Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 22 December 1989:
Vol. 246. no. 4937, pp. 1632 - 1634
DOI: 10.1126/science.2480644
Prev | Table of Contents | Next

Articles

Science, Vol 246, Issue 4937, 1632-1634
Copyright © 1989 by American Association for the Advancement of Science

articles

RNA editing in plant mitochondria

R Hiesel, B Wissinger, W Schuster, and A Brennicke

Institut fur Genbiologische Forschung, Berlin, Federal Republic of Germany.

Comparative sequence analysis of genomic and complementary DNA clones from several mitochondrial genes in the higher plant Oenothera revealed nucleotide sequence divergences between the genomic and the messenger RNA-derived sequences. These sequence alterations could be most easily explained by specific post-transcriptional nucleotide modifications. Most of the nucleotide exchanges in coding regions lead to altered codons in the mRNA that specify amino acids better conserved in evolution than those encoded by the genomic DNA. Several instances show that the genomic arginine codon CGG is edited in the mRNA to the tryptophan codon TGG in amino acid positions that are highly conserved as tryptophan in the homologous proteins of other species. This editing suggests that the standard genetic code is used in plant mitochondria and resolves the frequent coincidence of CGG codons and tryptophan in different plant species. The apparently frequent and non-species-specific equivalency of CGG and TGG codons in particular suggests that RNA editing is a common feature of all higher plant mitochondria.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The PREP suite: predictive RNA editors for plant mitochondrial genes, chloroplast genes and user-defined alignments.
J. P. Mower (2009)
Nucleic Acids Res. 37, W253-W259
   Abstract »    Full Text »    PDF »
Organellar RNA Editing and Plant-Specific Extensions of Pentatricopeptide Repeat Proteins in Jungermanniid but not in Marchantiid Liverworts.
M. Rudinger, M. Polsakiewicz, and V. Knoop (2008)
Mol. Biol. Evol. 25, 1405-1414
   Abstract »    Full Text »    PDF »
Modeling Sites of RNA Editing as a Fifth Nucleotide State Reveals Progressive Loss of Edited Sites from Angiosperm Mitochondria.
J. P. Mower (2008)
Mol. Biol. Evol. 25, 52-61
   Abstract »    Full Text »    PDF »
Computational Analysis of RNA Editing Sites in Plant Mitochondrial Genomes Reveals Similar Information Content and a Sporadic Distribution of Editing Sites.
R. M. Mulligan, K. L. C. Chang, and C. C. Chou (2007)
Mol. Biol. Evol. 24, 1971-1981
   Abstract »    Full Text »    PDF »
Rapid evolution of RNA editing sites in a small non-essential plastid gene.
A. Fiebig, S. Stegemann, and R. Bock (2004)
Nucleic Acids Res. 32, 3615-3622
   Abstract »    Full Text »    PDF »
Surprising features of plastid ndhD transcripts: addition of non-encoded nucleotides and polysome association of mRNAs with an unedited start codon.
A. Zandueta-Criado and R. Bock (2004)
Nucleic Acids Res. 32, 542-550
   Abstract »    Full Text »    PDF »
RNA editing in hornwort chloroplasts makes more than half the genes functional.
M. Kugita, Y. Yamamoto, T. Fujikawa, T. Matsumoto, and K. Yoshinaga (2003)
Nucleic Acids Res. 31, 2417-2423
   Abstract »    Full Text »    PDF »
Recognition of RNA Editing Sites Is Directed by Unique Proteins in Chloroplasts: Biochemical Identification of cis-Acting Elements and trans-Acting Factors Involved in RNA Editing in Tobacco and Pea Chloroplasts.
T. Miyamoto, J. Obokata, and M. Sugiura (2002)
Mol. Cell. Biol. 22, 6726-6734
   Abstract »    Full Text »    PDF »
cis Recognition Elements in Plant Mitochondrion RNA Editing.
J.-C. Farre, G. Leon, X. Jordana, and A. Araya (2001)
Mol. Cell. Biol. 21, 6731-6737
   Abstract »    Full Text »    PDF »
RNA editing in Arabidopsis mitochondria effects 441 C to U changes in ORFs.
P. Giege and A. Brennicke (1999)
PNAS 96, 15324-15329
   Abstract »    Full Text »    PDF »
Transfer of plastid RNA-editing activity to novel sites suggests a critical role for spacing in editing-site recognition.
M. Hermann and R. Bock (1999)
PNAS 96, 4856-4861
   Abstract »    Full Text »    PDF »
Secondary Structure for the Apolipoprotein B mRNA Editing Site. AU-BINDING PROTEINS INTERACT WITH A STEM LOOP.
N. Richardson, N. Navaratnam, and J. Scott (1998)
J. Biol. Chem. 273, 31707-31717
   Abstract »    Full Text »    PDF »
Occurrence of plastid RNA editing in all major lineages of land plants.
R. Freyer, M.-C. Kiefer-Meyer, and H. Kossel (1997)
PNAS 94, 6285-6290
   Abstract »    Full Text »    PDF »
RNA Editing Is Required for Efficient Excision of tRNA[IMAGE] from Precursors in Plant Mitochondria.
A. Marchfelder, A. Brennicke, and S. Binder (1996)
J. Biol. Chem. 271, 1898-1903
   Abstract »    Full Text »    PDF »
Evidence for a Site-specific Cytidine Deamination Reaction Involved in C to U RNA Editing of Plant Mitochondria.
W. Yu and W. Schuster (1995)
J. Biol. Chem. 270, 18227-18233
   Abstract »    Full Text »    PDF »
Editing of transfer RNAs in Acanthamoeba castellanii mitochondria.
K. Lonergan and M. Gray (1993)
Science 259, 812-816
   Abstract »    PDF »
Multiple trans-splicing events are required to produce a mature nad1 transcript in a plant mitochondrion..
P L Conklin, R K Wilson, and M R Hanson (1991)
Genes & Dev. 5, 1407-1415
   Abstract »    PDF »
The Texas Cytoplasm of Maize: Cytoplasmic Male Sterility and Disease Susceptibility.
C. S. Levings III (1990)
Science 250, 942-947
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)