proliferation in the chicken chorioallantoic membrane in a dose-dependent manner. Treatment of several cell types with rhPF4 in vitro suggested that the angiostatic effect was due to specific inhibition of growth factor-stimulated endothelial cell proliferation. The inhibitory activities were associated with the carboxyl-terminal, heparin-binding region of the molecule and could be abrogated by including heparin in the test samples, an indication that sulfated polysaccharides might modulate the angiostatic activity of platelet factor-4 in vivo. Understanding of the mechanisms of control of angiogenesis by endogenous proteins should facilitate the development of effective treatments for diseases of pathogenic neovascularization such as Kaposi's sarcoma, diabetic retinopathy, and malignant tumor growth.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Multifunctional angiogenic factors: add GnRH to the list. Focus on "Gonadotropin-releasing hormone-regulated chemokine expression in human placentation".
- W. J. Pearce (2009)
Am J Physiol Cell Physiol
297, C4-C5
| Full Text »
| PDF »
- Core2 1-6-N-Glucosaminyltransferase-I Deficiency Protects Injured Arteries From Neointima Formation in ApoE-Deficient Mice.
- H. Wang, W. Zhang, R. Tang, R. P. Hebbel, M. A. Kowalska, C. Zhang, J. D. Marth, M. Fukuda, C. Zhu, and Y. Huo (2009)
Arterioscler. Thromb. Vasc. Biol.
29, 1053-1059
| Abstract »
| Full Text »
| PDF »
- Chemokines as Mediators of Neovascularization.
- E. C. Keeley, B. Mehrad, and R. M. Strieter (2008)
Arterioscler. Thromb. Vasc. Biol.
28, 1928-1936
| Abstract »
| Full Text »
| PDF »
- Platelet Granule Secretion Continuously Prevents Intratumor Hemorrhage.
- B. Ho-Tin-Noe, T. Goerge, S. M. Cifuni, D. Duerschmied, and D. D. Wagner (2008)
Cancer Res.
68, 6851-6858
| Abstract »
| Full Text »
| PDF »
- Depletion of {beta}-Arrestin-2 Promotes Tumor Growth and Angiogenesis in a Murine Model of Lung Cancer.
- S. K. Raghuwanshi, M. W. Nasser, X. Chen, R. M. Strieter, and R. M. Richardson (2008)
J. Immunol.
180, 5699-5706
| Abstract »
| Full Text »
| PDF »
- Platelet factor 4/CXCL4-stimulated human monocytes induce apoptosis in endothelial cells by the release of oxygen radicals.
- G. Woller, E. Brandt, J. Mittelstadt, C. Rybakowski, and F. Petersen (2008)
J. Leukoc. Biol.
83, 936-945
| Abstract »
| Full Text »
| PDF »
- In vivo fate and therapeutic efficacy of PF-4/CTF microspheres in an orthotopic human glioblastoma model.
- O. Benny, S.-K. Kim, K. Gvili, I. S. Radzishevsky, A. Mor, L. Verduzco, L. G. Menon, P. M. Black, M. Machluf, and R. S. Carroll (2008)
FASEB J
22, 488-499
| Abstract »
| Full Text »
| PDF »
- Platelets may serve up biomarkers.
- B. S. Sachais (2008)
Blood
111, 974
| Full Text »
| PDF »
- Platelet-associated PF-4 as a biomarker of early tumor growth.
- D. Cervi, T.-T. Yip, N. Bhattacharya, V. N. Podust, J. Peterson, A. Abou-Slaybi, G. N. Naumov, E. Bender, N. Almog, J. E. Italiano Jr, et al. (2008)
Blood
111, 1201-1207
| Abstract »
| Full Text »
| PDF »
- Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet {alpha} granules and differentially released.
- J. E. Italiano Jr, J. L. Richardson, S. Patel-Hett, E. Battinelli, A. Zaslavsky, S. Short, S. Ryeom, J. Folkman, and G. L. Klement (2008)
Blood
111, 1227-1233
| Abstract »
| Full Text »
| PDF »
- Platelet Factor 4 (CXC Chemokine Ligand 4) Differentially Regulates Respiratory Burst, Survival, and Cytokine Expression of Human Monocytes by Using Distinct Signaling Pathways.
- B. Kasper, E. Brandt, S. Brandau, and F. Petersen (2007)
J. Immunol.
179, 2584-2591
| Abstract »
| Full Text »
| PDF »
- Platelet Factor-4 Variant Chemokine CXCL4L1 Inhibits Melanoma and Lung Carcinoma Growth and Metastasis by Preventing Angiogenesis.
- S. Struyf, M. D. Burdick, E. Peeters, K. Van den Broeck, C. Dillen, P. Proost, J. Van Damme, and R. M. Strieter (2007)
Cancer Res.
67, 5940-5948
| Abstract »
| Full Text »
| PDF »
- PF-4/CXCL4 and CXCL4L1 exhibit distinct subcellular localization and a differentially regulated mechanism of secretion.
- L. Lasagni, R. Grepin, B. Mazzinghi, E. Lazzeri, C. Meini, C. Sagrinati, F. Liotta, F. Frosali, E. Ronconi, N. Alain-Courtois, et al. (2007)
Blood
109, 4127-4134
| Abstract »
| Full Text »
| PDF »
- Platelet Factor 4 (CXCL4) Seals Blood Clots by Altering the Structure of Fibrin.
- A. A. Amelot, M. Tagzirt, G. Ducouret, R. L. Kuen, and B. F. Le Bonniec (2007)
J. Biol. Chem.
282, 710-720
| Abstract »
| Full Text »
| PDF »
- Antiangiogenic and Antitumor Activities of IL-27..
- M. Shimizu, M. Shimamura, T. Owaki, M. Asakawa, K. Fujita, M. Kudo, Y. Iwakura, Y. Takeda, A. D. Luster, J. Mizuguchi, et al. (2006)
J. Immunol.
176, 7317-7324
| Abstract »
| Full Text »
| PDF »
- Isolation and Characterization of Vasohibin-2 as a Homologue of VEGF-Inducible Endothelium-Derived Angiogenesis Inhibitor Vasohibin.
- T. Shibuya, K. Watanabe, H. Yamashita, K. Shimizu, H. Miyashita, M. Abe, T. Moriya, H. Ohta, H. Sonoda, T. Shimosegawa, et al. (2006)
Arterioscler. Thromb. Vasc. Biol.
26, 1051-1057
| Abstract »
| Full Text »
| PDF »
- CXC Chemokines in Angiogenesis and Metastases.
- B. N. Gomperts and R. M. Strieter (2006)
Am. Assoc. Cancer Res. Educ. Book
2006, 11-18
| Full Text »
| PDF »
- Neutrophil adhesion to endothelial cells induced by platelet factor 4 requires sequential activation of Ras, Syk, and JNK MAP kinases.
- B. Kasper, E. Brandt, M. Ernst, and F. Petersen (2006)
Blood
107, 1768-1775
| Abstract »
| Full Text »
| PDF »
- Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage.
- J. Kisucka, C. E. Butterfield, D. G. Duda, S. C. Eichenberger, S. Saffaripour, J. Ware, Z. M. Ruggeri, R. K. Jain, J. Folkman, and D. D. Wagner (2006)
PNAS
103, 855-860
| Abstract »
| Full Text »
| PDF »
- Evidence for a Granule Targeting Sequence within Platelet Factor 4.
- N. El.Golli, O. Issertial, J.-P. Rosa, and V. Briquet-Laugier (2005)
J. Biol. Chem.
280, 30329-30335
| Abstract »
| Full Text »
| PDF »
- Application of Plasmid DNA Encoding IL-18 Diminishes Development of Herpetic Stromal Keratitis by Antiangiogenic Effects.
- B. Kim, S. Lee, S. Suvas, and B. T. Rouse (2005)
J. Immunol.
175, 509-516
| Abstract »
| Full Text »
| PDF »
- Endogenous Inhibitors of Angiogenesis.
- P. Nyberg, L. Xie, and R. Kalluri (2005)
Cancer Res.
65, 3967-3979
| Abstract »
| Full Text »
| PDF »
- The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis.
- D. J. Brat, A. C. Bellail, and E. G. Van Meir (2005)
Neuro-oncol
7, 122-133
| Abstract »
| PDF »
- 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice.
- X. Chang, J. C. Tou, C. Hong, H.-A. Kim, J. E. Riby, G. L. Firestone, and L. F. Bjeldanes (2005)
Carcinogenesis
26, 771-778
| Abstract »
| Full Text »
| PDF »
- Platelets and Chemokines in Atherosclerosis: Partners in Crime.
- C. Weber (2005)
Circ. Res.
96, 612-616
| Abstract »
| Full Text »
| PDF »
- Osteoarthritis, angiogenesis and inflammation.
- C. S. Bonnet and D. A. Walsh (2005)
Rheumatology
44, 7-16
| Abstract »
| Full Text »
| PDF »
- BRAK/CXCL14 Is a Potent Inhibitor of Angiogenesis and a Chemotactic Factor for Immature Dendritic Cells.
- T. D. Shellenberger, M. Wang, M. Gujrati, A. Jayakumar, R. M. Strieter, M. D. Burdick, C. G. Ioannides, C. L. Efferson, A. K. El-Naggar, D. Roberts, et al. (2004)
Cancer Res.
64, 8262-8270
| Abstract »
| Full Text »
| PDF »
- Platelets Release CXCL4L1, a Nonallelic Variant of the Chemokine Platelet Factor-4/CXCL4 and Potent Inhibitor of Angiogenesis.
- S. Struyf, M. D. Burdick, P. Proost, J. Van Damme, and R. M. Strieter (2004)
Circ. Res.
95, 855-857
| Abstract »
| Full Text »
| PDF »
- CCL16 activates an angiogenic program in vascular endothelial cells.
- M. Strasly, G. Doronzo, P. Capello, D. Valdembri, M. Arese, S. Mitola, P. Moore, G. Alessandri, M. Giovarelli, and F. Bussolino (2004)
Blood
103, 40-49
| Abstract »
| Full Text »
| PDF »
- Hemostatic Regulators of Tumor Angiogenesis: A Source of Antiangiogenic Agents for Cancer Treatment?.
- M. E. Daly, A. Makris, M. Reed, and C. E. Lewis (2003)
J Natl Cancer Inst
95, 1660-1673
| Abstract »
| Full Text »
| PDF »
- PARC/CCL18 Is a Plasma CC Chemokine with Increased Levels in Childhood Acute Lymphoblastic Leukemia.
- S. Struyf, E. Schutyser, M. Gouwy, K. Gijsbers, P. Proost, Y. Benoit, G. Opdenakker, J. Van Damme, and G. Laureys (2003)
Am. J. Pathol.
163, 2065-2075
| Abstract »
| Full Text »
| PDF »
- Angiosuppressive and Angiostimulatory Effects Exerted by Synthetic Partial Sequences of Endostatin.
- L. Morbidelli, S. Donnini, F. Chillemi, A. Giachetti, and M. Ziche (2003)
Clin. Cancer Res.
9, 5358-5369
| Abstract »
| Full Text »
| PDF »
- Generation and role of angiostatin in human platelets.
- P. Jurasz, D. Alonso, S. Castro-Blanco, F. Murad, and M. W. Radomski (2003)
Blood
102, 3217-3223
| Abstract »
| Full Text »
| PDF »
- Effect of CXC chemokine platelet factor 4 on differentiation and function of monocyte-derived dendritic cells.
- C.-Q. Xia and K.-J. Kao (2003)
Int. Immunol.
15, 1007-1015
| Abstract »
| Full Text »
| PDF »
- Platelet factor 4 enhances generation of activated protein C in vitro and in vivo.
- A. Slungaard, J. A. Fernandez, J. H. Griffin, N. S. Key, J. R. Long, D. J. Piegors, and S. R. Lentz (2003)
Blood
102, 146-151
| Abstract »
| Full Text »
| PDF »
- Platelet factor 4 promotes adhesion of hematopoietic progenitor cells and binds IL-8: novel mechanisms for modulation of hematopoiesis.
- A. Z. Dudek, I. Nesmelova, K. Mayo, C. M. Verfaillie, S. Pitchford, and A. Slungaard (2003)
Blood
101, 4687-4694
| Abstract »
| Full Text »
| PDF »
- An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4.
- L. Lasagni, M. Francalanci, F. Annunziato, E. Lazzeri, S. Giannini, L. Cosmi, C. Sagrinati, B. Mazzinghi, C. Orlando, E. Maggi, et al. (2003)
J. Exp. Med.
197, 1537-1549
| Abstract »
| Full Text »
| PDF »
- Platelet Factor 4 Enhances the Binding of Oxidized Low-density Lipoprotein to Vascular Wall Cells.
- T. Nassar, B. S. Sachais, S.'e. Akkawi, M. A. Kowalska, K. Bdeir, E. Leitersdorf, E. Hiss, L. Ziporen, M. Aviram, D. Cines, et al. (2003)
J. Biol. Chem.
278, 6187-6193
| Abstract »
| Full Text »
| PDF »
- Matrix Metalloproteinases Cleave Connective Tissue Growth Factor and Reactivate Angiogenic Activity of Vascular Endothelial Growth Factor 165.
- G. Hashimoto, I. Inoki, Y. Fujii, T. Aoki, E. Ikeda, and Y. Okada (2002)
J. Biol. Chem.
277, 36288-36295
| Abstract »
| Full Text »
| PDF »
- Inhibition of Prostate Tumor Angiogenesis by the Tumor Suppressor CEACAM1.
- O. Volpert, W. Luo, T.-J. Liu, V. T. Estrera, C. Logothetis, and S.-H. Lin (2002)
J. Biol. Chem.
277, 35696-35702
| Abstract »
| Full Text »
| PDF »
- Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8.
- F. Marti, E. Bertran, M. Llucia, E. Villen, M. Peiro, J. Garcia, and F. Rueda (2002)
J. Leukoc. Biol.
72, 590-597
| Abstract »
| Full Text »
| PDF »
- Dermatan sulfate: new functions from an old glycosaminoglycan.
- J. M. Trowbridge and R. L. Gallo (2002)
Glycobiology
12, 117R-125R
| Abstract »
| Full Text »
| PDF »
- Regulation of Angiogenesis in Diabetic Retinopathy: Possible Balance Between Vascular Endothelial Growth Factor and Endostatin.
- H. Noma, H. Funatsu, H. Yamashita, S. Kitano, H. K. Mishima, and S. Hori (2002)
Arch Ophthalmol
120, 1075-1080
| Abstract »
| Full Text »
| PDF »
- AAV-Mediated Gene Transfer of Pigment Epithelium-Derived Factor Inhibits Choroidal Neovascularization.
- K. Mori, P. Gehlbach, S. Yamamoto, E. Duh, D. J. Zack, Q. Li, K. I. Berns, B. J. Raisler, W. W. Hauswirth, and P. A. Campochiaro (2002)
Invest. Ophthalmol. Vis. Sci.
43, 1994-2000
| Abstract »
| Full Text »
| PDF »
- Eotaxin/CCL11 Suppresses IL-8/CXCL8 Secretion from Human Dermal Microvascular Endothelial Cells.
- S. S. Cheng, N. W. Lukacs, and S. L. Kunkel (2002)
J. Immunol.
168, 2887-2894
| Abstract »
| Full Text »
| PDF »
- Pigment Epithelium-Derived Factor Suppresses Ischemia-Induced Retinal Neovascularization and VEGF-Induced Migration and Growth.
- E. J. Duh, H. S. Yang, I. Suzuma, M. Miyagi, E. Youngman, K. Mori, M. Katai, L. Yan, K. Suzuma, K. West, et al. (2002)
Invest. Ophthalmol. Vis. Sci.
43, 821-829
| Abstract »
| Full Text »
| PDF »
- Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus.
- C. Zhang, M. A. Thornton, M. A. Kowalska, B. S. Sachis, M. Feldman, M. Poncz, S. E. McKenzie, and M. P. Reilly (2001)
Blood
98, 610-617
| Abstract »
| Full Text »
| PDF »
- Inhibition of Choroidal Neovascularization by Intravenous Injection of Adenoviral Vectors Expressing Secretable Endostatin.
- K. Mori, A. Ando, P. Gehlbach, D. Nesbitt, K. Takahashi, D. Goldsteen, M. Penn, C. T. Chen, K. Mori, M. Melia, et al. (2001)
Am. J. Pathol.
159, 313-320
| Abstract »
| Full Text »
| PDF »
- Identification of a blood-derived chemoattractant for neutrophils and lymphocytes as a novel CC chemokine, Regakine-1.
- S. Struyf, P. Proost, J.-P. Lenaerts, G. Stoops, A. Wuyts, and J. Van Damme (2001)
Blood
97, 2197-2204
| Abstract »
| Full Text »
| PDF »
- Radiation Therapy to a Primary Tumor Accelerates Metastatic Growth in Mice.
- K. Camphausen, M. A. Moses, W.-D. Beecken, M. K. Khan, J. Folkman, and M. S. OReilly (2001)
Cancer Res.
61, 2207-2211
| Abstract »
| Full Text »
- HGF/NK4, a Four-Kringle Antagonist of Hepatocyte Growth Factor, Is an Angiogenesis Inhibitor that Suppresses Tumor Growth and Metastasis in Mice.
- K. Kuba, K. Matsumoto, K. Date, H. Shimura, M. Tanaka, and T. Nakamura (2000)
Cancer Res.
60, 6737-6743
| Abstract »
| Full Text »
- The CXC Chemokine Receptor 2, CXCR2, Is the Putative Receptor for ELR+ CXC Chemokine-Induced Angiogenic Activity.
- C. L. Addison, T. O. Daniel, M. D. Burdick, H. Liu, J. E. Ehlert, Y. Y. Xue, L. Buechi, A. Walz, A. Richmond, and R. M. Strieter (2000)
J. Immunol.
165, 5269-5277
| Abstract »
| Full Text »
| PDF »
- The Antiangiogenic Factor 16K PRL Induces Programmed Cell Death in Endothelial Cells by Caspase Activation.
- J.-F. Martini, C. Piot, L. M. Humeau, I. Struman, J. A. Martial, and R. I. Weiner (2000)
Mol. Endocrinol.
14, 1536-1549
| Abstract »
| Full Text »
- CXC chemokines in angiogenesis.
- J. A. Belperio, M. P. Keane, D. A. Arenberg, C. L. Addison, J. E. Ehlert, M. D. Burdick, and R. M. Strieter (2000)
J. Leukoc. Biol.
68, 1-8
| Abstract »
| Full Text »
- Bactericidal/permeability-increasing protein (BPI) inhibits angiogenesis via induction of apoptosis in vascular endothelial cells.
- D. W. J. van der Schaft, E. A. H. Toebes, J. R. Haseman, K. H. Mayo, and A. W. Griffioen (2000)
Blood
96, 176-181
| Abstract »
| Full Text »
| PDF »
- Chemokine receptors and their role in inflammation and infectious diseases.
- C. Murdoch and A. Finn (2000)
Blood
95, 3032-3043
| Abstract »
| Full Text »
| PDF »
- B cell- and monocyte-activating chemokine (BMAC), a novel non-ELR {alpha}-chemokine.
- M. A. Sleeman, J. K. Fraser, J. G. Murison, S. L. Kelly, R. L. Prestidge, D. J. Palmer, J. D. Watson, and K. D. Kumble (2000)
Int. Immunol.
12, 677-689
| Abstract »
| Full Text »
| PDF »
- Antiangiogenic Strategies and Agents in Clinical Trials.
- L. Rosen (2000)
Oncologist
5, 20-27
| Abstract »
| Full Text »
- Lipopolysaccharide Inhibits HIV-1 Infection of Monocyte- Derived Macrophages Through Direct and Sustained Down-Regulation of CC Chemokine Receptor 5.
- G. Franchin, G. Zybarth, W. W. Dai, L. Dubrovsky, N. Reiling, H. Schmidtmayerova, M. Bukrinsky, and B. Sherry (2000)
J. Immunol.
164, 2592-2601
| Abstract »
| Full Text »
| PDF »
- The Hemostatic System as a Regulator of Angiogenesis.
- T. Browder, J. Folkman, and S. Pirie-Shepherd (2000)
J. Biol. Chem.
275, 1521-1524
| Full Text »
| PDF »
- Interleukin-18 acts as an angiogenesis and tumor suppressor.
- R. CAO, J. FARNEBO, M. KURIMOTO, and Y. CAO (1999)
FASEB J
13, 2195-2202
| Abstract »
| Full Text »
- Regulation of Angiostatin Production by Matrix Metalloproteinase-2 in a Model of Concomitant Resistance.
- M. S. O'Reilly, D. Wiederschain, W. G. Stetler-Stevenson, J. Folkman, and M. A. Moses (1999)
J. Biol. Chem.
274, 29568-29571
| Abstract »
| Full Text »
| PDF »
- Angiogenesis inhibitor endostatin is a distinct component of elastic fibers in vessel walls.
- N. MIOSGE, T. SASAKI, and R. TIMPL (1999)
FASEB J
13, 1743-1750
| Abstract »
| Full Text »
- Antiangiogenic Activity of the Cleaved Conformation of the Serpin Antithrombin.
- M. S. O'Reilly, S. Pirie-Shepherd, W. S. Lane, and J. Folkman (1999)
Science
285, 1926-1928
| Abstract »
| Full Text »
- Expression of CCR2 by Endothelial Cells : Implications for MCP-1 Mediated Wound Injury Repair and In Vivo Inflammatory Activation of Endothelium.
- K. S. C. Weber, P. J. Nelson, H.-J. Grone, and C. Weber (1999)
Arterioscler. Thromb. Vasc. Biol.
19, 2085-2093
| Abstract »
| Full Text »
| PDF »
- A Novel Disintegrin Salmosin Inhibits Tumor Angiogenesis.
- I.-C. Kang, Y.-D. Lee, and D.-S. Kim (1999)
Cancer Res.
59, 3754-3760
| Abstract »
| Full Text »
| PDF »
- Inhibition of In Vitro Angiogenesis by Platelet Factor-4-Derived Peptides and Mechanism of Action.
- V. Jouan, X. Canron, M. Alemany, J. P. Caen, G. Quentin, J. Plouet, and A. Bikfalvi (1999)
Blood
94, 984-993
| Abstract »
| Full Text »
| PDF »
- 16K Human Prolactin Inhibits Vascular Endothelial Growth Factor-Induced Activation of Ras in Capillary Endothelial Cells.
- G. DAngelo, J.-F. Martini, T. Iiri, W. J. Fantl, J. Martial, and R. I. Weiner (1999)
Mol. Endocrinol.
13, 692-704
| Abstract »
| Full Text »
- Glypican-1 Is a VEGF165 Binding Proteoglycan That Acts as an Extracellular Chaperone for VEGF165.
- S. Gengrinovitch, B. Berman, G. David, L. Witte, G. Neufeld, and D. Ron (1999)
J. Biol. Chem.
274, 10816-10822
| Abstract »
| Full Text »
| PDF »
- Endostatin: Yeast Production, Mutants, and Antitumor Effect in Renal Cell Carcinoma.
- M. Dhanabal, R. Ramchandran, R. Volk, I. E. Stillman, M. Lombardo, M. L. Iruela-Arispe, M. Simons, and V. P. Sukhatme (1999)
Cancer Res.
59, 189-197
| Abstract »
| Full Text »
| PDF »
- Inhibition of Human Umbilical Vein Endothelial Cell Proliferation by the CXC Chemokine, Platelet Factor 4 (PF4), Is Associated With Impaired Downregulation of p21Cip1/WAF1.
- G. Gentilini, N. E. Kirschbaum, J. A. Augustine, R. H. Aster, and G. P. Visentin (1999)
Blood
93, 25-33
| Abstract »
| Full Text »
| PDF »
- Vasostatin, a Calreticulin Fragment, Inhibits Angiogenesis and Suppresses Tumor Growth.
- S. E. Pike, L. Yao, K. D. Jones, B. Cherney, E. Appella, K. Sakaguchi, H. Nakhasi, J. Teruya-Feldstein, P. Wirth, G. Gupta, et al. (1998)
J. Exp. Med.
188, 2349-2356
| Abstract »
| Full Text »
| PDF »
- SPARC (BM-40, Osteonectin) Inhibits the Mitogenic Effect of Vascular Endothelial Growth Factor on Microvascular Endothelial Cells.
- C. Kupprion, K. Motamed, and E. H. Sage (1998)
J. Biol. Chem.
273, 29635-29640
| Abstract »
| Full Text »
| PDF »
- Platelet Factor 4 Modulates Fibroblast Growth Factor 2 (FGF-2) Activity and Inhibits FGF-2 Dimerization.
- C. Perollet, Z. C. Han, C. Savona, J. P. Caen, and A. Bikfalvi (1998)
Blood
91, 3289-3299
| Abstract »
| Full Text »
| PDF »
- New Insights Into the Negative Regulation of Hematopoiesis by Chemokine Platelet Factor 4 and Related Peptides.
- L. Lecomte-Raclet, M. Alemany, A. S.-L. Grand, J. Amiral, G. Quentin, A. M. Vissac, J. P. Caen, and Z. C. Han (1998)
Blood
91, 2772-2780
| Abstract »
| Full Text »
| PDF »
- Noncompetitive, Chemokine-mediated Inhibition of Basic Fibroblast Growth Factor-induced Endothelial Cell Proliferation.
- M. Presta, M. Belleri, A. Vecchi, J. Hesselgesser, A. Mantovani, and R. Horuk (1998)
J. Biol. Chem.
273, 7911-7919
| Abstract »
| Full Text »
| PDF »
- Chemokine Receptors in Human Endothelial Cells. FUNCTIONAL EXPRESSION OF CXCR4 AND ITS TRANSCRIPTIONAL REGULATION BY INFLAMMATORY CYTOKINES.
- S. K. Gupta, P. G. Lysko, K. Pillarisetti, E. Ohlstein, and J. M. Stadel (1998)
J. Biol. Chem.
273, 4282-4287
| Abstract »
| Full Text »
| PDF »
- A Ubiquitin-specific Protease That Efficiently Cleaves the Ubiquitin-Proline Bond.
- C. A. Gilchrist, D. A. Gray, and R. T. Baker (1997)
J. Biol. Chem.
272, 32280-32285
| Abstract »
| Full Text »
| PDF »
- Identification of Chondromodulin I as a Novel Endothelial Cell Growth Inhibitor. PURIFICATION AND ITS LOCALIZATION IN THE AVASCULAR ZONE OF EPIPHYSEAL CARTILAGE.
- Y. Hiraki, H. Inoue, K.-i. Iyama, A. Kamizono, M. Ochiai, C. Shukunami, S. Iijima, F. Suzuki, and J. Kondo (1997)
J. Biol. Chem.
272, 32419-32426
| Abstract »
| Full Text »
| PDF »
- Specific Binding of the Chemokine Platelet Factor 4 to Heparan Sulfate.
- S. E. Stringer and J. T. Gallagher (1997)
J. Biol. Chem.
272, 20508-20514
| Abstract »
| Full Text »
| PDF »
- Chemokines.
- B. J. Rollins (1997)
Blood
90, 909-928
| Full Text »
| PDF »
- Cloning and Characterization of a Novel Murine beta Chemokine Receptor, D6. COMPARISON TO THREE OTHER RELATED MACROPHAGE INFLAMMATORY PROTEIN-1alpha RECEPTORS, CCR-1, CCR-3, AND CCR-5.
- R. J. B. Nibbs, S. M. Wylie, I. B. Pragnell, and G. J. Graham (1997)
J. Biol. Chem.
272, 12495-12504
| Abstract »
| Full Text »
| PDF »
- Biological Roles of Fibroblast Growth Factor-2.
- A. Bikfalvi, S. Klein, G. Pintucci, and D. B. Rifkin (1997)
Endocr. Rev.
18, 26-45
| Abstract »
| Full Text »
- Interferon-inducible protein-10 identified as a mediator of tumor necrosis in vivo.
- C. Sgadari, A. L. Angiolillo, B. W. Cherney, S. E. Pike, J. M. Farber, L. G. Koniaris, P. Vanguri, P. R. Burd, N. Sheikh, G. Gupta, et al. (1996)
PNAS
93, 13791-13796
| Abstract »
| Full Text »
| PDF »
- Kringle Domains of Human Angiostatin. CHARACTERIZATION OF THE ANTI-PROLIFERATIVE ACTIVITY ON ENDOTHELIAL CELLS.
- Y. Cao, RichardW. Ji, D. Davidson, J. Schaller, D. Marti, S. Sohndel, StephenG. McCance, MichaelS. O'Reilly, M. Llinas, and J. Folkman (1996)
J. Biol. Chem.
271, 29461-29467
| Abstract »
| Full Text »
| PDF »
- Review : Angiogenesis: A new target for antineoplastic therapy.
- K. R. Dover and A. W. Valley (1996)
Journal of Oncology Pharmacy Practice
2, 43-60
| Abstract »
| PDF »
- The Functional Role of the ELR Motif in CXC Chemokine-mediated Angiogenesis.
- R. M. Strieter, P. J. Polverini, S. L. Kunkel, D. A. Arenberg, M. D. Burdick, J. Kasper, J. Dzuiba, J. Van Damme, A. Walz, D. Marriott, et al. (1995)
J. Biol. Chem.
270, 27348-27357
| Abstract »
| Full Text »
| PDF »
- High Activity Suppression of Myeloid Progenitor Proliferation by Chimeric Mutants of Interleukin 8 and Platelet Factor 4.
- T. J. Daly, G. J. LaRosa, S. Dolich, T. E. Maione, S. Cooper, and H. E. Broxmeyer (1995)
J. Biol. Chem.
270, 23282-23292
| Abstract »
| Full Text »
| PDF »
- Replacing a Surface Loop Endows Ribonuclease A with Angiogenic Activity.
- R. T. Raines, M. P. Toscano, D. M. Nierengarten, J. H. Ha, and R. Auerbach (1995)
J. Biol. Chem.
270, 17180-17184
| Abstract »
| Full Text »
| PDF »
- Platelet Factor-4 Inhibits the Mitogenic Activity of VEGF[IMAGE] and VEGF[IMAGE] Using Several Concurrent Mechanisms.
- S. Gengrinovitch, S. M. Greenberg, T. Cohen, H. Gitay-Goren, P. Rockwell, T. E. Maione, B.-Z. Levi, and G. Neufeld (1995)
J. Biol. Chem.
270, 15059-15065
| Abstract »
| Full Text »
| PDF »
- Recombinant platelet factor 4 reversal of heparin in human cardiopulmonary bypass blood.
- R. D. Williams, M. N. D'Ambra, T. E. Maione, K. E. Lynch, and D. F. Keene (1994)
J. Thorac. Cardiovasc. Surg.
108, 975-983
| Abstract »
| Full Text »
- Angiostatin: A Circulating Endothelial Cell Inhibitor That Suppresses Angiogenesis and Tumor Growth.
- M.S. O'Reilly, L. Holmgren, Y. Shing, C. Chen, R.A. Rosenthal, Y. Cao, M. Moses, W.S. Lane, E.H. Sage, and J. Folkman (1994)
Cold Spring Harb Symp Quant Biol
59, 471-482
| Abstract »
| PDF »
- Interleukin-8 as a macrophage-derived mediator of angiogenesis.
- A. Koch, P. Polverini, S. Kunkel, L. Harlow, L. DiPietro, V. Elner, S. Elner, and R. Strieter (1992)
Science
258, 1798-1801
| Abstract »
| PDF »
- Inhibition of development of Kaposi's sarcoma-related lesions by a bacterial cell wall complex.
- S Nakamura, S Sakurada, S. Salahuddin, Y Osada, N. Tanaka, N Sakamoto, M Sekiguchi, and R. Gallo (1992)
Science
255, 1437-1440
| Abstract »
| PDF »
- Identification of an inhibitor of neovascularization from cartilage.
- M. Moses, J Sudhalter, and R Langer (1990)
Science
248, 1408-1410
| Abstract »
| PDF »
- Distinct Antitumor Properties of a Type IV Collagen Domain Derived from Basement Membrane.
- Y. Maeshima, P. C. Colorado, A. Torre, K. A. Holthaus, J. A. Grunkemeyer, M. B. Ericksen, H. Hopfer, Y. Xiao, I. E. Stillman, and R. Kalluri (2000)
J. Biol. Chem.
275, 21340-21348
| Abstract »
| Full Text »
| PDF »
- Solution Structure and Interaction with Basic and Acidic Fibroblast Growth Factor of a 3-kDa Human Platelet Factor-4 Fragment with Antiangiogenic Activity.
- R. M. Lozano, M. Redondo-Horcajo, M. A. Jimenez, L. Zilberberg, P. Cuevas, A. Bikfalvi, M. Rico, and G. Gimenez-Gallego (2001)
J. Biol. Chem.
276, 35723-35734
| Abstract »
| Full Text »
| PDF »
- Mechanisms of normal and tumor-derived angiogenesis.
- M. Papetti and I. M. Herman (2002)
Am J Physiol Cell Physiol
282, C947-C970
| Abstract »
| Full Text »
| PDF »
|
|